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$533+ Cheap flights from Charleston (CHS) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/26. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Nov 13 — Nov 201
Thu 11/13
Thu 11/20
1 adult, Economy
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Cheap flight deals from Charleston to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 14, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$655
(LATAM Airlines)

One-way from

$533
(American Airlines)

Popular in

July

Cheapest in

September

Average price

$673
Provider with most accurate pricing for Charleston-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Charleston-Santiago Arturo Merino Benitez flights.
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From Charleston to Santiago Arturo Merino Benitez
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One-way flight from Charleston to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 33% potential increase in price ($447 potential increase over avg. RT price).
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Cheapest flight prices on average. 11% potential price decrease ($89 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Charleston to Santiago

Cheapest flights from Charleston to Santiago
Explore the most affordable flight options available from Charleston to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

This LATAM Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2911:25 amCHS - SCL
2 stops17h 35mLATAM Airlines
Tue 11/411:10 pmSCL - CHS
1 stop13h 10mLATAM Airlines
Deal found 10/14$655
This LATAM Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/133:47 pmCHS - SCL
1 stop13h 53mLATAM Airlines
Mon 11/178:50 amSCL - CHS
2 stops17h 07mLATAM Airlines
Deal found 10/13$664
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2912:15 pmCHS - SCL
2 stops19h 40mAmerican Airlines
Tue 11/411:15 pmSCL - CHS
2 stops18h 00mAmerican Airlines
Deal found 10/13$669
This Copa Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/297:45 pmCHS - SCL
2 stops23h 35mCopa Airlines
Mon 11/33:23 amSCL - CHS
2 stops32h 45mCopa Airlines
Deal found 10/13$987
This LATAM Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/273:00 pmCHS - SCL
2 stops21h 05mLATAM Airlines
Wed 12/34:35 amSCL - CHS
2 stops21h 22mLATAM Airlines
Deal found 10/13$1,004
This Mytrip deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/278:31 amCHS - SCL
3 stops28h 49mMultiple Airlines
Thu 12/45:59 amSCL - CHS
3 stops29h 46mMultiple Airlines
Deal found 10/13$1,146
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/154:14 pmCHS - SCL
1 stop13h 46mMultiple Airlines
Fri 10/173:33 pmSCL - CHS
2 stops42h 33mMultiple Airlines
Deal found 10/12$1,242
This Mytrip deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/268:31 amCHS - SCL
3 stops28h 49mMultiple Airlines
Wed 12/33:37 pmSCL - CHS
3 stops20h 08mMultiple Airlines
Deal found 10/12$1,292
This Cheapflightsfares deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/154:14 pmCHS - SCL
1 stop13h 46mLATAM Airlines
Fri 10/179:40 pmSCL - CHS
1 stop13h 41mLATAM Airlines
Deal found 10/12$1,331

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Charleston to Santiago that are best for you.

Fly from

Charleston

Fly to

Santiago

Route

Depart

Return

Price

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Wed 10/29

11:25 am-6:00 am

2 stops17h 35m

Santiago Arturo Merino Benitez

Tue 11/4

6:40 am-11:59 pm

2 stops19h 19m

$655

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 11/27

6:15 am-8:50 am

2 stops24h 35m

Santiago Arturo Merino Benitez

Thu 12/4

10:45 pm-4:24 pm

1 stop19h 39m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Tue 3/10

2:25 pm-7:00 am

1 stop15h 35m

Santiago Arturo Merino Benitez

Tue 3/17

5:15 am-11:38 pm

2 stops19h 23m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Tue 3/10

4:50 pm-7:50 am

1 stop14h 00m

Santiago Arturo Merino Benitez

Tue 3/17

9:45 pm-3:57 pm

1 stop19h 12m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Tue 3/10

4:30 pm-7:00 am

1 stop13h 30m

Santiago Arturo Merino Benitez

Sun 3/15

12:25 am-10:03 pm

2 stops22h 38m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Thu 11/13

3:47 pm-7:40 am

1 stop13h 53m

Santiago Arturo Merino Benitez

Mon 11/17

8:15 am-10:50 pm

2 stops16h 35m

$664

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Fri 12/26

2:33 pm-9:25 am

2 stops16h 52m

$533

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Fri 12/26

3:33 pm-7:00 am

3 stops37h 27m

$562

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Fri 12/26

5:58 pm-6:35 pm

2 stops22h 37m

$1,890

CharlestonSantiago

CHS - SCL

CHSSCL

Charleston

Fri 12/26

2:41 pm-6:10 am

1 stop13h 29m

$2,138

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/14

Compare providers for flights from Charleston to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Santiago in October.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Charleston-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Charleston-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Charleston to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Santiago

What is the cheapest time of day to fly from CHS to SCL?

Find hourly flight availability from Charleston to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 14, 2025.

It’s optimal to fly from Charleston to Santiago in the morning. By choosing this option you can save up to 32% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated October 14, 2025.
Read reviews from past customers who have flown Delta, LATAM Airlines, and American Airlines from Charleston to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,975 reviews
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
LATAM Airlines
7.5
Good
1,866 reviews
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,042 reviews
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Charleston to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Charleston to Santiago?

    Airlines like LATAM Airlines fly from Charleston to Santiago in about 17h 35m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 4616 mi.

  • What are the cheapest airlines flying from Charleston to Santiago round-trip?

    Currently priced at $532, Delta will fly you from Charleston to Santiago and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and American Airlines - these airlines can fly you to your destination from $571 and $702, respectively. Delta is priced at 40% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Charleston to Santiago that include hotel bookings?

    Yes. In addition to deals on Charleston to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Santiago.

  • Can I find deals for business class flights from Charleston to Santiago?

    Yes. Cheapflights offers flight deals from Charleston to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Charleston to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Charleston to Santiago

Discover the top 3 airlines that operate flights from Charleston to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$532Average$852FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$571Average$1,072FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$702Average$722FlexibilityNo cancel feeOn-time71%

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