$311+ Cheap flights from O'Hare Intl (ORD) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — SCL
Sep 27 — Oct 41
Round-trip
1 adult, Economy
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Find cheap flights from O'Hare Intl to Santiago with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from O'Hare Intl to Santiago
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Cheapest flights from O'Hare Intl to SantiagoExplore the most affordable flight options available from O'Hare Intl to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 28, 2026.
Explore the most affordable flight options available from O'Hare Intl to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 28, 2026.
This Bravofly deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:23 pm -
2 stops15h 32m
Wed 10/216:40 am -
2 stops19h 17m
Deal found 8/28![LATAM Airlines logo]()
$636
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/153:50 pm -
2 stops34h 06m
Fri 9/251:43 am -
1 stop14h 16m
Deal found 8/27![Multiple Airlines logo]()
$637
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:50 pm -
2 stops32h 56m
Tue 10/203:15 am -
1 stop23h 42m
Deal found 8/26![Multiple Airlines logo]()
$646
This Justfly.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2010:44 am -
2 stops16h 51m
Sun 10/2510:50 pm -
1 stop20h 30m
Deal found 8/28![LATAM Airlines logo]()
$664
Best flights from O'Hare Intl to SantiagoDiscover carefully curated flight deals from O'Hare Intl to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 28, 2026.
Discover carefully curated flight deals from O'Hare Intl to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 28, 2026.
This Copa Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:35 am -
1 stop13h 44m
Sat 11/215:07 am -
1 stop22h 04m
Deal found 8/28![Copa Airlines logo]()
$680
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:25 am -
1 stop19h 00m
Tue 10/208:55 pm -
2 stops19h 33m
Deal found 8/24![Delta logo]()
$756
This LATAM Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/193:26 pm -
1 stop36h 34m
Thu 11/2611:10 pm -
1 stop20h 30m
Deal found 8/28![Multiple Airlines logo]()
$820
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/811:21 am -
2 stops17h 39m
Thu 10/1511:55 pm -
1 stop19h 25m
Deal found 8/24![Delta logo]()
$756
This Copa Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/178:01 am -
1 stop17h 55m
Tue 9/2212:22 pm -
1 stop14h 40m
Deal found 8/28![Copa Airlines logo]()
$798
This Copa Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/162:13 pm -
1 stop27h 02m
Sun 11/2912:15 pm -
1 stop27h 31m
Deal found 8/25![Copa Airlines logo]()
$820
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:46 am -
1 stop20h 29m
Fri 9/1811:55 pm -
1 stop19h 08m
Deal found 8/27![Delta logo]()
$823
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/243:00 pm -
1 stop12h 40m
Fri 4/211:25 pm -
1 stop19h 56m
Deal found 8/27![Delta logo]()
$823
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3011:10 am -
1 stop17h 30m
Fri 4/210:55 pm -
1 stop15h 41m
Deal found 8/27![Delta logo]()
$823
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/281:30 pm -
1 stop14h 25m
Mon 3/2910:55 pm -
1 stop15h 41m
Deal found 8/27![Delta logo]()
$823
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:30 am -
1 stop18h 55m
Fri 10/168:45 am -
2 stops17h 12m
Deal found 8/25![Delta logo]()
$827
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/161:30 pm -
1 stop14h 25m
Sun 3/288:45 pm -
2 stops22h 49m
Deal found 8/25![Delta logo]()
$827
Last-minute flights from O'Hare Intl to SantiagoDiscover last-minute flight deals from O'Hare Intl to Santiago. Data last updated August 28, 2026 and is based on user searches.
Discover last-minute flight deals from O'Hare Intl to Santiago. Data last updated August 28, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:44 pm -
2 stops49h 55m
Fri 9/1812:22 pm -
1 stop14h 40m
Deal found 8/26![Multiple Airlines logo]()
$675
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/512:44 am -
2 stops44h 55m
Fri 9/1812:22 pm -
1 stop14h 40m
Deal found 8/26![Multiple Airlines logo]()
$682
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:44 pm -
2 stops49h 55m
Thu 9/175:14 am -
1 stop34h 45m
Deal found 8/26![Multiple Airlines logo]()
$710
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/512:44 am -
2 stops44h 55m
Thu 9/175:14 am -
1 stop34h 45m
Deal found 8/26![Multiple Airlines logo]()
$717
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:05 am -
2 stops19h 51m
Thu 9/173:56 am -
1 stop23h 06m
Deal found 8/26![Multiple Airlines logo]()
$714
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/153:50 pm -
2 stops34h 06m
Fri 9/251:43 am -
1 stop14h 16m
Deal found 8/27![Multiple Airlines logo]()
$637
This Justfly.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/158:05 am -
2 stops19h 35m
Wed 9/2311:55 pm -
1 stop19h 04m
Deal found 8/28![LATAM Airlines logo]()
$671
This LATAM Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:44 am -
3 stops25h 41m
Wed 9/238:50 am -
2 stops17h 09m
Deal found 8/28![LATAM Airlines logo]()
$690
This Justfly.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1710:25 am -
1 stop19h 00m
Tue 9/228:50 am -
2 stops17h 09m
Deal found 8/28![LATAM Airlines logo]()
$719
One-way flights from O'Hare Intl to SantiagoSearch for one-way flight options from O'Hare Intl to Santiago. Find affordable one-way fares based on user searches. Data last updated August 28, 2026.
Search for one-way flight options from O'Hare Intl to Santiago. Find affordable one-way fares based on user searches. Data last updated August 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:30 am -
3 stops48h 08m
Deal found 8/23![Multiple Airlines logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:50 pm -
2 stops34h 06m
Deal found 8/27![Multiple Airlines logo]()
$319
This Arajet deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Arajet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:45 am -
1 stop21h 53m
Deal found 8/26![Arajet logo]()
$343
This Arajet deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Arajet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:45 am -
1 stop21h 53m
Deal found 8/28![Arajet logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:11 am -
3 stops43h 44m
Deal found 8/28![Multiple Airlines logo]()
$356
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/49:51 am -
2 stops16h 55m
Deal found 8/28![Multiple Airlines logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:28 pm -
3 stops30h 28m
Deal found 8/28![Multiple Airlines logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:45 am -
1 stop15h 10m
Deal found 8/28![Arajet logo]()
$362
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:25 am -
3 stops42h 10m
Deal found 8/28![Multiple Airlines logo]()
$363
Find flight deals from O'Hare Intl to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $636 (Bravofly) |
One-way from | $311 (Kiwi.com) |
Popular in | October |
Cheapest in | June |
Average price | $955 |
Cheapflights Fare Finder
Customize your flight search to find flights from O'Hare Intl to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 28, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoSantiago
ORD Chicago O'Hare Intl - SCL Santiago Arturo Merino Benitez
ORDSCL
Chicago O'Hare Intl
Sat 11/7
7:35 am-12:19 am
1 stop13h 44m
Santiago Arturo Merino Benitez
Sat 11/21
5:07 am-12:11 am
1 stop22h 04m
$680
ChicagoSantiago
ORD Chicago O'Hare Intl - SCL Santiago Arturo Merino Benitez
ORDSCL
Chicago O'Hare Intl
Mon 10/5
10:25 am-7:25 am
1 stop19h 00m
Santiago Arturo Merino Benitez
Tue 10/20
8:55 pm-2:28 pm
2 stops19h 33m
$756
ChicagoSantiago
ORD Chicago O'Hare Intl - SCL Santiago Arturo Merino Benitez
ORDSCL
Chicago O'Hare Intl
Thu 10/8
11:21 am-7:00 am
2 stops17h 39m
Santiago Arturo Merino Benitez
Thu 10/15
11:55 pm-5:20 pm
1 stop19h 25m
$756
ChicagoSantiago
ORD Chicago O'Hare Intl - SCL Santiago Arturo Merino Benitez
ORDSCL
Chicago O'Hare Intl
Thu 9/17
8:01 am-3:56 am
1 stop17h 55m
Santiago Arturo Merino Benitez
Tue 9/22
12:22 pm-1:02 am
1 stop14h 40m
$798
ChicagoSantiago
ORD Chicago O'Hare Intl - SCL Santiago Arturo Merino Benitez
ORDSCL
Chicago O'Hare Intl
Thu 11/19
3:26 pm-7:00 am
1 stop36h 34m
Santiago Arturo Merino Benitez
Thu 11/26
11:10 pm-4:40 pm
1 stop20h 30m
$820
ChicagoSantiago
ORD Chicago O'Hare Intl - SCL Santiago Arturo Merino Benitez
ORDSCL
Chicago O'Hare Intl
Mon 11/16
2:13 pm-8:15 pm
1 stop27h 02m
Santiago Arturo Merino Benitez
Sun 11/29
12:15 pm-12:46 pm
1 stop27h 31m
$820
ChicagoSantiago
ORD Chicago O'Hare Intl - SCL Santiago Arturo Merino Benitez
ORDSCL
Chicago O'Hare Intl
Mon 9/14
9:46 am-8:15 am
1 stop20h 29m
Santiago Arturo Merino Benitez
Fri 9/18
11:55 pm-5:03 pm
1 stop19h 08m
$823
ChicagoSantiago
ORD Chicago O'Hare Intl - SCL Santiago Arturo Merino Benitez
ORDSCL
Chicago O'Hare Intl
Sun 1/24
3:00 pm-6:40 am
1 stop12h 40m
Santiago Arturo Merino Benitez
Fri 4/2
11:25 pm-5:21 pm
1 stop19h 56m
$823
ChicagoSantiago
ORD Chicago O'Hare Intl - SCL Santiago Arturo Merino Benitez
ORDSCL
Chicago O'Hare Intl
Sat 1/30
11:10 am-7:40 am
1 stop17h 30m
Santiago Arturo Merino Benitez
Fri 4/2
10:55 pm-12:36 pm
1 stop15h 41m
$823
Quickest round-trip
ChicagoSantiago
ORD Chicago O'Hare Intl - SCL Santiago Arturo Merino Benitez
ORDSCL
Chicago O'Hare Intl
Thu 1/28
1:30 pm-6:55 am
1 stop14h 25m
Santiago Arturo Merino Benitez
Mon 3/29
10:55 pm-12:36 pm
1 stop15h 41m
$823
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from O'Hare Intl to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from O'Hare Intl to Santiago in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Chicago O'Hare Intl Airport-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from O'Hare Intl to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from O'Hare Intl with our price prediction graph.
ORD-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago O'Hare Intl Airport to Santiago
Prices
Delays
More
How far ahead should I book a flight from Chicago O'Hare Intl Airport to Santiago?
The price you pay for your flight from Chicago O'Hare Intl Airport to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 37 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Santiago?
Currently, June is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Santiago (average of $638). Flying from Chicago O'Hare Intl Airport to Santiago in October is currently the most expensive (average of $1,135). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Chicago O'Hare Intl Airport to Santiago?
Airfare is below average for this route at the moment.
Chicago O'Hare Intl Airport to Santiago flights typically cost between $790 and $1,063 in October.The cheapest round-trip price found within the last 5 days was $636 on LATAM Airlines (Oct 6-Oct 21).
How often are flights from Chicago to Santiago delayed?
About 0% of weekly flights between Chicago and Santiago have experienced delays in the past year, with the average delay time being 0 minutes.
What is the most punctual flight time for Chicago to Santiago flights?
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the evening tend to experience delays more often.
What’s the top layover airport for flights from Chicago O'Hare Intl Airport to Santiago?
Share of 1-stop round-trip flights from Chicago O'Hare Intl Airport to Santiago chosen by Cheapflights users in the past 12 months, using the same layover each way.
Panama City (PTY) – chosen by Cheapflights users on 80% of 1-stop itineraries from Chicago O'Hare Intl Airport to Santiago on Cheapflights.
What’s the cheapest layover airport for flights from Chicago O'Hare Intl Airport to Santiago?
Average round-trip fare for 1-stop flights from Chicago O'Hare Intl Airport to Santiago, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Panama City (PTY) is the most affordable 1-stop option, with an average round-trip price of $667.
What’s the fastest layover option from Chicago O'Hare Intl Airport to Santiago?
Shortest average travel time for 1-stop one-way flights from Chicago O'Hare Intl Airport to Santiago, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Panama City (PTY) have the shortest average one-way travel time for 1-stop routes: 12h 58m.
Which airport typically offers the quickest layover for flights from Chicago O'Hare Intl Airport to Santiago?
Average layover duration for 1-stop one-way flights from Chicago O'Hare Intl Airport to Santiago, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Panama City (PTY) offer the fastest connection on this route, with an average layover time of 1h 24m.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated August 28, 2026.
See what other customers who have flown with Delta,Copa Airlines, andLATAM Airlines from Chicago O'Hare Intl Airport to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
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O'Hare Intl and Santiago flights
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Top 6 airlines flying from O'Hare Intl to Santiago
Discover the top 6 airlines that operate flights from O'Hare Intl to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$537 | Average$700 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$540 | Average$772 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$546 | Average$895 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$558 | Average$819 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$597 | Average$899 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$626 | Average$788 | FlexibilityNo cancel fee | On-time69% |