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$114+ Cheap flights from Knoxville (TYS) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — JAN
Mar 24 — Mar 311
Tue 3/24
Tue 3/31
1 adult, Economy
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Cheap flight deals from Knoxville to Mississippi

Cheapest flights from Knoxville to Mississippi
Explore the most affordable flight options available from Knoxville to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:46 pm
TYS
-
MEM
1 stop10h 24m
Allegiant Air
Sun 4/58:52 pm
MEM
-
TYS
1 stop25h 28m
Allegiant Air
Deal found 2/20$212
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:46 pm
TYS
-
MEM
1 stop10h 24m
Allegiant Air
Thu 4/97:00 pm
MEM
-
TYS
1 stop25h 48m
Allegiant Air
Deal found 2/21$233
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/229:43 pm
TYS
-
MEM
1 stop10h 31m
Multiple Airlines
Tue 3/2411:14 am
MEM
-
TYS
1 stop24h 37m
Multiple Airlines
Deal found 2/21$251
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:00 am
TYS
-
MEM
1 stop8h 01m
Multiple Airlines
Sun 3/18:09 pm
MEM
-
TYS
1 stop22h 09m
Multiple Airlines
Deal found 2/19$268
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:46 pm
TYS
-
MEM
1 stop10h 24m
Multiple Airlines
Thu 4/95:54 pm
MEM
-
TYS
2 stops17h 31m
Multiple Airlines
Deal found 2/21$272
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:46 pm
TYS
-
MEM
1 stop10h 24m
Multiple Airlines
Wed 4/811:14 am
MEM
-
TYS
2 stops32h 32m
Multiple Airlines
Deal found 2/21$273
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/244:02 pm
TYS
-
MEM
1 stop8h 57m
American Airlines
Tue 3/315:04 am
MEM
-
TYS
1 stop10h 27m
American Airlines
Deal found 2/18$275
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:15 pm
TYS
-
MEM
1 stop21h 52m
Multiple Airlines
Mon 4/278:05 am
MEM
-
TYS
1 stop13h 19m
Multiple Airlines
Deal found 2/22$278
This Southwest deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:35 am
TYS
-
MEM
2 stops9h 10m
Southwest
Tue 3/313:55 pm
MEM
-
TYS
1 stop3h 10m
Southwest
Deal found 2/18$284
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:46 pm
TYS
-
MEM
1 stop10h 24m
Multiple Airlines
Sun 4/511:14 am
MEM
-
TYS
2 stops19h 56m
Multiple Airlines
Deal found 2/20$287
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/76:21 pm
TYS
-
BTR
1 stop5h 18m
American Airlines
Wed 3/114:33 pm
BTR
-
TYS
1 stop4h 21m
American Airlines
Deal found 2/20$291
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:40 am
TYS
-
BTR
1 stop5h 04m
Delta
Mon 4/67:05 pm
BTR
-
TYS
1 stop3h 52m
Delta
Deal found 2/18$304

Find flight deals from Knoxville to Mississippi

Keep the following information in mind while searching for Knoxville to Mississippi flight deals. Data was last updated February 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$212
(Kiwi.com)

One-way from

$114
(Trip.com)

Popular in

September

Cheapest in

April

Average price

$383
Provider with most accurate pricing for Knoxville McGhee Tyson-Jackson-Evers Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Jackson-Evers Intl flights.
Search Deals
From Knoxville McGhee Tyson to Mississippi
Search Deals
One-way flight from Knoxville McGhee Tyson to Mississippi
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($77 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($37 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2026.
Use the filters below to find and compare flights from Knoxville to Mississippi that are best for you.

Fly from

Knoxville

Fly to

Mississippi

Route

Depart

Return

Price

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Sun 3/22

9:43 pm-7:14 am

1 stop10h 31m

Memphis

Tue 3/24

11:14 am-12:51 pm

1 stop24h 37m

$251

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Tue 3/24

6:35 am-2:45 pm

2 stops9h 10m

Memphis

Tue 3/31

9:45 am-8:05 pm

2 stops9h 20m

$289

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Thu 3/19

6:00 am-6:20 pm

2 stops13h 20m

Memphis

Mon 3/23

5:40 pm-2:10 pm

1 stop19h 30m

$303

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Wed 4/1

5:40 am-9:44 am

1 stop5h 04m

Baton Rouge Ryan

Mon 4/6

7:05 pm-11:57 pm

1 stop3h 52m

$304

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Fri 4/17

5:57 pm-11:47 pm

1 stop6h 50m

Memphis

Mon 4/20

7:01 pm-11:55 pm

1 stop3h 54m

$318

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Thu 3/19

6:38 pm-10:15 pm

1 stop4h 37m

Gulfport Biloxi Regional

Thu 3/26

5:57 pm-11:57 pm

1 stop5h 00m

$329

KnoxvilleJackson

TYS - JAN

TYSJAN

Knoxville McGhee Tyson

Mon 3/23

6:38 pm-11:24 pm

1 stop5h 46m

Jackson-Evers Intl

Wed 3/25

5:07 pm-11:57 pm

1 stop5h 50m

$330

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Sat 2/28

2:54 pm-9:36 pm

1 stop7h 42m

Baton Rouge Ryan

Tue 3/3

1:30 pm-7:12 pm

1 stop4h 42m

$339

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Sat 2/28

1:52 pm-2:01 pm

1 stop25h 09m

Memphis

Tue 3/3

11:15 am-10:10 am

2 stops21h 55m

$345

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Thu 3/12

7:30 am-6:20 pm

2 stops11h 50m

Memphis

Sun 3/15

8:55 pm-9:54 pm

1 stop23h 59m

$345

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Showing 1-10 of 57 results
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Best time to book a flight from Knoxville to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mississippi

What is the cheapest month to book a flight from Knoxville to Mississippi?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $130). Flying from Knoxville to Mississippi in December is currently the most expensive (average of $520). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Mississippi?

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated February 22, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Mississippi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,241 reviews

Boarding

8.1

Food

7.2

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,241 reviews
Delta
7.9
Good
8,241 reviews

Boarding

8.1

Food

7.2

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,338 reviews
Delta
7.9
Good
8,241 reviews

Boarding

8.1

Food

7.2

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mississippi?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Mississippi. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Mississippi?

    For as low as $304, Southwest can have you in Mississippi from Knoxville in 5h 04m. The distance between Knoxville and Mississippi is about 551 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Mississippi?

    While some choose either Knoxville McGhee Tyson - Gulfport Biloxi Regional or Knoxville McGhee Tyson - Mobile, Knoxville McGhee Tyson - Memphis is the most popular route from Knoxville to Mississippi.

  • Can I find deals for flights from Knoxville to Mississippi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mississippi.

  • Can I find deals for business class flights from Knoxville to Mississippi?

    Yes. Cheapflights offers flight deals from Knoxville to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mississippi?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $130). Flying from Knoxville to Mississippi in December is currently the most expensive (average of $520). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to Mississippi

Discover the top 2 airlines that operate flights from Knoxville to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$209Average$393FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$233Average$344FlexibilityNo cancel feeOn-time71%

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