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$222+ Cheap flights from Cleveland (CLE) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/8. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — PTY
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Cleveland to Panama

Keep the following information in mind while searching for Cleveland to Panama flight deals. Data was last updated May 1, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$474
(American Airlines)

One-way from

$222
(Delta)

Popular in

December

Cheapest in

September

Average price

$568
Provider with most accurate pricing for Cleveland Hopkins Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Panama City Tocumen Intl flights.
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From Cleveland Hopkins Intl to Panama
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One-way flight from Cleveland Hopkins Intl to Panama
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Highest demand for flights based on searches. 5% potential increase in price ($32 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Cleveland to Panama

Cheapest flights from Cleveland to Panama
Explore the most affordable flight options available from Cleveland to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/38:43 pmCLE - PTY
2 stops18h 42mAmerican Airlines
Fri 7/111:55 pmPTY - CLE
1 stop9h 18mAmerican Airlines
Deal found 4/30$474
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/296:22 pmCLE - PTY
1 stop22h 50mUnited Airlines
Thu 7/39:45 amPTY - CLE
1 stop11h 01mUnited Airlines
Deal found 4/29$479
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/36:00 amCLE - PTY
1 stop8h 08mDelta
Sun 7/132:23 pmPTY - CLE
1 stop9h 30mDelta
Deal found 4/30$489
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/17:10 pmCLE - PTY
2 stops27h 00mMultiple Airlines
Wed 6/43:20 amPTY - CLE
3 stops37h 55mMultiple Airlines
Deal found 4/30$559
This Flightnetwork deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/298:50 amCLE - PTY
2 stops16h 20mAvianca
Thu 6/51:30 pmPTY - CLE
3 stops19h 12mAvianca
Deal found 5/1$1,037

Cheapflights Fare Finder

Customize your flight search to find flights from Cleveland to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Cleveland to Panama that are best for you.

Fly from

Cleveland

Fly to

Panama

Route

Depart

Return

Price

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Thu 7/3

8:43 pm-2:25 pm

2 stops18h 42m

Panama City Tocumen Intl

Fri 7/11

1:55 pm-12:13 am

1 stop9h 18m

$474

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Sun 6/29

6:22 pm-4:12 pm

1 stop22h 50m

Panama City Tocumen Intl

Thu 7/3

9:45 am-9:46 pm

1 stop11h 01m

$479

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Thu 7/3

6:00 am-1:08 pm

1 stop8h 08m

Panama City Tocumen Intl

Sun 7/13

2:23 pm-12:53 am

1 stop9h 30m

$489

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Sun 6/1

7:10 pm-9:10 pm

2 stops27h 00m

Panama City Tocumen Intl

Wed 6/4

3:20 am-6:15 pm

3 stops37h 55m

$559

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Thu 5/29

8:50 am-12:10 am

2 stops16h 20m

Panama City Tocumen Intl

Thu 6/5

1:30 pm-9:42 am

3 stops19h 12m

$1,037

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Tue 7/8

6:00 am-1:03 pm

1 stop8h 03m

$222

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Mon 7/7

6:15 pm-12:54 pm

2 stops19h 39m

$228

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Tue 5/6

2:49 pm-4:39 pm

3 stops26h 50m

$324

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Mon 7/7

6:05 am-12:35 pm

3 stops31h 30m

$532

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Best time to book a flight from Cleveland to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Cleveland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cleveland to Panama

What is the cheapest month to book a flight from Cleveland to Panama?

Currently, October is the cheapest month in which you can book a flight from Cleveland to Panama (average of $478). Flying from Cleveland to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CLE to PA?

Find hourly flight availability from Cleveland to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Cleveland to Panama as you normally would.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated May 1, 2025.
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,317 reviews
Delta
8.0
Very good
7,934 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Cleveland to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Cleveland to Panama?

    Cleveland Hopkins Intl (CLE) is the airport you will fly out of if you book a flight from Cleveland to Panama. It is only a 10.1 mi journey to Hopkins Intl (CLE) from Cleveland’s city center.

  • What are the cheapest airlines to fly from Cleveland to Panama one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $222. American Airlines flights start at $228 while deals on Avianca start at $532 one-way.

  • Can I find deals for flights from Cleveland to Panama that include hotel bookings?

    Yes. In addition to deals on Cleveland to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cleveland to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cleveland to Panama.

  • Can I find deals for business class flights from Cleveland to Panama?

    Yes. Cheapflights offers flight deals from Cleveland to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cleveland to Panama?

    Currently, October is the cheapest month in which you can book a flight from Cleveland to Panama (average of $478). Flying from Cleveland to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Cleveland to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Cleveland to Panama

Discover the top 3 airlines that operate flights from Cleveland to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$384Average$607FlexibilityNo cancel feeOn-time71%
DeltaCheapest$449Average$553FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$458Average$623FlexibilityNo cancel feeOn-time69%

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