$255+ Cheap flights from O'Hare Intl (ORD) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — SCL
Mar 5 — Mar 121
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from O'Hare Intl to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from O'Hare Intl to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from O'Hare Intl to SantiagoExplore the most affordable flight options available from O'Hare Intl to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from O'Hare Intl to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This LATAM Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:15 pm
ORD
- SCL
1 stop17h 00m
LATAM Airlines
Sun 8/238:40 pm
SCL
- ORD
1 stop14h 24m
LATAM Airlines
Deal found 2/1![LATAM Airlines logo]()
$597
This KAYAK deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:44 am
ORD
- SCL
2 stops19h 16m
LATAM Airlines
Mon 6/811:00 pm
SCL
- ORD
2 stops16h 20m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$602
This Copa Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:02 am
ORD
- SCL
1 stop14h 24m
Copa Airlines
Sun 6/712:01 am
SCL
- ORD
1 stop15h 05m
Copa Airlines
Deal found 2/2![Copa Airlines logo]()
$605
This Mytrip deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:17 am
ORD
- SCL
2 stops25h 22m
Multiple Airlines
Wed 3/2511:24 am
SCL
- ORD
3 stops28h 52m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$611
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:20 pm
ORD
- SCL
1 stop35h 30m
United Airlines
Sun 3/229:45 pm
SCL
- ORD
1 stop28h 14m
United Airlines
Deal found 1/31![United Airlines logo]()
$614
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/166:45 am
ORD
- SCL
1 stop21h 55m
LATAM Airlines
Sun 2/227:15 am
SCL
- ORD
3 stops36h 35m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$617
This Travelocity deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:59 pm
ORD
- SCL
2 stops58h 46m
LATAM Airlines
Sat 3/2110:35 am
SCL
- ORD
2 stops25h 25m
LATAM Airlines
Deal found 1/31![LATAM Airlines logo]()
$622
This Orbitz deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:53 pm
ORD
- SCL
2 stops41h 37m
Multiple Airlines
Tue 3/107:25 am
SCL
- ORD
1 stop15h 55m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$623
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:59 pm
ORD
- SCL
2 stops34h 36m
Multiple Airlines
Sat 6/610:55 pm
SCL
- ORD
1 stop35h 53m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$625
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/191:37 pm
ORD
- SCL
1 stop14h 18m
Multiple Airlines
Sun 3/299:15 pm
SCL
- ORD
2 stops38h 35m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$626
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/191:37 pm
ORD
- SCL
1 stop14h 18m
Multiple Airlines
Sun 3/2210:35 am
SCL
- ORD
1 stop24h 08m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$627
Best flights from O'Hare Intl to SantiagoDiscover carefully curated flight deals from O'Hare Intl to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from O'Hare Intl to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This KAYAK deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:00 am
ORD
- SCL
2 stops30h 35m
LATAM Airlines
Sun 8/911:05 pm
SCL
- ORD
2 stops25h 52m
LATAM Airlines
Deal found 2/1![LATAM Airlines logo]()
$597
This Copa Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:02 am
ORD
- SCL
1 stop14h 24m
Copa Airlines
Sun 6/712:01 am
SCL
- ORD
1 stop15h 05m
Copa Airlines
Deal found 2/2![Copa Airlines logo]()
$605
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:20 pm
ORD
- SCL
1 stop35h 30m
United Airlines
Sun 3/229:45 pm
SCL
- ORD
1 stop28h 14m
United Airlines
Deal found 1/31![United Airlines logo]()
$614
This Mytrip deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:01 pm
ORD
- SCL
3 stops33h 13m
Multiple Airlines
Wed 3/2511:24 am
SCL
- ORD
3 stops28h 52m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$616
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/12:24 pm
ORD
- SCL
1 stop15h 26m
American Airlines
Sun 8/98:30 pm
SCL
- ORD
1 stop16h 06m
American Airlines
Deal found 2/2![American Airlines logo]()
$671
This Travelocity deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:59 pm
ORD
- SCL
2 stops58h 46m
LATAM Airlines
Sat 3/2110:35 am
SCL
- ORD
2 stops25h 25m
LATAM Airlines
Deal found 1/31![LATAM Airlines logo]()
$622
This Copa Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:02 am
ORD
- SCL
1 stop14h 24m
Copa Airlines
Fri 6/124:09 am
SCL
- ORD
1 stop22h 06m
Copa Airlines
Deal found 2/1![Copa Airlines logo]()
$622
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/191:37 pm
ORD
- SCL
1 stop14h 18m
Multiple Airlines
Sun 3/2210:35 am
SCL
- ORD
1 stop24h 08m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$627
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:10 pm
ORD
- SCL
2 stops38h 29m
Multiple Airlines
Sun 3/2210:35 am
SCL
- ORD
1 stop24h 08m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$655
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:00 am
ORD
- SCL
2 stops28h 40m
Multiple Airlines
Wed 3/1111:24 am
SCL
- ORD
3 stops31h 32m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$658
Last-minute flights from O'Hare Intl to SantiagoDiscover last-minute flight deals from O'Hare Intl to Santiago. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from O'Hare Intl to Santiago. Data last updated February 3, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/166:45 am
ORD
- SCL
1 stop21h 55m
LATAM Airlines
Sun 2/227:15 am
SCL
- ORD
3 stops36h 35m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$617
This Orbitz deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:53 pm
ORD
- SCL
2 stops41h 37m
Multiple Airlines
Tue 3/107:25 am
SCL
- ORD
1 stop15h 55m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$623
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:00 am
ORD
- SCL
2 stops28h 40m
Multiple Airlines
Wed 3/1111:24 am
SCL
- ORD
2 stops25h 53m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$637
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:20 pm
ORD
- SCL
1 stop35h 30m
United Airlines
Sun 3/229:45 pm
SCL
- ORD
1 stop28h 14m
United Airlines
Deal found 1/31![United Airlines logo]()
$614
This Travelocity deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:59 pm
ORD
- SCL
2 stops58h 46m
LATAM Airlines
Sat 3/2110:35 am
SCL
- ORD
2 stops25h 25m
LATAM Airlines
Deal found 1/31![LATAM Airlines logo]()
$622
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:10 pm
ORD
- SCL
2 stops38h 29m
Multiple Airlines
Sun 3/2210:35 am
SCL
- ORD
1 stop24h 08m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$655
This Mytrip deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:17 am
ORD
- SCL
2 stops25h 22m
Multiple Airlines
Wed 3/2511:24 am
SCL
- ORD
3 stops28h 52m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$611
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/191:37 pm
ORD
- SCL
1 stop14h 18m
Multiple Airlines
Sun 3/299:15 pm
SCL
- ORD
2 stops38h 35m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$626
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/191:37 pm
ORD
- SCL
1 stop14h 18m
Multiple Airlines
Sun 3/2210:35 am
SCL
- ORD
1 stop24h 08m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$627
One-way flights from O'Hare Intl to SantiagoSearch for one-way flight options from O'Hare Intl to Santiago. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from O'Hare Intl to Santiago. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/184:51 pm
ORD
- SCL
2 stops27h 24m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$255
This Avianca deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2311:20 pm
ORD
- SCL
1 stop14h 00m
Avianca
Deal found 2/1![Avianca logo]()
$263
This LATAM Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/182:38 pm
ORD
- SCL
3 stops21h 32m
LATAM Airlines
Deal found 1/31![LATAM Airlines logo]()
$267
This LATAM Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/155:30 am
ORD
- SCL
2 stops22h 25m
LATAM Airlines
Deal found 2/1![LATAM Airlines logo]()
$278
This deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:20 pm
ORD
- SCL
1 stop13h 55m
Avianca
Deal found 2/2![Avianca logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/235:01 am
ORD
- SCL
3 stops22h 13m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$322
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/1510:55 am
ORD
- SCL
3 stops23h 05m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$338
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1510:17 am
ORD
- SCL
2 stops17h 28m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/117:35 am
ORD
- SCL
1 stop22h 15m
United Airlines
Deal found 2/1![United Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/199:48 am
ORD
- SCL
1 stop18h 52m
Delta
Deal found 2/3![Delta logo]()
$381
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:45 am
ORD
- SCL
1 stop24h 05m
United Airlines
Deal found 2/1![United Airlines logo]()
$396
Find flight deals from O'Hare Intl to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $536 (Booking.com) |
One-way from | $255 (Kiwi.com) |
Popular in | August |
Cheapest in | April |
Average price | $811 |
Cheapflights Fare Finder
Customize your flight search to find flights from O'Hare Intl to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Santiago that are best for you.
Fly from
O'Hare Intl
Fly to
Santiago
Route
Depart
Return
Price
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Sat 8/1
6:00 am-1:35 pm
2 stops30h 35m
Santiago Arturo Merino Benitez
Sun 8/9
11:05 pm-11:57 pm
2 stops25h 52m
$597
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Mon 6/1
8:02 am-11:26 pm
1 stop14h 24m
Santiago Arturo Merino Benitez
Sun 6/7
12:01 am-2:06 pm
1 stop15h 05m
$605
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Fri 3/13
6:20 pm-7:50 am
1 stop35h 30m
Santiago Arturo Merino Benitez
Sun 3/22
9:45 pm-11:59 pm
1 stop28h 14m
$614
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Wed 3/18
6:01 pm-5:14 am
3 stops33h 13m
Santiago Arturo Merino Benitez
Wed 3/25
11:24 am-2:16 pm
3 stops28h 52m
$616
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Fri 3/13
5:59 pm-6:45 am
2 stops58h 46m
Santiago Arturo Merino Benitez
Sat 3/21
10:35 am-10:00 am
2 stops25h 25m
$622
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Fri 6/5
8:02 am-11:26 pm
1 stop14h 24m
Santiago Arturo Merino Benitez
Fri 6/12
4:09 am-1:15 am
1 stop22h 06m
$622
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Thu 3/19
1:37 pm-5:55 am
1 stop14h 18m
Santiago Arturo Merino Benitez
Sun 3/22
10:35 am-8:43 am
1 stop24h 08m
$627
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Fri 3/13
6:10 pm-10:39 am
2 stops38h 29m
Santiago Arturo Merino Benitez
Sun 3/22
10:35 am-8:43 am
1 stop24h 08m
$655
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Wed 3/4
7:00 am-2:40 pm
2 stops28h 40m
Santiago Arturo Merino Benitez
Wed 3/11
11:24 am-4:56 pm
3 stops31h 32m
$658
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Sat 8/1
2:24 pm-6:50 am
1 stop15h 26m
Santiago Arturo Merino Benitez
Sun 8/9
8:30 pm-11:36 am
1 stop16h 06m
$671
Showing 1-10 of 21 results
Compare providers for flights from O'Hare Intl to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from O'Hare Intl to Santiago in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy2 stars | Trust Score*2 stars |
- Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Chicago O'Hare Intl Airport-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from O'Hare Intl to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from O'Hare Intl with our price prediction graph.
ORD-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago O'Hare Intl Airport to Santiago
Prices
Delays
More
How far ahead should I book a flight from Chicago O'Hare Intl Airport to Santiago?
Use this chart to determine the optimal time to book a round-trip flight from O'Hare Intl to Santiago. Price data was last updated on January 30, 2026.
The price you pay for your flight from Chicago O'Hare Intl Airport to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 38 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Santiago?
Currently, February is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Santiago (average of $419). Flying from Chicago O'Hare Intl Airport to Santiago in August is currently the most expensive (average of $890). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How often are flights from Chicago to Santiago delayed?
About 0% of weekly flights between Chicago and Santiago have experienced delays in the past year, with the average delay time being 0 minutes.
What is the most punctual flight time for Chicago to Santiago flights?
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the evening tend to experience delays more often.
What’s the top layover airport for flights from Chicago O'Hare Intl Airport to Santiago?
Share of 1-stop round-trip flights from Chicago O'Hare Intl Airport to Santiago chosen by Cheapflights users in the past 12 months, using the same layover each way.
Panama City (PTY) – chosen by Cheapflights users on 80% of 1-stop itineraries from Chicago O'Hare Intl Airport to Santiago on Cheapflights.
What’s the cheapest layover airport for flights from Chicago O'Hare Intl Airport to Santiago?
Average round-trip fare for 1-stop flights from Chicago O'Hare Intl Airport to Santiago, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Panama City (PTY) is the most affordable 1-stop option, with an average round-trip price of $667.
What’s the fastest layover option from Chicago O'Hare Intl Airport to Santiago?
Shortest average travel time for 1-stop one-way flights from Chicago O'Hare Intl Airport to Santiago, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Bogotá (BOG) have the shortest average one-way travel time for 1-stop routes: 12h 40m.
Which airport typically offers the quickest layover for flights from Chicago O'Hare Intl Airport to Santiago?
Average layover duration for 1-stop one-way flights from Chicago O'Hare Intl Airport to Santiago, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Panama City (PTY) offer the fastest connection on this route, with an average layover time of 1h 24m.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated February 3, 2026.
See what other customers who have flown with Copa Airlines, LATAM Airlines, and United Airlines from Chicago O'Hare Intl Airport to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.8
Boarding
7.8
Crew
8.1
Overall
7.6
Comfort
7.4
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Food
6.8
Boarding
7.8
Crew
8.1
Overall
7.6
Comfort
7.4
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Food
6.8
Boarding
7.8
Crew
8.1
Overall
7.6
Comfort
7.4
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Food
6.8
Boarding
7.8
Crew
8.1
Overall
7.6
Comfort
7.4
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Food
6.8
Boarding
7.8
Crew
8.1
Overall
7.6
Comfort
7.4
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Food
6.8
Boarding
7.8
Crew
8.1
Overall
7.6
Comfort
7.4
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from O'Hare Intl to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from O'Hare Intl
Popular flights
Santiago flight routes
Alternative routes for O'Hare Intl to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from O'Hare Intl to Santiago by cabin class
Find flights from O'Hare Intl to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
O'Hare Intl and Santiago flights
Browse other O'Hare Intl and Santiago flight options. Last updated on February 3, 2026.
Other flights from O'Hare Intl
Browse through other flights departing from O'Hare Intl. Flights are based on user searches made on Cheapflights and were last updated on February 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 3, 2026.
Top 7 airlines flying from O'Hare Intl to Santiago
Discover the top 7 airlines that operate flights from O'Hare Intl to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$468 | Average$763 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$484 | Average$951 | FlexibilityNo cancel fee | On-time67% | |
| Cheapest$537 | Average$751 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$564 | Average$741 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$583 | Average$883 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$597 | Average$940 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$713 | Average$813 | FlexibilityNo cancel fee | On-time69% |