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$232+ Cheap flights from Cleveland (CLE) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/3. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — PTY
Nov 13 — Nov 201
Thu 11/13
Thu 11/20
1 adult, Economy
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Find flight deals from Cleveland to Panama

Cheapest flights from Cleveland to Panama
Explore the most affordable flight options available from Cleveland to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:15 amCLE - PTY
1 stop14h 04mMultiple Airlines
Thu 12/412:03 pmPTY - CLE
1 stop10h 01mMultiple Airlines
Deal found 10/13$486
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:00 amCLE - PTY
1 stop7h 47mAmerican Airlines
Sat 12/62:50 pmPTY - CLE
1 stop9h 06mAmerican Airlines
Deal found 10/12$510
This Mytrip deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/125:45 amCLE - PTY
2 stops18h 55mMultiple Airlines
Sun 11/165:55 pmPTY - CLE
2 stops30h 04mMultiple Airlines
Deal found 10/12$512
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:03 amCLE - PTY
1 stop13h 35mUnited Airlines
Sat 12/2011:55 pmPTY - CLE
1 stop9h 52mUnited Airlines
Deal found 10/13$530
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:30 amCLE - PTY
2 stops31h 13mAmerican Airlines
Thu 12/42:50 pmPTY - CLE
2 stops18h 42mAmerican Airlines
Deal found 10/13$532
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/295:25 amCLE - PTY
2 stops9h 38mAmerican Airlines
Tue 4/141:55 pmPTY - CLE
2 stops17h 56mAmerican Airlines
Deal found 10/13$534
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/102:56 pmCLE - PTY
1 stop23h 49mUnited Airlines
Mon 11/178:55 amPTY - CLE
1 stop13h 15mUnited Airlines
Deal found 10/13$541
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:15 amCLE - PTY
1 stop8h 30mUnited Airlines
Sun 11/164:41 pmPTY - CLE
1 stop18h 26mUnited Airlines
Deal found 10/13$550
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/226:04 amCLE - PTY
1 stop8h 59mAmerican Airlines
Wed 4/151:55 pmPTY - CLE
1 stop9h 00mAmerican Airlines
Deal found 10/12$551
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/105:39 pmCLE - PTY
2 stops20h 10mAmerican Airlines
Mon 11/172:49 pmPTY - CLE
2 stops21h 04mAmerican Airlines
Deal found 10/13$554

Cheap flight deals from Cleveland to Panama

Keep the following information in mind while searching for Cleveland to Panama flight deals. Data was last updated October 14, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$490
(United Airlines)

One-way from

$232
(Delta)

Popular in

December

Cheapest in

November

Average price

$570
Provider with most accurate pricing for Cleveland Hopkins Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Panama City Tocumen Intl flights.
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From Cleveland Hopkins Intl to Panama
Search Deals
One-way flight from Cleveland Hopkins Intl to Panama
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($35 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($29 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Cleveland to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Cleveland to Panama that are best for you.

Fly from

Cleveland

Fly to

Panama

Route

Depart

Return

Price

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Thu 1/22

6:00 am-3:38 pm

1 stop9h 38m

Panama City Tocumen Intl

Tue 2/24

2:30 pm-10:39 pm

1 stop8h 09m

$490

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Mon 4/6

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Thu 4/9

2:20 pm-12:37 am

1 stop9h 17m

$490

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Thu 1/29

6:00 am-5:07 pm

1 stop11h 07m

Panama City Tocumen Intl

Mon 2/2

8:55 am-9:58 pm

1 stop13h 03m

$490

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Fri 2/6

6:00 am-3:38 pm

1 stop9h 38m

Panama City Tocumen Intl

Wed 2/11

2:27 pm-10:23 am

2 stops19h 56m

$494

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Thu 12/11

6:03 am-7:38 pm

1 stop13h 35m

Panama City Tocumen Intl

Sun 12/21

11:55 pm-9:47 am

1 stop9h 52m

$510

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Sat 1/31

7:25 pm-5:10 am

1 stop9h 45m

Panama City Tocumen Intl

Wed 2/4

10:00 am-6:32 pm

1 stop8h 32m

$510

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Thu 12/11

6:03 am-2:45 pm

1 stop8h 42m

Panama City Tocumen Intl

Sat 12/20

11:55 pm-9:47 am

1 stop9h 52m

$510

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Tue 3/3

8:09 pm-1:10 pm

2 stops17h 01m

$232

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Tue 3/3

7:00 am-2:02 pm

1 stop7h 02m

$232

ClevelandPanama City

CLE - PTY

CLEPTY

Cleveland Hopkins Intl

Sun 12/14

2:58 pm-5:07 pm

1 stop26h 09m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/12

Showing 1-10 of 13 results
1
2

Best time to book a flight from Cleveland to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Cleveland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cleveland to Panama

What is the cheapest month to book a flight from Cleveland to Panama?

Currently, November is the cheapest month in which you can book a flight from Cleveland to Panama (average of $384). Flying from Cleveland to Panama in May is currently the most expensive (average of $567). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CLE to PA?

Find hourly flight availability from Cleveland to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 14, 2025.

It’s typically best to fly out from Cleveland to Panama in the afternoon. Doing so could potentially save you 42% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 14, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Cleveland to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,973 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,973 reviews
Delta
8.0
Very good
7,973 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,974 reviews
Delta
8.0
Very good
7,973 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,045 reviews
Delta
8.0
Very good
7,973 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Cleveland to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Cleveland to Panama?

    Cleveland Hopkins Intl (CLE) is the airport you will fly out of if you book a flight from Cleveland to Panama. It is only a 10.1 mi journey to Hopkins Intl (CLE) from Cleveland’s city center.

  • How long is the flight from Cleveland to Panama?

    There are many flights that can get you from Cleveland to Panama in 7h 55m. Fly via American Airlines, Delta, or United Airlines to get the fastest option. There are 2238 mi between Cleveland and Panama. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Cleveland to Panama one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $232. Delta flights start at $232 while deals on United Airlines start at $249 one-way.

  • Can I find deals for flights from Cleveland to Panama that include hotel bookings?

    Yes. In addition to deals on Cleveland to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cleveland to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cleveland to Panama.

  • Can I find deals for business class flights from Cleveland to Panama?

    Yes. Cheapflights offers flight deals from Cleveland to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cleveland to Panama?

    Currently, November is the cheapest month in which you can book a flight from Cleveland to Panama (average of $384). Flying from Cleveland to Panama in May is currently the most expensive (average of $567). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Cleveland to Panama

Discover the top 3 airlines that operate flights from Cleveland to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$389Average$570FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$469Average$683FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$469Average$600FlexibilityNo cancel feeOn-time69%

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