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$307+ Cheap flights from Charleston (CHS) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Jan 26 — Feb 21
Mon 1/26
Mon 2/2
1 adult, Economy
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Cheap flight deals from Charleston to Santiago

Cheapest flights from Charleston to Santiago
Explore the most affordable flight options available from Charleston to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 27, 2025.

This KAYAK deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/294:09 pmCHS - SCL
2 stops19h 56mLATAM Airlines
Wed 12/3111:10 pmSCL - CHS
1 stop14h 26mLATAM Airlines
Deal found 12/25$1,296
This Expedia deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:35 amCHS - SCL
3 stops29h 55mMultiple Airlines
Wed 12/314:25 pmSCL - CHS
2 stops28h 58mMultiple Airlines
Deal found 12/25$1,535
This Expedia deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:03 pmCHS - SCL
2 stops32h 27mMultiple Airlines
Thu 1/11:35 amSCL - CHS
2 stops18h 32mMultiple Airlines
Deal found 12/26$1,735
This LATAM Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2512:23 pmCHS - SCL
3 stops24h 07mLATAM Airlines
Fri 1/212:10 amSCL - CHS
2 stops25h 48mLATAM Airlines
Deal found 12/25$1,954
This Cheapflightsfares deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/275:58 pmCHS - SCL
1 stop11h 42mLATAM Airlines
Fri 1/28:10 amSCL - CHS
2 stops17h 48mLATAM Airlines
Deal found 12/26$1,957
This oojo deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:03 pmCHS - SCL
2 stops32h 27mMultiple Airlines
Fri 1/21:35 amSCL - CHS
2 stops18h 31mMultiple Airlines
Deal found 12/25$1,999
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/275:00 pmCHS - SCL
1 stop13h 50mUnited Airlines
Fri 1/210:45 pmSCL - CHS
1 stop19h 25mUnited Airlines
Deal found 12/26$2,139

Find flight deals from Charleston to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 27, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$704
(American Airlines)

One-way from

$307
(Kiwi.com)

Popular in

July

Cheapest in

September

Average price

$1,121
Provider with most accurate pricing for Charleston-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Santiago Arturo Merino Benitez flights.
Search Deals
From Charleston to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Charleston to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($354 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($94 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 27, 2025.
Use the filters below to find and compare flights from Charleston to Santiago that are best for you.

Fly from

Charleston

Fly to

Santiago

Route

Depart

Return

Price

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 2/4

5:30 pm-7:40 am

1 stop12h 10m

Santiago Arturo Merino Benitez

Fri 2/13

5:15 am-10:35 pm

2 stops19h 20m

$704

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 1/15

3:16 pm-8:15 am

1 stop14h 59m

Santiago Arturo Merino Benitez

Sat 1/24

10:30 pm-2:25 pm

1 stop17h 55m

$704

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Sat 1/31

8:00 am-4:30 am

2 stops18h 30m

Santiago Arturo Merino Benitez

Thu 2/5

11:10 pm-5:53 pm

1 stop20h 43m

$704

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Sat 1/31

3:16 pm-8:15 am

1 stop14h 59m

Santiago Arturo Merino Benitez

Thu 2/5

11:55 pm-6:48 pm

1 stop20h 53m

$704

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Fri 5/1

3:21 pm-1:25 pm

2 stops46h 04m

$307

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 2/4

5:55 pm-3:20 pm

3 stops43h 25m

$413

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 2/4

5:13 pm-8:50 am

1 stop13h 37m

$493

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 2/4

12:29 pm-8:15 am

2 stops17h 46m

$493

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 1/1

2:33 pm-9:25 am

2 stops16h 52m

$578

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 1/1

4:09 pm-2:30 pm

3 stops20h 21m

$598

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/26

Compare providers for flights from Charleston to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Santiago in December.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Charleston-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Charleston-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Charleston-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Charleston-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Charleston to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Santiago

What is the cheapest time of day to fly from CHS to SCL?

Find hourly flight availability from Charleston to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 27, 2025.

It’s optimal to fly from Charleston to Santiago in the morning. By choosing this option you can save up to 32% on the cost of your flight, compared to a flight in the afternoon.

How much does it cost to fly round-trip from Charleston to Santiago?

Related info for your journey

Find useful and relevant information for your journey from Charleston to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Charleston to Santiago?

    Airlines like LATAM Airlines and American Airlines fly from Charleston to Santiago in about 12h 10m. The time it takes to get you to your destination can typically vary by up to 2h 49m. Airlines will cover a distance of 4616 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Charleston to Santiago that include hotel bookings?

    Yes. In addition to deals on Charleston to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Santiago.

  • Can I find deals for business class flights from Charleston to Santiago?

    Yes. Cheapflights offers flight deals from Charleston to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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