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Santa Cruz de la Sierra

$345+ Cheap flights from Mexico City (MEX) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Find cheap flights from Mexico City to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

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Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santa Cruz de la Sierra Viru Viru Intl are usually found in May or March, booked 57 days in advance, depart on a Sunday or Saturday and return on a Monday

Find flight deals from Mexico City to Santa Cruz de la Sierra

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Copa Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:55 amMEX - VVI
1 stop19h 41mCopa Airlines
Sat 1/311:15 amVVI - MEX
1 stop15h 15mCopa Airlines
Deal found 11/5$554
This LATAM Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/39:00 pmMEX - VVI
2 stops29h 35mMultiple Airlines
Mon 12/85:25 amVVI - MEX
1 stop10h 25mMultiple Airlines
Deal found 11/6$591
This LATAM Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/41:01 amMEX - VVI
2 stops25h 34mMultiple Airlines
Sun 2/15:25 amVVI - MEX
1 stop10h 25mMultiple Airlines
Deal found 11/5$605
This Copa Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/21:20 amMEX - VVI
1 stop19h 26mCopa Airlines
Mon 12/811:40 amVVI - MEX
1 stop14h 35mCopa Airlines
Deal found 11/6$606
This LATAM Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/41:01 amMEX - VVI
2 stops25h 34mMultiple Airlines
Wed 12/175:25 amVVI - MEX
1 stop10h 25mMultiple Airlines
Deal found 11/4$621
This Copa Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/221:20 amMEX - VVI
1 stop19h 26mCopa Airlines
Tue 12/21:09 amVVI - MEX
1 stop20h 11mCopa Airlines
Deal found 11/4$640
This FlightHub deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1212:40 amMEX - VVI
1 stop23h 55mAvianca
Wed 11/193:40 amVVI - MEX
1 stop25h 20mAvianca
Deal found 11/5$647
This Copa Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/222:00 amMEX - VVI
1 stop18h 46mCopa Airlines
Fri 12/121:09 amVVI - MEX
1 stop15h 21mCopa Airlines
Deal found 11/6$675

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$519
(FlightHub)

One-way from

$271
(Priceline)

Popular in

December

Cheapest in

May

Average price

$585
Provider with most accurate pricing for Mexico City Benito Juarez-Santa Cruz de la Sierra Viru Viru Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Santa Cruz de la Sierra Viru Viru Intl flights.
Search Deals
From Mexico City Benito Juarez to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from Mexico City Benito Juarez to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($37 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Mexico City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Mon 4/20

2:00 am-10:50 pm

1 stop18h 50m

Santa Cruz de la Sierra Viru Viru Intl

Thu 4/30

11:44 am-12:15 am

1 stop14h 31m

$554

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 3/27

5:55 am-3:38 am

1 stop19h 43m

Santa Cruz de la Sierra Viru Viru Intl

Sat 4/11

1:15 am-7:20 pm

1 stop20h 05m

$554

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 3/14

9:25 am-10:50 pm

1 stop11h 25m

Santa Cruz de la Sierra Viru Viru Intl

Sat 3/21

11:42 am-12:15 am

1 stop14h 33m

$554

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 12/5

5:55 am-3:36 am

1 stop19h 41m

Santa Cruz de la Sierra Viru Viru Intl

Sat 1/31

1:15 am-2:30 pm

1 stop15h 15m

$554

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 3/31

1:40 am-10:50 pm

1 stop19h 10m

Santa Cruz de la Sierra Viru Viru Intl

Mon 4/6

1:15 am-2:30 pm

1 stop15h 15m

$573

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 4/29

1:40 am-10:50 pm

1 stop19h 10m

Santa Cruz de la Sierra Viru Viru Intl

Mon 5/4

11:44 am-12:15 am

1 stop14h 31m

$573

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 11/13

2:00 am-10:46 pm

1 stop18h 46m

$345

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Compare providers for flights from Mexico City to Santa Cruz de la Sierra

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Mexico City to Santa Cruz de la Sierra in November.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Mexico City-Santa Cruz de la Sierra flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Mexico City-Santa Cruz de la Sierra flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Mexico City-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Mexico City-Santa Cruz de la Sierra flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mexico City-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santa Cruz de la Sierra. Price data was last updated on October 31, 2025.

The best time to book flights from Mexico City to Santa Cruz de la Sierra is 56 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of $414). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of $544). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to VVI?

Find hourly flight availability from Mexico City to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 39% on flights from Mexico City to Santa Cruz de la Sierra by exploring options for tickets at noon.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated November 6, 2025.
Read reviews from past customers who have flown Copa Airlines and Avianca from Mexico City to Santa Cruz de la Sierra. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,563 reviews

Crew

8.1

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Food

6.9

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,563 reviews
Copa Airlines
7.6
Good
1,563 reviews

Crew

8.1

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Food

6.9

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,469 reviews
Copa Airlines
7.6
Good
1,563 reviews

Crew

8.1

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Food

6.9

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Airlines like Copa Airlines fly from Mexico City to Santa Cruz de la Sierra in about 18h 50m. The time it takes to get you to your destination can typically vary by up to . Mexico City and Santa Cruz de la Sierra are separated by a distance of 3534 mi.

  • What are the cheapest airlines flying from Mexico City to Santa Cruz de la Sierra round-trip?

    Cheapflights users have booked flights from Mexico City to Santa Cruz de la Sierra round-trip from $471. Another airline that can offer you cheap pricing is Copa Airlines. Avianca is currently priced 20% below the average price you’ll pay for this route.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of $414). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of $544). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Mexico City to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
Mexico City to La Paz flights

Top 2 airlines flying from Mexico City to Santa Cruz de la Sierra

Discover the top 2 airlines that operate flights from Mexico City to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$471Average$556FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$558Average$667FlexibilityNo cancel feeOn-time70%

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