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$41+ Cheap flights from Knoxville (TYS) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — JAN
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Knoxville to Mississippi

Keep the following information in mind while searching for Knoxville to Mississippi flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$78
(Kiwi.com)

One-way from

$41
(Trip.com)

Popular in

September

Cheapest in

April

Average price

$378
Provider with most accurate pricing for Knoxville McGhee Tyson-Jackson-Evers Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Jackson-Evers Intl flights.
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From Knoxville McGhee Tyson to Mississippi
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One-way flight from Knoxville McGhee Tyson to Mississippi
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Highest demand for flights based on searches. 21% potential increase in price ($105 potential increase over avg. RT price).
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Cheapest flight prices on average. 11% potential price decrease ($40 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Knoxville to Mississippi

Cheapest flights from Knoxville to Mississippi
Explore the most affordable flight options available from Knoxville to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2812:45 pmTYS - MEM
Nonstop1h 27mAllegiant Air
Mon 12/12:07 pmMEM - TYS
Nonstop1h 22mAllegiant Air
Deal found 10/30$76
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2012:24 pmTYS - MEM
Nonstop1h 27mAllegiant Air
Sun 11/231:41 pmMEM - TYS
Nonstop1h 22mAllegiant Air
Deal found 10/28$82
This FlightHub deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/61:16 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Sun 11/92:30 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Deal found 10/29$117
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:04 pmTYS - MEM
1 stop26h 44mAllegiant Air
Sun 11/231:41 pmMEM - TYS
Nonstop1h 22mAllegiant Air
Deal found 10/29$153
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/239:31 amTYS - BTR
1 stop5h 04mDelta
Fri 11/286:55 pmBTR - TYS
1 stop3h 46mDelta
Deal found 10/29$249
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:10 amTYS - BTR
1 stop5h 40mAmerican Airlines
Tue 11/187:29 amBTR - TYS
1 stop6h 23mAmerican Airlines
Deal found 10/28$254
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:04 pmTYS - GPT
1 stop4h 53mAmerican Airlines
Sat 11/157:15 amGPT - TYS
1 stop4h 43mAmerican Airlines
Deal found 10/29$259
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:10 amTYS - BTR
1 stop5h 40mAmerican Airlines
Mon 11/176:34 pmBTR - TYS
1 stop4h 34mAmerican Airlines
Deal found 10/28$259
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/158:45 amTYS - BTR
1 stop4h 44mDelta
Tue 11/182:21 pmBTR - TYS
1 stop3h 41mDelta
Deal found 10/28$264
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:00 amTYS - GPT
1 stop5h 17mUnited Airlines
Mon 11/105:15 pmGPT - TYS
1 stop5h 29mUnited Airlines
Deal found 10/28$279
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/124:32 pmTYS - GPT
2 stops27h 43mMultiple Airlines
Sun 11/167:55 pmGPT - TYS
1 stop17h 02mMultiple Airlines
Deal found 10/28$317
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:18 pmTYS - BTR
1 stop5h 37mAmerican Airlines
Tue 11/185:30 amBTR - TYS
2 stops10h 07mAmerican Airlines
Deal found 10/27$329

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Knoxville to Mississippi that are best for you.

Fly from

Knoxville

Fly to

Mississippi

Route

Depart

Return

Price

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Thu 11/20

8:00 am-7:48 pm

1 stop12h 48m

Memphis

Sun 11/23

1:41 pm-4:03 pm

Nonstop1h 22m

$140

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Wed 11/19

5:07 pm-10:03 am

1 stop17h 56m

Memphis

Thu 11/20

1:41 pm-4:03 pm

Nonstop1h 22m

$169

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Thu 12/4

6:30 am-7:12 pm

1 stop13h 42m

Memphis

Sun 12/7

8:07 pm-3:57 pm

1 stop18h 50m

$219

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Thu 11/20

9:18 pm-5:08 pm

3 stops20h 50m

Memphis

Sun 11/23

1:41 pm-4:03 pm

Nonstop1h 22m

$223

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Fri 11/28

12:45 pm-1:12 pm

Nonstop1h 27m

Memphis

Mon 12/1

9:16 pm-12:03 pm

2 stops37h 47m

$224

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Sun 11/9

1:16 pm-1:40 pm

Nonstop1h 24m

Memphis

Wed 11/12

9:33 pm-1:44 pm

2 stops15h 11m

$228

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Wed 11/19

8:15 am-10:03 am

3 stops26h 48m

Memphis

Sun 11/23

1:41 pm-4:03 pm

Nonstop1h 22m

$238

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Sun 11/23

9:31 am-1:35 pm

1 stop5h 04m

Baton Rouge Ryan

Fri 11/28

6:55 pm-11:41 pm

1 stop3h 46m

$249

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Thu 11/13

5:10 am-9:50 am

1 stop5h 40m

Baton Rouge Ryan

Tue 11/18

7:29 am-2:52 pm

1 stop6h 23m

$254

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Sat 11/15

8:45 am-12:29 pm

1 stop4h 44m

Baton Rouge Ryan

Tue 11/18

6:00 am-10:45 am

1 stop3h 45m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 48 results
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Best time to book a flight from Knoxville to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mississippi

What is the cheapest month to book a flight from Knoxville to Mississippi?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $130). Flying from Knoxville to Mississippi in October is currently the most expensive (average of $280). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MS?

Find hourly flight availability from Knoxville to Mississippi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

It’s typically best to fly out from Knoxville to Mississippi in the evening. Doing so could potentially save you 47% on the flight price compared to flying in the morning, which is usually more expensive.

How much does it cost to fly round-trip from Knoxville to Mississippi?

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated October 30, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Mississippi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mississippi?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Mississippi. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Mississippi?

    For as low as $249, Allegiant Air can have you in Mississippi from Knoxville in 5h 04m. The distance between Knoxville and Mississippi is about 551 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Mississippi?

    While some choose either Knoxville McGhee Tyson - Gulfport Biloxi Regional or Knoxville McGhee Tyson - Baton Rouge Ryan, Knoxville McGhee Tyson - Memphis is the most popular route from Knoxville to Mississippi.

  • Can I find deals for flights from Knoxville to Mississippi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mississippi.

  • Can I find deals for business class flights from Knoxville to Mississippi?

    Yes. Cheapflights offers flight deals from Knoxville to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mississippi?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $130). Flying from Knoxville to Mississippi in October is currently the most expensive (average of $280). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to Mississippi

Discover the top 2 airlines that operate flights from Knoxville to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$308FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$323FlexibilityNo cancel feeOn-time71%

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