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$208+ Cheap flights from Cleveland (CLE) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/17. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — PTY
Aug 25 — Sep 11
Mon 8/25
Mon 9/1
1 adult, Economy
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Cheap flight deals from Cleveland to Panama

Keep the following information in mind while searching for Cleveland to Panama flight deals. Data was last updated August 20, 2025.

Round-trip from

$489
(Delta)

One-way from

$208
(Kiwi.com)

Popular in

December

Cheapest in

November

Average price

$761
From Cleveland Hopkins Intl to Panama
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One-way flight from Cleveland Hopkins Intl to Panama
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Highest demand for flights based on searches. 3% potential increase in price ($24 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($25 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Cleveland to Panama

Cheapest flights from Cleveland to Panama
Explore the most affordable flight options available from Cleveland to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:00 amCLE - PTY
1 stop7h 56mDelta
Tue 10/282:21 pmPTY - CLE
1 stop9h 15mDelta
Deal found 8/18$489
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:30 pmCLE - PTY
2 stops20h 33mAmerican Airlines
Tue 10/283:15 pmPTY - CLE
1 stop8h 02mAmerican Airlines
Deal found 8/18$494
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:05 amCLE - PTY
1 stop13h 32mUnited Airlines
Thu 10/99:45 amPTY - CLE
1 stop8h 39mUnited Airlines
Deal found 8/17$509
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:01 amCLE - PTY
2 stops9h 30mAmerican Airlines
Thu 10/93:15 pmPTY - CLE
2 stops17h 23mAmerican Airlines
Deal found 8/17$514
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1811:13 amCLE - PTY
1 stop9h 16mMultiple Airlines
Mon 9/2212:48 pmPTY - CLE
1 stop8h 02mMultiple Airlines
Deal found 8/18$519
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:20 amCLE - PTY
1 stop8h 35mUnited Airlines
Sat 11/84:41 pmPTY - CLE
1 stop18h 26mUnited Airlines
Deal found 8/18$529
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:00 amCLE - PTY
1 stop9h 03mAmerican Airlines
Sat 11/13:15 pmPTY - CLE
2 stops21h 05mAmerican Airlines
Deal found 8/19$534
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:05 amCLE - PTY
1 stop9h 09mUnited Airlines
Tue 9/303:30 pmPTY - CLE
1 stop18h 38mUnited Airlines
Deal found 8/17$549
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/126:00 amCLE - PTY
2 stops9h 31mAmerican Airlines
Tue 9/161:45 pmPTY - CLE
2 stops21h 13mAmerican Airlines
Deal found 8/18$554
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/136:00 amCLE - PTY
1 stop7h 55mDelta
Wed 9/172:10 pmPTY - CLE
1 stop9h 29mDelta
Deal found 8/18$569
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/134:22 pmCLE - PTY
2 stops23h 09mAmerican Airlines
Wed 9/171:45 pmPTY - CLE
1 stop8h 05mAmerican Airlines
Deal found 8/19$574

Cheapflights Fare Finder

 
Customize your flight search to find flights from Cleveland to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Cleveland to Panama that are best for you.

Fly from

Cleveland

Fly to

Panama

Route

Depart

Return

Price

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Tue 10/21

6:00 am-12:56 pm

1 stop7h 56m

Panama City Tocumen Intl

Tue 10/28

2:21 pm-12:36 am

1 stop9h 15m

$489

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Tue 10/21

6:45 pm-2:03 pm

2 stops20h 18m

Panama City Tocumen Intl

Tue 10/28

3:15 pm-8:17 am

2 stops16h 02m

$494

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Sun 1/11

1:00 pm-2:45 pm

1 stop25h 45m

Panama City Tocumen Intl

Wed 1/14

4:40 pm-10:59 am

1 stop18h 19m

$500

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Thu 10/2

6:05 am-6:37 pm

1 stop13h 32m

Panama City Tocumen Intl

Thu 10/9

9:45 am-7:24 pm

1 stop8h 39m

$509

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Fri 10/3

6:00 am-2:31 pm

1 stop9h 31m

Panama City Tocumen Intl

Fri 10/10

3:15 pm-12:16 am

1 stop8h 01m

$509

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Sun 1/11

6:55 pm-3:35 pm

2 stops20h 40m

Panama City Tocumen Intl

Wed 1/14

2:45 pm-9:00 am

2 stops18h 15m

$514

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Thu 10/2

7:29 pm-2:31 pm

2 stops20h 02m

Panama City Tocumen Intl

Thu 10/9

3:15 pm-12:16 am

1 stop8h 01m

$514

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Wed 9/17

2:00 pm-9:10 pm

3 stops32h 10m

$208

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Wed 9/17

6:00 am-12:55 pm

1 stop7h 55m

$232

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Sun 12/14

1:16 pm-10:40 am

2 stops45h 24m

$293

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/19

Showing 1-10 of 11 results
1
2

Best time to book a flight from Cleveland to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Cleveland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cleveland to Panama

What is the cheapest month to book a flight from Cleveland to Panama?

Currently, October is the cheapest month in which you can book a flight from Cleveland to Panama (average of $478). Flying from Cleveland to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CLE to PA?

Find hourly flight availability from Cleveland to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Cleveland to Panama as you normally would.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated August 20, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Cleveland to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,928 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Cleveland to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Cleveland to Panama?

    Cleveland Hopkins Intl (CLE) is the airport you will fly out of if you book a flight from Cleveland to Panama. It is only a 10.1 mi journey to Hopkins Intl (CLE) from Cleveland’s city center.

  • How long is the flight from Cleveland to Panama?

    There are many flights that can get you from Cleveland to Panama in 7h 56m. Fly via Delta or American Airlines to get the fastest option. There are 2238 mi between Cleveland and Panama. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Cleveland to Panama that include hotel bookings?

    Yes. In addition to deals on Cleveland to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cleveland to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cleveland to Panama.

  • Can I find deals for business class flights from Cleveland to Panama?

    Yes. Cheapflights offers flight deals from Cleveland to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cleveland to Panama?

    Currently, October is the cheapest month in which you can book a flight from Cleveland to Panama (average of $478). Flying from Cleveland to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Cleveland to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Cleveland to Panama

Discover the top 3 airlines that operate flights from Cleveland to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$389Average$597FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$469Average$673FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$469Average$623FlexibilityNo cancel feeOn-time69%

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