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$164+ Cheap flights from St. Louis (STL) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Dec 12 — Dec 191
Fri 12/12
Fri 12/19
1 adult, Economy
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Find flight deals from St. Louis to Panama

Cheapest flights from St. Louis to Panama
Explore the most affordable flight options available from St. Louis to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2025.

This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:53 pmSTL - PTY
2 stops17h 54mAmerican Airlines
Tue 12/164:43 pmPTY - STL
1 stop8h 16mAmerican Airlines
Deal found 11/12$398
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/145:27 pmSTL - PTY
2 stops20h 18mUnited Airlines
Sun 12/2111:35 amPTY - STL
1 stop11h 20mUnited Airlines
Deal found 11/11$415
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/146:53 pmSTL - PTY
2 stops17h 54mAmerican Airlines
Sun 12/212:53 pmPTY - STL
2 stops19h 03mAmerican Airlines
Deal found 11/11$487
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:00 amSTL - PTY
1 stop7h 21mDelta
Wed 12/33:46 pmPTY - STL
1 stop17h 38mDelta
Deal found 11/10$570
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:00 amSTL - PTY
1 stop7h 21mDelta
Sun 12/78:05 amPTY - STL
1 stop10h 51mDelta
Deal found 11/12$590
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:27 pmSTL - PTY
2 stops20h 18mUnited Airlines
Sun 12/711:55 pmPTY - STL
2 stops15h 28mUnited Airlines
Deal found 11/12$594
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:43 pmSTL - PTY
2 stops19h 02mUnited Airlines
Fri 11/288:55 amPTY - STL
1 stop10h 51mUnited Airlines
Deal found 11/11$615
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/225:24 pmSTL - PTY
2 stops20h 21mUnited Airlines
Fri 12/511:55 pmPTY - STL
2 stops13h 20mUnited Airlines
Deal found 11/11$635
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:15 amSTL - PTY
1 stop7h 30mUnited Airlines
Wed 12/34:41 pmPTY - STL
2 stops20h 34mUnited Airlines
Deal found 11/10$649

Cheap flight deals from St. Louis to Panama

Keep the following information in mind while searching for St. Louis to Panama flight deals. Data was last updated November 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$394
(United Airlines)

One-way from

$164
(Delta)

Popular in

January

Cheapest in

April

Average price

$510
Provider with most accurate pricing for Lambert-St Louis-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City Tocumen Intl flights.
Search Deals
From Lambert-St Louis to Panama
Search Deals
One-way flight from Lambert-St Louis to Panama
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($40 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.

Fly from

St. Louis

Fly to

Panama

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 5/4

6:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Thu 5/7

2:20 pm-11:38 pm

1 stop9h 18m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Wed 2/25

10:00 am-10:59 pm

2 stops13h 59m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

5:55 pm-1:40 pm

2 stops18h 45m

Panama City Tocumen Intl

Wed 2/25

2:52 pm-12:46 pm

2 stops22h 54m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 5/4

5:18 pm-2:14 pm

2 stops20h 56m

Panama City Tocumen Intl

Thu 5/7

9:45 am-9:55 pm

1 stop12h 10m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 3/4

2:06 pm-1:40 pm

2 stops22h 34m

Panama City Tocumen Intl

Wed 3/11

1:50 pm-12:06 pm

2 stops22h 16m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 1/23

6:00 am-5:07 pm

1 stop10h 07m

Panama City Tocumen Intl

Tue 1/27

4:41 pm-9:22 am

1 stop17h 41m

$411

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 4/10

7:03 pm-12:15 pm

2 stops17h 12m

Panama City Tocumen Intl

Fri 4/17

1:55 pm-9:40 am

2 stops19h 45m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/10

5:04 pm-1:27 pm

2 stops19h 23m

Panama City Tocumen Intl

Sat 2/14

2:52 pm-8:28 am

2 stops18h 36m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 12/14

5:27 pm-2:45 pm

2 stops20h 18m

Panama City Tocumen Intl

Sun 12/21

11:35 am-9:55 pm

1 stop11h 20m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 2/9

3:37 pm-1:27 pm

2 stops20h 50m

$164

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Showing 1-10 of 20 results
1
2

Best time to book a flight from St. Louis to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama

What is the cheapest month to book a flight from St. Louis to Panama?

Currently, June is the cheapest month in which you can book a flight from St. Louis to Panama (average of $208). Flying from St. Louis to Panama in February is currently the most expensive (average of $509). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to PA?

Find hourly flight availability from St. Louis to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 12, 2025.

It’s optimal to fly from St. Louis to Panama at noon. By choosing this option you can save up to 32% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated November 12, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from St. Louis to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,009 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,009 reviews
Delta
7.9
Good
8,009 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,015 reviews
Delta
7.9
Good
8,009 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,009 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to Panama?

    For a flight from St. Louis to Panama, you will be flying from Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How long is the flight from St. Louis to Panama?

    There are many flights that can get you from St. Louis to Panama in 6h 55m. Fly via Delta, United Airlines, or American Airlines to get the fastest option. There are 2159 mi between St. Louis and Panama. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from St. Louis to Panama one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $164. Delta flights start at $164 while deals on United Airlines start at $170 one-way.

  • Can I find deals for flights from St. Louis to Panama that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama.

  • Can I find deals for business class flights from St. Louis to Panama?

    Yes. Cheapflights offers flight deals from St. Louis to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama?

    Currently, June is the cheapest month in which you can book a flight from St. Louis to Panama (average of $208). Flying from St. Louis to Panama in February is currently the most expensive (average of $509). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for St. Louis to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from St. Louis to Panama

Discover the top 3 airlines that operate flights from St. Louis to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$373Average$582FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$394Average$576FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$401Average$563FlexibilityNo cancel feeOn-time69%

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