$420+ Cheap flights from Guayaquil (GYE) to Santa Cruz de la Sierra (VVI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/29. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — VVI
Dec 4 — Dec 111
Round-trip
1 adult, Economy
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Find cheap flights from Guayaquil to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Guayaquil to Santa Cruz de la Sierra
Cheapest
Best
Last-minute
One-way
Cheapest flights from Guayaquil to Santa Cruz de la SierraExplore the most affordable flight options available from Guayaquil to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from Guayaquil to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This Copa Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:38 pm -
1 stop27h 00m
Sat 11/711:41 am -
1 stop13h 14m
Deal found 11/2![Copa Airlines logo]()
$713
Best flights from Guayaquil to Santa Cruz de la SierraDiscover carefully curated flight deals from Guayaquil to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from Guayaquil to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This Copa Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Mon 11/236:38 pm -
1 stop27h 00m
Tue 12/111:34 am -
1 stop10h 23m
Deal found 11/4![Copa Airlines logo]()
$713
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/512:21 pm -
1 stop14h 22m
Thu 2/1111:55 am -
1 stop26h 48m
Deal found 10/31![Copa Airlines logo]()
$797
Last-minute flights from Guayaquil to Santa Cruz de la SierraDiscover last-minute flight deals from Guayaquil to Santa Cruz de la Sierra. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from Guayaquil to Santa Cruz de la Sierra. Data last updated November 4, 2026 and is based on user searches.
This Copa Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:38 pm -
1 stop27h 00m
Thu 11/1211:41 am -
1 stop27h 01m
Deal found 11/4![Copa Airlines logo]()
$713
One-way flights from Guayaquil to Santa Cruz de la SierraSearch for one-way flight options from Guayaquil to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from Guayaquil to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This Copa Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/296:34 pm -
1 stop27h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Copa Airlines logo]()
$420
This Avianca deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/93:30 am -
1 stop22h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Avianca logo]()
$464
Find flight deals from Guayaquil to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $713 (Copa Airlines) |
One-way from | $420 (Copa Airlines) |
Popular in | January |
Cheapest in | November |
Average price | $473 |
Cheapflights Fare Finder
Customize your flight search to find flights from Guayaquil to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from Guayaquil to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GuayaquilSanta Cruz de la Sierra
GYE Guayaquil Jose Joaquin de Olmedo - VVI Santa Cruz de la Sierra Viru Viru Intl
GYEVVI
Guayaquil Jose Joaquin de Olmedo
Tue 12/29
6:34 pm-10:48 pm
1 stop27h 14m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$420
Quickest round-trip
GuayaquilSanta Cruz de la Sierra
GYE Guayaquil Jose Joaquin de Olmedo - VVI Santa Cruz de la Sierra Viru Viru Intl
GYEVVI
Guayaquil Jose Joaquin de Olmedo
Sat 1/9
3:30 am-2:40 am
1 stop22h 10m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$464
GuayaquilSanta Cruz de la Sierra
GYE Guayaquil Jose Joaquin de Olmedo - VVI Santa Cruz de la Sierra Viru Viru Intl
GYEVVI
Guayaquil Jose Joaquin de Olmedo
Mon 11/23
6:38 pm-10:38 pm
1 stop27h 00m
Santa Cruz de la Sierra Viru Viru Intl
Tue 12/1
11:34 am-8:57 pm
1 stop10h 23m
$713
GuayaquilSanta Cruz de la Sierra
GYE Guayaquil Jose Joaquin de Olmedo - VVI Santa Cruz de la Sierra Viru Viru Intl
GYEVVI
Guayaquil Jose Joaquin de Olmedo
Fri 2/5
12:21 pm-3:43 am
1 stop14h 22m
Santa Cruz de la Sierra Viru Viru Intl
Thu 2/11
11:55 am-1:43 pm
1 stop26h 48m
$797
Sorted by cheapest first
Compare providers for flights from Guayaquil to Santa Cruz de la Sierra
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Guayaquil to Santa Cruz de la Sierra in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Guayaquil-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Guayaquil-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Guayaquil-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Guayaquil-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Guayaquil-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Guayaquil to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Guayaquil with our price prediction graph.
GYE-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Guayaquil to Santa Cruz de la Sierra
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated November 4, 2026.
See what other customers who have flown with LATAM Airlines from Guayaquil to Santa Cruz de la Sierra have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.8
Overall
7.4
Crew
8.0
Comfort
7.3
Boarding
7.5
Entertainment
7.0
Reviews
1 / 20
2.0
MediocrePedro,Oct 2026
MDW - ATL
Food
6.8
Overall
7.4
Crew
8.0
Comfort
7.3
Boarding
7.5
Entertainment
7.0
Reviews
1 / 20
2.0
MediocrePedro,Oct 2026
MDW - ATL
Related info for your journey
Find useful and relevant information for your journey from Guayaquil to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Guayaquil and Santa Cruz de la Sierra flights
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Top airline flying from Guayaquil to Santa Cruz de la Sierra
Discover the top airline that operate flights from Guayaquil to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$508 | Average$662 | FlexibilityNo cancel fee | On-time81% |