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$108+ Cheap flights from Chicago (CHI) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — PTY
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Chicago to Panama

Keep the following information in mind while searching for Chicago to Panama flight deals. Data was last updated September 15, 2025.

Round-trip from

$272
(Cheapflightsfares)

One-way from

$108
(Priceline)

Popular in

December

Cheapest in

November

Average price

$548

Good round-trip deal

$429 or less

Good one-way deal

$178 or less
From Chicago (CHI) to Panama
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One-way flight from Chicago (CHI) to Panama
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Highest demand for flights based on searches. 3% potential increase in price ($18 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Chicago (CHI) to Panama.
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Price to beat on a one-way flight from Chicago (CHI) to Panama.
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Find flight deals from Chicago to Panama

Cheapest flights from Chicago to Panama
Explore the most affordable flight options available from Chicago to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/173:07 pmORD - PTY
Nonstop5h 28mCopa Airlines
Fri 10/246:45 pmPTY - ORD
Nonstop5h 36mCopa Airlines
Deal found 9/15$451
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/185:05 amORD - PTY
2 stops19h 05mMultiple Airlines
Thu 10/235:25 pmPTY - ORD
2 stops30h 20mMultiple Airlines
Deal found 9/15$453
This Mytrip deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1510:20 pmORD - PTY
1 stop17h 35mAvianca
Mon 12/297:50 pmPTY - ORD
1 stop20h 00mAvianca
Deal found 9/13$455
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/27:55 pmORD - PTY
1 stop18h 19mUnited Airlines
Sun 10/123:30 pmPTY - ORD
1 stop8h 44mUnited Airlines
Deal found 9/14$456
This Cheapflightsfares deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2010:20 pmORD - PTY
1 stop9h 30mAvianca
Mon 11/249:45 amPTY - ORD
1 stop11h 35mAvianca
Deal found 9/12$457
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/152:35 pmORD - PTY
1 stop10h 10mAvianca
Mon 9/2210:05 pmPTY - ORD
2 stops20h 41mAvianca
Deal found 9/13$461
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1311:55 amORD - PTY
1 stop8h 24mMultiple Airlines
Mon 10/2012:03 pmPTY - ORD
1 stop11h 42mMultiple Airlines
Deal found 9/14$462
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/296:00 amMDW - PTY
1 stop7h 12mDelta
Wed 12/33:46 pmPTY - MDW
1 stop8h 46mDelta
Deal found 9/15$465
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:00 amORD - PTY
1 stop8h 14mUnited Airlines
Sat 10/183:30 pmPTY - ORD
1 stop18h 40mUnited Airlines
Deal found 9/15$465
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:56 amORD - PTY
Nonstop5h 26mCopa Airlines
Sun 11/307:50 amPTY - ORD
Nonstop5h 56mCopa Airlines
Deal found 9/14$466
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/159:32 amMDW - PTY
2 stops9h 27mDelta
Sat 11/223:37 pmPTY - MDW
1 stop8h 55mDelta
Deal found 9/13$470
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:44 pmORD - PTY
2 stops17h 19mAmerican Airlines
Fri 10/243:15 pmPTY - ORD
1 stop17h 38mAmerican Airlines
Deal found 9/14$470

Cheapflights Fare Finder

 
Customize your flight search to find flights from Chicago to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Chicago to Panama that are best for you.

Fly from

Chicago

Fly to

Panama

Route

Depart

Return

Price

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 10/23

3:07 pm-8:35 pm

Nonstop5h 28m

Panama City Tocumen Intl

Mon 10/27

7:55 am-1:41 pm

Nonstop5h 46m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 10/17

3:07 pm-8:35 pm

Nonstop5h 28m

Panama City Tocumen Intl

Fri 10/24

6:45 pm-12:21 am

Nonstop5h 36m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Tue 10/21

7:59 am-1:21 pm

Nonstop5h 22m

Panama City Tocumen Intl

Sat 10/25

6:45 pm-12:21 am

Nonstop5h 36m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Sun 10/12

3:07 pm-8:35 pm

Nonstop5h 28m

Panama City Tocumen Intl

Fri 10/17

6:45 pm-12:21 am

Nonstop5h 36m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Sat 10/18

3:07 pm-8:35 pm

Nonstop5h 28m

Panama City Tocumen Intl

Thu 10/23

6:45 pm-12:21 am

Nonstop5h 36m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 1/8

2:13 pm-8:35 pm

Nonstop5h 22m

Panama City Tocumen Intl

Thu 1/15

5:37 pm-10:21 pm

Nonstop5h 44m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Wed 10/29

3:07 pm-8:35 pm

Nonstop5h 28m

Panama City Tocumen Intl

Mon 12/8

7:56 am-12:52 pm

Nonstop5h 56m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 10/17

3:07 pm-8:35 pm

Nonstop5h 28m

Panama City Tocumen Intl

Tue 10/21

6:45 pm-12:21 am

Nonstop5h 36m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Sat 11/1

3:07 pm-8:35 pm

Nonstop5h 28m

Panama City Tocumen Intl

Sat 11/8

7:20 pm-12:05 am

Nonstop5h 45m

$451

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 11/6

2:07 pm-8:35 pm

Nonstop5h 28m

Panama City Tocumen Intl

Sun 11/9

7:20 pm-12:05 am

Nonstop5h 45m

$451

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 49 results
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Best time to book a flight from Chicago to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Chicago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Chicago to Panama

What is the cheapest month to book a flight from Chicago to Panama?

Currently, October is the cheapest month in which you can book a flight from Chicago to Panama (average of $478). Flying from Chicago to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHI to PA?

Find hourly flight availability from Chicago to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

One of the essential ways to save on airfare from Chicago to Panama is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 17% on airfare.

What is the cheapest day to fly from Chicago to Panama?

Use this chart to determine the cheapest time to fly round-trip from Chicago to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Chicago to Panama flight should consider departing on Monday evenings when fares are most often at their lowest. Tuesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Chicago to Panama

Explore weekly flight availability from Chicago to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 15, 2025.

The most flights from CHI to PA0 are scheduled on a Monday (5 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (3 on average).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated September 15, 2025.
See what other customers who have flown with Delta, Copa Airlines, and United Airlines from Chicago to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.6
Good
1,531 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,929 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Avianca
6.7
Okay
2,435 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Chicago to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Chicago to Panama?

    For as low as $451, Copa Airlines can have you in Panama from Chicago in 5h 28m. Airlines will cover a distance of 2330 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Chicago to Panama?

    The most popular route from Chicago to Panama is Chicago O'Hare Intl - Panama City Tocumen Intl. You may also consider Chicago Midway - Panama City Tocumen Intl or Chicago O'Hare Intl - David Enrique Malek.

  • What are the most reliable airlines from Chicago to Panama?

    The top 3 most reliable airlines when flying from Chicago to Panama are EVA Air (92%), United Airlines (85%) and Copa Airlines (75%).

  • What are the cheapest flights from Chicago to Panama?

    While on average a flight from Chicago to Panama is generally $700, our data shows the cheapest flight currently is $133. When looking at the most popular route, (Chicago O'Hare Intl - Panama City Tocumen Intl), you can expect to pay $359 for that flight.

  • Can I find deals for flights from Chicago to Panama that include hotel bookings?

    Yes. In addition to deals on Chicago to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Chicago to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Chicago to Panama.

  • Can I find deals for business class flights from Chicago to Panama?

    Yes. Cheapflights offers flight deals from Chicago to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Chicago to Panama?

    Currently, October is the cheapest month in which you can book a flight from Chicago to Panama (average of $478). Flying from Chicago to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Chicago to Panama

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to San José flights
O'Hare Intl to Panama City flights
O'Hare Intl to Guatemala City flights
O'Hare Intl to Liberia flights
O'Hare Intl to Philip S.W.Goldson flights
Midway to San José flights
Midway to Guatemala City flights
O'Hare Intl to San Salvador flights
Midway to Panama City flights
Midway to Liberia flights
O'Hare Intl to Managua flights
St. Louis to Philip S.W.Goldson flights
St. Louis to San José flights
O'Hare Intl to Coxen Hole flights
Midway to Philip S.W.Goldson flights
St. Louis to Liberia flights
Midway to San Salvador flights
O'Hare Intl to San Pedro Sula flights
Evansville to Panama City flights
St. Louis to Panama City flights
St. Louis to Guatemala City flights
Midway to Coxen Hole flights
Midway to San Pedro Sula flights
St. Louis to Coxen Hole flights
Bloomington to Philip S.W.Goldson flights
O'Hare Intl to David flights
Midway to Managua flights
Bloomington to San José flights
Moline to San José flights
Moline to San Salvador flights
Peoria to San Salvador flights
St. Louis to Managua flights
Midway to Tegucigalpa flights
St. Louis to San Pedro Sula flights
Moline to Liberia flights
Moline to Guatemala City flights
O'Hare Intl to Tegucigalpa flights
Moline to Philip S.W.Goldson flights
St. Louis to Tegucigalpa flights
Springfield to Liberia flights

Top 5 airlines flying from Chicago to Panama

Discover the top 5 airlines that operate flights from Chicago to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$334Average$457FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$464Average$679FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$478Average$653FlexibilityNo cancel feeOn-time69%
DeltaCheapest$479Average$653FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$563Average$707FlexibilityNo cancel feeOn-time71%

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