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$264+ Cheap flights from South Carolina to Santa Fe (SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SAF
Nov 16 — Nov 231
Sun 11/16
Sun 11/23
1 adult, Economy
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Cheap flight deals from South Carolina to Santa Fe

Keep the following information in mind while searching for South Carolina to Santa Fe flight deals. Data was last updated October 17, 2025.

Round-trip from

$264
(American Airlines)
From South Carolina to Santa Fe
Search Deals

Find flight deals from South Carolina to Santa Fe

Cheapest flights from South Carolina to Santa Fe
Explore the most affordable flight options available from South Carolina to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 17, 2025.

This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:21 pmCHS - SAF
1 stop8h 27mAmerican Airlines
Sun 12/146:15 amSAF - CHS
1 stop6h 02mAmerican Airlines
Deal found 10/15$264
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/305:55 pmGSP - SAF
1 stop6h 04mAmerican Airlines
Mon 11/35:16 pmSAF - GSP
1 stop4h 59mAmerican Airlines
Deal found 10/15$314
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:20 amCLT - SAF
1 stop6h 06mAmerican Airlines
Wed 12/176:15 amSAF - CLT
1 stop5h 25mAmerican Airlines
Deal found 10/15$314
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/302:26 pmCHS - SAF
1 stop8h 35mAmerican Airlines
Mon 11/36:31 pmSAF - CHS
2 stops12h 11mAmerican Airlines
Deal found 10/15$324
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/611:36 amCLT - SAF
1 stop6h 49mAmerican Airlines
Wed 12/105:10 pmSAF - CLT
1 stop5h 18mAmerican Airlines
Deal found 10/15$344
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1012:52 pmHHH - SAF
2 stops10h 56mAmerican Airlines
Sat 12/136:15 amSAF - HHH
2 stops9h 57mAmerican Airlines
Deal found 10/15$359
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/137:25 amCLT - SAF
1 stop9h 30mAmerican Airlines
Wed 12/311:30 pmSAF - CLT
1 stop16h 34mAmerican Airlines
Deal found 10/15$360
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/281:56 pmCLT - SAF
2 stops10h 03mUnited Airlines
Tue 11/41:25 pmSAF - CLT
1 stop7h 28mUnited Airlines
Deal found 10/15$368
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/232:26 pmCHS - SAF
1 stop8h 35mAmerican Airlines
Sun 10/266:15 amSAF - CHS
1 stop5h 21mAmerican Airlines
Deal found 10/14$374
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/314:15 pmCLT - SAF
1 stop7h 44mUnited Airlines
Tue 11/41:25 pmSAF - CLT
1 stop7h 28mUnited Airlines
Deal found 10/16$394
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/169:20 amCLT - SAF
1 stop7h 35mAmerican Airlines
Mon 12/224:43 pmSAF - CLT
1 stop5h 32mAmerican Airlines
Deal found 10/15$399
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:40 amCLT - SAF
2 stops12h 17mUnited Airlines
Mon 11/31:26 pmSAF - CLT
1 stop7h 27mUnited Airlines
Deal found 10/15$404

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 17, 2025.
Use the filters below to find and compare flights from South Carolina to Santa Fe that are best for you.

Fly from

South Carolina

Fly to

Santa Fe

Route

Depart

Return

Price

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Fri 12/12

3:21 pm-9:48 pm

1 stop8h 27m

Santa Fe

Sun 12/14

6:15 am-2:17 pm

1 stop6h 02m

$264

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Thu 10/30

5:55 pm-9:59 pm

1 stop6h 04m

Santa Fe

Mon 11/3

5:16 pm-12:15 am

1 stop4h 59m

$314

CharlestonSanta Fe

CHS - SAF

CHSSAF

Charleston

Sat 2/21

3:55 pm-8:00 pm

1 stop6h 05m

Santa Fe

Wed 2/25

6:03 am-1:18 pm

1 stop5h 15m

$344

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Sat 12/6

4:40 pm-9:48 pm

1 stop7h 08m

Santa Fe

Wed 12/10

9:58 am-10:57 pm

2 stops10h 59m

$354

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Tue 12/16

5:15 am-12:46 pm

2 stops9h 31m

Santa Fe

Thu 12/25

10:05 am-7:21 pm

1 stop7h 16m

$354

Hilton Head IslandSanta Fe

HHH - SAF

HHHSAF

Hilton Head Island

Wed 12/10

12:52 pm-9:48 pm

2 stops10h 56m

Santa Fe

Sat 12/13

6:15 am-6:12 pm

2 stops9h 57m

$359

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Sat 12/13

7:25 am-2:55 pm

1 stop9h 30m

Santa Fe

Wed 12/31

1:30 pm-8:04 am

1 stop16h 34m

$360

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Tue 10/28

1:56 pm-9:59 pm

2 stops10h 03m

Santa Fe

Tue 11/4

1:25 pm-10:53 pm

1 stop7h 28m

$368

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Fri 10/31

4:15 pm-9:59 pm

1 stop7h 44m

Santa Fe

Tue 11/4

1:25 pm-10:53 pm

1 stop7h 28m

$394

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Sat 4/4

4:18 pm-7:58 pm

1 stop5h 40m

Santa Fe

Wed 4/8

6:21 am-3:30 pm

1 stop7h 09m

$394

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Showing 1-10 of 24 results
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Best time to book a flight from South Carolina to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santa Fe

What is the cheapest month to book a flight from South Carolina to Santa Fe?

Currently, July is the cheapest month in which you can book a flight from South Carolina to Santa Fe (average of $254). Flying from South Carolina to Santa Fe in December is currently the most expensive (average of $328). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SAF?

Find hourly flight availability from South Carolina to Santa Fe. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 17, 2025.

It’s typically best to fly out from South Carolina to Santa Fe in the evening. Doing so could potentially save you 44% on the flight price compared to flying in the afternoon, which is usually more expensive.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Fe from South Carolina?

    If you book a flight to Santa Fe from South Carolina, you will be flying to Santa Fe, which is the city’s only airport. Santa Fe (SAF) is located 9.8 mi from the center of Santa Fe.

  • How long is the flight from South Carolina to Santa Fe?

    Airlines like American Airlines and United Airlines fly from South Carolina to Santa Fe in about 8h 27m. The time it takes to get you to your destination can typically vary by up to 1h 36m. The distance from South Carolina to Santa Fe is about 1494 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from South Carolina to Santa Fe?

    While some choose either Charlotte Douglas - Santa Fe or Greenville - Santa Fe, Charleston - Santa Fe is the most popular route from South Carolina to Santa Fe.

  • Can I find deals for flights from South Carolina to Santa Fe that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santa Fe.

  • Can I find deals for business class flights from South Carolina to Santa Fe?

    Yes. Cheapflights offers flight deals from South Carolina to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santa Fe?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to Santa Fe (average of $254). Flying from South Carolina to Santa Fe in December is currently the most expensive (average of $328). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Alternative routes for South Carolina to Santa Fe

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from South Carolina to Santa Fe

Discover the top airline that operate flights from South Carolina to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$615FlexibilityNo cancel feeOn-time71%

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