Palermo

$284+ Cheap flights from South Carolina to Palermo (PMO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/24. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PMO
Mar 8 — Mar 151
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Cheap flight deals from South Carolina to Palermo

Cheapest flights from South Carolina to Palermo
Explore the most affordable flight options available from South Carolina to Palermo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 6, 2026.

This KLM deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2212:43 pm
CLT
-
PMO
2 stops17h 57m
KLM
Tue 3/316:10 am
PMO
-
CLT
2 stops20h 08m
KLM
Deal found 2/5$644
This Gotogate deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:50 pm
CLT
-
PMO
2 stops37h 40m
SWISS
Sun 3/297:35 pm
PMO
-
CLT
2 stops51h 10m
SWISS
Deal found 2/4$681
This oojo deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:50 pm
CLT
-
PMO
2 stops17h 35m
SWISS
Sat 2/289:45 am
PMO
-
CLT
2 stops37h 10m
SWISS
Deal found 2/5$683
This FlightHub deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:50 pm
CLT
-
PMO
2 stops37h 40m
Multiple Airlines
Sat 2/2812:10 pm
PMO
-
CLT
1 stop34h 45m
Multiple Airlines
Deal found 2/5$696
This KLM deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:00 pm
CLT
-
PMO
2 stops15h 25m
KLM
Tue 4/289:10 am
PMO
-
CLT
2 stops18h 18m
KLM
Deal found 2/6$715
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:10 am
CLT
-
PMO
2 stops23h 55m
Delta
Thu 5/141:00 pm
PMO
-
CLT
2 stops25h 58m
Delta
Deal found 2/3$723
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:51 pm
CLT
-
PMO
2 stops36h 14m
Delta
Thu 5/141:00 pm
PMO
-
CLT
2 stops26h 05m
Delta
Deal found 2/3$728
This FlightHub deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:50 am
CLT
-
PMO
2 stops22h 15m
Multiple Airlines
Mon 3/237:15 pm
PMO
-
CLT
2 stops27h 40m
Multiple Airlines
Deal found 2/6$736
This Cheapflightsfares deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:40 pm
CLT
-
PMO
2 stops18h 30m
SWISS
Wed 5/138:00 pm
PMO
-
CLT
2 stops26h 45m
SWISS
Deal found 2/3$746
This oojo deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 pm
CLT
-
PMO
2 stops35h 10m
British Airways
Tue 4/2812:15 pm
PMO
-
CLT
1 stop30h 45m
British Airways
Deal found 2/6$748
This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:32 pm
CAE
-
PMO
2 stops40h 08m
American Airlines
Mon 10/57:50 pm
PMO
-
CAE
2 stops29h 48m
American Airlines
Deal found 2/5$1,058
This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:20 am
CAE
-
PMO
3 stops23h 50m
Multiple Airlines
Mon 10/57:50 pm
PMO
-
CAE
2 stops29h 48m
Multiple Airlines
Deal found 2/5$1,212

Find flight deals from South Carolina to Palermo

Keep the following information in mind while searching for South Carolina to Palermo flight deals. Data was last updated February 6, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$622
(Air Canada)

One-way from

$284
(Kiwi.com)
Provider with most accurate pricing for Myrtle Beach Intl-Palermo Punta Raisi flight deals.
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Palermo Punta Raisi flights.
From South Carolina to Palermo Punta Raisi
One-way flight from South Carolina to Palermo Punta Raisi

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Palermo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 6, 2026.
Use the filters below to find and compare flights from South Carolina to Palermo that are best for you.

Fly from

South Carolina

Fly to

Palermo

Route

Depart

Return

Price

CharlottePalermo

CLT - PMO

CLTPMO

Charlotte Douglas

Sun 3/22

12:43 pm-11:40 am

2 stops17h 57m

Palermo Punta Raisi

Tue 3/31

6:10 am-8:18 pm

2 stops20h 08m

$644

CharlottePalermo

CLT - PMO

CLTPMO

Charlotte Douglas

Sun 3/22

7:50 pm-2:30 pm

2 stops37h 40m

Palermo Punta Raisi

Sun 3/29

7:35 pm-4:45 pm

2 stops51h 10m

$681

CharlottePalermo

CLT - PMO

CLTPMO

Charlotte Douglas

Sun 2/22

6:50 pm-6:25 pm

2 stops17h 35m

Palermo Punta Raisi

Sat 2/28

9:45 am-4:55 pm

2 stops37h 10m

$683

CharlottePalermo

CLT - PMO

CLTPMO

Charlotte Douglas

Sun 3/22

7:50 pm-6:25 pm

2 stops17h 35m

Palermo Punta Raisi

Tue 3/31

6:10 pm-4:45 pm

1 stop28h 35m

$696

CharlottePalermo

CLT - PMO

CLTPMO

Charlotte Douglas

Sun 2/22

6:50 pm-2:30 pm

2 stops37h 40m

Palermo Punta Raisi

Sat 2/28

12:10 pm-4:55 pm

1 stop34h 45m

$696

CharlottePalermo

CLT - PMO

CLTPMO

Charlotte Douglas

Tue 4/21

5:00 pm-2:25 pm

2 stops15h 25m

Palermo Punta Raisi

Tue 4/28

9:10 am-9:28 pm

2 stops18h 18m

$715

CharlottePalermo

CLT - PMO

CLTPMO

Charlotte Douglas

Thu 5/7

6:10 am-12:05 pm

2 stops23h 55m

Palermo Punta Raisi

Thu 5/14

1:00 pm-8:58 am

2 stops25h 58m

$723

CharlottePalermo

CLT - PMO

CLTPMO

Charlotte Douglas

Wed 5/6

5:51 pm-12:05 pm

2 stops36h 14m

Palermo Punta Raisi

Thu 5/14

1:00 pm-9:05 am

2 stops26h 05m

$728

CharlottePalermo

CLT - PMO

CLTPMO

Charlotte Douglas

Wed 3/18

7:50 am-11:05 am

2 stops22h 15m

Palermo Punta Raisi

Mon 3/23

7:15 pm-5:55 pm

2 stops27h 40m

$736

CharlottePalermo

CLT - PMO

CLTPMO

Charlotte Douglas

Tue 5/5

6:40 pm-7:10 pm

2 stops18h 30m

Palermo Punta Raisi

Wed 5/13

8:00 pm-4:45 pm

2 stops26h 45m

$746

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/6

Showing 1-10 of 18 results
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Best time to book a flight from South Carolina to Palermo

Have a flexible travel schedule? Discover the best time to fly to Palermo from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Palermo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Palermo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to Palermo from South Carolina?

    Palermo Punta Raisi (PMO), located 15.2 mi from the city center, is the airport you fly into when you book flights from South Carolina to Palermo.

  • How long is the flight from South Carolina to Palermo?

    For as low as $1,432, KLM can have you in Palermo from South Carolina in 15h 01m. Airlines will cover a distance of 5020 mi. This flight may include one or multiple stops.

  • What are the most popular routes from South Carolina to Palermo?

  • Can I find deals for flights from South Carolina to Palermo that include hotel bookings?

    Yes. In addition to deals on South Carolina to Palermo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Palermo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Palermo.

  • Can I find deals for business class flights from South Carolina to Palermo?

    Yes. Cheapflights offers flight deals from South Carolina to Palermo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Palermo?

Book flights to Palermo if you plan to visit one of these locations
Agrigento
Cefalù

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Alternative routes for South Carolina to Palermo

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from South Carolina to Palermo

Discover the top airline that operate flights from South Carolina to Palermo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 6, 2026.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$635Average$1,459FlexibilityNo cancel feeOn-time76%

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