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$392+ Cheap flights from Greenville (GSP) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Find flight deals from Greenville to Panama

Cheapest flights from Greenville to Panama
Explore the most affordable flight options available from Greenville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:10 amGSP - PTY
1 stop10h 32mAmerican Airlines
Tue 1/132:27 pmPTY - GSP
2 stops20h 52mAmerican Airlines
Deal found 11/3$396
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:00 amGSP - PTY
1 stop8h 49mAmerican Airlines
Thu 11/132:49 pmPTY - GSP
1 stop9h 10mAmerican Airlines
Deal found 10/31$404
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:47 pmGSP - PTY
2 stops18h 56mAmerican Airlines
Wed 11/262:43 pmPTY - GSP
2 stops19h 45mAmerican Airlines
Deal found 11/3$408
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1610:07 amGSP - PTY
1 stop28h 05mDelta
Mon 11/243:37 pmPTY - GSP
1 stop8h 08mDelta
Deal found 11/3$410
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:45 amGSP - PTY
1 stop12h 53mUnited Airlines
Thu 11/274:41 pmPTY - GSP
1 stop29h 18mUnited Airlines
Deal found 11/3$412
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1610:07 amGSP - PTY
1 stop28h 05mDelta
Wed 11/263:37 pmPTY - GSP
1 stop27h 36mDelta
Deal found 11/3$416
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/114:56 pmGSP - PTY
1 stop26h 42mUnited Airlines
Thu 11/274:41 pmPTY - GSP
1 stop29h 18mUnited Airlines
Deal found 11/3$420
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:45 amGSP - PTY
1 stop12h 53mUnited Airlines
Sun 11/238:55 amPTY - GSP
1 stop13h 04mUnited Airlines
Deal found 11/3$424
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/176:19 pmGSP - PTY
2 stops19h 30mAmerican Airlines
Mon 11/242:43 pmPTY - GSP
2 stops19h 20mAmerican Airlines
Deal found 11/1$428
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1410:07 amGSP - PTY
1 stop9h 52mDelta
Wed 11/263:37 pmPTY - GSP
1 stop27h 36mDelta
Deal found 11/3$430
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/166:45 amGSP - PTY
1 stop12h 53mUnited Airlines
Tue 11/254:41 pmPTY - GSP
1 stop29h 18mUnited Airlines
Deal found 11/3$432

Cheap flight deals from Greenville to Panama

Keep the following information in mind while searching for Greenville to Panama flight deals. Data was last updated November 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$392
(United Airlines)

Popular in

January

Cheapest in

August

Average price

$495
Provider with most accurate pricing for Greenville-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Panama City Tocumen Intl flights.
Search Deals
From Greenville to Panama
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($91 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Greenville

Fly to

Panama

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:40 am-2:45 pm

1 stop8h 05m

Panama City Tocumen Intl

Wed 2/4

11:35 am-9:57 pm

1 stop10h 22m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

7:00 am-1:27 pm

1 stop6h 27m

Panama City Tocumen Intl

Wed 2/4

2:27 pm-11:57 pm

1 stop9h 30m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 1/19

5:26 pm-1:27 pm

2 stops20h 01m

Panama City Tocumen Intl

Thu 1/22

4:50 pm-11:57 pm

1 stop7h 07m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 11/19

5:00 am-1:49 pm

1 stop8h 49m

Panama City Tocumen Intl

Wed 11/26

2:43 pm-11:59 pm

1 stop9h 16m

$404

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 11/19

6:45 am-2:45 pm

1 stop8h 00m

Panama City Tocumen Intl

Wed 11/26

4:41 pm-3:39 pm

1 stop22h 58m

$412

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 11/16

7:59 pm-2:12 pm

1 stop18h 13m

Panama City Tocumen Intl

Tue 11/25

3:37 pm-9:02 am

1 stop17h 25m

$416

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 11/15

8:30 am-7:59 pm

1 stop11h 29m

Panama City Tocumen Intl

Mon 11/24

3:37 pm-10:34 pm

1 stop6h 57m

$424

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Fri 11/14

10:07 am-7:59 pm

1 stop9h 52m

Panama City Tocumen Intl

Mon 11/24

3:37 pm-10:34 pm

1 stop6h 57m

$424

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 11/17

6:47 pm-1:49 pm

2 stops19h 02m

Panama City Tocumen Intl

Mon 11/24

2:43 pm-11:59 pm

1 stop9h 16m

$428

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Best time to book a flight from Greenville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama

What is the cheapest month to book a flight from Greenville to Panama?

Currently, November is the cheapest month in which you can book a flight from Greenville to Panama (average of $241). Flying from Greenville to Panama in January is currently the most expensive (average of $435). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to PA?

Find hourly flight availability from Greenville to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

It’s optimal to fly from Greenville to Panama in the afternoon. By choosing this option you can save up to 58% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated November 3, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Greenville to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,002 reviews

Crew

8.5

Overall

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
8,002 reviews
Delta
7.9
Good
8,002 reviews

Crew

8.5

Overall

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
United Airlines
7.4
Good
8,997 reviews
Delta
7.9
Good
8,002 reviews

Crew

8.5

Overall

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,038 reviews
Delta
7.9
Good
8,002 reviews

Crew

8.5

Overall

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Panama?

    Greenville (GSP), located 10.4 mi from the city center, is the airport you fly out of when you book flights from Greenville to Panama.

  • How long is the flight from Greenville to Panama?

    There are many flights that can get you from Greenville to Panama in 6h 27m. Fly via United Airlines or American Airlines to get the fastest option. Airlines will cover a distance of 1792 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Greenville to Panama that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama.

  • Can I find deals for business class flights from Greenville to Panama?

    Yes. Cheapflights offers flight deals from Greenville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Panama?

    Currently, November is the cheapest month in which you can book a flight from Greenville to Panama (average of $241). Flying from Greenville to Panama in January is currently the most expensive (average of $435). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Greenville to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Greenville to Panama

Discover the top 3 airlines that operate flights from Greenville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$371Average$435FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$383Average$419FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$383Average$577FlexibilityNo cancel feeOn-time71%

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