HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Cruz de la Sierra

$258+ Cheap flights from Key Largo, FL to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/6. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — VVI
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key Largo to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Key Largo to Santa Cruz de la Sierra Viru Viru Intl are usually found in April or March, booked 49 days in advance, depart on a Thursday or Tuesday and return on a Tuesday

Cheap flight deals from Key Largo to Santa Cruz de la Sierra

Keep the following information in mind while searching for Key Largo to Santa Cruz de la Sierra flight deals. Data was last updated July 31, 2025.

Round-trip from

$490
(Copa Airlines)

One-way from

$258
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$624
From Key Largo to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from Key Largo to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($76 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Key Largo to Santa Cruz de la Sierra

Cheapest flights from Key Largo to Santa Cruz de la Sierra
Explore the most affordable flight options available from Key Largo to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This Copa Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/202:20 pmMIA - VVI
1 stop13h 17mCopa Airlines
Tue 9/3012:15 pmVVI - MIA
1 stop10h 11mCopa Airlines
Deal found 7/31$490
This Priceline deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/174:35 pmMIA - VVI
1 stop9h 00mAvianca
Thu 11/273:40 amVVI - MIA
1 stop19h 50mAvianca
Deal found 7/31$495
This Gotogate deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/185:10 pmMIA - VVI
1 stop11h 25mLATAM Airlines
Mon 8/255:20 amVVI - MIA
1 stop15h 15mLATAM Airlines
Deal found 7/31$520
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/68:40 amMIA - VVI
2 stops37h 45mUnited Airlines
Fri 9/121:09 amVVI - MIA
2 stops33h 53mUnited Airlines
Deal found 7/31$571
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/66:31 pmMIA - VVI
1 stop27h 48mMultiple Airlines
Thu 8/72:50 amVVI - MIA
1 stop9h 40mMultiple Airlines
Deal found 7/30$575
This Trip.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2710:00 pmMIA - VVI
Nonstop6h 50mBoA
Sat 11/18:35 amVVI - MIA
Nonstop6h 50mBoA
Deal found 7/30$598

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Key Largo to Santa Cruz de la Sierra that are best for you.

Fly from

Key Largo

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Wed 8/20

2:20 pm-3:37 am

1 stop13h 17m

Santa Cruz de la Sierra Viru Viru Intl

Tue 9/30

12:15 pm-10:26 pm

1 stop10h 11m

$490

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Mon 8/18

5:10 pm-4:35 am

1 stop11h 25m

Santa Cruz de la Sierra Viru Viru Intl

Mon 8/25

5:20 am-8:35 pm

1 stop15h 15m

$520

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Thu 8/7

5:00 pm-1:50 am

1 stop8h 50m

Santa Cruz de la Sierra Viru Viru Intl

Sun 8/10

2:50 am-5:55 pm

1 stop15h 05m

$556

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Sat 9/6

8:40 am-10:25 pm

2 stops37h 45m

Santa Cruz de la Sierra Viru Viru Intl

Fri 9/12

1:09 am-11:02 am

2 stops33h 53m

$571

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Wed 8/6

6:31 pm-10:19 pm

1 stop27h 48m

Santa Cruz de la Sierra Viru Viru Intl

Sun 8/10

2:50 am-12:30 pm

1 stop9h 40m

$575

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Mon 10/27

10:00 pm-4:50 am

Nonstop6h 50m

Santa Cruz de la Sierra Viru Viru Intl

Sat 11/1

8:35 am-3:25 pm

Nonstop6h 50m

$598

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Wed 8/6

6:31 pm-10:19 pm

1 stop27h 48m

$258

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Fri 9/5

8:40 am-10:25 pm

2 stops37h 45m

$264

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Sun 8/17

5:45 pm-1:50 am

3 stops32h 05m

$279

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Tue 8/19

10:00 pm-4:50 am

Nonstop6h 50m

$283

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Showing 1-10 of 12 results
1
2

Best time to book a flight from Key Largo to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Santa Cruz de la Sierra

How far ahead should I book a flight from Key Largo to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Santa Cruz de la Sierra. Price data was last updated on July 25, 2025.

Booking 49 days in advance of your planned departure date is, on average, the best time to get cheap flights from Key Largo to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Key Largo to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from Key Largo to Santa Cruz de la Sierra (average of $597). Flying from Key Largo to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to VVI?

Find hourly flight availability from Key Largo to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

When flying from Key Largo to Santa Cruz de la Sierra, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated July 31, 2025.
Peruse reviews from past customers who have flown with LATAM Airlines, Copa Airlines, and United Airlines from Key Largo to Santa Cruz de la Sierra to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,822 reviews

Comfort

7.4

Overall

7.5

Boarding

7.6

Crew

8.1

Entertainment

7.0

Food

6.7

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
LATAM Airlines
7.5
Good
1,822 reviews
LATAM Airlines
7.5
Good
1,822 reviews

Comfort

7.4

Overall

7.5

Boarding

7.6

Crew

8.1

Entertainment

7.0

Food

6.7

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Copa Airlines
7.5
Good
1,493 reviews
LATAM Airlines
7.5
Good
1,822 reviews

Comfort

7.4

Overall

7.5

Boarding

7.6

Crew

8.1

Entertainment

7.0

Food

6.7

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
United Airlines
7.4
Good
8,900 reviews
LATAM Airlines
7.5
Good
1,822 reviews

Comfort

7.4

Overall

7.5

Boarding

7.6

Crew

8.1

Entertainment

7.0

Food

6.7

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
BoA
6.8
Okay
136 reviews
LATAM Airlines
7.5
Good
1,822 reviews

Comfort

7.4

Overall

7.5

Boarding

7.6

Crew

8.1

Entertainment

7.0

Food

6.7

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Avianca
6.7
Okay
2,388 reviews
LATAM Airlines
7.5
Good
1,822 reviews

Comfort

7.4

Overall

7.5

Boarding

7.6

Crew

8.1

Entertainment

7.0

Food

6.7

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Cruz de la Sierra from Key Largo?

    For a flight from Key Largo to Santa Cruz de la Sierra, you will be flying into Viru Viru Intl. Santa Cruz de la Sierra Viru Viru Intl (VVI) is just 11.5 mi from the center of the city. Viru Viru Intl is the only Santa Cruz de la Sierra airport and it handles 0 inbound flights from Key Largo per day. 4 airlines have flights to Santa Cruz de la Sierra Viru Viru Intl from Key Largo on a regular basis.

  • How popular is this Key Largo to Santa Cruz de la Sierra flight route?

    Flights from Key Largo to Santa Cruz de la Sierra Viru Viru Intl have been viewed 12 times in the past calendar month.

  • What are the cheapest airlines to fly from Key Largo to Santa Cruz de la Sierra one-way?

    To fly one-way, consider booking your trip with Copa Airlines, which is currently one of the cheapest options available, starting at $258. United Airlines flights start at $264 while deals on Avianca start at $279 one-way.

  • What are the cheapest flights from Key Largo to Santa Cruz de la Sierra?

    Looking at all options, your cheapest flight can be booked for $275. While the most popular route (Miami - Santa Cruz de la Sierra Viru Viru Intl) can be booked for $469 on average our data indicates $1,080 when flying from Key Largo to Santa Cruz de la Sierra.

  • Can I find deals for flights from Key Largo to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Key Largo to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Key Largo to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Key Largo to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from Key Largo to Santa Cruz de la Sierra (average of $597). Flying from Key Largo to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 4 airlines flying from Key Largo to Santa Cruz de la Sierra

Discover the top 4 airlines that operate flights from Key Largo to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$376Average$647FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$379Average$542FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$528Average$630FlexibilityNo cancel feeOn-time81%
BoACheapest$532Average$690FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.