It’s generally more expensive to depart on a Wednesday, if you have to leave on this day you can still search on Cheapflights to find great options that meet your needs.
December can be a great time to fly to Milan from Tucson with a flight ticket averaging about $1,168. Cheapflights users have found deals in the month of December for as cheap as $626. The most expensive prices can be found in the month of July.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Tucson to Milan as you normally would.