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Santa Cruz de la Sierra

$192+ Cheap flights from Key Largo, FL to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/28. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — VVI
nov. 29 — dic. 61
sáb. 11/29
sáb. 12/6
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Santa Cruz de la Sierra Viru Viru Intl are usually found in September or April, booked 80 days in advance, depart on a Thursday or Tuesday and return on a Tuesday

Cheap flight deals from Key Largo to Santa Cruz de la Sierra

Keep the following information in mind while searching for Key Largo to Santa Cruz de la Sierra flight deals. Data was last updated octubre 30, 2025.

Most accurate provider

CheapOair
3 stars

Most trusted provider

CheapOair
3 stars

Round-trip from

$396
(Priceline)

One-way from

$192
(FlightHub)

Popular in

December

Cheapest in

September

Average price

$592
Provider with most accurate pricing for Miami-Santa Cruz de la Sierra Viru Viru Intl flight deals.
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Provider most trusted by Cheapflights users for Miami-Santa Cruz de la Sierra Viru Viru Intl flights.
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From Key Largo to Santa Cruz de la Sierra Viru Viru Intl
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One-way flight from Key Largo to Santa Cruz de la Sierra Viru Viru Intl
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Highest demand for flights based on searches. 11% potential increase in price ($76 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Key Largo to Santa Cruz de la Sierra

Cheapest flights from Key Largo to Santa Cruz de la Sierra
Explore the most affordable flight options available from Key Largo to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 30, 2025.

This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/254:59 amMIA - VVI
1 stop16h 47mCopa Airlines
dom. 12/71:09 amVVI - MIA
1 stop18h 42mCopa Airlines
Deal found 10/30$397
This FlightHub deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/307:00 amMIA - VVI
1 stop18h 35mAvianca
jue. 12/43:40 amVVI - MIA
1 stop14h 25mAvianca
Deal found 10/28$409
This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/316:09 amMIA - VVI
1 stop16h 31mCopa Airlines
jue. 11/61:09 amVVI - MIA
1 stop13h 49mCopa Airlines
Deal found 10/30$419
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/274:10 pmMIA - VVI
1 stop29h 36mCopa Airlines
jue. 12/411:40 amVVI - MIA
1 stop11h 05mCopa Airlines
Deal found 10/28$428
This Travelocity deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/132:05 amMIA - VVI
1 stop23h 30mAvianca
lun. 11/173:40 amVVI - MIA
1 stop8h 50mAvianca
Deal found 10/30$435
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/234:59 amMIA - VVI
1 stop16h 47mCopa Airlines
mar. 12/211:40 amVVI - MIA
1 stop11h 05mCopa Airlines
Deal found 10/29$437
This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/74:59 amMIA - VVI
1 stop16h 47mCopa Airlines
dom. 12/141:09 amVVI - MIA
1 stop15h 36mCopa Airlines
Deal found 10/30$440
This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/134:59 amMIA - VVI
1 stop16h 47mCopa Airlines
jue. 11/2011:40 amVVI - MIA
1 stop14h 05mCopa Airlines
Deal found 10/30$444
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/2012:46 pmMIA - VVI
1 stop9h 00mCopa Airlines
mar. 12/211:40 amVVI - MIA
1 stop29h 05mCopa Airlines
Deal found 10/30$449
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/1812:46 pmMIA - VVI
1 stop9h 00mCopa Airlines
lun. 12/11:09 amVVI - MIA
1 stop11h 12mCopa Airlines
Deal found 10/28$452
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/234:10 pmMIA - VVI
1 stop29h 36mCopa Airlines
mar. 12/211:40 amVVI - MIA
1 stop11h 05mCopa Airlines
Deal found 10/28$454

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from Key Largo to Santa Cruz de la Sierra that are best for you.

Fly from

Key Largo

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

sáb. 11/29

4:59 am-10:46 pm

1 stop16h 47m

Santa Cruz de la Sierra Viru Viru Intl

jue. 12/4

1:09 am-3:45 pm

1 stop15h 36m

$419

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

sáb. 3/28

6:01 am-10:50 pm

1 stop16h 49m

Santa Cruz de la Sierra Viru Viru Intl

vie. 4/3

1:15 am-7:56 pm

1 stop18h 41m

$440

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

vie. 11/28

4:59 am-10:46 pm

1 stop16h 47m

Santa Cruz de la Sierra Viru Viru Intl

sáb. 12/13

11:40 am-12:45 am

1 stop14h 05m

$444

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

mié. 11/26

5:24 am-10:46 pm

1 stop16h 22m

Santa Cruz de la Sierra Viru Viru Intl

lun. 12/1

11:40 am-12:45 am

1 stop14h 05m

$444

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

vie. 11/14

12:46 pm-10:46 pm

1 stop9h 00m

Santa Cruz de la Sierra Viru Viru Intl

vie. 11/28

1:09 am-11:21 am

1 stop11h 12m

$465

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

mié. 11/12

5:24 am-10:46 pm

1 stop16h 22m

Santa Cruz de la Sierra Viru Viru Intl

jue. 11/13

1:09 am-3:45 pm

1 stop15h 36m

$472

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

vie. 11/14

12:46 pm-10:46 pm

1 stop9h 00m

Santa Cruz de la Sierra Viru Viru Intl

lun. 11/24

11:40 am-9:45 pm

1 stop11h 05m

$490

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

dom. 12/28

1:00 pm-2:35 am

1 stop12h 35m

$192

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

jue. 1/1

5:05 am-2:35 am

2 stops20h 30m

$235

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

sáb. 11/8

4:59 am-10:46 pm

1 stop16h 47m

$250

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 16 results
1
2

Best time to book a flight from Key Largo to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Santa Cruz de la Sierra

How far ahead should I book a flight from Key Largo to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Santa Cruz de la Sierra. Price data was last updated on October 24, 2025.

Booking 62 days in advance of your planned departure date is, on average, the best time to get cheap flights from Key Largo to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Key Largo to Santa Cruz de la Sierra?

Currently, June is the cheapest month in which you can book a flight from Key Largo to Santa Cruz de la Sierra (average of $308). Flying from Key Largo to Santa Cruz de la Sierra in July is currently the most expensive (average of $466). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to VVI?

Find hourly flight availability from Key Largo to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 30, 2025.

It’s typically best to fly out from Key Largo to Santa Cruz de la Sierra at noon. Doing so could potentially save you 27% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated octubre 30, 2025.
Peruse reviews from past customers who have flown with Copa Airlines, LATAM Airlines, and BoA from Key Largo to Santa Cruz de la Sierra to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,561 reviews
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
LATAM Airlines
7.5
Good
1,873 reviews
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
BoA
6.7
Okay
137 reviews
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,467 reviews
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Cruz de la Sierra from Key Largo?

    For a flight from Key Largo to Santa Cruz de la Sierra, you will be flying into Viru Viru Intl. Santa Cruz de la Sierra Viru Viru Intl (VVI) is just 11.5 mi from the center of the city. Viru Viru Intl is the only Santa Cruz de la Sierra airport and it handles 0 inbound flights from Key Largo per day. 4 airlines have flights to Santa Cruz de la Sierra Viru Viru Intl from Key Largo on a regular basis.

  • How popular is this Key Largo to Santa Cruz de la Sierra flight route?

    Flights from Key Largo to Santa Cruz de la Sierra Viru Viru Intl have been viewed 13 times in the past calendar month.

  • How long is the flight from Key Largo to Santa Cruz de la Sierra?

    Departing from Key Largo to Santa Cruz de la Sierra will take you 16h 47m. Airlines will cover a distance of 3213 mi.

  • What are the cheapest flights from Key Largo to Santa Cruz de la Sierra?

    Looking at all options, your cheapest flight can be booked for $273. While the most popular route (Miami - Santa Cruz de la Sierra Viru Viru Intl) can be booked for $396 on average, our data indicates $1,011 when flying from Key Largo to Santa Cruz de la Sierra.

  • Can I find deals for flights from Key Largo to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Key Largo to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Key Largo to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Key Largo to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Santa Cruz de la Sierra?

    Currently, June is the cheapest month in which you can book a flight from Key Largo to Santa Cruz de la Sierra (average of $308). Flying from Key Largo to Santa Cruz de la Sierra in July is currently the most expensive (average of $466). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 4 airlines flying from Key Largo to Santa Cruz de la Sierra

Discover the top 4 airlines that operate flights from Key Largo to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$375Average$495FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$380Average$540FlexibilityNo cancel feeOn-time70%
BoACheapest$524Average$700FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$528Average$640FlexibilityNo cancel feeOn-time81%

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