HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Cruz de la Sierra

$264+ Cheap flights from O'Hare Intl (ORD) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/13. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — VVI
nov. 27 — déc. 41
jeu. 11/27
jeu. 12/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from O'Hare Intl to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from O'Hare Intl to Santa Cruz de la Sierra

Cheapest flights from O'Hare Intl to Santa Cruz de la Sierra
Explore the most affordable flight options available from O'Hare Intl to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octobre 28, 2025.

This Copa Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/106:56 amORD - VVI
1 stop13h 50mCopa Airlines
dim. 11/161:09 amVVI - ORD
1 stop13h 37mCopa Airlines
Deal found 10/27$417
This Copa Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven. 11/146:56 amORD - VVI
1 stop13h 50mCopa Airlines
mer. 12/101:09 amVVI - ORD
1 stop13h 43mCopa Airlines
Deal found 10/27$528
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/107:55 pmORD - VVI
2 stops24h 51mUnited Airlines
lun. 11/1711:40 amVVI - ORD
3 stops31h 25mUnited Airlines
Deal found 10/27$604
This Copa Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 11/192:07 pmORD - VVI
1 stop11h 29mCopa Airlines
mar. 12/91:09 amVVI - ORD
1 stop13h 43mCopa Airlines
Deal found 10/27$613
This Copa Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 11/296:56 amORD - VVI
1 stop13h 50mCopa Airlines
dim. 12/141:09 amVVI - ORD
1 stop13h 43mCopa Airlines
Deal found 10/27$639
This Copa Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 11/66:56 amORD - VVI
1 stop13h 50mCopa Airlines
sam. 11/151:09 amVVI - ORD
1 stop13h 37mCopa Airlines
Deal found 10/28$656
This Avianca deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/1010:35 amORD - VVI
2 stops14h 00mAvianca
dim. 11/163:40 amVVI - ORD
1 stop18h 40mAvianca
Deal found 10/27$671
This Copa Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/17:33 amORD - VVI
1 stop13h 13mCopa Airlines
sam. 12/2711:40 amVVI - ORD
1 stop14h 25mCopa Airlines
Deal found 10/27$702

Cheap flight deals from O'Hare Intl to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated octobre 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$417
(Copa Airlines)

One-way from

$264
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$581
Provider with most accurate pricing for Chicago O'Hare Intl-Santa Cruz de la Sierra Viru Viru Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Chicago O'Hare Intl-Santa Cruz de la Sierra Viru Viru Intl flights.
Search Deals
From Chicago O'Hare Intl to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from Chicago O'Hare Intl to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($102 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from O'Hare Intl to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octobre 28, 2025.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra that are best for you.

Fly from

O'Hare Intl

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

lun. 11/10

6:56 am-10:46 pm

1 stop13h 50m

Santa Cruz de la Sierra Viru Viru Intl

dim. 11/16

1:09 am-12:46 pm

1 stop13h 37m

$417

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

ven. 11/14

6:56 am-10:46 pm

1 stop13h 50m

Santa Cruz de la Sierra Viru Viru Intl

mer. 12/10

1:09 am-12:52 pm

1 stop13h 43m

$528

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

lun. 11/10

7:55 pm-10:46 pm

2 stops24h 51m

Santa Cruz de la Sierra Viru Viru Intl

lun. 11/17

11:40 am-5:05 pm

3 stops31h 25m

$604

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

mar. 12/2

6:00 am-10:46 pm

2 stops14h 46m

Santa Cruz de la Sierra Viru Viru Intl

jeu. 1/1

11:44 am-9:38 am

2 stops23h 54m

$604

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

dim. 1/11

7:35 am-3:44 am

1 stop18h 09m

Santa Cruz de la Sierra Viru Viru Intl

mar. 2/10

11:44 am-12:04 am

1 stop14h 20m

$613

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

dim. 4/5

8:35 am-3:44 am

1 stop18h 09m

Santa Cruz de la Sierra Viru Viru Intl

ven. 4/17

1:15 am-1:46 pm

1 stop13h 31m

$656

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

mar. 1/13

4:11 pm-2:35 am

3 stops56h 24m

$264

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

lun. 4/20

3:13 pm-3:44 am

1 stop11h 31m

$270

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

mar. 1/13

11:05 am-10:50 pm

2 stops33h 45m

$275

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

mar. 1/13

7:35 am-10:50 pm

1 stop13h 15m

$339

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 14 results
1
2

Compare providers for flights from O'Hare Intl to Santa Cruz de la Sierra

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from O'Hare Intl to Santa Cruz de la Sierra in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Santa Cruz de la Sierra flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Chicago O'Hare Intl Airport-Santa Cruz de la Sierra flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Santa Cruz de la Sierra flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from O'Hare Intl to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from O'Hare Intl with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra

What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra?

Currently, November is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra (average of $258). Flying from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra in January is currently the most expensive (average of $899). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ORD to VVI?

Find hourly flight availability from O'Hare Intl to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octobre 28, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 10% on flights from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra by exploring options for tickets in the morning.

How much does it cost to fly round-trip from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra?

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated octobre 28, 2025.
Read reviews from past customers who have flown Copa Airlines and United Airlines from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,560 reviews

Boarding

7.8

Entertainment

6.8

Crew

8.1

Comfort

7.4

Overall

7.6

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,560 reviews
Copa Airlines
7.6
Good
1,560 reviews

Boarding

7.8

Entertainment

6.8

Crew

8.1

Comfort

7.4

Overall

7.6

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
8,996 reviews
Copa Airlines
7.6
Good
1,560 reviews

Boarding

7.8

Entertainment

6.8

Crew

8.1

Comfort

7.4

Overall

7.6

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from O'Hare Intl to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Cruz de la Sierra from Chicago O'Hare Intl?

    Santa Cruz de la Sierra Viru Viru Intl (VVI), located 11.5 mi from the city center, is the airport you fly into when you book flights from Chicago O'Hare Intl to Santa Cruz de la Sierra. 2 airlines have flights to Viru Viru Intl from Chicago O'Hare Intl on a regular basis. Booking flights from Chicago O'Hare Intl to Santa Cruz de la Sierra Viru Viru Intl should not be difficult; the airport handles an average of 0 inbound flights from Chicago O'Hare Intl per day.

  • How long is the flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra?

    A quick flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra can take about 13h 50m. Copa Airlines provides one of the quickest options available for as low as $417. The distance from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra is about 4410 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra round-trip?

    Our cheapest airline available from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra is Copa Airlines. Our recent data shows that you can find tickets from as low as $566 on this airline. An additional option worth looking into is United Airlines, starting at $581. You may be able to fly from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra for 19% less than the average price by searching for these airlines.

  • Can I find deals for flights from O'Hare Intl to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on O'Hare Intl to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from O'Hare Intl to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from O'Hare Intl to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from O'Hare Intl to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from O'Hare Intl to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra?

    Currently, November is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra (average of $258). Flying from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra in January is currently the most expensive (average of $899). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for O'Hare Intl to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to La Paz flights
O'Hare Intl to Cochabamba flights

Top 2 airlines flying from O'Hare Intl to Santa Cruz de la Sierra

Discover the top 2 airlines that operate flights from O'Hare Intl to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octobre 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$566Average$780FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$581Average$619FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.