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$252+ Cheap flights from St. Louis (STL) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from St. Louis to Panama

Keep the following information in mind while searching for St. Louis to Panama flight deals. Data was last updated September 16, 2025.

Round-trip from

$386
(Delta)

One-way from

$252
(Delta)

Popular in

February

Cheapest in

April

Average price

$551
From Lambert-St Louis to Panama
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One-way flight from Lambert-St Louis to Panama
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Highest demand for flights based on searches. 9% potential increase in price ($58 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from St. Louis to Panama

Cheapest flights from St. Louis to Panama
Explore the most affordable flight options available from St. Louis to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:00 amSTL - PTY
1 stop6h 56mDelta
Wed 10/222:21 pmPTY - STL
1 stop17h 44mDelta
Deal found 9/15$386
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:15 amSTL - PTY
1 stop7h 59mUnited Airlines
Tue 10/2110:00 amPTY - STL
1 stop12h 00mUnited Airlines
Deal found 9/15$393
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/138:25 amSTL - PTY
1 stop10h 12mUnited Airlines
Thu 10/233:30 pmPTY - STL
2 stops19h 19mUnited Airlines
Deal found 9/15$398
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/143:03 pmSTL - PTY
2 stops23h 00mAmerican Airlines
Thu 10/233:15 pmPTY - STL
2 stops18h 20mAmerican Airlines
Deal found 9/14$399
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:15 amSTL - PTY
1 stop12h 22mUnited Airlines
Mon 10/273:41 pmPTY - STL
1 stop27h 06mUnited Airlines
Deal found 9/15$401
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:00 amSTL - PTY
1 stop6h 56mDelta
Fri 10/242:21 pmPTY - STL
1 stop9h 20mDelta
Deal found 9/15$403
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:15 amSTL - PTY
1 stop7h 59mUnited Airlines
Tue 10/2110:00 amPTY - STL
1 stop12h 00mUnited Airlines
Deal found 9/15$410
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:25 amSTL - PTY
1 stop10h 12mUnited Airlines
Wed 10/223:30 pmPTY - STL
2 stops19h 19mUnited Airlines
Deal found 9/15$415
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:25 amSTL - PTY
1 stop10h 12mUnited Airlines
Fri 10/2410:00 amPTY - STL
1 stop8h 57mUnited Airlines
Deal found 9/15$427
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/165:00 amSTL - PTY
2 stops13h 37mUnited Airlines
Tue 10/213:30 pmPTY - STL
2 stops19h 19mUnited Airlines
Deal found 9/14$443
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/165:00 amSTL - PTY
2 stops13h 37mUnited Airlines
Fri 10/243:30 pmPTY - STL
2 stops20h 58mUnited Airlines
Deal found 9/14$460

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.

Fly from

St. Louis

Fly to

Panama

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

6:00 am-12:56 pm

1 stop6h 56m

Panama City Tocumen Intl

Thu 10/23

2:21 pm-11:41 pm

1 stop9h 20m

$386

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 10/14

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Tue 10/21

10:00 am-10:00 pm

1 stop12h 00m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/16

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Tue 10/21

10:00 am-10:00 pm

1 stop12h 00m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

8:25 am-6:37 pm

1 stop10h 12m

Panama City Tocumen Intl

Tue 10/21

10:00 am-10:00 pm

1 stop12h 00m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

8:25 am-6:37 pm

1 stop10h 12m

Panama City Tocumen Intl

Thu 10/23

3:30 pm-10:49 am

2 stops19h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/16

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 10/20

3:30 pm-10:49 am

2 stops19h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 10/15

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Tue 10/21

3:30 pm-10:49 am

2 stops19h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/16

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Thu 10/23

3:30 pm-10:49 am

2 stops19h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 10/15

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Wed 10/22

3:30 pm-10:49 am

2 stops19h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

8:25 am-6:37 pm

1 stop10h 12m

Panama City Tocumen Intl

Wed 10/22

3:30 pm-10:49 am

2 stops19h 19m

$398

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 13 results
1
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Best time to book a flight from St. Louis to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama

What is the cheapest month to book a flight from St. Louis to Panama?

Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama (average of $478). Flying from St. Louis to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to PA?

Find hourly flight availability from St. Louis to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

When flying from St. Louis to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated September 16, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from St. Louis to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,924 reviews
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to Panama?

    For a flight from St. Louis to Panama, you will be flying from Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How long is the flight from St. Louis to Panama?

    There are many flights that can get you from St. Louis to Panama in 6h 56m. Fly via Delta or United Airlines to get the fastest option. There are 2159 mi between St. Louis and Panama. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from St. Louis to Panama that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama.

  • Can I find deals for business class flights from St. Louis to Panama?

    Yes. Cheapflights offers flight deals from St. Louis to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama?

    Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama (average of $478). Flying from St. Louis to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from St. Louis to Panama

Discover the top 3 airlines that operate flights from St. Louis to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$373Average$569FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$401Average$558FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$410Average$576FlexibilityNo cancel feeOn-time71%

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