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$74+ Cheap flights from Islip, NY (ISP) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
ISP — STL
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Islip to Missouri

Cheapest flights from Islip to Missouri
Explore the most affordable flight options available from Islip to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:10 pm
ISP
-
STL
1 stop7h 30m
Southwest
Thu 5/145:00 am
STL
-
ISP
1 stop10h 30m
Southwest
Deal found 1/27$264
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:07 pm
ISP
-
MCI
1 stop8h 52m
Multiple Airlines
Sun 4/1912:12 pm
MCI
-
ISP
2 stops20h 01m
Multiple Airlines
Deal found 1/27$367
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:30 pm
ISP
-
MCI
1 stop7h 10m
Southwest
Sun 4/196:15 am
MCI
-
ISP
1 stop4h 35m
Southwest
Deal found 1/27$407
This Frontier deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/271:42 pm
ISP
-
STL
1 stop10h 42m
Frontier
Sun 3/297:52 am
STL
-
ISP
1 stop7h 21m
Frontier
Deal found 1/28$660
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/297:43 pm
ISP
-
MCI
1 stop21h 26m
Multiple Airlines
Mon 2/25:04 pm
MCI
-
ISP
2 stops41h 06m
Multiple Airlines
Deal found 1/29$708
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3111:50 am
ISP
-
STL
2 stops12h 43m
Multiple Airlines
Mon 2/210:16 am
STL
-
ISP
1 stop7h 32m
Multiple Airlines
Deal found 1/27$746
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/309:43 pm
ISP
-
MCI
1 stop19h 26m
Multiple Airlines
Mon 2/25:04 pm
MCI
-
ISP
2 stops24h 40m
Multiple Airlines
Deal found 1/27$794
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/317:40 am
ISP
-
STL
1 stop9h 00m
Southwest
Mon 2/22:35 pm
STL
-
ISP
1 stop6h 20m
Southwest
Deal found 1/27$845
This Southwest deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/296:00 am
ISP
-
MCI
1 stop5h 35m
Southwest
Mon 2/25:45 am
MCI
-
ISP
1 stop7h 50m
Southwest
Deal found 1/29$977

Find flight deals from Islip to Missouri

Keep the following information in mind while searching for Islip to Missouri flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$264
(Southwest)

One-way from

$74
(Priceline)

Popular in

November

Cheapest in

March

Average price

$334
Provider with most accurate pricing for New York (NYC)-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for New York (NYC)-Lambert-St Louis flights.
Search Deals
From Islip Long Island to Missouri
Search Deals
One-way flight from Islip Long Island to Missouri
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($57 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Islip to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Islip to Missouri that are best for you.

Fly from

Islip

Fly to

Missouri

Route

Depart

Return

Price

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Mon 5/11

5:10 pm-11:40 pm

1 stop7h 30m

Lambert-St Louis

Thu 5/14

5:00 am-4:30 pm

1 stop10h 30m

$264

IslipKansas City

ISP - MCI

ISPMCI

Islip Long Island

Fri 4/17

4:07 pm-11:59 pm

1 stop8h 52m

Kansas City

Sun 4/19

12:12 pm-9:13 am

2 stops20h 01m

$367

IslipKansas City

ISP - MCI

ISPMCI

Islip Long Island

Fri 4/17

4:30 pm-10:40 pm

1 stop7h 10m

Kansas City

Sun 4/19

6:15 am-11:50 am

1 stop4h 35m

$407

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Fri 3/27

1:42 pm-11:24 pm

1 stop10h 42m

Lambert-St Louis

Sun 3/29

7:52 am-4:13 pm

1 stop7h 21m

$660

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Thu 2/26

3:34 pm-11:59 pm

1 stop9h 25m

$74

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Mon 3/2

2:17 pm-6:51 am

2 stops41h 34m

$98

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Mon 3/2

3:34 pm-6:51 am

3 stops40h 17m

$115

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Tue 2/24

3:45 pm-9:00 pm

2 stops6h 15m

$127

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Mon 3/2

4:05 pm-10:40 pm

1 stop7h 35m

$130

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Thu 2/26

1:10 pm-9:25 pm

2 stops9h 15m

$135

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 13 results
1
2

Best time to book a flight from Islip to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Islip with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Islip to Missouri

What is the cheapest month to book a flight from Islip, New York to Missouri?

Currently, March is the cheapest month in which you can book a flight from Islip, New York to Missouri (average of $59). Flying from Islip, New York to Missouri in July is currently the most expensive (average of $221). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated January 29, 2026.
Peruse reviews from past customers who have flown with Southwest from Islip to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,267 reviews
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Islip to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Islip to Missouri?

    If you book a flight to Missouri from Islip, you will be flying from Long Island, which is the city’s only airport. Islip Long Island (ISP) is located 7.2 mi from the center of Islip.

  • How long is the flight from Islip, New York to Missouri?

    There are many flights that can get you from Islip, New York to Missouri in 7h 30m. Fly via Southwest or Frontier to get the fastest option. Airlines will cover a distance of 926 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Islip, New York to Missouri?

    While some choose either Islip Long Island - Kansas City or Islip Long Island - Columbia Regional, Islip Long Island - Lambert-St Louis is the most popular route from Islip, New York to Missouri.

  • Can I find deals for flights from Islip to Missouri that include hotel bookings?

    Yes. In addition to deals on Islip to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Islip to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Islip to Missouri.

  • Can I find deals for business class flights from Islip to Missouri?

    Yes. Cheapflights offers flight deals from Islip to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Islip, New York to Missouri?

    Currently, March is the cheapest month in which you can book a flight from Islip, New York to Missouri (average of $59). Flying from Islip, New York to Missouri in July is currently the most expensive (average of $221). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Islip to Missouri

Discover the top airline that operate flights from Islip to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$259Average$366FlexibilityNo cancel feeOn-time63%

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