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$169+ Cheap flights from Greenville (GSP) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/26. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Jan 19 — Jan 261
Mon 1/19
Mon 1/26
1 adult, Economy
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Cheap flight deals from Greenville to Panama

Cheapest flights from Greenville to Panama
Explore the most affordable flight options available from Greenville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 20, 2025.

This United Airlines deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:44 pmGSP - PTY
1 stop25h 54mUnited Airlines
Tue 1/64:41 pmPTY - GSP
1 stop29h 16mUnited Airlines
Deal found 12/19$647
This American Airlines deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/224:00 pmGSP - PTY
2 stops21h 53mAmerican Airlines
Tue 1/64:31 pmPTY - GSP
2 stops17h 59mAmerican Airlines
Deal found 12/20$710
This American Airlines deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:04 pmGSP - PTY
1 stop19h 50mAmerican Airlines
Fri 1/22:53 pmPTY - GSP
1 stop9h 58mAmerican Airlines
Deal found 12/20$948
This United Airlines deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:45 amGSP - PTY
1 stop12h 53mUnited Airlines
Fri 1/24:41 pmPTY - GSP
1 stop29h 16mUnited Airlines
Deal found 12/18$1,102
This Delta deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:50 amGSP - PTY
1 stop13h 10mDelta
Fri 1/28:00 amPTY - GSP
1 stop15h 32mDelta
Deal found 12/19$1,185

Find flight deals from Greenville to Panama

Keep the following information in mind while searching for Greenville to Panama flight deals. Data was last updated December 20, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$392
(United Airlines)

One-way from

$169
(American Airlines)

Popular in

December

Cheapest in

August

Average price

$1,387
Provider with most accurate pricing for Greenville-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Panama City Tocumen Intl flights.
Search Deals
From Greenville to Panama
Search Deals
One-way flight from Greenville to Panama
Search Deals
Highest demand for flights based on searches. 33% potential increase in price ($278 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 16% potential price decrease ($77 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 20, 2025.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Greenville

Fly to

Panama

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:49 am-5:07 pm

1 stop10h 18m

Panama City Tocumen Intl

Wed 2/4

9:55 am-9:57 pm

1 stop12h 02m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

7:42 pm-3:38 pm

2 stops19h 56m

Panama City Tocumen Intl

Wed 2/4

2:27 pm-12:07 pm

2 stops21h 40m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 1/19

4:50 pm-2:45 pm

1 stop21h 55m

Panama City Tocumen Intl

Thu 1/22

11:35 am-9:57 pm

1 stop10h 22m

$400

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 1/5

6:45 am-7:38 pm

1 stop12h 53m

Panama City Tocumen Intl

Tue 1/27

4:41 pm-3:35 pm

1 stop22h 54m

$406

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/7

4:50 pm-5:07 pm

1 stop24h 17m

Panama City Tocumen Intl

Tue 1/27

4:41 pm-3:35 pm

1 stop22h 54m

$414

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/7

4:50 pm-7:38 pm

1 stop26h 48m

Panama City Tocumen Intl

Mon 1/26

4:41 pm-3:35 pm

1 stop22h 54m

$414

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 1/5

6:45 am-5:07 pm

1 stop10h 22m

Panama City Tocumen Intl

Sat 1/24

4:41 pm-9:57 pm

1 stop29h 16m

$424

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 1/6

6:49 am-7:38 pm

1 stop12h 49m

Panama City Tocumen Intl

Tue 1/27

4:41 pm-3:35 pm

1 stop22h 54m

$425

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 1/10

6:49 am-2:45 pm

1 stop7h 56m

Panama City Tocumen Intl

Tue 1/27

4:41 pm-3:35 pm

1 stop22h 54m

$426

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 1/26

6:23 pm-1:27 pm

2 stops19h 04m

$169

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/18

Showing 1-10 of 14 results
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Best time to book a flight from Greenville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama

What is the cheapest month to book a flight from Greenville to Panama?

Currently, August is the cheapest month in which you can book a flight from Greenville to Panama (average of $267). Flying from Greenville to Panama in January is currently the most expensive (average of $435). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to PA?

Find hourly flight availability from Greenville to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 20, 2025.

It’s optimal to fly from Greenville to Panama in the afternoon. By choosing this option you can save up to 58% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated December 20, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Greenville to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,021 reviews

Boarding

8.1

Crew

8.5

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,021 reviews
Delta
7.9
Good
8,021 reviews

Boarding

8.1

Crew

8.5

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,099 reviews
Delta
7.9
Good
8,021 reviews

Boarding

8.1

Crew

8.5

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,021 reviews

Boarding

8.1

Crew

8.5

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Panama?

    Greenville (GSP), located 10.4 mi from the city center, is the airport you fly out of when you book flights from Greenville to Panama.

  • How long is the flight from Greenville to Panama?

    There are many flights that can get you from Greenville to Panama in 10h 18m. Fly via United Airlines or American Airlines to get the fastest option. Airlines will cover a distance of 1792 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Greenville to Panama that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama.

  • Can I find deals for business class flights from Greenville to Panama?

    Yes. Cheapflights offers flight deals from Greenville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Panama?

    Currently, August is the cheapest month in which you can book a flight from Greenville to Panama (average of $267). Flying from Greenville to Panama in January is currently the most expensive (average of $435). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Greenville to Panama

Discover the top 3 airlines that operate flights from Greenville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$371Average$435FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$383Average$419FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$383Average$613FlexibilityNo cancel feeOn-time71%

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