$207+ Cheap flights from O'Hare Intl (ORD) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — SCL
Apr 5 — Apr 121
Round-trip
1 adult, Economy
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Cheapest flights from O'Hare Intl to SantiagoExplore the most affordable flight options available from O'Hare Intl to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 6, 2026.
Explore the most affordable flight options available from O'Hare Intl to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 6, 2026.
This Copa Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/198:06 am
ORD
- SCL
1 stop13h 37m
Copa Airlines
Fri 4/2411:25 am
SCL
- ORD
1 stop14h 48m
Copa Airlines
Deal found 3/2![Copa Airlines logo]()
$513
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1911:20 pm
ORD
- SCL
1 stop13h 55m
Multiple Airlines
Wed 5/68:20 pm
SCL
- ORD
2 stops28h 39m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$515
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/143:05 pm
ORD
- SCL
1 stop13h 05m
Multiple Airlines
Tue 4/218:20 pm
SCL
- ORD
2 stops41h 45m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$524
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1011:20 pm
ORD
- SCL
1 stop13h 55m
Multiple Airlines
Wed 5/135:00 am
SCL
- ORD
2 stops33h 05m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$526
This Avianca deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1711:20 pm
ORD
- SCL
1 stop13h 55m
Avianca
Fri 5/226:40 am
SCL
- ORD
1 stop15h 40m
Avianca
Deal found 3/2![Avianca logo]()
$531
This eDestinos deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/193:52 pm
ORD
- SCL
2 stops28h 13m
Multiple Airlines
Sun 4/268:20 pm
SCL
- ORD
3 stops58h 48m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$532
This Copa Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/198:06 am
ORD
- SCL
1 stop13h 37m
Copa Airlines
Sat 4/254:17 am
SCL
- ORD
1 stop21h 56m
Copa Airlines
Deal found 3/5![Copa Airlines logo]()
$533
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/53:05 pm
ORD
- SCL
1 stop31h 21m
Multiple Airlines
Sun 4/128:20 pm
SCL
- ORD
2 stops38h 30m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$534
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:20 pm
ORD
- SCL
1 stop13h 55m
Multiple Airlines
Wed 5/135:00 am
SCL
- ORD
2 stops33h 05m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$536
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/111:20 pm
ORD
- SCL
1 stop13h 55m
Multiple Airlines
Tue 4/712:40 am
SCL
- ORD
3 stops34h 10m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$539
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:20 pm
ORD
- SCL
1 stop13h 55m
Multiple Airlines
Sun 5/105:00 am
SCL
- ORD
2 stops19h 59m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$541
Best flights from O'Hare Intl to SantiagoDiscover carefully curated flight deals from O'Hare Intl to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 6, 2026.
Discover carefully curated flight deals from O'Hare Intl to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 6, 2026.
This Copa Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/118:06 am
ORD
- SCL
1 stop14h 20m
Copa Airlines
Sat 4/254:17 am
SCL
- ORD
1 stop21h 56m
Copa Airlines
Deal found 3/4![Copa Airlines logo]()
$563
This Delta deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:05 pm
ORD
- SCL
1 stop12h 10m
Delta
Sat 5/3010:55 pm
SCL
- ORD
1 stop19h 54m
Delta
Deal found 3/2![Delta logo]()
$671
This Gurufare deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/49:49 am
ORD
- SCL
2 stops19h 11m
LATAM Airlines
Thu 7/211:05 pm
SCL
- ORD
2 stops25h 50m
LATAM Airlines
Deal found 3/5![LATAM Airlines logo]()
$721
This Copa Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:02 am
ORD
- SCL
1 stop17h 58m
Copa Airlines
Fri 6/1211:17 am
SCL
- ORD
1 stop17h 43m
Copa Airlines
Deal found 3/6![Copa Airlines logo]()
$598
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/29:49 am
ORD
- SCL
2 stops19h 11m
Delta
Wed 6/1011:25 pm
SCL
- ORD
1 stop25h 20m
Delta
Deal found 3/4![Delta logo]()
$705
This Copa Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:02 am
ORD
- SCL
1 stop17h 58m
Copa Airlines
Sun 8/302:27 am
SCL
- ORD
1 stop23h 35m
Copa Airlines
Deal found 3/3![Copa Airlines logo]()
$651
This Copa Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:20 am
ORD
- SCL
1 stop17h 03m
Copa Airlines
Sat 8/82:27 am
SCL
- ORD
1 stop23h 35m
Copa Airlines
Deal found 3/1![Copa Airlines logo]()
$659
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/221:30 pm
ORD
- SCL
1 stop16h 20m
Delta
Sun 7/58:40 pm
SCL
- ORD
2 stops20h 56m
Delta
Deal found 3/5![Delta logo]()
$726
This Copa Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/318:02 am
ORD
- SCL
1 stop17h 58m
Copa Airlines
Sat 8/82:27 am
SCL
- ORD
1 stop23h 35m
Copa Airlines
Deal found 3/1![Copa Airlines logo]()
$659
This Copa Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/138:02 am
ORD
- SCL
1 stop13h 41m
Copa Airlines
Fri 8/214:46 am
SCL
- ORD
1 stop21h 16m
Copa Airlines
Deal found 3/2![Copa Airlines logo]()
$659
Last-minute flights from O'Hare Intl to SantiagoDiscover last-minute flight deals from O'Hare Intl to Santiago. Data last updated March 6, 2026 and is based on user searches.
Discover last-minute flight deals from O'Hare Intl to Santiago. Data last updated March 6, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/313:28 pm
ORD
- SCL
1 stop12h 35m
Multiple Airlines
Thu 4/235:00 am
SCL
- ORD
2 stops19h 59m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$552
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/111:20 pm
ORD
- SCL
1 stop13h 55m
Multiple Airlines
Tue 4/712:40 am
SCL
- ORD
3 stops34h 10m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$539
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/53:05 pm
ORD
- SCL
1 stop31h 21m
Multiple Airlines
Sun 4/128:20 pm
SCL
- ORD
2 stops38h 30m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$534
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/143:05 pm
ORD
- SCL
1 stop13h 05m
Multiple Airlines
Tue 4/218:20 pm
SCL
- ORD
2 stops41h 45m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$524
This Copa Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/198:06 am
ORD
- SCL
1 stop13h 37m
Copa Airlines
Tue 5/512:38 am
SCL
- ORD
1 stop14h 28m
Copa Airlines
Deal found 3/2![Copa Airlines logo]()
$513
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1911:20 pm
ORD
- SCL
1 stop13h 55m
Multiple Airlines
Wed 5/68:20 pm
SCL
- ORD
2 stops28h 39m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$515
This Avianca deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1911:20 pm
ORD
- SCL
1 stop13h 55m
Avianca
Wed 5/66:40 am
SCL
- ORD
1 stop15h 40m
Avianca
Deal found 3/3![Avianca logo]()
$531
This eDestinos deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/193:52 pm
ORD
- SCL
2 stops28h 13m
Multiple Airlines
Sun 4/268:20 pm
SCL
- ORD
3 stops58h 48m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$532
This Copa Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/198:06 am
ORD
- SCL
1 stop13h 37m
Copa Airlines
Sat 4/254:17 am
SCL
- ORD
1 stop21h 56m
Copa Airlines
Deal found 3/5![Copa Airlines logo]()
$533
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/191:54 pm
ORD
- SCL
2 stops16h 11m
American Airlines
Fri 4/248:35 pm
SCL
- ORD
2 stops16h 43m
American Airlines
Deal found 3/3![American Airlines logo]()
$550
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2911:20 pm
ORD
- SCL
1 stop13h 55m
Multiple Airlines
Wed 5/68:20 pm
SCL
- ORD
2 stops28h 39m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$543
One-way flights from O'Hare Intl to SantiagoSearch for one-way flight options from O'Hare Intl to Santiago. Find affordable one-way fares based on user searches. Data last updated March 6, 2026.
Search for one-way flight options from O'Hare Intl to Santiago. Find affordable one-way fares based on user searches. Data last updated March 6, 2026.
This Trip.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:15 pm
ORD
- SCL
3 stops38h 50m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:15 pm
ORD
- SCL
2 stops39h 15m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$220
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:51 pm
ORD
- SCL
2 stops35h 39m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/174:51 pm
ORD
- SCL
3 stops41h 09m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$237
This Copa Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:34 am
ORD
- SCL
1 stop14h 00m
Copa Airlines
Deal found 3/2![Copa Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:40 am
ORD
- SCL
2 stops37h 25m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$243
This Avianca deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:20 pm
ORD
- SCL
1 stop13h 55m
Avianca
Deal found 3/6![Avianca logo]()
$249
This Copa Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:56 am
ORD
- SCL
1 stop18h 02m
Copa Airlines
Deal found 3/6![Copa Airlines logo]()
$250
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/233:16 pm
ORD
- SCL
2 stops15h 49m
American Airlines
Deal found 3/2![American Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:05 pm
ORD
- SCL
3 stops40h 35m
Multiple Airlines
Deal found 3/2![Multiple Airlines logo]()
$254
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/253:16 pm
ORD
- SCL
2 stops15h 49m
American Airlines
Deal found 3/2![American Airlines logo]()
$258
Find flight deals from O'Hare Intl to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $513 (Copa Airlines) |
One-way from | $207 (Trip.com) |
Popular in | August |
Cheapest in | April |
Average price | $786 |
Cheapflights Fare Finder
Customize your flight search to find flights from O'Hare Intl to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Sat 4/11
8:06 am-11:26 pm
1 stop14h 20m
Santiago Arturo Merino Benitez
Sat 4/25
4:17 am-1:13 am
1 stop21h 56m
$563
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Fri 6/5
8:02 am-3:00 am
1 stop17h 58m
Santiago Arturo Merino Benitez
Fri 6/12
11:17 am-4:00 am
1 stop17h 43m
$598
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Wed 8/19
8:02 am-3:00 am
1 stop17h 58m
Santiago Arturo Merino Benitez
Sun 8/30
2:27 am-1:02 am
1 stop23h 35m
$651
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Fri 7/31
1:20 am-7:23 pm
1 stop17h 03m
Santiago Arturo Merino Benitez
Sat 8/8
2:27 am-1:02 am
1 stop23h 35m
$659
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Fri 7/31
8:02 am-3:00 am
1 stop17h 58m
Santiago Arturo Merino Benitez
Sat 8/8
2:27 am-1:02 am
1 stop23h 35m
$659
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Thu 8/13
8:02 am-10:43 pm
1 stop13h 41m
Santiago Arturo Merino Benitez
Fri 8/21
4:46 am-1:02 am
1 stop21h 16m
$659
Quickest round-trip
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Sun 5/24
6:05 pm-7:15 am
1 stop12h 10m
Santiago Arturo Merino Benitez
Sat 5/30
10:55 pm-5:49 pm
1 stop19h 54m
$671
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Tue 6/2
9:49 am-6:00 am
2 stops19h 11m
Santiago Arturo Merino Benitez
Wed 6/10
11:25 pm-11:45 pm
1 stop25h 20m
$705
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Thu 6/4
9:49 am-6:00 am
2 stops19h 11m
Santiago Arturo Merino Benitez
Thu 7/2
11:05 pm-11:55 pm
2 stops25h 50m
$721
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Mon 6/22
1:30 pm-6:50 am
1 stop16h 20m
Santiago Arturo Merino Benitez
Sun 7/5
8:40 pm-4:36 pm
2 stops20h 56m
$726
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from O'Hare Intl to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from O'Hare Intl to Santiago in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy2 stars | Trust Score*2 stars |
- Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Chicago O'Hare Intl Airport-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from O'Hare Intl to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from O'Hare Intl with our price prediction graph.
ORD-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago O'Hare Intl Airport to Santiago
Prices
Delays
More
How far ahead should I book a flight from Chicago O'Hare Intl Airport to Santiago?
Use this chart to determine the optimal time to book a round-trip flight from O'Hare Intl to Santiago. Price data was last updated on February 27, 2026.
The price you pay for your flight from Chicago O'Hare Intl Airport to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 36 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Santiago?
Currently, May is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Santiago (average of $367). Flying from Chicago O'Hare Intl Airport to Santiago in August is currently the most expensive (average of $767). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How often are flights from Chicago to Santiago delayed?
About 0% of weekly flights between Chicago and Santiago have experienced delays in the past year, with the average delay time being 0 minutes.
What is the most punctual flight time for Chicago to Santiago flights?
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the evening tend to experience delays more often.
What’s the top layover airport for flights from Chicago O'Hare Intl Airport to Santiago?
Share of 1-stop round-trip flights from Chicago O'Hare Intl Airport to Santiago chosen by Cheapflights users in the past 12 months, using the same layover each way.
Panama City (PTY) – chosen by Cheapflights users on 80% of 1-stop itineraries from Chicago O'Hare Intl Airport to Santiago on Cheapflights.
What’s the cheapest layover airport for flights from Chicago O'Hare Intl Airport to Santiago?
Average round-trip fare for 1-stop flights from Chicago O'Hare Intl Airport to Santiago, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Panama City (PTY) is the most affordable 1-stop option, with an average round-trip price of $667.
What’s the fastest layover option from Chicago O'Hare Intl Airport to Santiago?
Shortest average travel time for 1-stop one-way flights from Chicago O'Hare Intl Airport to Santiago, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Bogotá (BOG) have the shortest average one-way travel time for 1-stop routes: 12h 40m.
Which airport typically offers the quickest layover for flights from Chicago O'Hare Intl Airport to Santiago?
Average layover duration for 1-stop one-way flights from Chicago O'Hare Intl Airport to Santiago, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Panama City (PTY) offer the fastest connection on this route, with an average layover time of 1h 24m.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated March 6, 2026.
See what other customers who have flown with Copa Airlines, LATAM Airlines, and United Airlines from Chicago O'Hare Intl Airport to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.5
Entertainment
6.8
Comfort
7.4
Crew
8.1
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreKaterine,Mar 2026
LAX - PTY
Overall
7.5
Entertainment
6.8
Comfort
7.4
Crew
8.1
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreKaterine,Mar 2026
LAX - PTY
Overall
7.5
Entertainment
6.8
Comfort
7.4
Crew
8.1
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreKaterine,Mar 2026
LAX - PTY
Overall
7.5
Entertainment
6.8
Comfort
7.4
Crew
8.1
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreKaterine,Mar 2026
LAX - PTY
Overall
7.5
Entertainment
6.8
Comfort
7.4
Crew
8.1
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreKaterine,Mar 2026
LAX - PTY
Overall
7.5
Entertainment
6.8
Comfort
7.4
Crew
8.1
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreKaterine,Mar 2026
LAX - PTY
Related info for your journey
Find useful and relevant information for your journey from O'Hare Intl to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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O'Hare Intl and Santiago flights
Browse other O'Hare Intl and Santiago flight options. Last updated on March 6, 2026.
Other flights from O'Hare Intl
Browse through other flights departing from O'Hare Intl. Flights are based on user searches made on Cheapflights and were last updated on March 6, 2026.
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Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 6, 2026.
Top 7 airlines flying from O'Hare Intl to Santiago
Discover the top 7 airlines that operate flights from O'Hare Intl to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$484 | Average$951 | FlexibilityNo cancel fee | On-time67% | |
| Cheapest$537 | Average$713 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$540 | Average$759 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$558 | Average$742 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$568 | Average$853 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$597 | Average$927 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$626 | Average$788 | FlexibilityNo cancel fee | On-time69% |