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Santa Cruz de la Sierra

$341+ Cheap flights from Irvine, CA to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.
LAX — VVI
May 9 — May 161
Sat 5/9
Sat 5/16
1 adult, Economy
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Cheap flight deals from Irvine to Santa Cruz de la Sierra

Cheapest flights from Irvine to Santa Cruz de la Sierra
Explore the most affordable flight options available from Irvine to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.

This Justfly.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2012:15 am
LAX
-
VVI
2 stops23h 15m
Avianca
Sun 9/63:35 am
VVI
-
LAX
2 stops21h 35m
Avianca
Deal found 4/6$731
This Justfly.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/132:40 pm
LAX
-
VVI
2 stops32h 50m
Avianca
Fri 4/243:35 am
VVI
-
LAX
2 stops21h 35m
Avianca
Deal found 4/6$732
This Gotogate deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/71:50 pm
LAX
-
VVI
2 stops33h 40m
Avianca
Thu 5/283:35 am
VVI
-
LAX
3 stops36h 25m
Avianca
Deal found 4/7$735
This FlightHub deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/111:50 pm
LAX
-
VVI
2 stops33h 40m
Avianca
Sun 4/193:35 am
VVI
-
LAX
2 stops35h 50m
Avianca
Deal found 4/5$736
This FlightHub deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/201:00 am
LAX
-
VVI
2 stops22h 30m
Avianca
Thu 5/283:35 am
VVI
-
LAX
3 stops36h 25m
Avianca
Deal found 4/6$737
This FlightHub deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:40 pm
LAX
-
VVI
2 stops32h 50m
Avianca
Mon 4/203:35 am
VVI
-
LAX
2 stops36h 25m
Avianca
Deal found 4/7$738
This FlightHub deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:40 pm
LAX
-
VVI
2 stops32h 50m
Avianca
Sun 5/103:35 am
VVI
-
LAX
3 stops36h 25m
Avianca
Deal found 4/8$739
This FlightHub deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/112:40 pm
LAX
-
VVI
3 stops32h 50m
Avianca
Tue 8/253:35 am
VVI
-
LAX
3 stops36h 25m
Avianca
Deal found 4/6$744
This Justfly.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/262:40 pm
LAX
-
VVI
3 stops32h 50m
Avianca
Mon 6/13:35 am
VVI
-
LAX
3 stops29h 30m
Avianca
Deal found 4/8$757

Find flight deals from Irvine to Santa Cruz de la Sierra

Keep the following information in mind while searching for Irvine to Santa Cruz de la Sierra flight deals. Data was last updated April 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$731
(Justfly.com)

One-way from

$341
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$661
Provider with most accurate pricing for Los Angeles-Santa Cruz de la Sierra Viru Viru Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Los Angeles-Santa Cruz de la Sierra Viru Viru Intl flights.
Search Deals
From Irvine to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from Irvine to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($63 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Irvine to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from Irvine to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Los AngelesSanta Cruz de la Sierra

LAX - VVI

LAXVVI

Los Angeles

Fri 8/21

7:25 am-2:30 am

3 stops40h 05m

Santa Cruz de la Sierra Viru Viru Intl

Sun 9/6

3:35 am-10:10 pm

2 stops21h 35m

$731

Los AngelesSanta Cruz de la Sierra

LAX - VVI

LAXVVI

Los Angeles

Mon 4/20

1:50 pm-2:30 am

2 stops33h 40m

Santa Cruz de la Sierra Viru Viru Intl

Fri 5/8

3:35 am-10:10 pm

2 stops21h 35m

$769

Los AngelesSanta Cruz de la Sierra

LAX - VVI

LAXVVI

Los Angeles

Mon 4/20

12:15 am-2:30 am

2 stops23h 15m

Santa Cruz de la Sierra Viru Viru Intl

Sat 5/9

3:35 am-10:10 pm

2 stops21h 35m

$769

Los AngelesSanta Cruz de la Sierra

LAX - VVI

LAXVVI

Los Angeles

Tue 8/25

1:51 am-3:35 am

1 stop22h 44m

Santa Cruz de la Sierra Viru Viru Intl

Tue 9/8

1:12 am-4:47 pm

1 stop18h 35m

$788

Los AngelesSanta Cruz de la Sierra

LAX - VVI

LAXVVI

Los Angeles

Thu 8/20

2:19 am-10:40 pm

1 stop17h 21m

Santa Cruz de la Sierra Viru Viru Intl

Sun 9/6

1:12 am-10:58 pm

1 stop24h 46m

$788
Quickest round-trip

Los AngelesSanta Cruz de la Sierra

LAX - VVI

LAXVVI

Los Angeles

Mon 8/24

1:51 am-10:40 pm

1 stop17h 49m

Santa Cruz de la Sierra Viru Viru Intl

Tue 9/8

1:12 am-12:39 pm

1 stop14h 27m

$788
Cheapest one-way

Los AngelesSanta Cruz de la Sierra

LAX - VVI

LAXVVI

Los Angeles

Tue 4/21

4:17 pm-2:30 am

3 stops31h 13m

$341

Los AngelesSanta Cruz de la Sierra

LAX - VVI

LAXVVI

Los Angeles

Sat 4/18

12:15 am-2:30 am

2 stops23h 15m

$342

Los AngelesSanta Cruz de la Sierra

LAX - VVI

LAXVVI

Los Angeles

Fri 4/17

12:46 am-2:30 am

3 stops46h 44m

$358

Los AngelesSanta Cruz de la Sierra

LAX - VVI

LAXVVI

Los Angeles

Mon 6/8

1:00 am-2:30 am

2 stops22h 30m

$362

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/5

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Best time to book a flight from Irvine to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Irvine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Irvine to Santa Cruz de la Sierra

How far ahead should I book a flight from Irvine to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Irvine to Santa Cruz de la Sierra. Price data was last updated on April 3, 2026.

The price you pay for your flight from Irvine to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 26 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Irvine to Santa Cruz de la Sierra?

Currently, March is the cheapest month in which you can book a flight from Irvine to Santa Cruz de la Sierra (average of $354). Flying from Irvine to Santa Cruz de la Sierra in July is currently the most expensive (average of $656). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Irvine to Santa Cruz de la Sierra?

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated April 9, 2026.
Read through reviews of airlines operating flights from Irvine to Santa Cruz de la Sierra, such as Copa Airlines,LATAM Airlines, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,575 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.5

Food

6.8

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Copa Airlines
7.5
Good
1,575 reviews
Copa Airlines
7.5
Good
1,575 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.5

Food

6.8

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
LATAM Airlines
7.4
Good
1,909 reviews
Copa Airlines
7.5
Good
1,575 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.5

Food

6.8

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
United Airlines
7.4
Good
9,559 reviews
Copa Airlines
7.5
Good
1,575 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.5

Food

6.8

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Avianca
6.5
Okay
2,503 reviews
Copa Airlines
7.5
Good
1,575 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.5

Food

6.8

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.

Related info for your journey

Find useful and relevant information for your journey from Irvine to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Cruz de la Sierra from Irvine?

    Most people fly into Santa Cruz de la Sierra Viru Viru Intl (VVI) if they book a flight to Santa Cruz de la Sierra from Irvine. On average, Viru Viru Intl has 0 inbound flights from Irvine per day from 4 airlines. Santa Cruz de la Sierra Viru Viru Intl is conveniently located just 11.5 mi from Santa Cruz de la Sierra’s city center.

  • How long is the flight from Irvine to Santa Cruz de la Sierra?

    There are many flights that can get you from Irvine to Santa Cruz de la Sierra in 22h 44m. Fly via Avianca or Copa Airlines to get the fastest option. There are 5087 mi between Irvine and Santa Cruz de la Sierra. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Irvine to Santa Cruz de la Sierra one-way?

    The cheapest airlines for a one-way flight from Irvine to Santa Cruz de la Sierra are Avianca ($254), United Airlines ($264), and Copa Airlines ($324).

  • Can I find deals for flights from Irvine to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Irvine to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Irvine to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Irvine to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Irvine to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Irvine to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Irvine to Santa Cruz de la Sierra?

    Currently, March is the cheapest month in which you can book a flight from Irvine to Santa Cruz de la Sierra (average of $354). Flying from Irvine to Santa Cruz de la Sierra in July is currently the most expensive (average of $656). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 4 airlines flying from Irvine to Santa Cruz de la Sierra

Discover the top 4 airlines that operate flights from Irvine to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$354Average$631FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$556Average$718FlexibilityNo cancel feeOn-time70%
AviancaCheapest$580Average$675FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$1,034Average$1,159FlexibilityNo cancel feeOn-time81%

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