Mississippi

$124+ Cheap flights from Knoxville (TYS) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — JAN
Apr 4 — Apr 111
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Cheap flight deals from Knoxville to Mississippi

Cheapest flights from Knoxville to Mississippi
Explore the most affordable flight options available from Knoxville to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 5, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:46 pm
TYS
-
MEM
1 stop10h 24m
Allegiant Air
Sun 4/58:52 pm
MEM
-
TYS
1 stop25h 28m
Allegiant Air
Deal found 3/1$212
This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/48:15 am
TYS
-
MEM
1 stop12h 34m
Allegiant Air
Sun 6/78:39 pm
MEM
-
TYS
1 stop14h 13m
Allegiant Air
Deal found 3/1$221
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/231:14 pm
TYS
-
MEM
1 stop7h 31m
Allegiant Air
Sun 4/268:35 pm
MEM
-
TYS
1 stop24h 13m
Allegiant Air
Deal found 3/3$233
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:04 pm
TYS
-
GPT
1 stop14h 37m
Multiple Airlines
Mon 6/85:31 pm
GPT
-
TYS
1 stop16h 11m
Multiple Airlines
Deal found 3/3$237
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:36 pm
TYS
-
MEM
1 stop10h 39m
Multiple Airlines
Sun 4/125:54 pm
MEM
-
TYS
2 stops20h 34m
Multiple Airlines
Deal found 3/3$256
This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/32:06 pm
TYS
-
MEM
1 stop21h 09m
Multiple Airlines
Mon 4/68:00 am
MEM
-
TYS
1 stop7h 49m
Multiple Airlines
Deal found 3/1$268
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3011:25 am
TYS
-
MEM
1 stop23h 50m
Multiple Airlines
Mon 4/65:25 pm
MEM
-
TYS
2 stops16h 45m
Multiple Airlines
Deal found 3/2$270
This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/296:00 am
TYS
-
MEM
1 stop15h 10m
Allegiant Air
Sun 4/58:30 pm
MEM
-
TYS
1 stop10h 40m
Allegiant Air
Deal found 3/1$273
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/231:14 pm
TYS
-
MEM
1 stop7h 31m
Multiple Airlines
Sun 4/266:42 pm
MEM
-
TYS
2 stops21h 48m
Multiple Airlines
Deal found 3/3$277
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1112:20 pm
TYS
-
BTR
1 stop4h 33m
American Airlines
Tue 8/185:45 am
BTR
-
TYS
1 stop6h 51m
American Airlines
Deal found 3/4$289
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:05 am
TYS
-
BTR
1 stop5h 27m
United Airlines
Mon 3/306:08 pm
BTR
-
TYS
1 stop4h 33m
United Airlines
Deal found 3/5$303
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:15 pm
TYS
-
BTR
1 stop6h 21m
American Airlines
Fri 4/104:33 pm
BTR
-
TYS
1 stop6h 26m
American Airlines
Deal found 3/4$306

Find flight deals from Knoxville to Mississippi

Keep the following information in mind while searching for Knoxville to Mississippi flight deals. Data was last updated March 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$212
(Kiwi.com)

One-way from

$124
(Kiwi.com)

Popular in

September

Cheapest in

April

Average price

$603
Provider with most accurate pricing for Knoxville McGhee Tyson-Jackson-Evers Intl flight deals.
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Jackson-Evers Intl flights.
From Knoxville McGhee Tyson to Mississippi
One-way flight from Knoxville McGhee Tyson to Mississippi
Highest demand for flights based on searches. 15% potential increase in price ($77 potential increase over avg. RT price).
Cheapest flight prices on average. 9% potential price decrease ($37 potential savings vs. average RT price).
Average for round-trip flights in March 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 5, 2026.
Use the filters below to find and compare flights from Knoxville to Mississippi that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Thu 4/9

9:36 pm-7:15 am

1 stop10h 39m

Memphis

Sun 4/12

5:54 pm-3:28 pm

2 stops20h 34m

$256

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Mon 4/6

7:25 pm-11:25 pm

1 stop5h 00m

Memphis

Tue 4/7

3:25 pm-7:40 pm

1 stop3h 15m

$291

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Tue 4/21

5:00 am-9:14 am

1 stop5h 14m

Memphis

Wed 4/22

3:23 pm-10:24 pm

1 stop6h 01m

$299

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Thu 4/2

7:25 pm-11:25 pm

1 stop5h 00m

Memphis

Sat 4/4

5:00 pm-9:05 pm

1 stop3h 05m

$303

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Fri 4/10

5:40 am-8:50 am

1 stop4h 10m

Gulfport Biloxi Regional

Mon 4/13

5:55 pm-11:54 pm

1 stop4h 59m

$307

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Sat 4/18

6:40 am-12:25 pm

2 stops6h 45m

Memphis

Sat 4/25

2:45 pm-6:30 pm

1 stop2h 45m

$308

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Fri 4/3

6:38 pm-10:03 pm

1 stop4h 25m

Baton Rouge Ryan

Fri 4/10

7:05 pm-11:57 pm

1 stop3h 52m

$311

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Tue 4/21

7:05 am-12:45 pm

2 stops6h 40m

Memphis

Wed 4/22

6:00 am-2:20 pm

2 stops7h 20m

$311
Quickest round-trip

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Fri 4/3

7:10 am-9:25 am

1 stop3h 15m

Memphis

Tue 4/7

10:37 am-2:32 pm

1 stop2h 55m

$320

KnoxvilleMobile

TYS - MOB

TYSMOB

Knoxville McGhee Tyson

Sun 6/28

5:30 am-8:30 am

1 stop4h 00m

Mobile

Sat 7/4

5:00 pm-11:46 pm

1 stop5h 46m

$327

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/1

Showing 1-10 of 59 resultsSorted by cheapest first
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Best time to book a flight from Knoxville to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mississippi

What is the cheapest month to book a flight from Knoxville to Mississippi?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $130). Flying from Knoxville to Mississippi in December is currently the most expensive (average of $520). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated March 5, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Mississippi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Entertainment

7.8

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Entertainment

7.8

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Entertainment

7.8

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Knoxville to Mississippi?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Mississippi. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Mississippi?

    For as low as $307, Southwest can have you in Mississippi from Knoxville in 4h 10m. The distance between Knoxville and Mississippi is about 474 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Mississippi?

  • Can I find deals for flights from Knoxville to Mississippi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mississippi.

  • Can I find deals for business class flights from Knoxville to Mississippi?

    Yes. Cheapflights offers flight deals from Knoxville to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mississippi?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $130). Flying from Knoxville to Mississippi in December is currently the most expensive (average of $520). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Knoxville to Mississippi

Discover the top 2 airlines that operate flights from Knoxville to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$209Average$393FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$233Average$366FlexibilityNo cancel feeOn-time71%

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