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Santa Cruz de la Sierra

$255+ Cheap flights from O'Hare Intl (ORD) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — VVI
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from O'Hare Intl to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$528
(Copa Airlines)

One-way from

$255
(Orbitz)

Popular in

December

Cheapest in

October

Average price

$606
From Chicago O'Hare Intl to Santa Cruz de la Sierra Viru Viru Intl
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One-way flight from Chicago O'Hare Intl to Santa Cruz de la Sierra Viru Viru Intl
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Highest demand for flights based on searches. 14% potential increase in price ($119 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from O'Hare Intl to Santa Cruz de la Sierra

Cheapest flights from O'Hare Intl to Santa Cruz de la Sierra
Explore the most affordable flight options available from O'Hare Intl to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/153:07 pmORD - VVI
1 stop11h 29mCopa Airlines
Tue 10/141:09 amVVI - ORD
1 stop13h 32mCopa Airlines
Deal found 9/8$446
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/32:07 pmORD - VVI
1 stop11h 29mCopa Airlines
Thu 11/1311:40 amVVI - ORD
1 stop14h 25mCopa Airlines
Deal found 9/11$528
This Avianca Connect deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/155:05 amORD - VVI
2 stops19h 45mMultiple Airlines
Tue 10/142:50 amVVI - ORD
2 stops16h 48mMultiple Airlines
Deal found 9/8$574
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/227:45 pmORD - VVI
2 stops25h 40mUnited Airlines
Sat 9/271:09 amVVI - ORD
2 stops24h 05mUnited Airlines
Deal found 9/10$603
This Avianca deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/37:35 amORD - VVI
2 stops17h 00mAvianca
Wed 11/123:40 amVVI - ORD
1 stop18h 40mAvianca
Deal found 9/11$617
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3110:35 amORD - VVI
2 stops15h 00mMultiple Airlines
Thu 11/133:40 amVVI - ORD
1 stop18h 40mMultiple Airlines
Deal found 9/10$622
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2110:35 amORD - VVI
2 stops34h 11mUnited Airlines
Sat 11/291:09 amVVI - ORD
2 stops19h 11mUnited Airlines
Deal found 9/10$669
This Avianca deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/157:25 amORD - VVI
2 stops17h 25mAvianca
Tue 10/142:50 amVVI - ORD
1 stop11h 25mAvianca
Deal found 9/8$690
This Avianca deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1010:35 amORD - VVI
2 stops14h 15mMultiple Airlines
Thu 9/112:50 amVVI - ORD
1 stop11h 25mMultiple Airlines
Deal found 9/9$743
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/228:18 pmORD - VVI
2 stops48h 28mUnited Airlines
Sat 11/291:09 amVVI - ORD
2 stops24h 46mUnited Airlines
Deal found 9/9$744
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/227:25 amORD - VVI
2 stops17h 25mAvianca
Sat 9/272:50 amVVI - ORD
1 stop11h 25mAvianca
Deal found 9/10$765
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/288:50 amORD - VVI
2 stops15h 45mMultiple Airlines
Sun 12/283:40 amVVI - ORD
1 stop18h 40mMultiple Airlines
Deal found 9/10$770

Cheapflights Fare Finder

 
Customize your flight search to find flights from O'Hare Intl to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra that are best for you.

Fly from

O'Hare Intl

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Mon 9/15

3:07 pm-3:36 am

1 stop11h 29m

Santa Cruz de la Sierra Viru Viru Intl

Tue 10/14

1:09 am-1:41 pm

1 stop13h 32m

$446

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Mon 11/3

6:56 am-3:36 am

1 stop18h 40m

Santa Cruz de la Sierra Viru Viru Intl

Wed 11/12

1:09 am-12:46 pm

1 stop13h 37m

$528

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Mon 9/15

5:05 am-1:50 am

2 stops19h 45m

Santa Cruz de la Sierra Viru Viru Intl

Tue 10/14

2:50 am-6:38 pm

2 stops16h 48m

$574

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Sat 10/25

10:45 am-10:40 pm

2 stops34h 55m

Santa Cruz de la Sierra Viru Viru Intl

Fri 10/31

1:09 am-8:41 am

2 stops32h 32m

$603

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Fri 10/31

6:20 pm-10:46 pm

2 stops27h 26m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/13

1:09 am-5:00 am

2 stops29h 51m

$603

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Mon 11/3

9:10 pm-10:46 pm

2 stops23h 36m

Santa Cruz de la Sierra Viru Viru Intl

Wed 11/12

1:09 am-11:10 pm

2 stops24h 01m

$603

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Mon 11/3

7:35 am-2:35 am

2 stops17h 00m

Santa Cruz de la Sierra Viru Viru Intl

Wed 11/12

3:40 am-8:20 pm

1 stop18h 40m

$617

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Sat 11/22

9:10 pm-10:46 pm

2 stops23h 36m

Santa Cruz de la Sierra Viru Viru Intl

Sat 11/29

1:09 am-6:20 pm

2 stops19h 11m

$669

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Fri 11/21

10:35 am-10:46 pm

2 stops34h 11m

Santa Cruz de la Sierra Viru Viru Intl

Sat 11/29

1:09 am-6:20 pm

2 stops19h 11m

$669

ChicagoSanta Cruz de la Sierra

ORD - VVI

ORDVVI

Chicago O'Hare Intl

Mon 9/15

7:25 am-1:50 am

2 stops17h 25m

Santa Cruz de la Sierra Viru Viru Intl

Tue 10/14

2:50 am-1:15 pm

1 stop11h 25m

$690

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 21 results
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Best time to book a flight from O'Hare Intl to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from O'Hare Intl with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra

What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra (average of $597). Flying from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ORD to VVI?

Find hourly flight availability from O'Hare Intl to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 11% on flights from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra by exploring options for tickets in the morning.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated September 11, 2025.
Read reviews from past customers who have flown Copa Airlines and United Airlines from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Overall

7.6

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Overall

7.6

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
8,937 reviews
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Overall

7.6

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from O'Hare Intl to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Cruz de la Sierra from Chicago O'Hare Intl?

    Santa Cruz de la Sierra Viru Viru Intl (VVI), located 11.5 mi from the city center, is the airport you fly into when you book flights from Chicago O'Hare Intl to Santa Cruz de la Sierra. 2 airlines have flights to Viru Viru Intl from Chicago O'Hare Intl on a regular basis. Booking flights from Chicago O'Hare Intl to Santa Cruz de la Sierra Viru Viru Intl should not be difficult; the airport handles an average of 0 inbound flights from Chicago O'Hare Intl per day.

  • How long is the flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra?

    A quick flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra can take about 11h 29m. Copa Airlines provides one of the quickest options available for as low as $446. The distance from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra is about 4410 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra round-trip?

    Our cheapest airline available from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra is Copa Airlines. Our recent data shows that you can find tickets from as low as $566 on this airline. An additional option worth looking into is United Airlines, starting at $581. You may be able to fly from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra for 20% less than the average price by searching for these airlines.

  • Can I find deals for flights from O'Hare Intl to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on O'Hare Intl to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from O'Hare Intl to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from O'Hare Intl to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from O'Hare Intl to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from O'Hare Intl to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra (average of $597). Flying from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for O'Hare Intl to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to Cochabamba flights
O'Hare Intl to La Paz flights

Top 2 airlines flying from O'Hare Intl to Santa Cruz de la Sierra

Discover the top 2 airlines that operate flights from O'Hare Intl to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$566Average$779FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$581Average$649FlexibilityNo cancel feeOn-time69%

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