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Santa Cruz de la Sierra

$243+ Cheap flights from Mexico City (MEX) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
Aug 20 — Aug 271
Wed 8/20
Wed 8/27
1 adult, Economy
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Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santa Cruz de la Sierra Viru Viru Intl are usually found in May or February, booked 57 days in advance, depart on a Sunday or Saturday and return on a Monday

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 15, 2025.

Round-trip from

$508
(LATAM Airlines)

One-way from

$243
(Priceline)

Popular in

December

Cheapest in

May

Average price

$654
From Mexico City Benito Juarez to Santa Cruz de la Sierra Viru Viru Intl
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One-way flight from Mexico City Benito Juarez to Santa Cruz de la Sierra Viru Viru Intl
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Highest demand for flights based on searches. 6% potential increase in price ($40 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Mexico City to Santa Cruz de la Sierra

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 15, 2025.

This LATAM Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/197:55 pmMEX - VVI
2 stops30h 40mMultiple Airlines
Tue 9/305:20 amVVI - MEX
2 stops29h 10mMultiple Airlines
Deal found 8/14$508
This LATAM Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2710:50 amMEX - VVI
2 stops39h 45mMultiple Airlines
Sat 10/45:20 amVVI - MEX
2 stops25h 35mMultiple Airlines
Deal found 8/13$523
This LATAM Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/188:40 amMEX - VVI
2 stops17h 55mMultiple Airlines
Thu 9/255:20 amVVI - MEX
2 stops30h 20mMultiple Airlines
Deal found 8/14$524
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/185:50 amMEX - VVI
1 stop14h 35mCopa Airlines
Thu 9/2512:15 pmVVI - MEX
1 stop11h 50mCopa Airlines
Deal found 8/14$540
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/111:50 pmMEX - VVI
1 stop10h 45mAvianca
Sun 12/283:40 amVVI - MEX
1 stop10h 30mAvianca
Deal found 8/14$553
This LATAM Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/144:00 pmMEX - VVI
1 stop10h 35mMultiple Airlines
Sat 11/295:25 amVVI - MEX
2 stops26h 05mMultiple Airlines
Deal found 8/14$558
This LATAM Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/3012:15 amMEX - VVI
2 stops26h 20mMultiple Airlines
Wed 10/155:20 amVVI - MEX
2 stops30h 20mMultiple Airlines
Deal found 8/13$561
This Copa Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/262:00 amMEX - VVI
1 stop18h 25mCopa Airlines
Sat 10/411:59 amVVI - MEX
1 stop15h 01mCopa Airlines
Deal found 8/13$567

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 15, 2025.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Mexico City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 9/19

7:55 pm-4:35 am

2 stops30h 40m

Santa Cruz de la Sierra Viru Viru Intl

Tue 9/30

5:20 am-8:30 am

2 stops29h 10m

$508

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 9/27

10:50 am-4:35 am

2 stops39h 45m

Santa Cruz de la Sierra Viru Viru Intl

Sat 10/4

5:20 am-4:55 am

2 stops25h 35m

$523

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 9/18

8:40 am-4:35 am

2 stops17h 55m

Santa Cruz de la Sierra Viru Viru Intl

Thu 9/25

5:20 am-9:40 am

2 stops30h 20m

$524

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 9/18

5:50 am-10:25 pm

1 stop14h 35m

Santa Cruz de la Sierra Viru Viru Intl

Thu 9/25

12:15 pm-10:05 pm

1 stop11h 50m

$540

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 12/11

1:50 pm-2:35 am

1 stop10h 45m

Santa Cruz de la Sierra Viru Viru Intl

Sun 12/28

3:40 am-12:10 pm

1 stop10h 30m

$553

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 11/14

4:00 pm-4:35 am

1 stop10h 35m

Santa Cruz de la Sierra Viru Viru Intl

Sat 11/29

5:25 am-5:30 am

2 stops26h 05m

$558

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 9/30

12:15 am-4:35 am

2 stops26h 20m

Santa Cruz de la Sierra Viru Viru Intl

Wed 10/15

5:20 am-9:40 am

2 stops30h 20m

$561

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 9/26

2:00 am-10:25 pm

1 stop18h 25m

Santa Cruz de la Sierra Viru Viru Intl

Sat 10/4

11:59 am-1:00 am

1 stop15h 01m

$567

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 2/10

1:20 am-10:50 pm

1 stop19h 30m

Santa Cruz de la Sierra Viru Viru Intl

Tue 2/24

11:44 am-1:00 am

1 stop15h 16m

$567

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sun 8/31

5:50 am-10:19 pm

1 stop14h 29m

$317

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 11 results
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Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santa Cruz de la Sierra. Price data was last updated on August 8, 2025.

The best time to book flights from Mexico City to Santa Cruz de la Sierra is 56 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of $597). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to VVI?

Find hourly flight availability from Mexico City to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 15, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 41% on flights from Mexico City to Santa Cruz de la Sierra by exploring options for tickets at noon.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated August 15, 2025.
Read reviews from past customers who have flown Copa Airlines and Avianca from Mexico City to Santa Cruz de la Sierra. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,509 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Overall

7.5

Crew

8.1

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Copa Airlines
7.5
Good
1,509 reviews
Copa Airlines
7.5
Good
1,509 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Overall

7.5

Crew

8.1

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Avianca
6.7
Okay
2,401 reviews
Copa Airlines
7.5
Good
1,509 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Overall

7.5

Crew

8.1

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Mexico City to Santa Cruz de la Sierra round-trip?

    Cheapflights users have booked flights from Mexico City to Santa Cruz de la Sierra round-trip from $473. Another airline that can offer you cheap pricing is Copa Airlines. Avianca is currently priced 19% below the average price you’ll pay for this route.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of $597). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mexico City to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
Mexico City to La Paz flights

Top 2 airlines flying from Mexico City to Santa Cruz de la Sierra

Discover the top 2 airlines that operate flights from Mexico City to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$473Average$532FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$558Average$828FlexibilityNo cancel feeOn-time70%

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