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$298+ Cheap flights from Santo Domingo (SDQ) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/24. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — STL
Dec 1 — Dec 81
Mon 12/1
Mon 12/8
1 adult, Economy
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Find flight deals from Santo Domingo to Missouri

Cheapest flights from Santo Domingo to Missouri
Explore the most affordable flight options available from Santo Domingo to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 1, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:59 amSDQ - MCI
1 stop15h 11mSpirit Airlines
Wed 12/316:15 pmMCI - SDQ
1 stop6h 39mSpirit Airlines
Deal found 11/1$366
This Cheapflightsfares deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/253:47 amSDQ - MCI
1 stop15h 23mSpirit Airlines
Sat 1/33:47 pmMCI - SDQ
1 stop9h 45mSpirit Airlines
Deal found 10/30$412
This Cheapflightsfares deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:20 amSDQ - MCI
1 stop16h 39mSpirit Airlines
Sun 1/43:47 pmMCI - SDQ
1 stop9h 45mSpirit Airlines
Deal found 10/31$424
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:50 amSDQ - MCI
1 stop16h 22mDelta
Fri 1/165:50 amMCI - SDQ
1 stop6h 31mDelta
Deal found 10/31$566
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:00 amSDQ - MCI
1 stop13h 10mAmerican Airlines
Sat 1/36:36 pmMCI - SDQ
2 stops13h 31mAmerican Airlines
Deal found 11/1$580
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:49 pmSDQ - MCI
1 stop10h 05mAmerican Airlines
Fri 1/165:48 amMCI - SDQ
2 stops14h 51mAmerican Airlines
Deal found 11/1$585
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2111:07 amSDQ - MCI
2 stops13h 57mAmerican Airlines
Wed 12/316:35 amMCI - SDQ
2 stops15h 24mAmerican Airlines
Deal found 11/1$590

Cheap flight deals from Santo Domingo to Missouri

Keep the following information in mind while searching for Santo Domingo to Missouri flight deals. Data was last updated November 1, 2025.

Round-trip from

$366
(Cheapflightsfares)

One-way from

$298
(Kiwi.com)

Popular in

January

Cheapest in

March

Average price

$697
From Santo Domingo Las Americas to Missouri
Search Deals
One-way flight from Santo Domingo Las Americas to Missouri
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($222 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($48 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 1, 2025.
Use the filters below to find and compare flights from Santo Domingo to Missouri that are best for you.

Fly from

Santo Domingo

Fly to

Missouri

Route

Depart

Return

Price

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Sat 12/20

3:59 am-5:10 pm

1 stop15h 11m

Kansas City

Wed 12/31

6:15 pm-2:54 am

1 stop6h 39m

$366

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Fri 12/26

3:59 am-5:10 pm

1 stop15h 11m

Kansas City

Sun 1/4

3:47 pm-3:32 am

1 stop9h 45m

$447

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Thu 2/19

6:55 pm-12:39 pm

2 stops19h 44m

Kansas City

Sun 2/22

1:44 pm-1:39 am

1 stop9h 55m

$461

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Fri 12/26

6:50 am-9:12 pm

1 stop16h 22m

Kansas City

Fri 1/16

5:50 am-2:21 pm

1 stop6h 31m

$566

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Thu 2/19

7:05 am-6:08 pm

1 stop13h 03m

Kansas City

Sun 2/22

9:59 am-11:59 pm

1 stop12h 00m

$575

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Fri 12/26

3:16 pm-11:55 pm

2 stops10h 39m

Kansas City

Sat 1/3

6:36 pm-10:07 am

2 stops13h 31m

$580

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Mon 11/24

4:35 pm-12:03 pm

2 stops21h 28m

$298

Santo DomingoKansas City

SDQ - MCI

SDQMCI

Santo Domingo Las Americas

Mon 11/24

3:05 pm-11:59 pm

1 stop10h 54m

$310

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/1

Best time to book a flight from Santo Domingo to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Missouri

What is the cheapest month to book a flight from Santo Domingo to Missouri?

Currently, March is the cheapest month in which you can book a flight from Santo Domingo to Missouri (average of $270). Flying from Santo Domingo to Missouri in August is currently the most expensive (average of $672). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to MO?

Find hourly flight availability from Santo Domingo to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 1, 2025.

It’s typically best to fly out from Santo Domingo to Missouri in the afternoon. Doing so could potentially save you 68% on the flight price compared to flying in the evening, which is usually more expensive.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated November 1, 2025.
Read through reviews of airlines operating flights from Santo Domingo to Missouri, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,031 reviews

Boarding

7.5

Comfort

7.2

Entertainment

6.9

Food

6.4

Crew

8.0

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Nordia,Sep 2025

KIN - MIA

We were to land in Miami sometime after 3pm but couldn’t due to bad weather, we flew around for 2 hrs until we had to land in Forth Myers to refuel, we had to sit another 2 hrs at Forth Myers until given the clearance to refuel, we were hungry, thirsty and frustrated at that point. All the had on the flight to offer was a small plastic glass of water and a pack of biscoff, I requested a cup of tea and was told none was there. We were basically at another airport and not one of the staff could consider that the passengers might be hungry or thirsty being on a plane for around 8 hrs, which you weren’t prepared for, at least find some hot water on board.
American Airlines
7.2
Good
11,031 reviews
American Airlines
7.2
Good
11,031 reviews

Boarding

7.5

Comfort

7.2

Entertainment

6.9

Food

6.4

Crew

8.0

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Nordia,Sep 2025

KIN - MIA

We were to land in Miami sometime after 3pm but couldn’t due to bad weather, we flew around for 2 hrs until we had to land in Forth Myers to refuel, we had to sit another 2 hrs at Forth Myers until given the clearance to refuel, we were hungry, thirsty and frustrated at that point. All the had on the flight to offer was a small plastic glass of water and a pack of biscoff, I requested a cup of tea and was told none was there. We were basically at another airport and not one of the staff could consider that the passengers might be hungry or thirsty being on a plane for around 8 hrs, which you weren’t prepared for, at least find some hot water on board.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santo Domingo to Missouri?

    Located just 17.5 mi from the city center, Santo Domingo Las Americas (SDQ) is the airport most travelers will use when flying to Missouri from Santo Domingo.

  • How long is the flight from Santo Domingo to Missouri?

    There are many flights that can get you from Santo Domingo to Missouri in 15h 11m. Fly via Spirit Airlines to get the fastest option. Airlines will cover a distance of 2077 mi.

  • Can I find deals for flights from Santo Domingo to Missouri that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Missouri.

  • Can I find deals for business class flights from Santo Domingo to Missouri?

    Yes. Cheapflights offers flight deals from Santo Domingo to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Missouri?

    Currently, March is the cheapest month in which you can book a flight from Santo Domingo to Missouri (average of $270). Flying from Santo Domingo to Missouri in August is currently the most expensive (average of $672). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Santo Domingo to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
Santo Domingo to John F Kennedy Intl flights
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Santiago de los Caballeros to Newark flights
Punta Cana to Orlando flights
Santo Domingo to Miami flights
Santo Domingo to Boston flights
Santiago de los Caballeros to John F Kennedy Intl flights
Punta Cana to Fort Lauderdale flights
Punta Cana to O'Hare Intl flights
Punta Cana to Miami flights
Santo Domingo to Fort Lauderdale flights
Punta Cana to Newark flights
Punta Cana to John F Kennedy Intl flights
Santo Domingo to Orlando flights
Punta Cana to Midway flights
Punta Cana to LaGuardia flights
Santiago de los Caballeros to Boston flights
Santiago de los Caballeros to Orlando flights
Santiago de los Caballeros to LaGuardia flights
Santo Domingo to Atlanta flights
Santo Domingo to Philadelphia flights
Santo Domingo to Las Vegas flights
Puerto Plata to John F Kennedy Intl flights
Santiago de los Caballeros to Miami flights
Punta Cana to Atlanta flights
Santo Domingo to Dulles Intl flights
Santo Domingo to Los Angeles flights
Santo Domingo to Baltimore flights
Santiago de los Caballeros to Fort Lauderdale flights
Santo Domingo to O'Hare Intl flights
Santo Domingo to Reagan-National flights
Santo Domingo to West Palm Beach flights
Santo Domingo to Dallas/Fort Worth flights
Puerto Plata to Newark flights
Santo Domingo to Tampa flights
Santo Domingo to Charlotte flights
Punta Cana to Boston flights
Santo Domingo to Seattle flights
Santo Domingo to Raleigh flights
Punta Cana to Baltimore flights
Santo Domingo to Midway flights
Punta Cana to Dulles Intl flights
Punta Cana to Hobby flights
Santiago de los Caballeros to Philadelphia flights
Punta Cana to Philadelphia flights
Puerto Plata to LaGuardia flights
Santo Domingo to Hobby flights
Punta Cana to Dallas/Fort Worth flights
Santo Domingo to Huntsville flights

Top airline flying from Santo Domingo to Missouri

Discover the top airline that operate flights from Santo Domingo to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$571Average$645FlexibilityNo cancel feeOn-time71%

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