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$289+ Cheap flights from Greenville to Santa Fe (GSP - SAF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/31. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SAF
Mar 7 — Mar 141
Sat 3/7
Sat 3/14
1 adult, Economy
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Cheap flight deals from Greenville to Santa Fe

Cheapest flights from Greenville to Santa Fe
Explore the most affordable flight options available from Greenville to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.

This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:34 pm
GSP
-
SAF
1 stop6h 19m
American Airlines
Sat 8/227:15 am
SAF
-
GSP
1 stop7h 27m
American Airlines
Deal found 2/3$410
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/174:26 pm
GSP
-
SAF
1 stop6h 22m
American Airlines
Sat 2/2110:09 am
SAF
-
GSP
2 stops11h 45m
American Airlines
Deal found 2/2$420
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:34 pm
GSP
-
SAF
1 stop6h 19m
American Airlines
Mon 8/172:06 pm
SAF
-
GSP
1 stop6h 11m
American Airlines
Deal found 1/31$438
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:29 pm
GSP
-
SAF
1 stop6h 30m
American Airlines
Tue 6/167:30 am
SAF
-
GSP
1 stop7h 09m
American Airlines
Deal found 1/31$486
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:35 am
GSP
-
SAF
2 stops10h 19m
United Airlines
Sat 2/147:00 am
SAF
-
GSP
2 stops11h 41m
United Airlines
Deal found 2/3$499
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/157:20 am
GSP
-
SAF
1 stop8h 44m
American Airlines
Sun 3/222:35 pm
SAF
-
GSP
1 stop5h 39m
American Airlines
Deal found 2/1$522
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/134:30 pm
GSP
-
SAF
1 stop6h 45m
American Airlines
Mon 3/162:35 pm
SAF
-
GSP
1 stop7h 07m
American Airlines
Deal found 2/4$557
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:41 pm
GSP
-
SAF
2 stops17h 51m
United Airlines
Sat 8/226:01 pm
SAF
-
GSP
2 stops18h 09m
United Airlines
Deal found 2/4$558

Find flight deals from Greenville to Santa Fe

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$410
(American Airlines)

One-way from

$289
(United Airlines)
Provider with most accurate pricing for Greenville-Santa Fe flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Santa Fe flights.
Search Deals
From Greenville to Santa Fe
Search Deals
One-way flight from Greenville to Santa Fe
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Greenville to Santa Fe that are best for you.

Fly from

Greenville

Fly to

Santa Fe

Route

Depart

Return

Price

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Tue 2/17

4:26 pm-8:48 pm

1 stop6h 22m

Santa Fe

Sat 2/21

12:54 pm-10:45 pm

1 stop7h 51m

$410

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Sun 3/15

7:20 am-2:04 pm

1 stop8h 44m

Santa Fe

Sun 3/22

2:35 pm-10:14 pm

1 stop5h 39m

$522

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Fri 3/13

4:30 pm-9:15 pm

1 stop6h 45m

Santa Fe

Mon 3/16

2:35 pm-11:42 pm

1 stop7h 07m

$557

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Tue 6/9

5:41 pm-9:41 am

2 stops18h 00m

Santa Fe

Tue 6/16

6:00 pm-3:06 pm

1 stop19h 06m

$572

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Thu 5/7

5:12 pm-9:07 pm

1 stop5h 55m

Santa Fe

Sun 5/10

2:04 pm-10:40 pm

1 stop6h 36m

$686

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Tue 3/31

12:33 pm-9:13 pm

2 stops10h 40m

$289

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Tue 3/31

6:01 am-12:24 pm

1 stop8h 23m

$341

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Mon 3/30

7:40 am-2:04 pm

1 stop8h 24m

$341

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Fri 4/3

4:30 pm-9:15 pm

1 stop6h 45m

$341

GreenvilleSanta Fe

GSP - SAF

GSPSAF

Greenville

Sat 4/4

7:42 pm-2:48 pm

2 stops21h 06m

$405

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/1

Showing 1-10 of 13 results
1
2

Compare providers for flights from Greenville to Santa Fe

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Santa Fe in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Santa Fe flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Santa Fe flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Santa Fe flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Santa Fe flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Santa Fe flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santa Fe

What is the cheapest month to book a flight from Greenville to Santa Fe?

Currently, April is the cheapest month in which you can book a flight from Greenville to Santa Fe (average of $138). Flying from Greenville to Santa Fe in May is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Fe

Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated February 5, 2026.
Read reviews from past customers who have flown American Airlines from Greenville to Santa Fe. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,222 reviews

Comfort

7.2

Food

6.4

Crew

8.0

Boarding

7.5

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,222 reviews
American Airlines
7.2
Good
11,222 reviews

Comfort

7.2

Food

6.4

Crew

8.0

Boarding

7.5

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Santa Fe?

    A quick flight from Greenville to Santa Fe can take about 6h 22m. American Airlines provides one of the quickest options available for as low as $410. The distance between Greenville and Santa Fe is about 1343 mi.

  • What is the cheapest airline to fly from Greenville to Santa Fe round-trip?

    Flying on American Airlines is currently your cheapest option to Santa Fe, with prices starting at $264.

  • Can I find deals for flights from Greenville to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Greenville to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santa Fe.

  • Can I find deals for business class flights from Greenville to Santa Fe?

    Yes. Cheapflights offers flight deals from Greenville to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Santa Fe?

    Currently, April is the cheapest month in which you can book a flight from Greenville to Santa Fe (average of $138). Flying from Greenville to Santa Fe in May is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Top airline flying from Greenville to Santa Fe

Discover the top airline that operate flights from Greenville to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$410FlexibilityNo cancel feeOn-time71%

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