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$570+ Cheap flights from Prague (PRG) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/22. Fares are subject to change and may not be available on all flights or dates of travel.
PRG — STL
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheap flight deals from Prague to Missouri

Cheapest flights from Prague to Missouri
Explore the most affordable flight options available from Prague to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This Iberia deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/510:30 am
PRG
-
STL
2 stops16h 43m
Multiple Airlines
Mon 2/911:55 am
STL
-
PRG
2 stops22h 35m
Multiple Airlines
Deal found 1/21$853
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/510:30 am
PRG
-
STL
2 stops16h 43m
American Airlines
Sun 2/81:35 pm
STL
-
PRG
2 stops21h 35m
American Airlines
Deal found 1/21$855
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1910:30 am
PRG
-
MCI
2 stops20h 45m
American Airlines
Mon 2/234:16 pm
MCI
-
PRG
2 stops18h 14m
American Airlines
Deal found 1/20$855
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/283:45 pm
PRG
-
SGF
2 stops23h 51m
American Airlines
Sun 11/13:57 pm
SGF
-
PRG
2 stops21h 48m
American Airlines
Deal found 1/20$861
This Air Canada deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/57:35 am
PRG
-
STL
3 stops17h 08m
Air Canada
Mon 2/94:05 pm
STL
-
PRG
2 stops14h 50m
Air Canada
Deal found 1/21$1,216

Find flight deals from Prague to Missouri

Keep the following information in mind while searching for Prague to Missouri flight deals. Data was last updated January 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$853
(American Airlines)

One-way from

$570
(Kiwi.com)
Provider with most accurate pricing for Václav Havel Prague-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Václav Havel Prague-Lambert-St Louis flights.
Search Deals
From Václav Havel Prague to Missouri
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One-way flight from Václav Havel Prague to Missouri
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Prague to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Prague to Missouri that are best for you.

Fly from

Prague

Fly to

Missouri

Route

Depart

Return

Price

PragueSt. Louis

PRG - STL

PRGSTL

Václav Havel Prague

Thu 2/5

10:30 am-8:13 pm

2 stops16h 43m

Lambert-St Louis

Mon 2/9

11:55 am-5:30 pm

2 stops22h 35m

$853

PragueSt. Louis

PRG - STL

PRGSTL

Václav Havel Prague

Thu 2/5

6:45 am-6:14 pm

2 stops18h 29m

Lambert-St Louis

Sun 2/8

1:35 pm-1:35 pm

2 stops17h 00m

$853

PragueKansas City

PRG - MCI

PRGMCI

Václav Havel Prague

Thu 2/19

10:30 am-12:15 am

2 stops20h 45m

Kansas City

Mon 2/23

4:16 pm-5:30 pm

2 stops18h 14m

$855

PragueSt. Louis

PRG - STL

PRGSTL

Václav Havel Prague

Thu 2/5

7:35 am-5:43 pm

3 stops17h 08m

Lambert-St Louis

Mon 2/9

4:05 pm-1:55 pm

2 stops14h 50m

$1,216

PragueSt. Louis

PRG - STL

PRGSTL

Václav Havel Prague

Sun 3/22

10:45 pm-11:19 pm

3 stops54h 34m

$570

PragueKansas City

PRG - MCI

PRGMCI

Václav Havel Prague

Wed 7/1

8:40 am-6:49 pm

2 stops17h 09m

$596

PragueSt. Louis

PRG - STL

PRGSTL

Václav Havel Prague

Sun 3/29

9:20 pm-9:11 pm

2 stops30h 51m

$725

PragueKansas City

PRG - MCI

PRGMCI

Václav Havel Prague

Wed 7/1

10:15 am-7:59 pm

1 stop16h 44m

$740

PragueSt. Louis

PRG - STL

PRGSTL

Václav Havel Prague

Sun 3/29

6:50 am-6:07 pm

2 stops18h 17m

$746

PragueSt. Louis

PRG - STL

PRGSTL

Václav Havel Prague

Sun 3/29

6:10 am-1:25 pm

1 stop14h 15m

$1,198

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

Showing 1-10 of 13 results
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Best time to book a flight from Prague to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Prague with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Prague to Missouri
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Prague to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Prague to Missouri?

    Most people fly from Václav Havel Prague (PRG) if they book a flight from Prague to Missouri. Václav Havel Prague is conveniently located just 6.9 mi from Prague’s city center.

  • How long is the flight from Prague to Missouri?

    Departing from Prague to Missouri will take you 17h 08m. The distance from Prague to Missouri is about 4783 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Prague to Missouri?

    When deciding which route to take from Prague to Missouri consider Václav Havel Prague - Kansas City, Václav Havel Prague - Lambert-St Louis or Václav Havel Prague - Springfield-Branson as they are the most popular.

  • Can I find deals for flights from Prague to Missouri that include hotel bookings?

    Yes. In addition to deals on Prague to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Prague to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Prague to Missouri.

  • Can I find deals for business class flights from Prague to Missouri?

    Yes. Cheapflights offers flight deals from Prague to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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