$284+ Cheap flights from South Carolina to Palermo (PMO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/24. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PMO
Mar 8 — Mar 151
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from South Carolina to Palermo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Palermo
Cheapest
Best
Last-minute
One-way
Cheapest flights from South Carolina to PalermoExplore the most affordable flight options available from South Carolina to Palermo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 6, 2026.
Explore the most affordable flight options available from South Carolina to Palermo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 6, 2026.
This KLM deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2212:43 pm
CLT
- PMO
2 stops17h 57m
KLM
Tue 3/316:10 am
PMO
- CLT
2 stops20h 08m
KLM
Deal found 2/5![KLM logo]()
$644
This Gotogate deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:50 pm
CLT
- PMO
2 stops37h 40m
SWISS
Sun 3/297:35 pm
PMO
- CLT
2 stops51h 10m
SWISS
Deal found 2/4![SWISS logo]()
$681
This oojo deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:50 pm
CLT
- PMO
2 stops17h 35m
SWISS
Sat 2/289:45 am
PMO
- CLT
2 stops37h 10m
SWISS
Deal found 2/5![SWISS logo]()
$683
This FlightHub deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:50 pm
CLT
- PMO
2 stops37h 40m
Multiple Airlines
Sat 2/2812:10 pm
PMO
- CLT
1 stop34h 45m
Multiple Airlines
Deal found 2/5![Multiple Airlines logo]()
$696
This KLM deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:00 pm
CLT
- PMO
2 stops15h 25m
KLM
Tue 4/289:10 am
PMO
- CLT
2 stops18h 18m
KLM
Deal found 2/6![KLM logo]()
$715
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:10 am
CLT
- PMO
2 stops23h 55m
Delta
Thu 5/141:00 pm
PMO
- CLT
2 stops25h 58m
Delta
Deal found 2/3![Delta logo]()
$723
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:51 pm
CLT
- PMO
2 stops36h 14m
Delta
Thu 5/141:00 pm
PMO
- CLT
2 stops26h 05m
Delta
Deal found 2/3![Delta logo]()
$728
This FlightHub deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:50 am
CLT
- PMO
2 stops22h 15m
Multiple Airlines
Mon 3/237:15 pm
PMO
- CLT
2 stops27h 40m
Multiple Airlines
Deal found 2/6![Multiple Airlines logo]()
$736
This Cheapflightsfares deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:40 pm
CLT
- PMO
2 stops18h 30m
SWISS
Wed 5/138:00 pm
PMO
- CLT
2 stops26h 45m
SWISS
Deal found 2/3![SWISS logo]()
$746
This oojo deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 pm
CLT
- PMO
2 stops35h 10m
British Airways
Tue 4/2812:15 pm
PMO
- CLT
1 stop30h 45m
British Airways
Deal found 2/6![British Airways logo]()
$748
This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:32 pm
CAE
- PMO
2 stops40h 08m
American Airlines
Mon 10/57:50 pm
PMO
- CAE
2 stops29h 48m
American Airlines
Deal found 2/5![American Airlines logo]()
$1,058
This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:20 am
CAE
- PMO
3 stops23h 50m
Multiple Airlines
Mon 10/57:50 pm
PMO
- CAE
2 stops29h 48m
Multiple Airlines
Deal found 2/5![Multiple Airlines logo]()
$1,212
Best flights from South Carolina to PalermoDiscover carefully curated flight deals from South Carolina to Palermo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 6, 2026.
Discover carefully curated flight deals from South Carolina to Palermo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 6, 2026.
This KLM deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2212:43 pm
CLT
- PMO
2 stops17h 57m
KLM
Tue 3/316:10 am
PMO
- CLT
2 stops20h 08m
KLM
Deal found 2/5![KLM logo]()
$644
This Gotogate deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:50 pm
CLT
- PMO
2 stops37h 40m
SWISS
Sun 3/297:35 pm
PMO
- CLT
2 stops51h 10m
SWISS
Deal found 2/4![SWISS logo]()
$681
This FlightHub deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:50 pm
CLT
- PMO
2 stops17h 35m
Multiple Airlines
Tue 3/316:10 pm
PMO
- CLT
1 stop28h 35m
Multiple Airlines
Deal found 2/5![Multiple Airlines logo]()
$696
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:10 am
CLT
- PMO
2 stops23h 55m
Delta
Thu 5/141:00 pm
PMO
- CLT
2 stops25h 58m
Delta
Deal found 2/3![Delta logo]()
$723
This oojo deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:50 pm
CLT
- PMO
2 stops17h 35m
SWISS
Sat 2/289:45 am
PMO
- CLT
2 stops37h 10m
SWISS
Deal found 2/5![SWISS logo]()
$683
This FlightHub deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:50 pm
CLT
- PMO
2 stops37h 40m
Multiple Airlines
Sat 2/2812:10 pm
PMO
- CLT
1 stop34h 45m
Multiple Airlines
Deal found 2/5![Multiple Airlines logo]()
$696
This KLM deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:00 pm
CLT
- PMO
2 stops15h 25m
KLM
Tue 4/289:10 am
PMO
- CLT
2 stops18h 18m
KLM
Deal found 2/6![KLM logo]()
$715
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/192:39 pm
CAE
- PMO
2 stops15h 01m
United Airlines
Mon 2/236:10 am
PMO
- CAE
2 stops23h 34m
United Airlines
Deal found 2/3![United Airlines logo]()
$1,432
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:51 pm
CLT
- PMO
2 stops36h 14m
Delta
Thu 5/141:00 pm
PMO
- CLT
2 stops26h 05m
Delta
Deal found 2/3![Delta logo]()
$728
This FlightHub deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:50 am
CLT
- PMO
2 stops22h 15m
Multiple Airlines
Mon 3/237:15 pm
PMO
- CLT
2 stops27h 40m
Multiple Airlines
Deal found 2/6![Multiple Airlines logo]()
$736
This Cheapflightsfares deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:40 pm
CLT
- PMO
2 stops18h 30m
SWISS
Wed 5/138:00 pm
PMO
- CLT
2 stops26h 45m
SWISS
Deal found 2/3![SWISS logo]()
$746
Last-minute flights from South Carolina to PalermoDiscover last-minute flight deals from South Carolina to Palermo. Data last updated February 6, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Palermo. Data last updated February 6, 2026 and is based on user searches.
This FlightHub deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/156:50 pm
CLT
- PMO
2 stops17h 35m
Multiple Airlines
Sat 2/2112:25 pm
PMO
- CLT
2 stops38h 36m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$865
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/192:39 pm
CAE
- PMO
2 stops15h 01m
United Airlines
Mon 2/236:10 am
PMO
- CAE
2 stops23h 34m
United Airlines
Deal found 2/3![United Airlines logo]()
$1,432
This oojo deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:50 pm
CLT
- PMO
2 stops17h 35m
SWISS
Sat 2/289:45 am
PMO
- CLT
2 stops37h 10m
SWISS
Deal found 2/5![SWISS logo]()
$683
This FlightHub deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:50 pm
CLT
- PMO
2 stops37h 40m
Multiple Airlines
Sat 2/2812:10 pm
PMO
- CLT
1 stop34h 45m
Multiple Airlines
Deal found 2/5![Multiple Airlines logo]()
$696
This FlightHub deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:50 am
CLT
- PMO
2 stops22h 15m
Multiple Airlines
Mon 3/237:15 pm
PMO
- CLT
2 stops27h 40m
Multiple Airlines
Deal found 2/6![Multiple Airlines logo]()
$736
This KLM deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2212:43 pm
CLT
- PMO
2 stops17h 57m
KLM
Tue 3/316:10 am
PMO
- CLT
2 stops20h 08m
KLM
Deal found 2/5![KLM logo]()
$644
This Gotogate deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:50 pm
CLT
- PMO
2 stops37h 40m
SWISS
Sun 3/297:35 pm
PMO
- CLT
2 stops51h 10m
SWISS
Deal found 2/4![SWISS logo]()
$681
This Expedia deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:50 pm
CLT
- PMO
2 stops17h 35m
Multiple Airlines
Sun 3/2911:50 am
PMO
- CLT
1 stop34h 55m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$764
One-way flights from South Carolina to PalermoSearch for one-way flight options from South Carolina to Palermo. Find affordable one-way fares based on user searches. Data last updated February 6, 2026.
Search for one-way flight options from South Carolina to Palermo. Find affordable one-way fares based on user searches. Data last updated February 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/241:59 pm
CLT
- PMO
3 stops40h 11m
Multiple Airlines
Deal found 2/6![Multiple Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:00 am
CLT
- PMO
3 stops28h 10m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$389
This Lufthansa deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Lufthansa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:40 pm
CLT
- PMO
1 stop16h 40m
Lufthansa
Deal found 2/4![Lufthansa logo]()
$547
This Cheapflightsfares deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2910:26 am
CLT
- PMO
2 stops24h 54m
Lufthansa
Deal found 2/4![Lufthansa logo]()
$762
This oojo deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:41 pm
CLT
- PMO
2 stops36h 34m
British Airways
Deal found 2/5![British Airways logo]()
$788
This United Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/152:52 pm
CAE
- PMO
2 stops15h 48m
United Airlines
Deal found 2/6![United Airlines logo]()
$1,629
This Scandinavian Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Scandinavian Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:45 am
CLT
- PMO
3 stops25h 25m
Scandinavian Airlines
Deal found 2/6![Scandinavian Airlines logo]()
$3,206
Find flight deals from South Carolina to Palermo
Keep the following information in mind while searching for South Carolina to Palermo flight deals. Data was last updated February 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $622 (Air Canada) |
One-way from | $284 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Palermo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 6, 2026.
Use the filters below to find and compare flights from South Carolina to Palermo that are best for you.
Fly from
South Carolina
Fly to
Palermo
Route
Depart
Return
Price
CharlottePalermo
CLT - PMO
CLTPMO
Charlotte Douglas
Sun 3/22
12:43 pm-11:40 am
2 stops17h 57m
Palermo Punta Raisi
Tue 3/31
6:10 am-8:18 pm
2 stops20h 08m
$644
CharlottePalermo
CLT - PMO
CLTPMO
Charlotte Douglas
Sun 3/22
7:50 pm-2:30 pm
2 stops37h 40m
Palermo Punta Raisi
Sun 3/29
7:35 pm-4:45 pm
2 stops51h 10m
$681
CharlottePalermo
CLT - PMO
CLTPMO
Charlotte Douglas
Sun 2/22
6:50 pm-6:25 pm
2 stops17h 35m
Palermo Punta Raisi
Sat 2/28
9:45 am-4:55 pm
2 stops37h 10m
$683
CharlottePalermo
CLT - PMO
CLTPMO
Charlotte Douglas
Sun 3/22
7:50 pm-6:25 pm
2 stops17h 35m
Palermo Punta Raisi
Tue 3/31
6:10 pm-4:45 pm
1 stop28h 35m
$696
CharlottePalermo
CLT - PMO
CLTPMO
Charlotte Douglas
Sun 2/22
6:50 pm-2:30 pm
2 stops37h 40m
Palermo Punta Raisi
Sat 2/28
12:10 pm-4:55 pm
1 stop34h 45m
$696
CharlottePalermo
CLT - PMO
CLTPMO
Charlotte Douglas
Tue 4/21
5:00 pm-2:25 pm
2 stops15h 25m
Palermo Punta Raisi
Tue 4/28
9:10 am-9:28 pm
2 stops18h 18m
$715
CharlottePalermo
CLT - PMO
CLTPMO
Charlotte Douglas
Thu 5/7
6:10 am-12:05 pm
2 stops23h 55m
Palermo Punta Raisi
Thu 5/14
1:00 pm-8:58 am
2 stops25h 58m
$723
CharlottePalermo
CLT - PMO
CLTPMO
Charlotte Douglas
Wed 5/6
5:51 pm-12:05 pm
2 stops36h 14m
Palermo Punta Raisi
Thu 5/14
1:00 pm-9:05 am
2 stops26h 05m
$728
CharlottePalermo
CLT - PMO
CLTPMO
Charlotte Douglas
Wed 3/18
7:50 am-11:05 am
2 stops22h 15m
Palermo Punta Raisi
Mon 3/23
7:15 pm-5:55 pm
2 stops27h 40m
$736
CharlottePalermo
CLT - PMO
CLTPMO
Charlotte Douglas
Tue 5/5
6:40 pm-7:10 pm
2 stops18h 30m
Palermo Punta Raisi
Wed 5/13
8:00 pm-4:45 pm
2 stops26h 45m
$746
Showing 1-10 of 18 results
Best time to book a flight from South Carolina to Palermo
Have a flexible travel schedule? Discover the best time to fly to Palermo from South Carolina with our price prediction graph.
CLT-PMO
CAE-PMO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Palermo
USSC-PMO
CLT-PMO
CAE-PMO
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Palermo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Palermo?
Book flights to Palermo if you plan to visit one of these locationsAgrigento
Cefalù
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Palermo flight routes
Popular flights
Top destinations
Alternative routes for South Carolina to Palermo
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Palermo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Palermo by cabin class
Find flights from South Carolina to Palermo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Palermo flights
Browse other South Carolina and Palermo flight options. Last updated on February 6, 2026.
Other flights to Palermo
Explore flights to Palermo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Palermo flights
Consider these flights traveling from South Carolina to Palermo.
Top airline flying from South Carolina to Palermo
Discover the top airline that operate flights from South Carolina to Palermo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$635 | Average$1,459 | FlexibilityNo cancel fee | On-time76% |