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$222+ Cheap flights from South Carolina to Santa Fe (SAF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/20. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SAF
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from South Carolina to Santa Fe

Keep the following information in mind while searching for South Carolina to Santa Fe flight deals. Data was last updated May 1, 2025.

Round-trip from

$264
(American Airlines)

One-way from

$222
(American Airlines)
From South Carolina to Santa Fe
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One-way flight from South Carolina to Santa Fe
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Find flight deals from South Carolina to Santa Fe

Cheapest flights from South Carolina to Santa Fe
Explore the most affordable flight options available from South Carolina to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/284:21 pmGSP - SAF
1 stop6h 02mAmerican Airlines
Wed 6/46:20 amSAF - GSP
1 stop7h 15mAmerican Airlines
Deal found 4/30$264
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/165:00 amCHS - SAF
1 stop6h 25mAmerican Airlines
Sat 7/194:48 pmSAF - CHS
1 stop6h 08mAmerican Airlines
Deal found 4/30$264
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/304:35 pmGSP - SAF
1 stop7h 23mUnited Airlines
Fri 6/67:05 amSAF - GSP
1 stop5h 54mUnited Airlines
Deal found 4/30$394
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/202:43 pmCLT - SAF
1 stop6h 15mAmerican Airlines
Tue 6/2410:01 amSAF - CLT
1 stop6h 14mAmerican Airlines
Deal found 4/28$407
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/202:50 pmCLT - SAF
2 stops9h 10mUnited Airlines
Tue 8/267:15 amSAF - CLT
1 stop5h 55mUnited Airlines
Deal found 4/29$454
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/87:00 amCHS - SAF
2 stops28h 22mUnited Airlines
Sat 6/1410:30 amSAF - CHS
2 stops11h 27mUnited Airlines
Deal found 4/30$667
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/285:00 pmHHH - SAF
2 stops18h 22mUnited Airlines
Mon 6/305:59 pmSAF - HHH
2 stops15h 18mUnited Airlines
Deal found 4/30$693

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from South Carolina to Santa Fe that are best for you.

Fly from

South Carolina

Fly to

Santa Fe

Route

Depart

Return

Price

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Wed 5/28

4:21 pm-8:23 pm

1 stop6h 02m

Santa Fe

Wed 6/4

6:20 am-3:35 pm

1 stop7h 15m

$264

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Wed 7/16

5:00 am-9:25 am

1 stop6h 25m

Santa Fe

Sat 7/19

4:48 pm-12:56 am

1 stop6h 08m

$264

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Fri 5/30

4:35 pm-9:58 pm

1 stop7h 23m

Santa Fe

Fri 6/6

7:05 am-2:59 pm

1 stop5h 54m

$394

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Fri 6/20

2:43 pm-6:58 pm

1 stop6h 15m

Santa Fe

Tue 6/24

10:01 am-6:15 pm

1 stop6h 14m

$407

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Wed 8/20

2:50 pm-10:00 pm

2 stops9h 10m

Santa Fe

Tue 8/26

7:15 am-3:10 pm

1 stop5h 55m

$454

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Sun 6/8

7:00 am-9:22 am

2 stops28h 22m

Santa Fe

Sat 6/14

10:30 am-11:57 pm

2 stops11h 27m

$667

Hilton Head IslandSanta Fe

HHH - SAF

HHHSAF

Hilton Head Island

Sat 6/28

5:00 pm-9:22 am

2 stops18h 22m

Santa Fe

Mon 6/30

5:59 pm-11:17 am

2 stops15h 18m

$693

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Tue 5/20

7:00 am-1:39 pm

1 stop8h 39m

$222

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Thu 6/19

5:05 pm-9:22 am

2 stops18h 17m

$429

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Thu 6/19

5:39 am-9:31 am

1 stop5h 52m

$463

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Best time to book a flight from South Carolina to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santa Fe

What is the cheapest month to book a flight from South Carolina to Santa Fe?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Santa Fe (average of $372). Flying from South Carolina to Santa Fe in March is currently the most expensive (average of $535). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SAF?

Find hourly flight availability from South Carolina to Santa Fe. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from South Carolina to Santa Fe, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Santa Fe by month

Plan your trip to Santa Fe by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santa Fe ranges from 0.5 - 2.6 inches per month. August is typically the wettest month, when rainfall can reach 2.6 in. February is typically the driest time to visit Santa Fe when rainfall is around 0.5 in.

Temperature in Santa Fe by month

Plan your trip to Santa Fe by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santa Fe, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing Santa Fe

Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated May 1, 2025.
See what other customers who have flown with United Airlines and American Airlines from South Carolina to Santa Fe have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,696 reviews

Boarding

7.7

Overall

7.4

Entertainment

7.1

Crew

8.1

Comfort

7.3

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
United Airlines
7.4
Good
8,696 reviews
United Airlines
7.4
Good
8,696 reviews

Boarding

7.7

Overall

7.4

Entertainment

7.1

Crew

8.1

Comfort

7.3

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,696 reviews

Boarding

7.7

Overall

7.4

Entertainment

7.1

Crew

8.1

Comfort

7.3

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Fe from South Carolina?

    If you book a flight to Santa Fe from South Carolina, you will be flying to Santa Fe, which is the city’s only airport. Santa Fe (SAF) is located 9.8 mi from the center of Santa Fe.

  • What are the most popular routes from South Carolina to Santa Fe?

    While some choose either Greenville - Santa Fe or Charleston - Santa Fe, Charlotte Douglas - Santa Fe is the most popular route from South Carolina to Santa Fe.

  • Can I find deals for flights from South Carolina to Santa Fe that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santa Fe.

  • Can I find deals for business class flights from South Carolina to Santa Fe?

    Yes. Cheapflights offers flight deals from South Carolina to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santa Fe?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Santa Fe (average of $372). Flying from South Carolina to Santa Fe in March is currently the most expensive (average of $535). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Santa Rosa

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Top 2 airlines flying from South Carolina to Santa Fe

Discover the top 2 airlines that operate flights from South Carolina to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$261Average$369FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$263Average$615FlexibilityNo cancel feeOn-time71%

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