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$126+ Cheap flights from Knoxville (TYS) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/10. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — JAN
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Knoxville to Mississippi

Cheapest flights from Knoxville to Mississippi
Explore the most affordable flight options available from Knoxville to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:01 pmTYS - MEM
2 stops28h 07mMultiple Airlines
Sun 1/48:08 pmMEM - TYS
1 stop11h 25mMultiple Airlines
Deal found 12/16$253
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:44 pmTYS - GPT
2 stops26h 26mMultiple Airlines
Sun 1/47:50 pmGPT - TYS
1 stop13h 25mMultiple Airlines
Deal found 12/16$272
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:48 pmTYS - MEM
1 stop6h 30mAllegiant Air
Sun 1/48:08 pmMEM - TYS
1 stop10h 55mAllegiant Air
Deal found 12/16$297
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/231:22 pmTYS - MEM
1 stop7h 40mAllegiant Air
Wed 12/248:13 pmMEM - TYS
1 stop19h 39mAllegiant Air
Deal found 12/16$338
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:32 pmTYS - BTR
1 stop4h 25mAmerican Airlines
Sun 1/44:21 pmBTR - TYS
1 stop6h 24mAmerican Airlines
Deal found 12/16$339
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/215:52 pmTYS - MEM
1 stop27h 00mAllegiant Air
Tue 12/238:47 pmMEM - TYS
1 stop25h 04mAllegiant Air
Deal found 12/15$341
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:30 amTYS - MEM
1 stop14h 22mAllegiant Air
Tue 12/238:47 pmMEM - TYS
1 stop25h 04mAllegiant Air
Deal found 12/17$372
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/231:22 pmTYS - MEM
1 stop7h 40mMultiple Airlines
Wed 12/245:54 pmMEM - TYS
2 stops26h 37mMultiple Airlines
Deal found 12/16$408
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/177:02 pmTYS - MEM
1 stop25h 48mAllegiant Air
Tue 12/238:47 pmMEM - TYS
1 stop25h 04mAllegiant Air
Deal found 12/16$411
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/254:54 pmTYS - GPT
1 stop5h 46mDelta
Sun 12/286:00 amGPT - TYS
1 stop4h 09mDelta
Deal found 12/16$427
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:44 pmTYS - GPT
2 stops26h 26mMultiple Airlines
Sun 12/287:50 pmGPT - TYS
1 stop13h 25mMultiple Airlines
Deal found 12/17$450
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:23 amTYS - BTR
1 stop5h 16mAmerican Airlines
Mon 12/224:34 pmBTR - TYS
1 stop4h 24mAmerican Airlines
Deal found 12/16$457

Find flight deals from Knoxville to Mississippi

Keep the following information in mind while searching for Knoxville to Mississippi flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$253
(Kiwi.com)

One-way from

$126
(Kiwi.com)

Popular in

September

Cheapest in

April

Average price

$576
Provider with most accurate pricing for Knoxville McGhee Tyson-Jackson-Evers Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Jackson-Evers Intl flights.
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From Knoxville McGhee Tyson to Mississippi
Search Deals
One-way flight from Knoxville McGhee Tyson to Mississippi
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($84 potential increase over avg. RT price).
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Cheapest flight prices on average. 10% potential price decrease ($37 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Knoxville to Mississippi that are best for you.

Fly from

Knoxville

Fly to

Mississippi

Route

Depart

Return

Price

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Wed 12/31

12:01 pm-3:08 pm

2 stops28h 07m

Memphis

Sun 1/4

8:08 pm-8:33 am

1 stop11h 25m

$253

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Sat 1/17

5:59 pm-9:50 am

1 stop16h 51m

Memphis

Mon 1/19

3:40 pm-12:10 pm

1 stop19h 30m

$258

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Mon 2/2

6:00 am-2:50 pm

1 stop9h 50m

Memphis

Fri 2/6

3:40 pm-10:28 pm

1 stop5h 48m

$260

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Sun 2/1

9:29 am-7:28 pm

1 stop10h 59m

Memphis

Sun 2/8

3:12 pm-3:35 pm

1 stop23h 23m

$267

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Wed 1/14

6:10 pm-10:01 pm

1 stop4h 51m

Baton Rouge Ryan

Wed 1/21

6:18 am-1:50 pm

1 stop6h 32m

$269

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Wed 1/14

4:47 pm-10:49 am

2 stops19h 02m

Memphis

Wed 1/21

11:44 am-8:39 am

2 stops19h 55m

$270

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Wed 12/31

5:44 pm-7:10 pm

2 stops26h 26m

Gulfport Biloxi Regional

Sun 1/4

7:50 pm-10:15 am

1 stop13h 25m

$272

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Tue 1/6

5:17 pm-8:59 pm

1 stop4h 42m

Baton Rouge Ryan

Sun 1/11

6:00 am-11:31 am

1 stop4h 31m

$274

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Tue 1/6

5:40 am-9:52 am

1 stop5h 12m

Baton Rouge Ryan

Sat 1/10

6:18 am-1:50 pm

1 stop6h 32m

$274

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Wed 1/14

5:17 pm-8:59 pm

1 stop4h 42m

Baton Rouge Ryan

Wed 1/21

10:33 am-9:44 pm

2 stops10h 11m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 60 results
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Best time to book a flight from Knoxville to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mississippi

What is the cheapest month to book a flight from Knoxville to Mississippi?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $130). Flying from Knoxville to Mississippi in December is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MS?

Find hourly flight availability from Knoxville to Mississippi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

It’s typically best to fly out from Knoxville to Mississippi in the evening. Doing so could potentially save you 47% on the flight price compared to flying in the morning, which is usually more expensive.

How much does it cost to fly round-trip from Knoxville to Mississippi?

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated December 18, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Mississippi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Food

7.3

Boarding

8.1

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Food

7.3

Boarding

8.1

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,005 reviews

Food

7.3

Boarding

8.1

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mississippi?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Mississippi. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Mississippi?

    For as low as $274, Allegiant Air can have you in Mississippi from Knoxville in 4h 42m. The distance between Knoxville and Mississippi is about 551 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Mississippi?

    While some choose either Knoxville McGhee Tyson - Gulfport Biloxi Regional or Knoxville McGhee Tyson - Mobile, Knoxville McGhee Tyson - Memphis is the most popular route from Knoxville to Mississippi.

  • Can I find deals for flights from Knoxville to Mississippi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mississippi.

  • Can I find deals for business class flights from Knoxville to Mississippi?

    Yes. Cheapflights offers flight deals from Knoxville to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mississippi?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $130). Flying from Knoxville to Mississippi in December is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to Mississippi

Discover the top 2 airlines that operate flights from Knoxville to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$323FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$368FlexibilityNo cancel feeOn-timeN/A

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