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$164+ Cheap flights from St. Louis (STL) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheap flight deals from St. Louis to Panama

Keep the following information in mind while searching for St. Louis to Panama flight deals. Data was last updated junio 12, 2025.

Round-trip from

$393
(United Airlines)

One-way from

$164
(Delta)

Popular in

March

Cheapest in

April

Average price

$505
From Lambert-St Louis to Panama
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One-way flight from Lambert-St Louis to Panama
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Highest demand for flights based on searches. 3% potential increase in price ($22 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from St. Louis to Panama

Cheapest flights from St. Louis to Panama
Explore the most affordable flight options available from St. Louis to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/258:20 amSTL - PTY
1 stop10h 17mUnited Airlines
mar. 9/23:30 pmPTY - STL
1 stop18h 31mUnited Airlines
Deal found 6/10$393
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/281:29 pmSTL - PTY
1 stop23h 44mDelta
mié. 8/62:28 pmPTY - STL
1 stop17h 54mDelta
Deal found 6/11$401
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/318:01 pmSTL - PTY
2 stops18h 14mAmerican Airlines
vie. 8/83:30 pmPTY - STL
2 stops40h 36mAmerican Airlines
Deal found 6/11$476
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/3011:24 amSTL - PTY
3 stops36h 46mMultiple Airlines
mié. 8/611:05 amPTY - STL
3 stops29h 26mMultiple Airlines
Deal found 6/11$615

Cheapflights Fare Finder

Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.

Fly from

St. Louis

Fly to

Panama

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

lun. 8/25

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

lun. 9/8

3:30 pm-10:01 am

1 stop18h 31m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

lun. 7/28

1:29 pm-1:13 pm

1 stop23h 44m

Panama City Tocumen Intl

mié. 8/6

2:28 pm-8:22 am

1 stop17h 54m

$401

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

jue. 7/31

8:01 pm-2:15 pm

2 stops18h 14m

Panama City Tocumen Intl

vie. 8/8

3:30 pm-8:06 am

2 stops40h 36m

$476

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

mié. 7/30

11:24 am-12:10 am

3 stops36h 46m

Panama City Tocumen Intl

mié. 8/6

11:05 am-4:31 pm

3 stops29h 26m

$615

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

vie. 7/11

8:15 am-8:34 pm

1 stop12h 19m

Panama City Tocumen Intl

vie. 7/18

7:30 pm-9:59 am

1 stop14h 29m

$1,554

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

lun. 8/25

6:00 am-12:50 pm

1 stop6h 50m

$164

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

lun. 6/23

8:25 am-6:37 pm

1 stop10h 12m

$273

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

lun. 6/23

11:28 am-12:10 am

3 stops36h 42m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from St. Louis to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama

What is the cheapest month to book a flight from St. Louis to Panama?

Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama (average of $478). Flying from St. Louis to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to PA?

Find hourly flight availability from St. Louis to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

When flying from St. Louis to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated junio 12, 2025.
Delta
8.0
Very good
7,946 reviews

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,946 reviews
Delta
8.0
Very good
7,946 reviews

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,451 reviews
Delta
8.0
Very good
7,946 reviews

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,946 reviews

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,946 reviews

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to Panama?

    For a flight from St. Louis to Panama, you will be flying from Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • Can I find deals for flights from St. Louis to Panama that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama.

  • Can I find deals for business class flights from St. Louis to Panama?

    Yes. Cheapflights offers flight deals from St. Louis to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama?

    Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama (average of $478). Flying from St. Louis to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for St. Louis to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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St. Louis to Managua flights
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Springfield to Philip S.W.Goldson flights
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Top 3 airlines flying from St. Louis to Panama

Discover the top 3 airlines that operate flights from St. Louis to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$373Average$532FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$394Average$542FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$445Average$533FlexibilityNo cancel feeOn-time69%

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