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$237+ Cheap flights from St. Louis (STL) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
May 2 — May 91
Sat 5/2
Sat 5/9
1 adult, Economy
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Cheap flight deals from St. Louis to Panama

Cheapest flights from St. Louis to Panama
Explore the most affordable flight options available from St. Louis to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2026.

This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:00 am
STL
-
PTY
1 stop7h 02m
Delta
Tue 5/122:15 pm
PTY
-
STL
1 stop9h 44m
Delta
Deal found 3/30$505
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:45 am
STL
-
PTY
2 stops11h 46m
United Airlines
Mon 5/117:55 am
PTY
-
STL
1 stop14h 35m
United Airlines
Deal found 3/30$509
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:54 pm
STL
-
PTY
2 stops17h 52m
American Airlines
Fri 5/221:14 pm
PTY
-
STL
2 stops19h 18m
American Airlines
Deal found 3/31$512
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/34:41 pm
STL
-
PTY
1 stop20h 21m
Delta
Tue 5/192:15 pm
PTY
-
STL
1 stop9h 44m
Delta
Deal found 3/28$513
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:00 am
STL
-
PTY
1 stop12h 37m
United Airlines
Wed 5/67:55 am
PTY
-
STL
1 stop14h 35m
United Airlines
Deal found 3/31$522
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/37:25 am
STL
-
PTY
1 stop29h 37m
Delta
Sat 5/162:15 pm
PTY
-
STL
1 stop9h 44m
Delta
Deal found 3/28$530
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/26:14 am
STL
-
PTY
1 stop12h 23m
United Airlines
Mon 8/103:30 pm
PTY
-
STL
1 stop22h 38m
United Airlines
Deal found 3/31$531
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:00 am
STL
-
PTY
1 stop10h 12m
United Airlines
Fri 5/153:30 pm
PTY
-
STL
1 stop18h 00m
United Airlines
Deal found 3/28$539
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:13 pm
STL
-
PTY
2 stops20h 24m
American Airlines
Sun 12/132:50 pm
PTY
-
STL
2 stops19h 33m
American Airlines
Deal found 3/31$548
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:00 am
STL
-
PTY
1 stop6h 50m
Delta
Tue 5/262:15 pm
PTY
-
STL
1 stop9h 44m
Delta
Deal found 3/31$551

Find flight deals from St. Louis to Panama

Keep the following information in mind while searching for St. Louis to Panama flight deals. Data was last updated April 2, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$505
(Delta)

One-way from

$237
(United Airlines)

Popular in

December

Cheapest in

April

Average price

$459
Provider with most accurate pricing for Lambert-St Louis-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City Tocumen Intl flights.
Search Deals
From Lambert-St Louis to Panama
Search Deals
One-way flight from Lambert-St Louis to Panama
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($40 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2026.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 7/20

8:35 am-6:37 pm

1 stop10h 02m

Panama City Tocumen Intl

Thu 7/30

7:55 am-5:42 pm

1 stop9h 47m

$505
Quickest round-trip

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:00 am-1:02 pm

1 stop7h 02m

Panama City Tocumen Intl

Wed 5/6

2:27 pm-11:35 pm

1 stop9h 08m

$505

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 5/14

6:00 am-12:50 pm

1 stop6h 50m

Panama City Tocumen Intl

Thu 5/21

2:15 pm-11:59 pm

1 stop9h 44m

$505

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:30 am-6:37 pm

2 stops12h 07m

Panama City Tocumen Intl

Wed 5/6

7:55 am-4:01 pm

1 stop8h 06m

$509

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 5/3

8:30 pm-2:14 pm

2 stops17h 44m

Panama City Tocumen Intl

Mon 5/18

10:00 am-10:30 pm

1 stop12h 30m

$509

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 5/14

6:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Sun 5/17

7:55 am-10:30 pm

1 stop14h 35m

$522

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 5/6

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Sat 5/9

3:30 pm-9:30 am

1 stop18h 00m

$522

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 5/10

8:30 pm-4:12 pm

2 stops19h 42m

Panama City Tocumen Intl

Sat 5/16

3:30 pm-8:39 am

2 stops17h 09m

$526

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 5/1

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Fri 5/15

3:30 pm-9:30 am

1 stop18h 00m

$539

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 4/25

7:45 am-7:31 pm

2 stops11h 46m

Panama City Tocumen Intl

Sat 5/2

3:30 pm-9:30 am

1 stop18h 00m

$543

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/1

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

Best time to book a flight from St. Louis to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama

What is the cheapest month to book a flight from St. Louis to Panama?

Currently, June is the cheapest month in which you can book a flight from St. Louis to Panama (average of $198). Flying from St. Louis to Panama in May is currently the most expensive (average of $449). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated April 2, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from St. Louis to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,369 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Food

7.2

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,369 reviews
Delta
7.9
Good
8,369 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Food

7.2

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,533 reviews
Delta
7.9
Good
8,369 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Food

7.2

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,549 reviews
Delta
7.9
Good
8,369 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Food

7.2

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to Panama?

    For a flight from St. Louis to Panama, you will be flying from Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How long is the flight from St. Louis to Panama?

    There are many flights that can get you from St. Louis to Panama in 7h 02m. Fly via United Airlines or Delta to get the fastest option. There are 2159 mi between St. Louis and Panama. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from St. Louis to Panama that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama.

  • Can I find deals for business class flights from St. Louis to Panama?

    Yes. Cheapflights offers flight deals from St. Louis to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama?

    Currently, June is the cheapest month in which you can book a flight from St. Louis to Panama (average of $198). Flying from St. Louis to Panama in May is currently the most expensive (average of $449). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from St. Louis to Panama

Discover the top 3 airlines that operate flights from St. Louis to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$373Average$590FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$393Average$551FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$393Average$596FlexibilityNo cancel feeOn-time71%

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