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$653+ Cheap flights from Buffalo (BUF) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/10. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — SCL
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from Buffalo to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 31, 2025.

Round-trip from

$808
(American Airlines)

One-way from

$653
(LATAM Airlines)
From Buffalo to Santiago Arturo Merino Benitez
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One-way flight from Buffalo to Santiago Arturo Merino Benitez
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Find flight deals from Buffalo to Santiago

Cheapest flights from Buffalo to Santiago
Explore the most affordable flight options available from Buffalo to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2010:04 amBUF - SCL
2 stops20h 51mAmerican Airlines
Wed 8/279:55 pmSCL - BUF
2 stops16h 09mAmerican Airlines
Deal found 7/30$808
This LATAM Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/207:00 amBUF - SCL
1 stop23h 50mLATAM Airlines
Wed 8/278:40 pmSCL - BUF
1 stop14h 17mLATAM Airlines
Deal found 7/30$826
This LATAM Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/129:38 amBUF - SCL
1 stop21h 12mMultiple Airlines
Thu 9/1812:25 amSCL - BUF
2 stops35h 36mMultiple Airlines
Deal found 7/29$918
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/123:51 pmBUF - SCL
1 stop14h 54mDelta
Thu 9/181:40 amSCL - BUF
2 stops22h 57mDelta
Deal found 7/29$924
This Booking.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/136:00 amBUF - SCL
2 stops16h 40mCopa Airlines
Fri 9/191:13 amSCL - BUF
2 stops33h 33mCopa Airlines
Deal found 7/30$1,005

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Buffalo to Santiago that are best for you.

Fly from

Buffalo

Fly to

Santiago

Route

Depart

Return

Price

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Wed 8/20

10:04 am-6:55 am

2 stops20h 51m

Santiago Arturo Merino Benitez

Wed 8/27

9:55 pm-2:04 pm

2 stops16h 09m

$808

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Wed 8/20

7:00 am-6:50 am

1 stop23h 50m

Santiago Arturo Merino Benitez

Wed 8/27

8:40 pm-10:57 am

1 stop14h 17m

$826

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Fri 9/12

9:38 am-7:50 am

1 stop21h 12m

Santiago Arturo Merino Benitez

Thu 9/18

12:25 am-11:01 am

2 stops35h 36m

$918

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Fri 9/12

3:51 pm-7:45 am

1 stop14h 54m

Santiago Arturo Merino Benitez

Thu 9/18

1:40 am-11:37 pm

2 stops22h 57m

$924

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Sat 9/13

6:00 am-11:40 pm

2 stops16h 40m

Santiago Arturo Merino Benitez

Fri 9/19

1:13 am-9:46 am

2 stops33h 33m

$1,005

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

Sun 8/10

7:45 pm-5:45 am

2 stops34h 00m

$653

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Best time to book a flight from Buffalo to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated July 31, 2025.
Get a feel of what it's like to fly with Delta, LATAM Airlines, and Copa Airlines from Buffalo to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
LATAM Airlines
7.5
Good
1,822 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Copa Airlines
7.5
Good
1,493 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Buffalo to Santiago round-trip?

    Flying on American Airlines is currently your cheapest option to Santiago, with prices starting at $808. Additional round-trip tickets that might be worth considering are offered by LATAM Airlines and Delta, with the lowest prices starting at $826 and $924, respectively.

  • Can I find deals for flights from Buffalo to Santiago that include hotel bookings?

    Yes. In addition to deals on Buffalo to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Santiago.

  • Can I find deals for business class flights from Buffalo to Santiago?

    Yes. Cheapflights offers flight deals from Buffalo to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Buffalo to Santiago (average of $752). Flying from Buffalo to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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