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$180+ Cheap flights from Greenville (GSP) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Mar 10 — Mar 171
Tue 3/10
Tue 3/17
1 adult, Economy
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Cheap flight deals from Greenville to Panama

Cheapest flights from Greenville to Panama
Explore the most affordable flight options available from Greenville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 8, 2026.

This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/107:49 pm
GSP
-
PTY
1 stop9h 15m
United Airlines
Wed 8/1210:55 pm
PTY
-
GSP
1 stop10h 42m
United Airlines
Deal found 2/4$413
This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:05 pm
GSP
-
PTY
2 stops19h 41m
American Airlines
Wed 5/201:49 pm
PTY
-
GSP
1 stop9h 10m
American Airlines
Deal found 2/5$417
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/257:26 pm
GSP
-
PTY
1 stop18h 14m
American Airlines
Wed 4/13:51 pm
PTY
-
GSP
1 stop7h 30m
American Airlines
Deal found 2/8$422
This Gurufare deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:12 am
GSP
-
PTY
1 stop13h 50m
Azul
Wed 3/119:30 am
PTY
-
GSP
1 stop13h 29m
Azul
Deal found 2/6$429
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:25 pm
GSP
-
PTY
2 stops19h 55m
American Airlines
Sun 8/303:20 pm
PTY
-
GSP
2 stops18h 17m
American Airlines
Deal found 2/7$440
This United Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/234:36 pm
GSP
-
PTY
1 stop27h 02m
United Airlines
Thu 2/264:41 pm
PTY
-
GSP
1 stop29h 18m
United Airlines
Deal found 2/7$442
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/27:26 pm
GSP
-
PTY
1 stop20h 35m
American Airlines
Wed 4/81:49 pm
PTY
-
GSP
2 stops20h 55m
American Airlines
Deal found 2/7$448
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:00 am
GSP
-
PTY
1 stop12h 37m
United Airlines
Sat 4/187:55 am
PTY
-
GSP
1 stop13h 04m
United Airlines
Deal found 2/8$449
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:05 pm
GSP
-
PTY
2 stops19h 41m
American Airlines
Sat 4/181:49 pm
PTY
-
GSP
2 stops17h 46m
American Airlines
Deal found 2/8$453
This Gurufare deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:07 pm
GSP
-
PTY
1 stop8h 24m
Copa Airlines
Sat 5/97:55 am
PTY
-
GSP
1 stop13h 19m
Copa Airlines
Deal found 2/8$459

Find flight deals from Greenville to Panama

Keep the following information in mind while searching for Greenville to Panama flight deals. Data was last updated February 8, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$413
(American Airlines)

One-way from

$180
(United Airlines)

Popular in

December

Cheapest in

August

Average price

$527
Provider with most accurate pricing for Greenville-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Panama City Tocumen Intl flights.
Search Deals
From Greenville to Panama
Search Deals
One-way flight from Greenville to Panama
Search Deals
Highest demand for flights based on searches. 35% potential increase in price ($296 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 16% potential price decrease ($78 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Greenville

Fly to

Panama

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 5/6

6:00 am-12:46 pm

1 stop7h 46m

Panama City Tocumen Intl

Wed 5/20

1:49 pm-11:59 pm

1 stop9h 10m

$413

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 2/25

6:12 am-8:02 pm

1 stop13h 50m

Panama City Tocumen Intl

Wed 3/11

9:30 am-11:59 pm

1 stop13h 29m

$429

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 2/23

4:36 pm-7:38 pm

1 stop27h 02m

Panama City Tocumen Intl

Thu 2/26

4:41 pm-9:59 pm

1 stop29h 18m

$442

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 4/2

7:26 pm-3:01 pm

1 stop20h 35m

Panama City Tocumen Intl

Wed 4/8

1:49 pm-11:44 am

2 stops20h 55m

$448

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 4/11

5:40 am-1:03 pm

1 stop8h 23m

Panama City Tocumen Intl

Sat 4/18

2:27 pm-11:56 pm

1 stop8h 29m

$449

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 4/11

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Sat 4/18

7:55 am-9:59 pm

1 stop13h 04m

$449

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 4/11

6:05 pm-12:46 pm

2 stops19h 41m

Panama City Tocumen Intl

Sat 4/18

1:49 pm-8:35 am

2 stops17h 46m

$453

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 5/3

6:00 am-7:31 pm

1 stop14h 31m

Panama City Tocumen Intl

Sun 5/10

10:55 pm-5:10 pm

1 stop17h 15m

$459

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 5/2

12:07 pm-7:31 pm

1 stop8h 24m

Panama City Tocumen Intl

Sat 5/9

7:55 am-10:14 pm

1 stop13h 19m

$459

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 5/2

12:07 pm-7:31 pm

1 stop8h 24m

Panama City Tocumen Intl

Sat 5/9

10:55 pm-11:05 pm

1 stop23h 10m

$468

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/6

Showing 1-10 of 18 results
1
2

Best time to book a flight from Greenville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama

What is the cheapest month to book a flight from Greenville to Panama?

Currently, August is the cheapest month in which you can book a flight from Greenville to Panama (average of $267). Flying from Greenville to Panama in December is currently the most expensive (average of $520). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated February 8, 2026.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Greenville to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,173 reviews

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,173 reviews
Delta
7.9
Good
8,173 reviews

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,257 reviews
Delta
7.9
Good
8,173 reviews

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,255 reviews
Delta
7.9
Good
8,173 reviews

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Panama?

    Greenville (GSP), located 10.4 mi from the city center, is the airport you fly out of when you book flights from Greenville to Panama.

  • How long is the flight from Greenville to Panama?

    There are many flights that can get you from Greenville to Panama in 7h 46m. Fly via American Airlines, Azul, or United Airlines to get the fastest option. Airlines will cover a distance of 1792 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Greenville to Panama that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama.

  • Can I find deals for business class flights from Greenville to Panama?

    Yes. Cheapflights offers flight deals from Greenville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Panama?

    Currently, August is the cheapest month in which you can book a flight from Greenville to Panama (average of $267). Flying from Greenville to Panama in December is currently the most expensive (average of $520). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Greenville to Panama

Discover the top 3 airlines that operate flights from Greenville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$353Average$613FlexibilityNo cancel feeOn-time71%
DeltaCheapest$371Average$435FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$391Average$419FlexibilityNo cancel feeOn-time69%

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