HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Mississippi

$130+ Cheap flights from Knoxville (TYS) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — JAN
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Mississippi with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Mississippi

Keep the following information in mind while searching for Knoxville to Mississippi flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$214
(Delta)

One-way from

$130
(Mytrip)

Popular in

March

Cheapest in

April

Average price

$235
Provider with most accurate pricing for Knoxville McGhee Tyson-Jackson-Evers Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Jackson-Evers Intl flights.
Search Deals
From Knoxville McGhee Tyson to Mississippi
Search Deals
One-way flight from Knoxville McGhee Tyson to Mississippi
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($31 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2025
Search Deals

Find flight deals from Knoxville to Mississippi

Cheapest flights from Knoxville to Mississippi
Explore the most affordable flight options available from Knoxville to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/284:22 pmTYS - MEM
1 stop3h 02mDelta
Wed 6/47:05 amMEM - TYS
1 stop3h 18mDelta
Deal found 4/30$214
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/26:12 pmTYS - MEM
1 stop14h 37mMultiple Airlines
Wed 6/45:14 pmMEM - TYS
2 stops14h 05mMultiple Airlines
Deal found 4/30$227
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/228:25 pmTYS - GPT
1 stop4h 38mAmerican Airlines
Mon 8/2512:43 pmGPT - TYS
1 stop6h 02mAmerican Airlines
Deal found 4/29$229
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/26:12 pmTYS - MEM
1 stop14h 37mAllegiant Air
Wed 6/48:20 amMEM - TYS
1 stop7h 35mAllegiant Air
Deal found 4/30$236
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/155:45 amTYS - JAN
1 stop3h 44mDelta
Mon 5/197:18 pmJAN - TYS
1 stop3h 33mDelta
Deal found 4/30$239
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/187:05 amTYS - BTR
1 stop5h 30mDelta
Mon 7/2112:20 pmBTR - TYS
1 stop3h 52mDelta
Deal found 4/30$249
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/65:30 amTYS - GPT
1 stop4h 29mDelta
Tue 5/136:05 pmGPT - TYS
1 stop4h 46mDelta
Deal found 4/29$254
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/305:25 pmTYS - MEM
1 stop5h 49mUnited Airlines
Wed 5/78:00 amMEM - TYS
1 stop4h 22mUnited Airlines
Deal found 4/29$279
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/15:45 amTYS - MOB
1 stop6h 00mDelta
Sat 7/55:59 pmMOB - TYS
1 stop5h 00mDelta
Deal found 4/30$282
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/245:15 pmTYS - GPT
1 stop5h 19mUnited Airlines
Wed 5/285:15 pmGPT - TYS
1 stop5h 24mUnited Airlines
Deal found 4/29$285
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/15:24 amTYS - BTR
1 stop5h 20mAmerican Airlines
Tue 5/612:56 pmBTR - TYS
1 stop5h 18mAmerican Airlines
Deal found 4/30$339
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2811:24 amTYS - GPT
2 stops31h 25mMultiple Airlines
Sun 6/16:29 pmGPT - TYS
1 stop14h 47mMultiple Airlines
Deal found 4/30$390

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Knoxville to Mississippi that are best for you.

Fly from

Knoxville

Fly to

Mississippi

Route

Depart

Return

Price

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Wed 5/28

4:22 pm-6:24 pm

1 stop3h 02m

Memphis

Wed 6/4

7:05 am-11:23 am

1 stop3h 18m

$214

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Mon 6/2

6:12 pm-7:49 am

1 stop14h 37m

Memphis

Wed 6/4

5:14 pm-8:19 am

2 stops14h 05m

$227

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Fri 8/22

8:25 pm-12:03 am

1 stop4h 38m

Gulfport Biloxi Regional

Mon 8/25

12:43 pm-7:45 pm

1 stop6h 02m

$229

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Mon 6/2

6:12 pm-7:49 am

1 stop14h 37m

Memphis

Wed 6/4

8:20 am-4:55 pm

1 stop7h 35m

$236

KnoxvilleJackson

TYS - JAN

TYSJAN

Knoxville McGhee Tyson

Thu 5/15

5:45 am-8:29 am

1 stop3h 44m

Jackson-Evers Intl

Mon 5/19

7:18 pm-11:51 pm

1 stop3h 33m

$239

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Fri 7/18

7:05 am-11:35 am

1 stop5h 30m

Baton Rouge Ryan

Mon 7/21

12:20 pm-5:12 pm

1 stop3h 52m

$249

KnoxvilleMobile

TYS - MOB

TYSMOB

Knoxville McGhee Tyson

Tue 7/1

5:45 am-10:45 am

1 stop6h 00m

Mobile

Sat 7/5

5:59 pm-11:59 pm

1 stop5h 00m

$282

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Sat 5/24

5:15 pm-9:34 pm

1 stop5h 19m

Gulfport Biloxi Regional

Wed 5/28

5:15 pm-11:39 pm

1 stop5h 24m

$285

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Wed 5/14

5:45 am-8:29 am

1 stop3h 44m

Gulfport Biloxi Regional

Sun 5/18

6:05 pm-11:51 pm

1 stop4h 46m

$299

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Sat 6/14

7:00 am-11:02 am

1 stop5h 02m

Memphis

Sat 6/21

7:30 am-1:23 pm

1 stop4h 53m

$312

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 23 results
1
2
3

Best time to book a flight from Knoxville to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mississippi

What is the cheapest month to book a flight from Knoxville to Mississippi?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $371). Flying from Knoxville to Mississippi in March is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MS?

Find hourly flight availability from Knoxville to Mississippi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from Knoxville to Mississippi, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Mississippi by month

Plan your trip to Mississippi by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Mississippi ranges from 2.2 - 5.6 inches per month. December is typically the wettest month, when rainfall can reach 5.6 in. October is typically the driest time to visit Mississippi when rainfall is around 2.2 in.

Temperature in Mississippi by month

Plan your trip to Mississippi by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Mississippi, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 82.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated May 1, 2025.
To help decide which airline to fly from Knoxville to Mississippi, see what other customers have to say about Delta, United Airlines and Allegiant Air. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
734 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mississippi?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Mississippi. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to Mississippi one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $130. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Knoxville to Mississippi for a low price.

  • What are the most popular routes from Knoxville to Mississippi?

    While some choose either Knoxville McGhee Tyson - Jackson-Evers Intl or Knoxville McGhee Tyson - Gulfport Biloxi Regional, Knoxville McGhee Tyson - Mobile is the most popular route from Knoxville to Mississippi.

  • Can I find deals for flights from Knoxville to Mississippi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mississippi.

  • Can I find deals for business class flights from Knoxville to Mississippi?

    Yes. Cheapflights offers flight deals from Knoxville to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mississippi?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $371). Flying from Knoxville to Mississippi in March is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Seattle flights
Nashville to John F Kennedy Intl flights
Nashville to Newark flights
Nashville to Los Angeles flights
Nashville to LaGuardia flights
Nashville to Denver flights
Nashville to Las Vegas flights
Nashville to Fort Lauderdale flights
Nashville to Dallas/Fort Worth flights
Memphis to Los Angeles flights
Memphis to Miami flights
Memphis to Las Vegas flights
Nashville to Orlando flights
Memphis to Newark flights
Memphis to Orlando flights
Nashville to Boston flights
Nashville to San Francisco flights
Nashville to Miami flights
Nashville to O'Hare Intl flights
Nashville to Reagan-National flights
Memphis to Hobby flights
Memphis to O'Hare Intl flights
Memphis to LaGuardia flights
Knoxville to Denver flights
Nashville to Honolulu flights
Memphis to Seattle flights
Nashville to Baltimore flights
Nashville to Sky Harbor Intl flights
Memphis to Atlanta flights
Nashville to Dulles Intl flights
Memphis to Denver flights
Memphis to George Bush Intcntl flights
Memphis to John F Kennedy Intl flights
Nashville to Hobby flights
Memphis to Boston flights
Chattanooga to LaGuardia flights
Nashville to Ontario flights
Nashville to Love Field flights
Knoxville to O'Hare Intl flights
Nashville to Minneapolis flights
Nashville to Portland flights
Memphis to Dallas/Fort Worth flights
Chattanooga to John F Kennedy Intl flights
Knoxville to LaGuardia flights
Knoxville to John F Kennedy Intl flights
Nashville to Salt Lake City flights
Chattanooga to Seattle flights
Memphis to Dulles Intl flights
Nashville to Tampa flights
Memphis to Reagan-National flights

Top 2 airlines flying from Knoxville to Mississippi

Discover the top 2 airlines that operate flights from Knoxville to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$217Average$293FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$233Average$346FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.