HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Fe

$264+ Cheap flights from South Carolina to Santa Fe (SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/3. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SAF
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to Santa Fe with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to Santa Fe

Cheapest flights from South Carolina to Santa Fe
Explore the most affordable flight options available from South Carolina to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:25 amCLT - SAF
1 stop9h 30mAmerican Airlines
Wed 12/1712:36 pmSAF - CLT
1 stop8h 01mAmerican Airlines
Deal found 12/2$369
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:10 amCLT - SAF
1 stop6h 25mAmerican Airlines
Tue 1/65:05 pmSAF - CLT
1 stop5h 35mAmerican Airlines
Deal found 12/2$375
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:25 amCLT - SAF
1 stop9h 30mAmerican Airlines
Sat 12/136:15 amSAF - CLT
1 stop7h 54mAmerican Airlines
Deal found 12/2$404
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/118:15 amCLT - SAF
1 stop8h 24mUnited Airlines
Wed 12/177:00 amSAF - CLT
2 stops12h 59mUnited Airlines
Deal found 12/2$459
This American Airlines deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1911:25 amCLT - SAF
1 stop8h 45mAmerican Airlines
Sun 12/211:30 pmSAF - CLT
1 stop7h 02mAmerican Airlines
Deal found 12/4$463
This United Airlines deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:20 amCLT - SAF
2 stops12h 42mUnited Airlines
Sun 12/211:22 pmSAF - CLT
1 stop7h 16mUnited Airlines
Deal found 12/4$497
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/118:15 amCLT - SAF
1 stop8h 24mUnited Airlines
Sat 12/131:20 pmSAF - CLT
2 stops8h 39mUnited Airlines
Deal found 12/2$508
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/214:17 pmGSP - SAF
1 stop7h 41mAmerican Airlines
Thu 12/254:43 pmSAF - GSP
1 stop5h 09mAmerican Airlines
Deal found 12/3$562
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:17 pmGSP - SAF
1 stop7h 41mAmerican Airlines
Thu 12/254:43 pmSAF - GSP
1 stop5h 09mAmerican Airlines
Deal found 12/3$593
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:44 pmCLT - SAF
2 stops28h 15mUnited Airlines
Tue 1/67:00 amSAF - CLT
1 stop6h 16mUnited Airlines
Deal found 12/2$593
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/191:10 pmCLT - SAF
1 stop7h 00mAmerican Airlines
Tue 12/236:50 pmSAF - CLT
1 stop8h 53mAmerican Airlines
Deal found 12/3$595
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amGSP - SAF
1 stop9h 38mAmerican Airlines
Mon 12/226:15 amSAF - GSP
2 stops11h 22mAmerican Airlines
Deal found 12/2$602

Find flight deals from South Carolina to Santa Fe

Keep the following information in mind while searching for South Carolina to Santa Fe flight deals. Data was last updated December 4, 2025.

Round-trip from

$264
(American Airlines)
From South Carolina to Santa Fe
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from South Carolina to Santa Fe that are best for you.

Fly from

South Carolina

Fly to

Santa Fe

Route

Depart

Return

Price

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Tue 2/3

3:16 pm-9:09 pm

1 stop7h 53m

Santa Fe

Tue 2/17

6:15 am-2:52 pm

1 stop6h 37m

$264

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Wed 1/14

8:35 am-2:53 pm

1 stop8h 18m

Santa Fe

Sat 1/17

5:18 pm-12:40 am

1 stop5h 22m

$264

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Tue 2/10

3:16 pm-9:09 pm

1 stop7h 53m

Santa Fe

Tue 2/24

6:15 am-9:23 pm

2 stops13h 08m

$274

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Wed 2/4

3:16 pm-9:09 pm

1 stop7h 53m

Santa Fe

Wed 2/18

6:33 pm-8:33 am

2 stops12h 00m

$274

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Tue 1/13

3:16 pm-9:09 pm

1 stop7h 53m

Santa Fe

Sat 1/17

10:28 am-11:04 pm

2 stops10h 36m

$309

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Sat 1/10

4:15 pm-8:47 pm

1 stop6h 32m

Santa Fe

Tue 1/13

7:00 am-3:20 pm

1 stop6h 20m

$344

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Wed 1/14

4:19 pm-8:47 pm

1 stop6h 28m

Santa Fe

Sat 1/17

7:00 am-5:24 pm

2 stops8h 24m

$344

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Wed 1/7

8:00 am-2:54 pm

1 stop8h 54m

Santa Fe

Sat 1/10

3:30 pm-10:59 pm

1 stop5h 29m

$344

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Wed 1/7

5:23 am-12:29 pm

1 stop9h 06m

Santa Fe

Sat 1/10

5:18 pm-12:40 am

1 stop5h 22m

$344

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Thu 12/11

7:25 am-2:55 pm

1 stop9h 30m

Santa Fe

Wed 12/17

12:36 pm-10:37 pm

1 stop8h 01m

$369

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 23 results
1
2
3

Best time to book a flight from South Carolina to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santa Fe

What is the cheapest month to book a flight from South Carolina to Santa Fe?

Currently, July is the cheapest month in which you can book a flight from South Carolina to Santa Fe (average of $254). Flying from South Carolina to Santa Fe in April is currently the most expensive (average of $323). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SAF?

Find hourly flight availability from South Carolina to Santa Fe. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

It’s typically best to fly out from South Carolina to Santa Fe in the evening. Doing so could potentially save you 44% on the flight price compared to flying in the afternoon, which is usually more expensive.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Fe from South Carolina?

    If you book a flight to Santa Fe from South Carolina, you will be flying to Santa Fe, which is the city’s only airport. Santa Fe (SAF) is located 9.8 mi from the center of Santa Fe.

  • How long is the flight from South Carolina to Santa Fe?

    Airlines like American Airlines and United Airlines fly from South Carolina to Santa Fe in about 6h 32m. The time it takes to get you to your destination can typically vary by up to 1h 21m. The distance from South Carolina to Santa Fe is about 1343 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from South Carolina to Santa Fe?

    While some choose either Greenville - Santa Fe or Charlotte Douglas - Santa Fe, Charleston - Santa Fe is the most popular route from South Carolina to Santa Fe.

  • Can I find deals for flights from South Carolina to Santa Fe that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santa Fe.

  • Can I find deals for business class flights from South Carolina to Santa Fe?

    Yes. Cheapflights offers flight deals from South Carolina to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santa Fe?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to Santa Fe (average of $254). Flying from South Carolina to Santa Fe in April is currently the most expensive (average of $323). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Santa Fe

See prices for flight routes from nearby airports that may be better suited for you.
Dallas/Fort Worth to Albuquerque flights
John F Kennedy Intl to Albuquerque flights
Los Angeles to Albuquerque flights
Dallas/Fort Worth to El Paso flights
Newark to Albuquerque flights
O'Hare Intl to Albuquerque flights
San Francisco to Albuquerque flights
LaGuardia to Albuquerque flights
Seattle to Albuquerque flights
Baltimore to Albuquerque flights
Los Angeles to El Paso flights
Dulles Intl to Albuquerque flights
Denver to El Paso flights
Hobby to Albuquerque flights
Newark to Santa Fe flights
LaGuardia to Santa Fe flights
Austin to El Paso flights
Hobby to El Paso flights
Austin to Albuquerque flights
O'Hare Intl to El Paso flights
Dallas/Fort Worth to Santa Fe flights
Reagan-National to Albuquerque flights
Ontario to Albuquerque flights
Boston to Albuquerque flights
Minneapolis to Albuquerque flights
George Bush Intcntl to El Paso flights
George Bush Intcntl to Albuquerque flights
Love Field to Albuquerque flights
Los Angeles to Santa Fe flights
Midway to Albuquerque flights
John F Kennedy Intl to Santa Fe flights
Sky Harbor Intl to El Paso flights
Atlanta to Albuquerque flights
Seattle to El Paso flights
Portland to Albuquerque flights
Burbank to Albuquerque flights
Atlanta to El Paso flights
Tampa to Santa Fe flights
Salt Lake City to Albuquerque flights
Austin to Santa Fe flights
Las Vegas to El Paso flights
Portland to El Paso flights
O'Hare Intl to Santa Fe flights
Oakland to Albuquerque flights
Tampa to Albuquerque flights
Fort Lauderdale to Albuquerque flights
Reagan-National to El Paso flights
Boston to El Paso flights
Raleigh to El Paso flights
Dulles Intl to El Paso flights

Top airline flying from South Carolina to Santa Fe

Discover the top airline that operate flights from South Carolina to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$638FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.