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Santa Cruz de la Sierra

$357+ Cheap flights from Mexico City (MEX) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
Feb 6 — Feb 131
Fri 2/6
Fri 2/13
1 adult, Economy
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Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 7, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$582
(Copa Airlines)

One-way from

$357
(Copa Airlines)

Popular in

December

Cheapest in

May

Average price

$652
Provider with most accurate pricing for Mexico City Benito Juarez-Santa Cruz de la Sierra Viru Viru Intl flight deals.
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Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Santa Cruz de la Sierra Viru Viru Intl flights.
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From Mexico City Benito Juarez to Santa Cruz de la Sierra Viru Viru Intl
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One-way flight from Mexico City Benito Juarez to Santa Cruz de la Sierra Viru Viru Intl
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Highest demand for flights based on searches. 14% potential increase in price ($106 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Mexico City to Santa Cruz de la Sierra

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 7, 2026.

This Copa Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/312:10 amMEX - VVI
1 stop18h 32mCopa Airlines
Mon 4/61:15 amVVI - MEX
1 stop12h 55mCopa Airlines
Deal found 1/6$582
This Copa Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/195:55 amMEX - VVI
1 stop14h 55mCopa Airlines
Thu 1/2911:44 amVVI - MEX
1 stop14h 31mCopa Airlines
Deal found 1/7$583
This Copa Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/275:55 amMEX - VVI
1 stop14h 55mCopa Airlines
Thu 2/261:15 amVVI - MEX
1 stop20h 05mCopa Airlines
Deal found 1/6$586
This LATAM Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:10 pmMEX - VVI
1 stop11h 25mMultiple Airlines
Sat 5/165:25 amVVI - MEX
2 stops16h 30mMultiple Airlines
Deal found 1/5$627
This LATAM Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/54:00 pmMEX - VVI
1 stop10h 35mMultiple Airlines
Thu 2/125:20 amVVI - MEX
2 stops16h 45mMultiple Airlines
Deal found 1/6$663
This LATAM Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/274:00 pmMEX - VVI
1 stop10h 35mMultiple Airlines
Fri 2/275:20 amVVI - MEX
2 stops26h 10mMultiple Airlines
Deal found 1/6$677
This Copa Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/209:50 amMEX - VVI
1 stop10h 50mCopa Airlines
Wed 7/221:12 amVVI - MEX
1 stop19h 53mCopa Airlines
Deal found 1/7$680
This Copa Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/115:55 amMEX - VVI
1 stop14h 55mCopa Airlines
Tue 2/2411:44 amVVI - MEX
1 stop15h 16mCopa Airlines
Deal found 1/6$694
This LATAM Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/33:10 pmMEX - VVI
1 stop11h 25mMultiple Airlines
Sat 5/95:25 amVVI - MEX
2 stops16h 30mMultiple Airlines
Deal found 1/6$719
This Copa Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/72:00 amMEX - VVI
1 stop18h 50mCopa Airlines
Sat 2/141:15 amVVI - MEX
1 stop20h 05mCopa Airlines
Deal found 1/5$752

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Mexico City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 3/31

2:10 am-10:42 pm

1 stop18h 32m

Santa Cruz de la Sierra Viru Viru Intl

Mon 4/6

1:15 am-12:10 pm

1 stop12h 55m

$582

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 1/20

9:25 am-10:50 pm

1 stop11h 25m

Santa Cruz de la Sierra Viru Viru Intl

Thu 1/29

11:44 am-10:05 pm

1 stop12h 21m

$583

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Mon 1/19

5:55 am-10:50 pm

1 stop14h 55m

Santa Cruz de la Sierra Viru Viru Intl

Thu 1/29

11:44 am-12:15 am

1 stop14h 31m

$583

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 1/27

5:55 am-10:50 pm

1 stop14h 55m

Santa Cruz de la Sierra Viru Viru Intl

Thu 2/26

1:15 am-7:20 pm

1 stop20h 05m

$586

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 2/5

4:00 pm-4:35 am

1 stop10h 35m

Santa Cruz de la Sierra Viru Viru Intl

Thu 2/12

5:20 am-8:05 pm

2 stops16h 45m

$663

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 1/27

4:00 pm-4:35 am

1 stop10h 35m

Santa Cruz de la Sierra Viru Viru Intl

Fri 2/27

5:20 am-5:30 am

2 stops26h 10m

$677

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 5/13

12:30 am-4:35 am

2 stops26h 05m

Santa Cruz de la Sierra Viru Viru Intl

Sat 5/16

5:25 am-7:55 pm

2 stops16h 30m

$685

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 2/11

5:55 am-10:50 pm

1 stop14h 55m

Santa Cruz de la Sierra Viru Viru Intl

Tue 2/24

11:44 am-1:00 am

1 stop15h 16m

$694

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sun 5/3

10:55 am-4:35 am

2 stops15h 40m

Santa Cruz de la Sierra Viru Viru Intl

Sat 5/9

5:25 am-7:55 pm

2 stops16h 30m

$734

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 2/7

2:00 am-10:50 pm

1 stop18h 50m

Santa Cruz de la Sierra Viru Viru Intl

Sat 2/14

1:15 am-7:20 pm

1 stop20h 05m

$752

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/6

Showing 1-10 of 17 results
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Compare providers for flights from Mexico City to Santa Cruz de la Sierra

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Mexico City to Santa Cruz de la Sierra in January.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Mexico City-Santa Cruz de la Sierra flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Mexico City-Santa Cruz de la Sierra flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Mexico City-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Mexico City-Santa Cruz de la Sierra flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mexico City-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santa Cruz de la Sierra. Price data was last updated on January 2, 2026.

The best time to book flights from Mexico City to Santa Cruz de la Sierra is 85 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of $414). Flying from Mexico City to Santa Cruz de la Sierra in November is currently the most expensive (average of $511). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Mexico City to Santa Cruz de la Sierra?

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated January 7, 2026.
Read reviews from past customers who have flown Avianca from Mexico City to Santa Cruz de la Sierra. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Avianca
6.6
Okay
2,498 reviews

Comfort

6.3

Overall

6.6

Food

5.0

Crew

7.2

Boarding

6.9

Entertainment

5.4

Reviews

1 / 20
2.0
Mediocre

Kevin,Dec 2025

SAL - SJO

Horrible experience and I will never use the airline again I also will make sure I post a video to my 400k followers about this experience
Avianca
6.6
Okay
2,498 reviews
Avianca
6.6
Okay
2,498 reviews

Comfort

6.3

Overall

6.6

Food

5.0

Crew

7.2

Boarding

6.9

Entertainment

5.4

Reviews

1 / 20
2.0
Mediocre

Kevin,Dec 2025

SAL - SJO

Horrible experience and I will never use the airline again I also will make sure I post a video to my 400k followers about this experience

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Airlines like Copa Airlines fly from Mexico City to Santa Cruz de la Sierra in about 18h 32m. The time it takes to get you to your destination can typically vary by up to . Mexico City and Santa Cruz de la Sierra are separated by a distance of 3534 mi.

  • What is the cheapest airline to fly from Mexico City to Santa Cruz de la Sierra round-trip?

    Cheapflights users have booked flights from Mexico City to Santa Cruz de la Sierra round-trip from $471. Avianca is currently priced 22% below the average price you’ll pay for this route.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of $414). Flying from Mexico City to Santa Cruz de la Sierra in November is currently the most expensive (average of $511). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mexico City to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
Mexico City to La Paz flights

Top airline flying from Mexico City to Santa Cruz de la Sierra

Discover the top airline that operate flights from Mexico City to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$471Average$556FlexibilityNo cancel feeOn-time71%

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