What are the cheapest airlines to fly from Louisville to Mesa one-way?

To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $118. Delta flights start at $118 while deals on United Airlines start at $138 one-way.

In terms of precipitation, rainfall in Mesa ranges from 0.0 - 1.1 inches per month. July is typically the wettest month, when rainfall can reach 1.1 in. June is typically the driest time to visit Mesa when rainfall is around 0.0 in.

If weather is an important factor for your trip to Mesa, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 95.0 F. Travelers looking to avoid the cold should look outside of December, when temperatures are typically at their lowest (around 55.4 F).

What are the cheapest flights from Louisville to Mesa?

Looking for the cheapest flight from Louisville to Mesa? While on average our users pay $399, our data indicates the cheapest price to be $133. The most popular route (Louisville Intl - Phoenix Sky Harbor Intl), is priced around $378.

What are the most popular airlines that fly from Louisville to Mesa?

Before booking your flight from Louisville to Mesa check out the most popular airlines for this route: Southwest, American Airlines or Delta.

What airport do you fly from for flights from Louisville to Mesa?

If you book a flight to Mesa from Louisville, you will be flying from Louisville Intl, which is the city’s only airport. Louisville Intl (SDF) is located 5.3 mi from the center of Louisville. There are 0 flights from Louisville Intl to Mesa per day from 4 different airlines.

Can I find deals for flights from Louisville to Mesa that include hotel bookings?

Yes. In addition to deals on Louisville to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Louisville to Mesa?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Mesa.

Can I find deals for business class flights from Louisville to Mesa?

Yes. Cheapflights offers flight deals from Louisville to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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Cheapflights Tip: The best prices from Louisville Intl to Mesa are usually found in November or June, booked 84 days in advance, depart on a Wednesday or Thursday and return on a Tuesday

Find flight deals from Louisville to Mesa

Popular in	December
Cheapest in	November
Average price	$442

High demand for flights, 0% potential price rise

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Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).

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Average for round-trip flights in October 2026

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Everything you need to know about your flight from Louisville to Mesa

What is the cheapest time of day to fly from SDF to MS9?

A simple way to save on the total cost of your ticket is to fly from Louisville to Mesa in the afternoon. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Mesa

Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Louisville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

7.9

Good

4,212 reviews

Reviews

1 / 20

10.0

Excellent

Edward,Sep 2026

MCO - BWI

Changed flight which was easy. Gate Agent booked me from extra leg room seat on original flight to row 15 on new flight that did not have extra leg room - even though it was an exit row. The row in front of me with extra leg room had an empty seat.

Southwest

7.9

Good

4,212 reviews

Southwest

7.9

Good

4,212 reviews

Reviews

1 / 20

10.0

Excellent

Edward,Sep 2026

MCO - BWI

Delta

7.8

Good

8,628 reviews

Southwest

7.9

Good

4,212 reviews

Reviews

1 / 20

10.0

Excellent

Edward,Sep 2026

MCO - BWI

United Airlines

7.4

Good

10,285 reviews

Southwest

7.9

Good

4,212 reviews

Reviews

1 / 20

10.0

Excellent

Edward,Sep 2026

MCO - BWI

American Airlines

7.0

Good

12,128 reviews

Southwest

7.9

Good

4,212 reviews

Reviews

1 / 20

10.0

Excellent

Edward,Sep 2026

MCO - BWI

Related info for your journey

What airport do you fly from for flights from Louisville to Mesa?
If you book a flight to Mesa from Louisville, you will be flying from Louisville Intl, which is the city’s only airport. Louisville Intl (SDF) is located 5.3 mi from the center of Louisville. There are 0 flights from Louisville Intl to Mesa per day from 4 different airlines.
What are the cheapest airlines to fly from Louisville to Mesa one-way?
To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $118. Delta flights start at $118 while deals on United Airlines start at $138 one-way.
What are the cheapest flights from Louisville to Mesa?
Looking for the cheapest flight from Louisville to Mesa? While on average our users pay $399, our data indicates the cheapest price to be $133. The most popular route (Louisville Intl - Phoenix Sky Harbor Intl), is priced around $378.
Can I find deals for flights from Louisville to Mesa that include hotel bookings?
Yes. In addition to deals on Louisville to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Louisville to Mesa?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Mesa.
Can I find deals for business class flights from Louisville to Mesa?
Yes. Cheapflights offers flight deals from Louisville to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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Top 4 airlines flying from Louisville to Mesa

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$236	Average$387	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$236	Average$399	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$266	Average$353	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$307	Average$484	FlexibilityNo cancel fee	On-time63%

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Cheap flights from Louisville (SDF) to Mesa, AZ

Find cheap flights from Louisville to Mesa with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Louisville to Mesa

Popular in

Cheapest in

Average price

Cheapflights Insights

What is the cheapest time of day to fly from SDF to MS9?

A simple way to save on the total cost of your ticket is to fly from Louisville to Mesa in the afternoon. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated October 5, 2026.

Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Louisville to Mesa to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What airport do you fly from for flights from Louisville to Mesa?

What are the cheapest airlines to fly from Louisville to Mesa one-way?

What are the cheapest flights from Louisville to Mesa?

Can I find deals for flights from Louisville to Mesa that include hotel bookings?

How can I find direct flights from Louisville to Mesa?

Can I find deals for business class flights from Louisville to Mesa?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Louisville to Mesa

See prices for flight routes from nearby airports that may be better suited for you.

Complete your trip

Complete your trip to Mesa by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Louisville to Mesa by cabin class

Find flights from Louisville to Mesa, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Louisville and Mesa flights

Browse other Louisville and Mesa flight options. Last updated on October 5, 2026.

Other flights from Louisville

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Top 4 airlines flying from Louisville to Mesa

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