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$152+ Cheap flights from Chicago (CHI) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — PTY
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Chicago to Panama

Keep the following information in mind while searching for Chicago to Panama flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$451
(Avianca)

One-way from

$152
(Kiwi.com)

Popular in

October

Cheapest in

November

Average price

$700

Good round-trip deal

$437 or less

Good one-way deal

$162 or less
Provider with most accurate pricing for Chicago (CHI)-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Chicago (CHI)-Panama City Tocumen Intl flights.
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From Chicago (CHI) to Panama
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One-way flight from Chicago (CHI) to Panama
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a round-trip flight from Chicago (CHI) to Panama.
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Price to beat on a one-way flight from Chicago (CHI) to Panama.
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Find flight deals from Chicago to Panama

Cheapest flights from Chicago to Panama
Explore the most affordable flight options available from Chicago to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/292:07 pmORD - PTY
Nonstop5h 28mCopa Airlines
Wed 12/37:56 amPTY - ORD
Nonstop5h 56mCopa Airlines
Deal found 10/30$451
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:20 pmORD - PTY
2 stops14h 46mMultiple Airlines
Wed 12/1010:25 amPTY - ORD
1 stop9h 11mMultiple Airlines
Deal found 10/29$462
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/110:20 pmORD - PTY
1 stop17h 35mMultiple Airlines
Fri 12/511:25 amPTY - ORD
2 stops13h 44mMultiple Airlines
Deal found 10/29$465
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/185:23 amORD - PTY
1 stop7h 49mDelta
Sat 11/228:05 amPTY - ORD
1 stop11h 47mDelta
Deal found 10/30$466
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/186:00 amMDW - PTY
1 stop7h 12mDelta
Thu 11/273:37 pmPTY - MDW
1 stop9h 03mDelta
Deal found 10/30$466
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/3012:52 amORD - PTY
2 stops11h 51mAmerican Airlines
Fri 12/54:43 pmPTY - ORD
2 stops17h 25mAmerican Airlines
Deal found 10/29$470
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/186:00 amMDW - PTY
1 stop7h 12mDelta
Sun 11/238:05 amPTY - MDW
2 stops11h 03mDelta
Deal found 10/30$470
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/307:17 pmORD - PTY
1 stop17h 26mAmerican Airlines
Sun 12/74:43 pmPTY - ORD
1 stop8h 54mAmerican Airlines
Deal found 10/29$471
This Cheapflightsfares deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/110:20 pmORD - PTY
1 stop9h 30mAvianca
Fri 12/52:55 amPTY - ORD
1 stop18h 25mAvianca
Deal found 10/30$474
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/98:45 pmORD - PTY
2 stops16h 02mAmerican Airlines
Sun 12/214:55 pmPTY - ORD
2 stops17h 26mAmerican Airlines
Deal found 10/29$475
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/202:07 pmORD - PTY
Nonstop5h 28mCopa Airlines
Mon 11/247:20 pmPTY - ORD
Nonstop5h 45mCopa Airlines
Deal found 10/29$477
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1410:20 pmORD - PTY
1 stop17h 35mMultiple Airlines
Sun 11/2311:25 amPTY - ORD
2 stops12h 48mMultiple Airlines
Deal found 10/28$480

Cheapflights Fare Finder

 
Customize your flight search to find flights from Chicago to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Chicago to Panama that are best for you.

Fly from

Chicago

Fly to

Panama

Route

Depart

Return

Price

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 1/15

11:51 pm-6:13 am

Nonstop5h 22m

Panama City Tocumen Intl

Sun 1/18

7:40 pm-12:24 am

Nonstop5h 44m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Wed 12/24

7:33 am-2:00 pm

Nonstop5h 27m

Panama City Tocumen Intl

Wed 12/31

7:20 pm-12:05 am

Nonstop5h 45m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Sat 12/6

2:07 pm-8:35 pm

Nonstop5h 28m

Panama City Tocumen Intl

Wed 12/10

7:20 pm-12:05 am

Nonstop5h 45m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Mon 1/5

2:13 pm-8:35 pm

Nonstop5h 22m

Panama City Tocumen Intl

Tue 1/13

8:10 am-12:46 pm

Nonstop5h 36m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 11/6

6:56 am-1:22 pm

Nonstop5h 26m

Panama City Tocumen Intl

Mon 11/10

7:20 pm-12:05 am

Nonstop5h 45m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Wed 12/31

7:33 am-2:00 pm

Nonstop5h 27m

Panama City Tocumen Intl

Wed 12/31

7:20 pm-12:05 am

Nonstop5h 45m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 1/16

2:13 pm-8:35 pm

Nonstop5h 22m

Panama City Tocumen Intl

Sun 2/1

7:20 pm-12:04 am

Nonstop5h 44m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 1/9

2:13 pm-8:35 pm

Nonstop5h 22m

Panama City Tocumen Intl

Fri 1/16

7:40 pm-12:24 am

Nonstop5h 44m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 12/25

2:07 pm-8:35 pm

Nonstop5h 28m

Panama City Tocumen Intl

Mon 12/29

7:56 am-12:52 pm

Nonstop5h 56m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Sat 12/6

2:07 pm-8:35 pm

Nonstop5h 28m

Panama City Tocumen Intl

Thu 12/11

7:56 am-12:52 pm

Nonstop5h 56m

$451

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 49 results
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Best time to book a flight from Chicago to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Chicago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Chicago to Panama

What is the cheapest month to book a flight from Chicago to Panama?

Currently, November is the cheapest month in which you can book a flight from Chicago to Panama (average of $392). Flying from Chicago to Panama in April is currently the most expensive (average of $464). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHI to PA?

Find hourly flight availability from Chicago to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

One of the essential ways to save on airfare from Chicago to Panama is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 40% on airfare.

What is the cheapest day to fly from Chicago to Panama?

Use this chart to determine the cheapest time to fly round-trip from Chicago to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Chicago to Panama flight should consider departing on Monday evenings when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 30, 2025.
See what other customers who have flown with Delta, Copa Airlines, and United Airlines from Chicago to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Copa Airlines
7.6
Good
1,561 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,996 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,034 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Avianca
6.6
Okay
2,467 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Chicago to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Chicago to Panama?

    For as low as $451, Copa Airlines can have you in Panama from Chicago in 5h 22m. Airlines will cover a distance of 2330 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Chicago to Panama?

    The most popular route from Chicago to Panama is Chicago O'Hare Intl - Panama City Tocumen Intl. You may also consider Chicago Midway - Panama City Tocumen Intl or Chicago O'Hare Intl - David Enrique Malek.

  • What are the most reliable airlines from Chicago to Panama?

    The top 3 most reliable airlines when flying from Chicago to Panama are United Airlines (90%), EVA Air (89%) and Copa Airlines (60%).

  • What are the cheapest flights from Chicago to Panama?

    While on average a flight from Chicago to Panama is generally $757, our data shows the cheapest flight currently is $133. When looking at the most popular route, (Chicago O'Hare Intl - Panama City Tocumen Intl), you can expect to pay $451 for that flight.

  • Can I find deals for flights from Chicago to Panama that include hotel bookings?

    Yes. In addition to deals on Chicago to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Chicago to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Chicago to Panama.

  • Can I find deals for business class flights from Chicago to Panama?

    Yes. Cheapflights offers flight deals from Chicago to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Chicago to Panama?

    Currently, November is the cheapest month in which you can book a flight from Chicago to Panama (average of $392). Flying from Chicago to Panama in April is currently the most expensive (average of $464). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Chicago to Panama

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to San José flights
O'Hare Intl to Guatemala City flights
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Midway to Managua flights
O'Hare Intl to David flights
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Midway to Coxen Hole flights
Moline to Liberia flights
St. Louis to San Pedro Sula flights
Moline to Philip S.W.Goldson flights
Peoria to San Salvador flights
Moline to San Salvador flights
Moline to Guatemala City flights
Midway to Tegucigalpa flights
Moline to San José flights
O'Hare Intl to Tegucigalpa flights
St. Louis to Tegucigalpa flights
Bloomington to Philip S.W.Goldson flights
Springfield to Liberia flights
Bloomington to San José flights

Top 5 airlines flying from Chicago to Panama

Discover the top 5 airlines that operate flights from Chicago to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$334Average$457FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$464Average$672FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$479Average$653FlexibilityNo cancel feeOn-time69%
DeltaCheapest$479Average$658FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$589Average$737FlexibilityNo cancel feeOn-time71%

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