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$371+ Cheap flights from Santa Cruz de la Sierra (VVI) to Mexico City (MEX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
VVI — MEX
oct. 15 — oct. 221
mié. 10/15
mié. 10/22
1 adult, Economy
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Cheapflights Tip: The best prices from Santa Cruz de la Sierra Viru Viru Intl to Mexico City Benito Juarez are usually found in September or August, booked 78 days in advance, depart on a Monday or Saturday and return on a Sunday

Cheap flight deals from Santa Cruz de la Sierra to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Santa Cruz de la Sierra (VVI) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 15, 2025.

Round-trip from

$537
(Copa Airlines)

One-way from

$371
(Priceline)

Popular in

January

Cheapest in

September

Average price

$621
From Santa Cruz de la Sierra Viru Viru Intl to Mexico City Benito Juarez
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One-way flight from Santa Cruz de la Sierra Viru Viru Intl to Mexico City Benito Juarez
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Highest demand for flights based on searches. 5% potential increase in price ($37 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Santa Cruz de la Sierra to Mexico City

Cheapest flights from Santa Cruz de la Sierra to Mexico City
Explore the most affordable flight options available from Santa Cruz de la Sierra to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 15, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/1411:59 amVVI - MEX
1 stop15h 01mCopa Airlines
sáb. 11/291:20 amMEX - VVI
1 stop19h 26mCopa Airlines
Deal found 9/15$537
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/1111:59 amVVI - MEX
1 stop14h 16mCopa Airlines
sáb. 10/185:50 amMEX - VVI
1 stop14h 50mCopa Airlines
Deal found 9/14$557
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/1411:59 amVVI - MEX
1 stop14h 16mCopa Airlines
mar. 11/189:25 amMEX - VVI
1 stop11h 21mCopa Airlines
Deal found 9/15$589
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/51:09 amVVI - MEX
1 stop20h 11mCopa Airlines
mar. 12/22:00 amMEX - VVI
1 stop18h 46mCopa Airlines
Deal found 9/14$599
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/2212:15 pmVVI - MEX
1 stop14h 45mCopa Airlines
lun. 9/291:05 pmMEX - VVI
1 stop12h 31mCopa Airlines
Deal found 9/15$600
This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/223:40 amVVI - MEX
1 stop10h 30mAvianca
dom. 12/71:50 pmMEX - VVI
1 stop10h 45mAvianca
Deal found 9/15$609
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/231:09 amVVI - MEX
1 stop13h 01mCopa Airlines
mié. 10/11:40 amMEX - VVI
1 stop19h 00mCopa Airlines
Deal found 9/14$611
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/411:40 amVVI - MEX
1 stop12h 25mCopa Airlines
jue. 12/49:25 amMEX - VVI
1 stop11h 21mCopa Airlines
Deal found 9/15$612
This Avianca deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/303:40 amVVI - MEX
1 stop16h 30mAvianca
lun. 12/151:50 pmMEX - VVI
1 stop10h 45mAvianca
Deal found 9/14$626
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/231:09 amVVI - MEX
1 stop13h 01mCopa Airlines
vie. 10/31:40 amMEX - VVI
1 stop19h 00mCopa Airlines
Deal found 9/15$628

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Cruz de la Sierra to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
Use the filters below to find and compare flights from Santa Cruz de la Sierra to Mexico City that are best for you.

Fly from

Santa Cruz de la Sierra

Fly to

Mexico City

Route

Depart

Return

Price

Santa Cruz de la SierraMexico City

VVI - MEX

VVIMEX

Santa Cruz de la Sierra Viru Viru Intl

jue. 10/2

11:59 am-12:15 am

1 stop14h 16m

Mexico City Benito Juarez

dom. 10/5

5:50 am-10:40 pm

1 stop14h 50m

$537

Santa Cruz de la SierraMexico City

VVI - MEX

VVIMEX

Santa Cruz de la Sierra Viru Viru Intl

jue. 11/6

11:40 am-10:05 pm

1 stop12h 25m

Mexico City Benito Juarez

mar. 12/2

1:20 am-10:46 pm

1 stop19h 26m

$557

Santa Cruz de la SierraMexico City

VVI - MEX

VVIMEX

Santa Cruz de la Sierra Viru Viru Intl

sáb. 10/11

11:59 am-12:15 am

1 stop14h 16m

Mexico City Benito Juarez

vie. 10/17

1:40 am-10:40 pm

1 stop19h 00m

$557

Santa Cruz de la SierraMexico City

VVI - MEX

VVIMEX

Santa Cruz de la Sierra Viru Viru Intl

mar. 10/14

11:59 am-12:15 am

1 stop14h 16m

Mexico City Benito Juarez

mar. 11/18

9:25 am-10:46 pm

1 stop11h 21m

$589

Santa Cruz de la SierraMexico City

VVI - MEX

VVIMEX

Santa Cruz de la Sierra Viru Viru Intl

lun. 11/3

1:09 am-7:20 pm

1 stop20h 11m

Mexico City Benito Juarez

mié. 12/3

2:00 am-10:46 pm

1 stop18h 46m

$612

Santa Cruz de la SierraMexico City

VVI - MEX

VVIMEX

Santa Cruz de la Sierra Viru Viru Intl

vie. 11/14

5:25 am-1:50 pm

1 stop10h 25m

Mexico City Benito Juarez

lun. 11/24

8:45 am-4:35 am

2 stops17h 50m

$640

Santa Cruz de la SierraMexico City

VVI - MEX

VVIMEX

Santa Cruz de la Sierra Viru Viru Intl

mié. 10/29

5:25 am-11:25 pm

2 stops20h 00m

Mexico City Benito Juarez

lun. 11/17

8:45 am-4:35 am

2 stops17h 50m

$652

Santa Cruz de la SierraMexico City

VVI - MEX

VVIMEX

Santa Cruz de la Sierra Viru Viru Intl

mar. 3/10

11:42 am-10:05 pm

1 stop12h 23m

Mexico City Benito Juarez

sáb. 4/4

1:40 am-10:50 pm

1 stop19h 10m

$664

Santa Cruz de la SierraMexico City

VVI - MEX

VVIMEX

Santa Cruz de la Sierra Viru Viru Intl

lun. 9/29

2:50 am-6:05 pm

1 stop17h 15m

$371

Santa Cruz de la SierraMexico City

VVI - MEX

VVIMEX

Santa Cruz de la Sierra Viru Viru Intl

lun. 10/27

2:00 pm-11:00 am

3 stops23h 00m

$411

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 13 results
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Best time to book a flight from Santa Cruz de la Sierra to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Santa Cruz de la Sierra with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Cruz de la Sierra to Mexico City

How far ahead should I book a flight from Santa Cruz de la Sierra to Mexico City?

Use this chart to determine the optimal time to book a round-trip flight from Santa Cruz de la Sierra to Mexico City. Price data was last updated on September 12, 2025.

The price you pay for your flight from Santa Cruz de la Sierra to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 78 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santa Cruz de la Sierra to Mexico City?

Currently, May is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to Mexico City (average of $387). Flying from Santa Cruz de la Sierra to Mexico City in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Santa Cruz de la Sierra to Mexico City?

Reviews of airlines servicing Mexico City

Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated septiembre 15, 2025.
Get a feel of what it's like to fly with Copa Airlines, LATAM Airlines, and Avianca from Santa Cruz de la Sierra to Mexico City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
LATAM Airlines
7.5
Good
1,847 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,435 reviews
Copa Airlines
7.6
Good
1,531 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Santa Cruz de la Sierra to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Cruz de la Sierra to Mexico City?

    Copa Airlines can get you from Santa Cruz de la Sierra to Mexico City in just under 15h 01m. Your travel time can differ by up to . The distance between Santa Cruz de la Sierra and Mexico City is about 3534 mi.

  • What are the cheapest airlines flying from Santa Cruz de la Sierra to Mexico City round-trip?

    According to our current data, Avianca ($530), Copa Airlines ($554), and LATAM Airlines ($588) offers the cheapest pricing from Santa Cruz de la Sierra to Mexico City. Users have found that Avianca is 20% cheaper than the other options available to this destination.

  • Can I find deals for flights from Santa Cruz de la Sierra to Mexico City that include hotel bookings?

    Yes. In addition to deals on Santa Cruz de la Sierra to Mexico City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Cruz de la Sierra to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Cruz de la Sierra to Mexico City.

  • Can I find deals for business class flights from Santa Cruz de la Sierra to Mexico City?

    Yes. Cheapflights offers flight deals from Santa Cruz de la Sierra to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Cruz de la Sierra to Mexico City?

    Currently, May is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to Mexico City (average of $387). Flying from Santa Cruz de la Sierra to Mexico City in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santa Cruz de la Sierra to Mexico City

See prices for flight routes from nearby airports that may be better suited for you.
La Paz to Mexico City flights

Top 3 airlines flying from Santa Cruz de la Sierra to Mexico City

Discover the top 3 airlines that operate flights from Santa Cruz de la Sierra to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$530Average$646FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$554Average$677FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$588Average$781FlexibilityNo cancel feeOn-time81%

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