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$391+ Cheap flights from Greenville (GSP) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/4. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Jun 21 — Jun 281
Sat 6/21
Sat 6/28
1 adult, Economy
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Cheap flight deals from Greenville to Panama

Keep the following information in mind while searching for Greenville to Panama flight deals. Data was last updated June 16, 2025.

Round-trip from

$391
(Delta)

Popular in

March

Cheapest in

November

Average price

$471
From Greenville to Panama
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($42 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
Search Deals

Find flight deals from Greenville to Panama

Cheapest flights from Greenville to Panama
Explore the most affordable flight options available from Greenville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2025.

This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/47:30 amGSP - PTY
1 stop6h 43mDelta
Wed 8/132:05 pmPTY - GSP
1 stop7h 19mDelta
Deal found 6/14$391
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/286:48 pmGSP - PTY
2 stops18h 37mAmerican Airlines
Wed 11/54:20 pmPTY - GSP
2 stops15h 47mAmerican Airlines
Deal found 6/14$396
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1611:52 amGSP - PTY
1 stop8h 39mUnited Airlines
Wed 6/2510:00 amPTY - GSP
1 stop11h 15mUnited Airlines
Deal found 6/14$403
This Mytrip deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/309:42 pmGSP - PTY
2 stops27h 28mMultiple Airlines
Tue 8/53:20 amPTY - GSP
2 stops16h 31mMultiple Airlines
Deal found 6/15$678

Cheapflights Fare Finder

Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2025.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Greenville

Fly to

Panama

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 8/4

7:30 am-1:13 pm

1 stop6h 43m

Panama City Tocumen Intl

Wed 8/13

2:05 pm-10:24 pm

1 stop7h 19m

$391

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 10/28

5:53 am-12:25 pm

1 stop7h 32m

Panama City Tocumen Intl

Wed 11/5

2:45 pm-8:07 am

2 stops17h 22m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 8/13

5:34 pm-4:12 pm

1 stop23h 38m

Panama City Tocumen Intl

Tue 8/19

3:30 pm-10:00 pm

1 stop29h 30m

$408

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 7/30

9:42 pm-4:30 pm

3 stops43h 48m

Panama City Tocumen Intl

Tue 8/5

3:20 am-8:51 pm

3 stops16h 31m

$653

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/14

Best time to book a flight from Greenville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama

What is the cheapest month to book a flight from Greenville to Panama?

Currently, October is the cheapest month in which you can book a flight from Greenville to Panama (average of $478). Flying from Greenville to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to PA?

Find hourly flight availability from Greenville to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 16, 2025.

When flying from Greenville to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated June 16, 2025.
Delta
8.0
Very good
7,963 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,963 reviews
Delta
8.0
Very good
7,963 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,801 reviews
Delta
8.0
Very good
7,963 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,963 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Panama?

    Greenville (GSP), located 10.4 mi from the city center, is the airport you fly out of when you book flights from Greenville to Panama.

  • Can I find deals for flights from Greenville to Panama that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama.

  • Can I find deals for business class flights from Greenville to Panama?

    Yes. Cheapflights offers flight deals from Greenville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Panama?

    Currently, October is the cheapest month in which you can book a flight from Greenville to Panama (average of $478). Flying from Greenville to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Myrtle Beach to Philip S.W.Goldson flights
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Myrtle Beach to Panama City flights
Savannah to Liberia flights
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Columbia to Liberia flights
Myrtle Beach to Guatemala City flights
Myrtle Beach to Managua flights
Greenville to Tegucigalpa flights
Columbia to San Salvador flights
Columbia to San Pedro Sula flights

Top 3 airlines flying from Greenville to Panama

Discover the top 3 airlines that operate flights from Greenville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$285Average$401FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$352Average$577FlexibilityNo cancel feeOn-time71%
DeltaCheapest$371Average$482FlexibilityNo cancel feeOn-timeN/A

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