$306+ Cheap flights from Colorado to Panama
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — PTY
Oct 15 — Oct 221
Round-trip
1 adult, Economy
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Find cheap flights from Colorado to Panama with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Colorado to PanamaExplore the most affordable flight options available from Colorado to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
Explore the most affordable flight options available from Colorado to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:45 am -
2 stops9h 27m
Thu 12/1011:35 am -
1 stop12h 02m
Deal found 9/12![United Airlines logo]()
$611
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/211:59 pm -
1 stop12h 14m
Wed 11/113:13 pm -
1 stop9h 46m
Deal found 9/11![American Airlines logo]()
$627
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:43 pm -
Nonstop5h 50m
Sun 10/2512:56 pm -
Nonstop6h 15m
Deal found 9/11![Copa Airlines logo]()
$629
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/312:54 pm -
2 stops23h 19m
Thu 11/123:13 pm -
2 stops20h 37m
Deal found 9/11![American Airlines logo]()
$631
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:53 pm -
1 stop13h 20m
Wed 11/43:13 pm -
1 stop9h 46m
Deal found 9/15![American Airlines logo]()
$636
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/511:59 pm -
1 stop12h 14m
Fri 11/203:34 pm -
1 stop9h 32m
Deal found 9/15![American Airlines logo]()
$637
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/192:58 pm -
2 stops21h 36m
Fri 11/273:34 pm -
2 stops22h 07m
Deal found 9/15![American Airlines logo]()
$641
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/67:30 am -
1 stop7h 42m
Mon 12/148:55 am -
1 stop14h 42m
Deal found 9/12![United Airlines logo]()
$641
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:59 am -
1 stop11h 00m
Fri 10/302:24 pm -
1 stop9h 08m
Deal found 9/13![Delta logo]()
$644
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:20 pm -
2 stops20h 52m
Tue 12/158:55 am -
2 stops12h 01m
Deal found 9/12![United Airlines logo]()
$645
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:53 pm -
1 stop12h 09m
Wed 11/183:13 pm -
1 stop9h 46m
Deal found 9/11![American Airlines logo]()
$646
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:54 pm -
2 stops21h 08m
Fri 10/302:02 pm -
1 stop9h 44m
Deal found 9/14![American Airlines logo]()
$648
Best flights from Colorado to PanamaDiscover carefully curated flight deals from Colorado to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
Discover carefully curated flight deals from Colorado to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:45 am -
2 stops9h 27m
Mon 12/148:55 am -
1 stop14h 42m
Deal found 9/12![United Airlines logo]()
$611
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:43 pm -
Nonstop5h 50m
Mon 10/2612:56 pm -
Nonstop6h 15m
Deal found 9/11![Copa Airlines logo]()
$652
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am -
1 stop29h 59m
Thu 11/123:29 pm -
1 stop31h 21m
Deal found 9/11![Delta logo]()
$652
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:10 pm -
2 stops19h 35m
Sat 11/78:55 am -
1 stop14h 50m
Deal found 9/14![United Airlines logo]()
$645
This Copa Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/69:49 pm -
Nonstop5h 44m
Mon 11/1612:56 pm -
Nonstop6h 06m
Deal found 9/13![Copa Airlines logo]()
$678
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/154:40 pm -
1 stop17h 35m
Fri 1/223:20 pm -
1 stop11h 03m
Deal found 9/11![Delta logo]()
$732
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:10 pm -
2 stops19h 35m
Sun 11/154:41 pm -
2 stops18h 02m
Deal found 9/15![United Airlines logo]()
$679
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2410:43 pm -
Nonstop5h 50m
Fri 2/2612:56 pm -
Nonstop6h 18m
Deal found 9/15![Copa Airlines logo]()
$689
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/195:00 pm -
1 stop17h 15m
Sat 2/271:40 pm -
1 stop11h 39m
Deal found 9/13![Delta logo]()
$732
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:10 pm -
2 stops19h 35m
Fri 11/134:41 pm -
1 stop20h 38m
Deal found 9/11![United Airlines logo]()
$691
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/259:50 pm -
Nonstop5h 43m
Mon 2/112:56 pm -
Nonstop6h 18m
Deal found 9/14![Copa Airlines logo]()
$717
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:40 am -
1 stop9h 57m
Mon 10/263:41 pm -
2 stops18h 02m
Deal found 9/12![United Airlines logo]()
$701
This Copa Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/229:50 pm -
Nonstop5h 43m
Mon 2/112:56 pm -
Nonstop6h 18m
Deal found 9/13![Copa Airlines logo]()
$717
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/265:10 pm -
2 stops19h 35m
Mon 11/24:41 pm -
2 stops18h 02m
Deal found 9/11![United Airlines logo]()
$704
This Copa Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:49 pm -
Nonstop5h 44m
Wed 4/1412:45 pm -
Nonstop6h 19m
Deal found 9/12![Copa Airlines logo]()
$727
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:49 pm -
Nonstop5h 44m
Fri 11/2012:56 pm -
Nonstop6h 06m
Deal found 9/15![Copa Airlines logo]()
$727
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/295:00 am -
1 stop10h 12m
Sat 2/64:41 pm -
1 stop8h 46m
Deal found 9/13![United Airlines logo]()
$732
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/69:55 pm -
Nonstop5h 38m
Sun 2/1412:56 pm -
Nonstop6h 18m
Deal found 9/15![Copa Airlines logo]()
$735
Last-minute flights from Colorado to PanamaDiscover last-minute flight deals from Colorado to Panama. Data last updated September 15, 2026 and is based on user searches.
Discover last-minute flight deals from Colorado to Panama. Data last updated September 15, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:00 am -
1 stop29h 58m
Tue 10/62:24 pm -
1 stop9h 08m
Deal found 9/13![Delta logo]()
$657
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1212:59 am -
1 stop11h 00m
Sat 10/242:24 pm -
1 stop9h 08m
Deal found 9/11![Delta logo]()
$664
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2111:53 pm -
1 stop12h 09m
Mon 10/262:02 pm -
1 stop9h 44m
Deal found 9/15![American Airlines logo]()
$649
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:40 am -
1 stop9h 57m
Mon 10/263:41 pm -
2 stops18h 02m
Deal found 9/12![United Airlines logo]()
$701
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:59 am -
1 stop11h 00m
Fri 10/302:24 pm -
1 stop9h 08m
Deal found 9/13![Delta logo]()
$644
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:43 pm -
Nonstop5h 50m
Mon 10/2612:56 pm -
Nonstop6h 15m
Deal found 9/11![Copa Airlines logo]()
$652
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2211:53 pm -
1 stop12h 09m
Sun 10/252:02 pm -
2 stops19h 31m
Deal found 9/13![American Airlines logo]()
$653
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:43 pm -
Nonstop5h 50m
Fri 10/3012:56 pm -
Nonstop6h 15m
Deal found 9/11![Copa Airlines logo]()
$629
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:54 pm -
2 stops21h 08m
Fri 10/302:02 pm -
1 stop9h 44m
Deal found 9/14![American Airlines logo]()
$648
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/265:10 pm -
2 stops19h 35m
Mon 11/24:41 pm -
2 stops18h 02m
Deal found 9/11![United Airlines logo]()
$704
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:53 pm -
1 stop12h 09m
Wed 11/183:13 pm -
1 stop9h 46m
Deal found 9/11![American Airlines logo]()
$646
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:53 pm -
1 stop13h 20m
Wed 11/43:13 pm -
1 stop9h 46m
Deal found 9/15![American Airlines logo]()
$636
One-way flights from Colorado to PanamaSearch for one-way flight options from Colorado to Panama. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
Search for one-way flight options from Colorado to Panama. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
This CheapOair deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:15 pm -
2 stops18h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Multiple Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:10 pm -
1 stop19h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:59 pm -
1 stop12h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![American Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:10 pm -
1 stop18h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$322
This Orbitz deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:01 pm -
2 stops35h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/111:59 pm -
1 stop12h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![American Airlines logo]()
$326
This oojo deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/303:15 pm -
2 stops18h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:56 pm -
1 stop10h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:11 pm -
2 stops18h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/91:10 pm -
1 stop18h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$340
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/265:29 pm -
2 stops20h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$734
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:55 pm -
3 stops58h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$783
Find flight deals from Colorado to Panama
Keep the following information in mind while searching for Colorado to Panama flight deals. Data was last updated September 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $607 (United Airlines) |
One-way from | $306 (CheapOair) |
Popular in | December |
Cheapest in | April |
Average price | $619 |
Good round-trip deal | $597 or less |
Good one-way deal | $223 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Colorado to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
Use the filters below to find and compare flights from Colorado to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DenverPanama City
DEN Denver Intl - PTY Panama City Tocumen Intl
DENPTY
Denver Intl
Wed 10/21
3:15 pm-10:30 am
2 stops18h 15m
Panama City Tocumen Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$306
DenverPanama City
DEN Denver Intl - PTY Panama City Tocumen Intl
DENPTY
Denver Intl
Sat 11/7
11:59 pm-2:13 pm
1 stop12h 14m
Panama City Tocumen Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$315
DenverPanama City
DEN Denver Intl - PTY Panama City Tocumen Intl
DENPTY
Denver Intl
Sun 11/1
11:59 pm-2:13 pm
1 stop12h 14m
Panama City Tocumen Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$326
DenverPanama City
DEN Denver Intl - PTY Panama City Tocumen Intl
DENPTY
Denver Intl
Sat 12/5
11:55 pm-7:45 pm
3 stops17h 50m
Panama City Tocumen Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$428
DenverPanama City
DEN Denver Intl - PTY Panama City Tocumen Intl
DENPTY
Denver Intl
Fri 2/12
1:16 pm-1:46 pm
1 stop22h 30m
Panama City Tocumen Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$431
DenverPanama City
DEN Denver Intl - PTY Panama City Tocumen Intl
DENPTY
Denver Intl
Thu 11/12
10:44 pm-8:29 pm
3 stops43h 45m
Panama City Tocumen Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$436
DenverPanama City
DEN Denver Intl - PTY Panama City Tocumen Intl
DENPTY
Denver Intl
Tue 11/24
2:50 pm-6:04 am
2 stops13h 14m
Panama City Tocumen Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$439
DenverPanama City
DEN Denver Intl - PTY Panama City Tocumen Intl
DENPTY
Denver Intl
Mon 11/23
11:59 pm-8:29 pm
3 stops18h 30m
Panama City Tocumen Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$457
DenverPanama City
DEN Denver Intl - PTY Panama City Tocumen Intl
DENPTY
Denver Intl
Sat 1/30
3:10 pm-3:55 pm
2 stops22h 45m
Panama City Tocumen Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$501
Colorado SpringsPanama City
COS Colorado Springs - PTY Panama City Tocumen Intl
COSPTY
Colorado Springs
Tue 12/1
5:45 am-5:12 pm
2 stops9h 27m
Panama City Tocumen Intl
Mon 12/14
8:55 am-9:37 pm
1 stop14h 42m
$611
Showing 1-10 of 33 resultsSorted by cheapest first
Best time to book a flight from Colorado to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Colorado with our price prediction graph.
COS-PTY
DEN-PTY
DEN-PAC
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Colorado to Panama
USCO-PA0
COS-PTY
DEN-PTY
DEN-PAC
What is the cheapest month to book a flight from Colorado to Panama?
Currently, April is the cheapest month in which you can book a flight from Colorado to Panama (average of $597). Flying from Colorado to Panama in December is currently the most expensive (average of $810). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from CO to PA?
Find hourly flight availability from Colorado to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Colorado to Panama as you normally would.
How far ahead should I book a flight from Colorado to Panama?
The price you pay for your flight from Colorado to Panama may vary depending on when you book. For the best chance of a lower fare, look to book 81 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Related info for your journey
Find useful and relevant information for your journey from Colorado to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Colorado to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Colorado to Panama by cabin class
Find flights from Colorado to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Colorado and Panama flights
Browse other Colorado and Panama flight options. Last updated on September 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Panama
Find the right flight back to Colorado after your stay in Panama
Colorado to Panama flights
Consider these flights traveling from Colorado to Panama.
Top 3 airlines flying from Colorado to Panama
Discover the top 3 airlines that operate flights from Colorado to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$491 | Average$641 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$501 | Average$747 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$554 | Average$716 | FlexibilityNo cancel fee | On-time71% |