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Santa Cruz de la Sierra

$222+ Cheap flights from Mexico City (MEX) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/27. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santa Cruz de la Sierra Viru Viru Intl are usually found in May or March, booked 57 days in advance, depart on a Sunday or Saturday and return on a Monday

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$453
(Avianca)

One-way from

$222
(Avianca)

Popular in

December

Cheapest in

May

Average price

$580
From Mexico City Benito Juarez to Santa Cruz de la Sierra Viru Viru Intl
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One-way flight from Mexico City Benito Juarez to Santa Cruz de la Sierra Viru Viru Intl
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Highest demand for flights based on searches. 6% potential increase in price ($42 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Mexico City to Santa Cruz de la Sierra

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/25:50 amMEX - VVI
1 stop14h 50mCopa Airlines
Tue 10/1411:59 amVVI - MEX
1 stop14h 16mCopa Airlines
Deal found 9/15$457
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/12:00 amMEX - VVI
1 stop18h 46mCopa Airlines
Wed 11/51:09 amVVI - MEX
1 stop20h 11mCopa Airlines
Deal found 9/14$473
This Priceline deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/72:00 pmMEX - VVI
1 stop9h 50mAvianca
Mon 10/202:50 amVVI - MEX
1 stop17h 15mAvianca
Deal found 9/16$502
This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/192:00 amMEX - VVI
1 stop18h 25mCopa Airlines
Sat 9/2712:15 pmVVI - MEX
1 stop11h 50mCopa Airlines
Deal found 9/16$529
This LATAM Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/315:35 pmMEX - VVI
2 stops33h 00mMultiple Airlines
Fri 11/75:25 amVVI - MEX
2 stops16h 50mMultiple Airlines
Deal found 9/16$569
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/292:00 amMEX - VVI
1 stop18h 46mCopa Airlines
Tue 3/31:14 amVVI - MEX
1 stop20h 06mCopa Airlines
Deal found 9/15$575
This LATAM Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:00 pmMEX - VVI
2 stops29h 35mMultiple Airlines
Mon 11/245:25 amVVI - MEX
2 stops16h 50mMultiple Airlines
Deal found 9/16$579
This Priceline deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/202:00 pmMEX - VVI
1 stop9h 50mAvianca
Fri 9/262:50 amVVI - MEX
1 stop11h 15mAvianca
Deal found 9/16$586

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Mexico City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 1/9

1:50 pm-2:35 am

1 stop10h 45m

Santa Cruz de la Sierra Viru Viru Intl

Fri 1/16

3:40 am-12:10 pm

1 stop10h 30m

$453

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 10/2

5:50 am-10:40 pm

1 stop14h 50m

Santa Cruz de la Sierra Viru Viru Intl

Tue 10/14

11:59 am-12:15 am

1 stop14h 16m

$457

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 11/1

3:10 am-10:46 pm

1 stop17h 36m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/6

11:40 am-1:00 am

1 stop15h 20m

$473

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Mon 10/6

12:40 am-1:50 am

1 stop23h 10m

Santa Cruz de la Sierra Viru Viru Intl

Mon 10/20

2:50 am-12:05 pm

1 stop11h 15m

$516

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 11/28

3:30 pm-3:36 am

1 stop10h 06m

Santa Cruz de la Sierra Viru Viru Intl

Mon 12/8

11:40 am-12:15 am

1 stop14h 35m

$518

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 2/12

4:00 pm-4:35 am

1 stop10h 35m

Santa Cruz de la Sierra Viru Viru Intl

Thu 3/5

5:25 am-5:40 am

2 stops26h 15m

$551

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 10/31

5:35 pm-4:35 am

2 stops33h 00m

Santa Cruz de la Sierra Viru Viru Intl

Fri 11/7

5:25 am-8:15 pm

2 stops16h 50m

$569

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 11/29

2:00 am-10:46 pm

1 stop18h 46m

Santa Cruz de la Sierra Viru Viru Intl

Tue 3/3

1:14 am-7:20 pm

1 stop20h 06m

$575

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 1/27

1:50 pm-2:35 am

1 stop10h 45m

$222

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sun 11/2

12:40 am-2:35 am

1 stop23h 55m

$327

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Showing 1-10 of 14 results
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Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santa Cruz de la Sierra. Price data was last updated on September 12, 2025.

The best time to book flights from Mexico City to Santa Cruz de la Sierra is 56 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of $597). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to VVI?

Find hourly flight availability from Mexico City to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 41% on flights from Mexico City to Santa Cruz de la Sierra by exploring options for tickets at noon.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated September 17, 2025.
Read reviews from past customers who have flown Copa Airlines and Avianca from Mexico City to Santa Cruz de la Sierra. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,533 reviews

Crew

8.1

Food

6.8

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,533 reviews
Copa Airlines
7.6
Good
1,533 reviews

Crew

8.1

Food

6.8

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,533 reviews

Crew

8.1

Food

6.8

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Airlines like Avianca and Copa Airlines fly from Mexico City to Santa Cruz de la Sierra in about 10h 45m. The time it takes to get you to your destination can typically vary by up to 4h 05m. Mexico City and Santa Cruz de la Sierra are separated by a distance of 3534 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Mexico City to Santa Cruz de la Sierra round-trip?

    Cheapflights users have booked flights from Mexico City to Santa Cruz de la Sierra round-trip from $471. Another airline that can offer you cheap pricing is Copa Airlines. Avianca is currently priced 19% below the average price you’ll pay for this route.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of $597). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mexico City to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
Mexico City to La Paz flights

Top 2 airlines flying from Mexico City to Santa Cruz de la Sierra

Discover the top 2 airlines that operate flights from Mexico City to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$471Average$556FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$558Average$667FlexibilityNo cancel feeOn-time70%

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