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$733+ Cheap flights from Buffalo (BUF) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/28. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — SCL
oct. 14 — oct. 211
mar. 10/14
mar. 10/21
1 adult, Economy
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Cheap flight deals from Buffalo to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 14, 2025.

Round-trip from

$733
(LATAM Airlines)
From Buffalo to Santiago Arturo Merino Benitez
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Find flight deals from Buffalo to Santiago

Cheapest flights from Buffalo to Santiago
Explore the most affordable flight options available from Buffalo to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 14, 2025.

This LATAM Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/283:57 pmBUF - SCL
1 stop12h 58mLATAM Airlines
mar. 11/411:40 pmSCL - BUF
1 stop17h 30mLATAM Airlines
Deal found 9/12$733
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/2812:06 pmBUF - SCL
1 stop18h 34mDelta
mar. 11/46:30 pmSCL - BUF
2 stops18h 31mDelta
Deal found 9/12$764
This FlightHub deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/266:55 pmBUF - SCL
1 stop34h 45mLATAM Airlines
jue. 1/812:25 amSCL - BUF
2 stops38h 37mLATAM Airlines
Deal found 9/14$1,244
This FlightHub deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/115:14 pmBUF - SCL
2 stops19h 06mLATAM Airlines
vie. 10/1710:50 pmSCL - BUF
1 stop17h 20mLATAM Airlines
Deal found 9/12$1,277
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/2611:33 amBUF - SCL
2 stops19h 32mAmerican Airlines
vie. 1/910:15 pmSCL - BUF
2 stops19h 34mAmerican Airlines
Deal found 9/13$1,378

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 14, 2025.
Use the filters below to find and compare flights from Buffalo to Santiago that are best for you.

Fly from

Buffalo

Fly to

Santiago

Route

Depart

Return

Price

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

mar. 10/28

3:57 pm-5:55 am

1 stop12h 58m

Santiago Arturo Merino Benitez

mar. 11/4

11:40 pm-3:10 pm

1 stop17h 30m

$733

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

mar. 10/28

12:06 pm-7:40 am

1 stop18h 34m

Santiago Arturo Merino Benitez

mar. 11/4

6:30 pm-11:01 am

2 stops18h 31m

$764

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

vie. 12/26

6:55 pm-7:40 am

1 stop34h 45m

Santiago Arturo Merino Benitez

jue. 1/8

12:25 am-1:02 pm

2 stops38h 37m

$1,244

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

sáb. 10/11

5:14 pm-1:20 pm

2 stops19h 06m

Santiago Arturo Merino Benitez

vie. 10/17

8:45 pm-3:10 pm

2 stops19h 25m

$1,293

BuffaloSantiago

BUF - SCL

BUFSCL

Buffalo

vie. 12/26

11:33 am-9:05 am

2 stops19h 32m

Santiago Arturo Merino Benitez

vie. 1/9

10:15 pm-3:49 pm

2 stops19h 34m

$1,378

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Best time to book a flight from Buffalo to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Santiago?

    LATAM Airlines and Delta can get you from Buffalo to Santiago in just under 12h 58m. Your travel time can differ by up to 5h 36m. The distance between Buffalo and Santiago is about 5294 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Buffalo to Santiago that include hotel bookings?

    Yes. In addition to deals on Buffalo to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Santiago.

  • Can I find deals for business class flights from Buffalo to Santiago?

    Yes. Cheapflights offers flight deals from Buffalo to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Buffalo to Santiago (average of $752). Flying from Buffalo to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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