$154+ Cheap flights from St. Louis (STL) to Panama
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/29. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from St. Louis to Panama with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Panama
Keep the following information in mind while searching for St. Louis to Panama flight deals. Data was last updated April 30, 2025.
Most accurate provider | AranGrant 3 stars |
|---|---|
Most trusted provider | AranGrant 3 stars |
Round-trip from | $378 (American Airlines) |
One-way from | $154 (United Airlines) |
Popular in | March |
Cheapest in | April |
Average price | $441 |
Find flight deals from St. Louis to Panama
Cheapest flights from St. Louis to PanamaExplore the most affordable flight options available from St. Louis to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.
Explore the most affordable flight options available from St. Louis to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Ovago deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Mon 6/16
5:47 pm-1:00 pm
2 stops19h 13m
Panama City Tocumen Intl
Fri 6/20
3:20 pm-8:58 am
2 stops17h 38m
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Mon 6/16
6:00 am-1:08 pm
1 stop7h 08m
Panama City Tocumen Intl
Fri 6/20
2:23 pm-11:51 pm
1 stop9h 28m
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Wed 6/4
8:25 am-4:12 pm
1 stop7h 47m
Panama City Tocumen Intl
Mon 6/9
10:00 am-10:15 pm
1 stop12h 15m
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Thu 5/22
10:10 am-10:25 am
3 stops24h 15m
Panama City Tocumen Intl
Mon 5/26
3:25 am-12:10 pm
3 stops32h 45m
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Wed 6/4
9:50 am-12:35 pm
3 stops26h 45m
Panama City Tocumen Intl
Mon 6/9
5:25 pm-9:56 am
2 stops40h 31m
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Sun 6/29
5:30 pm-2:14 pm
2 stops20h 44m
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Sat 5/17
10:10 am-7:50 am
2 stops21h 40m
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Sat 5/17
6:00 am-12:48 pm
1 stop6h 48m
Best time to book a flight from St. Louis to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from St. Louis with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Panama
What is the cheapest month to book a flight from St. Louis to Panama?
Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama (average of $478). Flying from St. Louis to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to PA?
Find hourly flight availability from St. Louis to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 30, 2025.
When flying from St. Louis to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Rainfall in Panama by month
Plan your trip to Panama by taking into account the average rainfall totals by month.
In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.
Temperature in Panama by month
Plan your trip to Panama by taking into account the average temperature totals by month.
If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated April 30, 2025.
Read through reviews of airlines operating flights from St. Louis to Panama, such as Delta, United Airlines and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
Boarding
Comfort
Entertainment
Food
Overall
Reviews
Aaron,Oct 2024
LAX - LHR
Crew
Boarding
Comfort
Entertainment
Food
Overall
Reviews
Aaron,Oct 2024
LAX - LHR
Crew
Boarding
Comfort
Entertainment
Food
Overall
Reviews
Aaron,Oct 2024
LAX - LHR
Crew
Boarding
Comfort
Entertainment
Food
Overall
Reviews
Aaron,Oct 2024
LAX - LHR
Crew
Boarding
Comfort
Entertainment
Food
Overall
Reviews
Aaron,Oct 2024
LAX - LHR
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Top 3 airlines flying from St. Louis to Panama
Discover the top 3 airlines that operate flights from St. Louis to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$379 | Average$552 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$440 | Average$548 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$448 | Average$541 | FlexibilityNo cancel fee | On-time69% |