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Santa Cruz de la Sierra

$263+ Cheap flights from Key Largo, FL to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/19. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — VVI
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Santa Cruz de la Sierra Viru Viru Intl are usually found in September or August, booked 47 days in advance, depart on a Thursday or Tuesday and return on a Tuesday

Cheap flight deals from Key Largo to Santa Cruz de la Sierra

Cheapest flights from Key Largo to Santa Cruz de la Sierra
Explore the most affordable flight options available from Key Largo to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Avianca deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:00 am
MIA
-
VVI
1 stop18h 35m
Avianca
Wed 2/253:40 am
VVI
-
MIA
1 stop19h 50m
Avianca
Deal found 1/27$460
This Avianca deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/37:05 am
MIA
-
VVI
2 stops18h 30m
Avianca
Thu 3/123:40 am
VVI
-
MIA
1 stop8h 50m
Avianca
Deal found 1/26$461
This Avianca deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:00 pm
MIA
-
VVI
1 stop9h 30m
Avianca
Wed 5/273:35 am
VVI
-
MIA
1 stop8h 55m
Avianca
Deal found 1/28$470
This Priceline deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/261:00 pm
MIA
-
VVI
1 stop12h 35m
Avianca
Sat 3/73:40 am
VVI
-
MIA
1 stop8h 50m
Avianca
Deal found 1/27$480
This Copa Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/126:01 am
MIA
-
VVI
1 stop16h 49m
Copa Airlines
Wed 3/181:14 am
VVI
-
MIA
1 stop18h 41m
Copa Airlines
Deal found 1/27$482
This Copa Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/188:28 am
MIA
-
VVI
1 stop19h 03m
Copa Airlines
Mon 6/111:47 am
VVI
-
MIA
1 stop14h 00m
Copa Airlines
Deal found 1/27$492
This Copa Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:01 am
MIA
-
VVI
1 stop16h 49m
Copa Airlines
Sat 11/2111:44 am
VVI
-
MIA
1 stop13h 53m
Copa Airlines
Deal found 1/28$501
This Copa Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/206:01 am
MIA
-
VVI
1 stop16h 49m
Copa Airlines
Thu 4/21:15 am
VVI
-
MIA
1 stop18h 43m
Copa Airlines
Deal found 1/26$502
This Avianca deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:00 am
MIA
-
VVI
1 stop18h 35m
Avianca
Thu 3/53:40 am
VVI
-
MIA
1 stop14h 25m
Avianca
Deal found 1/27$504
This Avianca deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/234:35 pm
MIA
-
VVI
1 stop9h 00m
Avianca
Tue 3/33:40 am
VVI
-
MIA
2 stops18h 35m
Avianca
Deal found 1/27$505
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:10 pm
MIA
-
VVI
1 stop10h 21m
Copa Airlines
Sat 3/2111:54 am
VVI
-
MIA
1 stop13h 46m
Copa Airlines
Deal found 1/27$510

Find flight deals from Key Largo to Santa Cruz de la Sierra

Keep the following information in mind while searching for Key Largo to Santa Cruz de la Sierra flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$460
(Avianca)

One-way from

$263
(Booking.com)

Popular in

December

Cheapest in

September

Average price

$628
Provider with most accurate pricing for Miami-Santa Cruz de la Sierra Viru Viru Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Santa Cruz de la Sierra Viru Viru Intl flights.
Search Deals
From Key Largo to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from Key Largo to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($39 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Key Largo to Santa Cruz de la Sierra that are best for you.

Fly from

Key Largo

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Tue 3/3

7:00 am-2:35 am

1 stop18h 35m

Santa Cruz de la Sierra Viru Viru Intl

Thu 3/12

3:40 am-6:05 pm

1 stop14h 25m

$460

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Tue 3/3

1:00 pm-2:35 am

1 stop12h 35m

Santa Cruz de la Sierra Viru Viru Intl

Sun 4/19

2:55 am-5:55 pm

1 stop15h 00m

$460

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Mon 2/23

7:00 am-2:35 am

1 stop18h 35m

Santa Cruz de la Sierra Viru Viru Intl

Wed 2/25

3:40 am-10:30 pm

1 stop19h 50m

$460

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Thu 4/2

6:24 am-10:42 pm

1 stop16h 18m

Santa Cruz de la Sierra Viru Viru Intl

Sun 4/12

1:15 am-7:58 pm

1 stop18h 43m

$482

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Thu 3/12

6:01 am-10:50 pm

1 stop16h 49m

Santa Cruz de la Sierra Viru Viru Intl

Mon 3/16

11:54 am-10:24 pm

1 stop10h 30m

$482

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Thu 3/12

6:01 am-10:50 pm

1 stop16h 49m

Santa Cruz de la Sierra Viru Viru Intl

Wed 3/18

1:14 am-7:55 pm

1 stop18h 41m

$482

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Thu 2/26

7:34 am-10:50 pm

1 stop14h 16m

Santa Cruz de la Sierra Viru Viru Intl

Thu 3/19

11:54 am-10:24 pm

1 stop10h 30m

$482

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Mon 3/2

5:26 am-10:50 pm

1 stop16h 24m

Santa Cruz de la Sierra Viru Viru Intl

Sat 4/4

1:15 am-7:58 pm

1 stop18h 43m

$492

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Fri 3/20

6:01 am-10:50 pm

1 stop16h 49m

Santa Cruz de la Sierra Viru Viru Intl

Thu 4/2

1:15 am-7:58 pm

1 stop18h 43m

$502

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Sat 2/28

4:35 pm-2:35 am

1 stop9h 00m

Santa Cruz de la Sierra Viru Viru Intl

Thu 3/5

3:40 am-3:20 pm

3 stops36h 40m

$515

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 24 results
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Best time to book a flight from Key Largo to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Santa Cruz de la Sierra

How far ahead should I book a flight from Key Largo to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Santa Cruz de la Sierra. Price data was last updated on January 23, 2026.

Booking 47 days in advance of your planned departure date is, on average, the best time to get cheap flights from Key Largo to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Key Largo to Santa Cruz de la Sierra?

Currently, August is the cheapest month in which you can book a flight from Key Largo to Santa Cruz de la Sierra (average of $286). Flying from Key Largo to Santa Cruz de la Sierra in July is currently the most expensive (average of $466). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to VVI?

Find hourly flight availability from Key Largo to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

When flying from Key Largo to Santa Cruz de la Sierra, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated January 29, 2026.
Peruse reviews from past customers who have flown with LATAM Airlines, Copa Airlines, and BoA from Key Largo to Santa Cruz de la Sierra to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,918 reviews

Entertainment

7.0

Crew

8.0

Comfort

7.3

Overall

7.5

Boarding

7.5

Food

6.7

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken
LATAM Airlines
7.5
Good
1,918 reviews
LATAM Airlines
7.5
Good
1,918 reviews

Entertainment

7.0

Crew

8.0

Comfort

7.3

Overall

7.5

Boarding

7.5

Food

6.7

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken
Copa Airlines
7.5
Good
1,560 reviews
LATAM Airlines
7.5
Good
1,918 reviews

Entertainment

7.0

Crew

8.0

Comfort

7.3

Overall

7.5

Boarding

7.5

Food

6.7

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken
BoA
6.6
Okay
134 reviews
LATAM Airlines
7.5
Good
1,918 reviews

Entertainment

7.0

Crew

8.0

Comfort

7.3

Overall

7.5

Boarding

7.5

Food

6.7

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken
Avianca
6.6
Okay
2,492 reviews
LATAM Airlines
7.5
Good
1,918 reviews

Entertainment

7.0

Crew

8.0

Comfort

7.3

Overall

7.5

Boarding

7.5

Food

6.7

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Cruz de la Sierra from Key Largo?

    For a flight from Key Largo to Santa Cruz de la Sierra, you will be flying into Viru Viru Intl. Santa Cruz de la Sierra Viru Viru Intl (VVI) is just 11.5 mi from the center of the city. Viru Viru Intl is the only Santa Cruz de la Sierra airport and it handles 0 inbound flights from Key Largo per day. 4 airlines have flights to Santa Cruz de la Sierra Viru Viru Intl from Key Largo on a regular basis.

  • How popular is this Key Largo to Santa Cruz de la Sierra flight route?

    Flights from Key Largo to Santa Cruz de la Sierra Viru Viru Intl have been viewed 8 times in the past calendar month.

  • How long is the flight from Key Largo to Santa Cruz de la Sierra?

    Departing from Key Largo to Santa Cruz de la Sierra will take you 16h 18m. Airlines will cover a distance of 3213 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Key Largo to Santa Cruz de la Sierra one-way?

    To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $165. Copa Airlines flights start at $221 while deals on BoA start at $274 one-way.

  • What are the cheapest flights from Key Largo to Santa Cruz de la Sierra?

    Looking at all options, your cheapest flight can be booked for $277. While the most popular route (Miami - Santa Cruz de la Sierra Viru Viru Intl) can be booked for $476 on average, our data indicates $943 when flying from Key Largo to Santa Cruz de la Sierra.

  • Can I find deals for flights from Key Largo to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Key Largo to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Key Largo to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Key Largo to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Santa Cruz de la Sierra?

    Currently, August is the cheapest month in which you can book a flight from Key Largo to Santa Cruz de la Sierra (average of $286). Flying from Key Largo to Santa Cruz de la Sierra in July is currently the most expensive (average of $466). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Key Largo to Santa Cruz de la Sierra

Discover the top 4 airlines that operate flights from Key Largo to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$275Average$487FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$282Average$544FlexibilityNo cancel feeOn-time70%
BoACheapest$528Average$699FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$571Average$657FlexibilityNo cancel feeOn-time81%

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