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$288+ Cheap flights from Santo Domingo (SDQ) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — STL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Santo Domingo to Missouri

Keep the following information in mind while searching for Santo Domingo to Missouri flight deals. Data was last updated September 11, 2025.

Round-trip from

$413
(Kiwi.com)

One-way from

$288
(Kiwi.com)

Popular in

May

Cheapest in

September

Average price

$365
From Santo Domingo Las Americas to Missouri
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One-way flight from Santo Domingo Las Americas to Missouri
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Highest demand for flights based on searches. 11% potential increase in price ($77 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($31 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Santo Domingo to Missouri

Cheapest flights from Santo Domingo to Missouri
Explore the most affordable flight options available from Santo Domingo to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/25:05 pmSDQ - MCI
1 stop18h 13mMultiple Airlines
Thu 10/911:37 amMCI - SDQ
2 stops27h 30mMultiple Airlines
Deal found 9/10$413
This Mytrip deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:18 amSDQ - MCI
2 stops17h 49mMultiple Airlines
Sat 10/45:15 amMCI - SDQ
1 stop6h 52mMultiple Airlines
Deal found 9/9$417
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/21:20 pmSDQ - MCI
1 stop10h 47mSpirit Airlines
Sun 10/55:15 amMCI - SDQ
2 stops33h 52mSpirit Airlines
Deal found 9/10$429
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/25:05 pmSDQ - MCI
1 stop18h 13mMultiple Airlines
Mon 10/65:15 pmMCI - SDQ
2 stops27h 30mMultiple Airlines
Deal found 9/11$436
This Mytrip deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/15:05 pmSDQ - MCI
3 stops31h 02mSpirit Airlines
Sat 10/45:15 amMCI - SDQ
1 stop6h 52mSpirit Airlines
Deal found 9/9$443
This Mytrip deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/21:20 pmSDQ - MCI
1 stop10h 47mMultiple Airlines
Tue 10/72:55 pmMCI - SDQ
2 stops24h 35mMultiple Airlines
Deal found 9/10$445
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2710:19 amSDQ - MCI
2 stops28h 41mMultiple Airlines
Fri 12/512:13 pmMCI - SDQ
1 stop27h 37mMultiple Airlines
Deal found 9/11$455
This Mytrip deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/21:20 pmSDQ - MCI
2 stops21h 58mSpirit Airlines
Thu 10/96:36 pmMCI - SDQ
2 stops20h 31mSpirit Airlines
Deal found 9/10$471
This Mytrip deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:18 amSDQ - MCI
2 stops17h 49mMultiple Airlines
Mon 10/65:11 pmMCI - SDQ
3 stops27h 34mMultiple Airlines
Deal found 9/11$476

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Santo Domingo to Missouri that are best for you.

Fly from

Santo Domingo

Fly to

Missouri

Route

Depart

Return

Price

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Thu 10/2

5:05 pm-10:18 am

1 stop18h 13m

Kansas City

Thu 10/9

11:37 am-4:07 pm

2 stops27h 30m

$413

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Wed 10/1

6:18 am-11:07 pm

2 stops17h 49m

Kansas City

Sat 10/4

5:15 am-1:07 pm

1 stop6h 52m

$417

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Thu 10/2

1:20 pm-11:07 pm

1 stop10h 47m

Kansas City

Sun 10/5

5:15 am-4:07 pm

2 stops33h 52m

$429

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Wed 10/1

5:05 pm-11:07 pm

3 stops31h 02m

Kansas City

Sat 10/4

5:15 am-1:07 pm

1 stop6h 52m

$443

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Thu 10/2

1:20 pm-11:07 pm

1 stop10h 47m

Kansas City

Tue 10/7

2:55 pm-4:30 pm

2 stops24h 35m

$446

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Thu 10/2

1:20 pm-10:18 am

2 stops21h 58m

Kansas City

Mon 10/6

5:11 pm-9:45 pm

3 stops27h 34m

$452

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Mon 10/27

10:19 am-2:00 pm

2 stops28h 41m

Kansas City

Wed 12/3

12:13 pm-5:50 pm

1 stop27h 37m

$455

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Wed 10/1

6:18 am-11:07 pm

2 stops17h 49m

Kansas City

Mon 10/6

5:11 pm-9:45 pm

3 stops27h 34m

$476

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Mon 1/12

10:19 am-12:39 pm

3 stops52h 20m

$288

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Wed 10/1

2:50 pm-11:44 pm

1 stop9h 54m

$298

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 14 results
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Best time to book a flight from Santo Domingo to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Missouri

What is the cheapest month to book a flight from Santo Domingo to Missouri?

Currently, August is the cheapest month in which you can book a flight from Santo Domingo to Missouri (average of $311). Flying from Santo Domingo to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to MO?

Find hourly flight availability from Santo Domingo to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Santo Domingo to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from Santo Domingo to Missouri, such as Delta and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santo Domingo to Missouri?

    Located just 17.5 mi from the city center, Santo Domingo Las Americas (SDQ) is the airport most travelers will use when flying to Missouri from Santo Domingo.

  • How long is the flight from Santo Domingo to Missouri?

    There are many flights that can get you from Santo Domingo to Missouri in 10h 47m. Fly via Spirit Airlines to get the fastest option. Airlines will cover a distance of 2077 mi.

  • Can I find deals for flights from Santo Domingo to Missouri that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Missouri.

  • Can I find deals for business class flights from Santo Domingo to Missouri?

    Yes. Cheapflights offers flight deals from Santo Domingo to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Santo Domingo to Missouri (average of $311). Flying from Santo Domingo to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Santo Domingo to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
Santo Domingo to John F Kennedy Intl flights
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Punta Cana to Orlando flights
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Punta Cana to Atlanta flights
Puerto Plata to John F Kennedy Intl flights
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Santo Domingo to Dulles Intl flights
Punta Cana to Dallas/Fort Worth flights
Punta Cana to Miami flights
Punta Cana to O'Hare Intl flights
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Punta Cana to LaGuardia flights
Santo Domingo to Tampa flights
Santo Domingo to Cincinnati flights
Santo Domingo to San Francisco flights
Santo Domingo to Hobby flights
Santo Domingo to Baltimore flights
Santo Domingo to Charlotte flights
Santo Domingo to Reagan-National flights
Santo Domingo to George Bush Intcntl flights
Santo Domingo to Denver flights
Punta Cana to Love Field flights
Punta Cana to Hobby flights
Punta Cana to Fort Lauderdale flights
Punta Cana to Baltimore flights
Santo Domingo to Seattle flights
Punta Cana to Philadelphia flights
Santo Domingo to Jacksonville flights

Top 2 airlines flying from Santo Domingo to Missouri

Discover the top 2 airlines that operate flights from Santo Domingo to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$229Average$478FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$546Average$642FlexibilityNo cancel feeOn-time71%

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