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Santa Cruz de la Sierra

$249+ Cheap flights from Key Largo, FL to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — VVI
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Santa Cruz de la Sierra Viru Viru Intl are usually found in April or August, booked 54 days in advance, depart on a Thursday or Tuesday and return on a Tuesday

Cheap flight deals from Key Largo to Santa Cruz de la Sierra

Keep the following information in mind while searching for Key Largo to Santa Cruz de la Sierra flight deals. Data was last updated September 15, 2025.

Round-trip from

$395
(Mytrip)

One-way from

$249
(Cheapflightsfares)

Popular in

December

Cheapest in

April

Average price

$579
From Key Largo to Santa Cruz de la Sierra Viru Viru Intl
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One-way flight from Key Largo to Santa Cruz de la Sierra Viru Viru Intl
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Highest demand for flights based on searches. 11% potential increase in price ($77 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Key Largo to Santa Cruz de la Sierra

Cheapest flights from Key Largo to Santa Cruz de la Sierra
Explore the most affordable flight options available from Key Largo to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Mytrip deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/165:00 pmMIA - VVI
1 stop8h 50mAvianca
Tue 10/212:50 amVVI - MIA
1 stop9h 40mAvianca
Deal found 9/13$395
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/275:12 pmMIA - VVI
1 stop10h 24mCopa Airlines
Mon 11/1011:40 amVVI - MIA
1 stop14h 05mCopa Airlines
Deal found 9/15$397
This Booking.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1612:25 pmMIA - VVI
1 stop10h 15mCopa Airlines
Tue 10/2111:59 amVVI - MIA
1 stop10h 43mCopa Airlines
Deal found 9/13$399
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2111:20 amMIA - VVI
1 stop15h 16mCopa Airlines
Fri 11/281:09 amVVI - MIA
1 stop11h 03mCopa Airlines
Deal found 9/15$443
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2812:46 pmMIA - VVI
1 stop13h 50mCopa Airlines
Thu 12/1111:40 amVVI - MIA
1 stop10h 42mCopa Airlines
Deal found 9/14$472
This Mytrip deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/35:45 pmMIA - VVI
3 stops32h 05mAvianca
Sun 10/122:50 amVVI - MIA
1 stop9h 40mAvianca
Deal found 9/13$487
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/295:24 amMIA - VVI
1 stop16h 22mCopa Airlines
Sat 12/1311:40 amVVI - MIA
1 stop11h 05mCopa Airlines
Deal found 9/15$490
This Mytrip deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/136:29 pmMIA - VVI
1 stop27h 56mCopa Airlines
Wed 9/1712:15 pmVVI - MIA
1 stop24h 05mCopa Airlines
Deal found 9/13$505
This Cheapflightsfares deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/195:00 pmMIA - VVI
1 stop8h 50mAvianca
Sat 9/272:50 amVVI - MIA
1 stop15h 05mAvianca
Deal found 9/14$509
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2512:24 pmMIA - VVI
1 stop10h 01mCopa Airlines
Tue 9/3012:15 pmVVI - MIA
1 stop13h 21mCopa Airlines
Deal found 9/15$518
This Viajes Éxito deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Viajes Éxito is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/143:10 pmMIA - VVI
2 stops34h 40mAvianca
Mon 10/202:50 amVVI - MIA
2 stops35h 05mAvianca
Deal found 9/14$520

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Key Largo to Santa Cruz de la Sierra that are best for you.

Fly from

Key Largo

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Mon 10/27

6:23 am-10:40 pm

1 stop16h 17m

Santa Cruz de la Sierra Viru Viru Intl

Sun 11/9

1:09 am-6:51 pm

1 stop18h 42m

$397

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Fri 10/24

12:25 pm-10:40 pm

1 stop10h 15m

Santa Cruz de la Sierra Viru Viru Intl

Mon 10/27

11:41 am-10:25 pm

1 stop10h 44m

$397

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Sat 11/1

5:59 am-10:46 pm

1 stop16h 47m

Santa Cruz de la Sierra Viru Viru Intl

Sat 11/15

11:40 am-9:22 pm

1 stop10h 42m

$397

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Fri 10/17

12:25 pm-10:40 pm

1 stop10h 15m

Santa Cruz de la Sierra Viru Viru Intl

Fri 10/31

1:09 am-2:49 pm

1 stop13h 40m

$397

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Thu 11/20

7:32 am-10:46 pm

1 stop14h 14m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/27

1:09 am-6:51 pm

1 stop18h 42m

$443

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Mon 9/29

5:21 pm-3:36 am

1 stop10h 15m

Santa Cruz de la Sierra Viru Viru Intl

Thu 10/2

1:09 am-7:55 pm

1 stop18h 46m

$443

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Fri 11/7

4:59 am-10:46 pm

1 stop16h 47m

$250

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Wed 12/3

5:34 am-10:46 pm

1 stop16h 12m

$250

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Fri 9/26

12:24 pm-3:36 am

1 stop15h 12m

$250

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Sun 9/28

2:20 pm-3:36 am

1 stop13h 16m

$250

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 14 results
1
2

Best time to book a flight from Key Largo to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Santa Cruz de la Sierra

How far ahead should I book a flight from Key Largo to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Santa Cruz de la Sierra. Price data was last updated on September 12, 2025.

Booking 54 days in advance of your planned departure date is, on average, the best time to get cheap flights from Key Largo to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Key Largo to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from Key Largo to Santa Cruz de la Sierra (average of $597). Flying from Key Largo to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to VVI?

Find hourly flight availability from Key Largo to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Key Largo to Santa Cruz de la Sierra, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated September 15, 2025.
Peruse reviews from past customers who have flown with Copa Airlines, LATAM Airlines, and BoA from Key Largo to Santa Cruz de la Sierra to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Entertainment

6.8

Overall

7.6

Boarding

7.8

Comfort

7.4

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Entertainment

6.8

Overall

7.6

Boarding

7.8

Comfort

7.4

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
LATAM Airlines
7.5
Good
1,847 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Entertainment

6.8

Overall

7.6

Boarding

7.8

Comfort

7.4

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
BoA
6.8
Okay
136 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Entertainment

6.8

Overall

7.6

Boarding

7.8

Comfort

7.4

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,435 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Entertainment

6.8

Overall

7.6

Boarding

7.8

Comfort

7.4

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Cruz de la Sierra from Key Largo?

    For a flight from Key Largo to Santa Cruz de la Sierra, you will be flying into Viru Viru Intl. Santa Cruz de la Sierra Viru Viru Intl (VVI) is just 11.5 mi from the center of the city. Viru Viru Intl is the only Santa Cruz de la Sierra airport and it handles 0 inbound flights from Key Largo per day. 4 airlines have flights to Santa Cruz de la Sierra Viru Viru Intl from Key Largo on a regular basis.

  • How popular is this Key Largo to Santa Cruz de la Sierra flight route?

    Flights from Key Largo to Santa Cruz de la Sierra Viru Viru Intl have been viewed 12 times in the past calendar month.

  • How long is the flight from Key Largo to Santa Cruz de la Sierra?

    Departing from Key Largo to Santa Cruz de la Sierra will take you 16h 17m. Airlines will cover a distance of 3213 mi.

  • What are the cheapest flights from Key Largo to Santa Cruz de la Sierra?

    Looking at all options, your cheapest flight can be booked for $275. While the most popular route (Miami - Santa Cruz de la Sierra Viru Viru Intl) can be booked for $390 on average, our data indicates $1,005 when flying from Key Largo to Santa Cruz de la Sierra.

  • Can I find deals for flights from Key Largo to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Key Largo to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Key Largo to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Key Largo to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from Key Largo to Santa Cruz de la Sierra (average of $597). Flying from Key Largo to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Key Largo to Santa Cruz de la Sierra

Discover the top 4 airlines that operate flights from Key Largo to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$376Average$470FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$379Average$537FlexibilityNo cancel feeOn-time70%
BoACheapest$526Average$693FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$532Average$637FlexibilityNo cancel feeOn-time81%

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