$407+ Cheap flights from Guayaquil (GYE) to Santa Cruz de la Sierra (VVI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — VVI
Oct 13 — Oct 201
Round-trip
1 adult, Economy
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Find cheap flights from Guayaquil to Santa Cruz de la Sierra with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Guayaquil to Santa Cruz de la Sierra
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Best
Last-minute
One-way
Cheapest flights from Guayaquil to Santa Cruz de la SierraExplore the most affordable flight options available from Guayaquil to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
Explore the most affordable flight options available from Guayaquil to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:45 pm -
1 stop9h 45m
Tue 9/153:35 am -
1 stop15h 00m
Deal found 9/10![Avianca logo]()
$687
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:38 pm -
1 stop27h 00m
Thu 11/1211:49 am -
1 stop26h 53m
Deal found 9/11![Copa Airlines logo]()
$689
This Avianca deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/1310:05 am -
1 stop15h 25m
Mon 9/143:35 am -
1 stop12h 00m
Deal found 9/9![Avianca logo]()
$696
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:14 am -
1 stop22h 24m
Sun 10/251:12 am -
1 stop17h 20m
Deal found 9/9![Copa Airlines logo]()
$721
This FlightHub deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/218:00 pm -
2 stops11h 35m
Thu 11/269:05 pm -
2 stops18h 45m
Deal found 9/12![Multiple Airlines logo]()
$729
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:28 pm -
1 stop27h 16m
Sat 10/31:12 am -
1 stop11h 09m
Deal found 9/11![Copa Airlines logo]()
$746
This Copa Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/68:25 am -
1 stop13h 23m
Thu 12/3111:42 am -
1 stop13h 01m
Deal found 9/12![Copa Airlines logo]()
$756
This Booking.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/68:00 pm -
1 stop7h 35m
Thu 12/3110:10 pm -
2 stops17h 40m
Deal found 9/12![Multiple Airlines logo]()
$759
This FlightHub deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:00 am -
2 stops45h 56m
Wed 9/165:25 pm -
2 stops22h 20m
Deal found 9/10![Multiple Airlines logo]()
$801
Best flights from Guayaquil to Santa Cruz de la SierraDiscover carefully curated flight deals from Guayaquil to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
Discover carefully curated flight deals from Guayaquil to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
This Avianca deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:10 am -
1 stop16h 30m
Wed 10/283:45 am -
1 stop15h 40m
Deal found 9/8![Avianca logo]()
$687
This Copa Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:38 pm -
1 stop27h 00m
Thu 11/1211:49 am -
1 stop26h 53m
Deal found 9/8![Copa Airlines logo]()
$689
This FlightHub deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/218:00 pm -
2 stops11h 35m
Thu 11/269:05 pm -
2 stops18h 45m
Deal found 9/12![Multiple Airlines logo]()
$729
This Copa Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/88:27 am -
1 stop18h 10m
Wed 11/111:08 am -
1 stop20h 48m
Deal found 9/12![Copa Airlines logo]()
$689
Last-minute flights from Guayaquil to Santa Cruz de la SierraDiscover last-minute flight deals from Guayaquil to Santa Cruz de la Sierra. Data last updated September 13, 2026 and is based on user searches.
Discover last-minute flight deals from Guayaquil to Santa Cruz de la Sierra. Data last updated September 13, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/1310:05 am -
1 stop15h 25m
Mon 9/143:35 am -
1 stop12h 00m
Deal found 9/9![Avianca logo]()
$696
This Priceline deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/1310:05 am -
1 stop15h 25m
Tue 9/159:10 pm -
2 stops18h 35m
Deal found 9/9![Multiple Airlines logo]()
$894
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:45 pm -
1 stop9h 45m
Tue 9/153:35 am -
1 stop15h 00m
Deal found 9/10![Avianca logo]()
$687
This FlightHub deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:00 am -
2 stops45h 56m
Wed 9/165:25 pm -
2 stops22h 20m
Deal found 9/10![Multiple Airlines logo]()
$801
This SmartFares deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:38 pm -
2 stops15h 51m
Fri 9/185:25 am -
1 stop10h 20m
Deal found 9/12![LATAM Airlines logo]()
$858
This Copa Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:28 pm -
1 stop27h 16m
Mon 9/281:12 am -
1 stop23h 49m
Deal found 9/10![Copa Airlines logo]()
$689
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:28 pm -
1 stop27h 16m
Sat 10/31:12 am -
1 stop11h 09m
Deal found 9/11![Copa Airlines logo]()
$746
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:14 am -
1 stop22h 24m
Sun 10/251:12 am -
1 stop17h 20m
Deal found 9/9![Copa Airlines logo]()
$721
This Justfly.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/258:00 pm -
1 stop7h 35m
Thu 10/2911:15 am -
2 stops39h 25m
Deal found 9/8![LATAM Airlines logo]()
$817
One-way flights from Guayaquil to Santa Cruz de la SierraSearch for one-way flight options from Guayaquil to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
Search for one-way flight options from Guayaquil to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/299:10 am -
1 stop16h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Avianca logo]()
$407
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:28 pm -
1 stop27h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Copa Airlines logo]()
$408
This FlightHub deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:45 pm -
2 stops10h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$480
Find flight deals from Guayaquil to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $687 (Avianca) |
One-way from | $407 (Avianca) |
Popular in | January |
Cheapest in | March |
Average price | $689 |
Cheapflights Fare Finder
Customize your flight search to find flights from Guayaquil to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
Use the filters below to find and compare flights from Guayaquil to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GuayaquilSanta Cruz de la Sierra
GYE Guayaquil Jose Joaquin de Olmedo - VVI Santa Cruz de la Sierra Viru Viru Intl
GYEVVI
Guayaquil Jose Joaquin de Olmedo
Tue 9/29
9:10 am-2:30 am
1 stop16h 20m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$407
GuayaquilSanta Cruz de la Sierra
GYE Guayaquil Jose Joaquin de Olmedo - VVI Santa Cruz de la Sierra Viru Viru Intl
GYEVVI
Guayaquil Jose Joaquin de Olmedo
Wed 9/16
6:28 pm-10:44 pm
1 stop27h 16m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$408
Quickest round-trip
GuayaquilSanta Cruz de la Sierra
GYE Guayaquil Jose Joaquin de Olmedo - VVI Santa Cruz de la Sierra Viru Viru Intl
GYEVVI
Guayaquil Jose Joaquin de Olmedo
Tue 9/29
8:45 pm-8:35 am
2 stops10h 50m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$480
GuayaquilSanta Cruz de la Sierra
GYE Guayaquil Jose Joaquin de Olmedo - VVI Santa Cruz de la Sierra Viru Viru Intl
GYEVVI
Guayaquil Jose Joaquin de Olmedo
Sun 10/25
9:10 am-2:40 am
1 stop16h 30m
Santa Cruz de la Sierra Viru Viru Intl
Wed 10/28
3:45 am-6:25 pm
1 stop15h 40m
$687
GuayaquilSanta Cruz de la Sierra
GYE Guayaquil Jose Joaquin de Olmedo - VVI Santa Cruz de la Sierra Viru Viru Intl
GYEVVI
Guayaquil Jose Joaquin de Olmedo
Sat 11/7
6:38 pm-10:38 pm
1 stop27h 00m
Santa Cruz de la Sierra Viru Viru Intl
Thu 11/12
11:49 am-1:42 pm
1 stop26h 53m
$689
GuayaquilSanta Cruz de la Sierra
GYE Guayaquil Jose Joaquin de Olmedo - VVI Santa Cruz de la Sierra Viru Viru Intl
GYEVVI
Guayaquil Jose Joaquin de Olmedo
Sun 11/8
8:27 am-3:37 am
1 stop18h 10m
Santa Cruz de la Sierra Viru Viru Intl
Wed 11/11
1:08 am-8:56 pm
1 stop20h 48m
$689
GuayaquilSanta Cruz de la Sierra
GYE Guayaquil Jose Joaquin de Olmedo - VVI Santa Cruz de la Sierra Viru Viru Intl
GYEVVI
Guayaquil Jose Joaquin de Olmedo
Sat 11/21
8:00 pm-8:35 am
2 stops11h 35m
Santa Cruz de la Sierra Viru Viru Intl
Thu 11/26
9:05 pm-2:50 pm
2 stops18h 45m
$729
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Guayaquil-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Guayaquil-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Guayaquil-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Guayaquil-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Guayaquil-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Guayaquil to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Guayaquil with our price prediction graph.
GYE-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Guayaquil to Santa Cruz de la Sierra
How far ahead should I book a flight from Guayaquil to Santa Cruz de la Sierra?
Booking 30 days in advance of your planned departure date is, on average, the best time to get cheap flights from Guayaquil to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
How much does it cost to fly round-trip from Guayaquil to Santa Cruz de la Sierra?
Airfare is typical for this route at the moment.
Guayaquil to Santa Cruz de la Sierra flights typically cost between $665 and $690 in October.The cheapest round-trip price found within the last 5 days was $687 on Avianca (Oct 25-Oct 28).
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated September 13, 2026.
See what other customers who have flown with LATAM Airlines from Guayaquil to Santa Cruz de la Sierra have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.5
Food
6.7
Crew
8.0
Overall
7.4
Entertainment
7.0
Comfort
7.3
Reviews
1 / 20
6.0
GoodJuan,Apr 2026
BOG - CLO
Boarding
7.5
Food
6.7
Crew
8.0
Overall
7.4
Entertainment
7.0
Comfort
7.3
Reviews
1 / 20
6.0
GoodJuan,Apr 2026
BOG - CLO
Related info for your journey
Find useful and relevant information for your journey from Guayaquil to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
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Guayaquil and Santa Cruz de la Sierra flights
Browse other Guayaquil and Santa Cruz de la Sierra flight options. Last updated on September 13, 2026.
Other flights from Guayaquil
Browse through other flights departing from Guayaquil. Flights are based on user searches made on Cheapflights and were last updated on September 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Guayaquil to Santa Cruz de la Sierra
Discover the top airline that operate flights from Guayaquil to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$503 | Average$629 | FlexibilityNo cancel fee | On-time81% |