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$391+ Cheap flights from Greenville (GSP) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
oct. 16 — oct. 231
jue. 10/16
jue. 10/23
1 adult, Economy
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Cheap flight deals from Greenville to Panama

Keep the following information in mind while searching for Greenville to Panama flight deals. Data was last updated septiembre 16, 2025.

Round-trip from

$391
(American Airlines)

Popular in

January

Cheapest in

August

Average price

$414
From Greenville to Panama
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($94 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
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Find flight deals from Greenville to Panama

Cheapest flights from Greenville to Panama
Explore the most affordable flight options available from Greenville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 16, 2025.

This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/297:52 amGSP - PTY
1 stop6h 04mDelta
mié. 11/53:21 pmPTY - GSP
1 stop8h 34mDelta
Deal found 9/14$391
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/295:52 pmGSP - PTY
2 stops21h 11mAmerican Airlines
mié. 11/52:49 pmPTY - GSP
1 stop9h 10mAmerican Airlines
Deal found 9/14$396
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/1411:12 amGSP - PTY
1 stop8h 47mDelta
lun. 11/243:37 pmPTY - GSP
1 stop8h 18mDelta
Deal found 9/15$409
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/146:19 pmGSP - PTY
2 stops19h 30mAmerican Airlines
lun. 11/242:43 pmPTY - GSP
2 stops20h 07mAmerican Airlines
Deal found 9/15$432
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/176:33 pmGSP - PTY
2 stops20h 30mAmerican Airlines
dom. 10/193:15 pmPTY - GSP
2 stops25h 41mAmerican Airlines
Deal found 9/14$437
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/108:01 pmGSP - PTY
2 stops19h 02mAmerican Airlines
lun. 10/203:15 pmPTY - GSP
2 stops19h 25mAmerican Airlines
Deal found 9/14$440
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/256:05 amGSP - PTY
1 stop8h 45mUnited Airlines
lun. 11/38:55 amPTY - GSP
1 stop13h 04mUnited Airlines
Deal found 9/15$441
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/137:59 pmGSP - PTY
1 stop18h 13mDelta
mié. 11/193:37 pmPTY - GSP
1 stop8h 18mDelta
Deal found 9/13$453
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/136:45 amGSP - PTY
1 stop8h 00mUnited Airlines
mar. 11/188:55 amPTY - GSP
1 stop13h 04mUnited Airlines
Deal found 9/13$459
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/246:35 amGSP - PTY
1 stop7h 21mDelta
sáb. 11/12:21 pmPTY - GSP
1 stop8h 34mDelta
Deal found 9/15$464

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 16, 2025.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Greenville

Fly to

Panama

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mar. 11/11

5:00 am-1:49 pm

1 stop8h 49m

Panama City Tocumen Intl

jue. 11/20

2:43 pm-11:59 pm

1 stop9h 16m

$391

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 10/29

7:52 am-12:56 pm

1 stop6h 04m

Panama City Tocumen Intl

mié. 11/5

3:21 pm-11:55 pm

1 stop8h 34m

$391

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 1/21

5:38 am-1:10 pm

1 stop7h 32m

Panama City Tocumen Intl

mié. 2/4

4:40 pm-12:15 am

1 stop7h 35m

$391

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

jue. 11/13

6:47 pm-1:49 pm

2 stops19h 02m

Panama City Tocumen Intl

mié. 11/19

2:49 pm-11:59 pm

1 stop9h 10m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

jue. 2/5

8:34 pm-1:10 pm

2 stops16h 36m

Panama City Tocumen Intl

jue. 2/19

2:30 pm-10:51 am

2 stops20h 21m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 10/29

5:52 pm-2:03 pm

2 stops21h 11m

Panama City Tocumen Intl

mié. 11/5

2:49 pm-11:59 pm

1 stop9h 10m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

vie. 11/14

10:08 am-7:59 pm

1 stop9h 51m

Panama City Tocumen Intl

mié. 11/19

3:37 pm-11:55 pm

1 stop8h 18m

$409

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

vie. 11/14

11:12 am-7:59 pm

1 stop8h 47m

Panama City Tocumen Intl

lun. 11/24

3:37 pm-11:55 pm

1 stop8h 18m

$409

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 1/14

8:34 pm-1:10 pm

2 stops16h 36m

$396

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Best time to book a flight from Greenville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama

What is the cheapest month to book a flight from Greenville to Panama?

Currently, October is the cheapest month in which you can book a flight from Greenville to Panama (average of $478). Flying from Greenville to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to PA?

Find hourly flight availability from Greenville to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 16, 2025.

When flying from Greenville to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated septiembre 16, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Greenville to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,924 reviews
Delta
8.0
Very good
7,957 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Panama?

    Greenville (GSP), located 10.4 mi from the city center, is the airport you fly out of when you book flights from Greenville to Panama.

  • How long is the flight from Greenville to Panama?

    There are many flights that can get you from Greenville to Panama in 6h 04m. Fly via American Airlines or Delta to get the fastest option. Airlines will cover a distance of 1792 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Greenville to Panama that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama.

  • Can I find deals for business class flights from Greenville to Panama?

    Yes. Cheapflights offers flight deals from Greenville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Panama?

    Currently, October is the cheapest month in which you can book a flight from Greenville to Panama (average of $478). Flying from Greenville to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Greenville to Panama

Discover the top 3 airlines that operate flights from Greenville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$352Average$401FlexibilityNo cancel feeOn-time69%
DeltaCheapest$371Average$519FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$376Average$577FlexibilityNo cancel feeOn-time71%

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