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Santa Fe

$285+ Cheap flights from South Carolina to Santa Fe (SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/20. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SAF
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheap flight deals from South Carolina to Santa Fe

Cheapest flights from South Carolina to Santa Fe
Explore the most affordable flight options available from South Carolina to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/205:15 am
CLT
-
SAF
1 stop6h 24m
American Airlines
Thu 2/266:42 pm
SAF
-
CLT
1 stop9h 14m
American Airlines
Deal found 1/20$285
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:03 am
CHS
-
SAF
1 stop7h 21m
American Airlines
Tue 4/72:04 pm
SAF
-
CHS
1 stop6h 37m
American Airlines
Deal found 1/21$335
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/72:40 pm
CLT
-
SAF
1 stop6h 11m
American Airlines
Tue 8/112:06 pm
SAF
-
CLT
1 stop6h 28m
American Airlines
Deal found 1/21$335
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:11 am
CLT
-
SAF
1 stop9h 48m
American Airlines
Sat 4/116:40 pm
SAF
-
CLT
1 stop9h 26m
American Airlines
Deal found 1/20$386
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:17 pm
CLT
-
SAF
1 stop6h 56m
United Airlines
Tue 4/211:19 pm
SAF
-
CLT
1 stop7h 40m
United Airlines
Deal found 1/19$396
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:34 pm
GSP
-
SAF
1 stop6h 19m
American Airlines
Sat 8/227:15 am
SAF
-
GSP
1 stop7h 27m
American Airlines
Deal found 1/19$411
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:15 am
CLT
-
SAF
1 stop6h 52m
American Airlines
Wed 5/277:05 pm
SAF
-
CLT
1 stop8h 33m
American Airlines
Deal found 1/20$411
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1410:42 am
CLT
-
SAF
2 stops11h 49m
United Airlines
Tue 2/171:23 pm
SAF
-
CLT
1 stop7h 25m
United Airlines
Deal found 1/21$414
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/38:00 am
CLT
-
SAF
1 stop6h 39m
United Airlines
Sat 2/73:30 pm
SAF
-
CLT
1 stop5h 29m
United Airlines
Deal found 1/20$415
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/204:25 pm
CLT
-
SAF
1 stop6h 06m
United Airlines
Tue 2/247:00 am
SAF
-
CLT
2 stops12h 09m
United Airlines
Deal found 1/20$425
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/234:40 pm
GSP
-
SAF
1 stop6h 29m
American Airlines
Tue 1/276:25 am
SAF
-
GSP
1 stop7h 25m
American Airlines
Deal found 1/20$435
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/301:13 pm
CLT
-
SAF
1 stop6h 52m
American Airlines
Mon 5/46:40 pm
SAF
-
CLT
1 stop9h 26m
American Airlines
Deal found 1/20$439

Find flight deals from South Carolina to Santa Fe

Keep the following information in mind while searching for South Carolina to Santa Fe flight deals. Data was last updated January 21, 2026.

Round-trip from

$285
(American Airlines)
From South Carolina to Santa Fe
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from South Carolina to Santa Fe that are best for you.

Fly from

South Carolina

Fly to

Santa Fe

Route

Depart

Return

Price

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Fri 2/20

5:15 am-9:39 am

1 stop6h 24m

Santa Fe

Thu 2/26

6:42 pm-5:56 am

1 stop9h 14m

$285

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Tue 3/31

7:03 am-12:24 pm

1 stop7h 21m

Santa Fe

Tue 4/7

2:04 pm-10:41 pm

1 stop6h 37m

$335

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Tue 4/7

7:11 am-2:59 pm

1 stop9h 48m

Santa Fe

Sat 4/11

6:40 pm-6:06 am

1 stop9h 26m

$386

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Fri 4/17

4:17 pm-9:13 pm

1 stop6h 56m

Santa Fe

Tue 4/21

1:19 pm-11:57 pm

2 stops8h 38m

$406

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Wed 5/20

5:15 am-10:07 am

1 stop6h 52m

Santa Fe

Wed 5/27

4:53 pm-12:48 am

1 stop5h 55m

$411

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Sat 2/14

10:42 am-8:31 pm

2 stops11h 49m

Santa Fe

Tue 2/17

1:23 pm-10:48 pm

1 stop7h 25m

$414

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Tue 2/3

8:00 am-12:39 pm

1 stop6h 39m

Santa Fe

Sat 2/7

3:30 pm-10:59 pm

1 stop5h 29m

$415

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Fri 2/20

4:25 pm-8:31 pm

1 stop6h 06m

Santa Fe

Wed 2/25

3:20 pm-10:48 pm

1 stop5h 28m

$425

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Fri 2/20

4:25 pm-8:31 pm

1 stop6h 06m

Santa Fe

Tue 2/24

7:00 am-9:09 pm

2 stops12h 09m

$425

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Thu 4/30

1:13 pm-6:05 pm

1 stop6h 52m

Santa Fe

Mon 5/4

6:40 pm-6:06 am

1 stop9h 26m

$439

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

Showing 1-10 of 23 results
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Best time to book a flight from South Carolina to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santa Fe

What is the cheapest month to book a flight from South Carolina to Santa Fe?

Currently, July is the cheapest month in which you can book a flight from South Carolina to Santa Fe (average of $254). Flying from South Carolina to Santa Fe in April is currently the most expensive (average of $330). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Fe from South Carolina?

    If you book a flight to Santa Fe from South Carolina, you will be flying to Santa Fe, which is the city’s only airport. Santa Fe (SAF) is located 9.8 mi from the center of Santa Fe.

  • How long is the flight from South Carolina to Santa Fe?

    Airlines like American Airlines and United Airlines fly from South Carolina to Santa Fe in about 6h 24m. The time it takes to get you to your destination can typically vary by up to 32m. The distance from South Carolina to Santa Fe is about 1411 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from South Carolina to Santa Fe?

    While some choose either Charlotte Douglas - Santa Fe or Charleston - Santa Fe, Greenville - Santa Fe is the most popular route from South Carolina to Santa Fe.

  • Can I find deals for flights from South Carolina to Santa Fe that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santa Fe.

  • Can I find deals for business class flights from South Carolina to Santa Fe?

    Yes. Cheapflights offers flight deals from South Carolina to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santa Fe?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to Santa Fe (average of $254). Flying from South Carolina to Santa Fe in April is currently the most expensive (average of $330). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Alternative routes for South Carolina to Santa Fe

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from South Carolina to Santa Fe

Discover the top airline that operate flights from South Carolina to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$626FlexibilityNo cancel feeOn-time71%

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