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$39+ Cheap flights from Knoxville (TYS) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — JAN
ago. 19 — ago. 261
mar. 8/19
mar. 8/26
1 adult, Economy
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Cheap flight deals from Knoxville to Mississippi

Keep the following information in mind while searching for Knoxville to Mississippi flight deals. Data was last updated agosto 14, 2025.

Round-trip from

$78
(Booking.com)

One-way from

$39
(Booking.com)

Popular in

March

Cheapest in

April
From Knoxville McGhee Tyson to Mississippi
Search Deals
One-way flight from Knoxville McGhee Tyson to Mississippi
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Highest demand for flights based on searches. 7% potential increase in price ($26 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($23 potential savings vs. average RT price).
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Find flight deals from Knoxville to Mississippi

Cheapest flights from Knoxville to Mississippi
Explore the most affordable flight options available from Knoxville to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 14, 2025.

This Booking.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/165:34 pmTYS - MEM
Nonstop1h 24mAllegiant Air
dom. 10/196:48 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Deal found 8/14$78
This Booking.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/77:35 pmTYS - MEM
Nonstop1h 24mAllegiant Air
jue. 9/258:49 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Deal found 8/14$82
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/25:44 pmTYS - MEM
Nonstop1h 24mAllegiant Air
dom. 10/56:58 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Deal found 8/13$90
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/117:35 pmTYS - MEM
Nonstop1h 24mMultiple Airlines
lun. 9/157:55 pmMEM - TYS
1 stop13h 40mMultiple Airlines
Deal found 8/14$138
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/77:35 pmTYS - MEM
Nonstop1h 24mMultiple Airlines
jue. 9/258:35 pmMEM - TYS
1 stop19h 59mMultiple Airlines
Deal found 8/13$148
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/308:00 amTYS - MEM
2 stops16h 50mMultiple Airlines
jue. 10/26:58 pmMEM - TYS
Nonstop1h 19mMultiple Airlines
Deal found 8/13$223
This FlightHub deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/168:17 pmTYS - MEM
1 stop24h 06mFrontier
dom. 10/198:10 pmMEM - TYS
1 stop22h 22mFrontier
Deal found 8/14$225
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/207:45 pmTYS - GPT
1 stop3h 57mAmerican Airlines
sáb. 9/275:32 pmGPT - TYS
1 stop4h 31mAmerican Airlines
Deal found 8/13$229
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/275:45 amTYS - JAN
1 stop4h 42mDelta
sáb. 8/307:14 pmJAN - TYS
1 stop3h 34mDelta
Deal found 8/13$239
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/266:08 pmTYS - BTR
1 stop5h 04mDelta
mar. 9/307:01 pmBTR - TYS
1 stop3h 43mDelta
Deal found 8/14$249
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/131:25 pmTYS - BTR
1 stop7h 41mAmerican Airlines
mar. 11/182:15 pmBTR - TYS
2 stops7h 36mAmerican Airlines
Deal found 8/12$254
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/277:20 amTYS - BTR
1 stop6h 59mUnited Airlines
dom. 8/315:00 amBTR - TYS
1 stop7h 38mUnited Airlines
Deal found 8/12$259

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
Use the filters below to find and compare flights from Knoxville to Mississippi that are best for you.

Fly from

Knoxville

Fly to

Mississippi

Route

Depart

Return

Price

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

dom. 9/7

7:35 pm-7:59 pm

Nonstop1h 24m

Memphis

jue. 9/25

8:49 pm-11:08 pm

Nonstop1h 19m

$82

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

jue. 10/2

5:44 pm-6:08 pm

Nonstop1h 24m

Memphis

dom. 10/5

6:58 pm-9:17 pm

Nonstop1h 19m

$90

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

jue. 10/9

5:44 pm-6:08 pm

Nonstop1h 24m

Memphis

dom. 10/12

6:58 pm-9:17 pm

Nonstop1h 19m

$96

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

jue. 9/11

7:35 pm-7:59 pm

Nonstop1h 24m

Memphis

lun. 9/15

7:55 pm-10:35 am

1 stop13h 40m

$138

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

dom. 9/7

7:35 pm-7:59 pm

Nonstop1h 24m

Memphis

jue. 9/25

8:35 pm-5:34 pm

1 stop19h 59m

$148

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

vie. 9/26

1:22 pm-7:00 pm

1 stop6h 38m

Memphis

dom. 9/28

8:49 pm-11:08 pm

Nonstop1h 19m

$148

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

sáb. 9/20

7:45 pm-10:42 pm

1 stop3h 57m

Gulfport Biloxi Regional

sáb. 9/27

5:32 pm-11:03 pm

1 stop4h 31m

$229

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

mar. 10/21

7:43 pm-10:46 pm

1 stop4h 03m

Gulfport Biloxi Regional

sáb. 10/25

6:48 pm-11:50 pm

1 stop4h 02m

$229

KnoxvilleJackson

TYS - JAN

TYSJAN

Knoxville McGhee Tyson

mié. 8/27

5:45 am-9:27 am

1 stop4h 42m

Jackson-Evers Intl

dom. 8/31

5:50 am-10:52 am

1 stop4h 02m

$239

KnoxvilleJackson

TYS - JAN

TYSJAN

Knoxville McGhee Tyson

mié. 8/27

5:45 am-9:27 am

1 stop4h 42m

Jackson-Evers Intl

sáb. 8/30

7:14 pm-11:48 pm

1 stop3h 34m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 40 results
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Best time to book a flight from Knoxville to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mississippi

What is the cheapest month to book a flight from Knoxville to Mississippi?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $371). Flying from Knoxville to Mississippi in March is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MS?

Find hourly flight availability from Knoxville to Mississippi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 14, 2025.

When flying from Knoxville to Mississippi, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated agosto 14, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Mississippi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mississippi?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Mississippi. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • What are the most popular routes from Knoxville to Mississippi?

    While some choose either Knoxville McGhee Tyson - Memphis or Knoxville McGhee Tyson - Gulfport Biloxi Regional, Knoxville McGhee Tyson - Baton Rouge Ryan is the most popular route from Knoxville to Mississippi.

  • Can I find deals for flights from Knoxville to Mississippi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mississippi.

  • Can I find deals for business class flights from Knoxville to Mississippi?

    Yes. Cheapflights offers flight deals from Knoxville to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mississippi?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $371). Flying from Knoxville to Mississippi in March is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to Mississippi

Discover the top 2 airlines that operate flights from Knoxville to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$308FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$323FlexibilityNo cancel feeOn-time71%

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