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$164+ Cheap flights from St. Louis (STL) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
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Cheap flight deals from St. Louis to Panama

Keep the following information in mind while searching for St. Louis to Panama flight deals. Data was last updated July 30, 2025.

Round-trip from

$393
(American Airlines)

One-way from

$164
(United Airlines)

Popular in

March

Cheapest in

April

Average price

$590
From Lambert-St Louis to Panama
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One-way flight from Lambert-St Louis to Panama
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Highest demand for flights based on searches. 2% potential increase in price ($14 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from St. Louis to Panama

Cheapest flights from St. Louis to Panama
Explore the most affordable flight options available from St. Louis to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:01 amSTL - PTY
1 stop6h 54mDelta
Thu 9/182:10 pmPTY - STL
1 stop9h 14mDelta
Deal found 7/27$393
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:00 pmSTL - PTY
2 stops20h 31mAmerican Airlines
Thu 9/183:31 pmPTY - STL
2 stops17h 43mAmerican Airlines
Deal found 7/27$398
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:15 amSTL - PTY
1 stop12h 22mUnited Airlines
Thu 9/183:30 pmPTY - STL
1 stop27h 20mUnited Airlines
Deal found 7/28$401
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/55:26 pmSTL - PTY
3 stops31h 19mMultiple Airlines
Sat 8/93:20 amPTY - STL
3 stops30h 32mMultiple Airlines
Deal found 7/28$834

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.

Fly from

St. Louis

Fly to

Panama

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 9/11

6:01 am-12:55 pm

1 stop6h 54m

Panama City Tocumen Intl

Thu 9/18

2:10 pm-11:24 pm

1 stop9h 14m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 9/11

6:00 pm-2:31 pm

2 stops20h 31m

Panama City Tocumen Intl

Thu 9/18

3:31 pm-11:59 pm

1 stop8h 28m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 9/11

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Thu 9/18

3:30 pm-6:50 pm

1 stop27h 20m

$401

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 10/22

1:00 pm-12:10 am

3 stops35h 10m

Panama City Tocumen Intl

Sat 10/25

2:55 am-12:00 pm

3 stops33h 05m

$906

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 9/18

6:15 am-6:37 pm

1 stop12h 22m

$164

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 9/19

6:00 pm-2:31 pm

2 stops20h 31m

$187

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 9/19

1:57 pm-4:52 pm

3 stops26h 55m

$339

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from St. Louis to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama

What is the cheapest month to book a flight from St. Louis to Panama?

Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama (average of $478). Flying from St. Louis to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to PA?

Find hourly flight availability from St. Louis to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2025.

When flying from St. Louis to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated July 30, 2025.
Read reviews from past customers who have flown United Airlines and American Airlines from St. Louis to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,896 reviews

Boarding

7.7

Comfort

7.3

Crew

8.1

Overall

7.4

Food

6.6

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
United Airlines
7.4
Good
8,896 reviews
United Airlines
7.4
Good
8,896 reviews

Boarding

7.7

Comfort

7.3

Crew

8.1

Overall

7.4

Food

6.6

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,896 reviews

Boarding

7.7

Comfort

7.3

Crew

8.1

Overall

7.4

Food

6.6

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to Panama?

    For a flight from St. Louis to Panama, you will be flying from Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • Can I find deals for flights from St. Louis to Panama that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama.

  • Can I find deals for business class flights from St. Louis to Panama?

    Yes. Cheapflights offers flight deals from St. Louis to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama?

    Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama (average of $478). Flying from St. Louis to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for St. Louis to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from St. Louis to Panama

Discover the top 3 airlines that operate flights from St. Louis to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$373Average$564FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$410Average$565FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$435Average$566FlexibilityNo cancel feeOn-time69%

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