$122+ Cheap flights from South Carolina to Medellín
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — MDE
Apr 28 — May 51
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Medellín with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to MedellínExplore the most affordable flight options available from South Carolina to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 29, 2026.
Explore the most affordable flight options available from South Carolina to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 29, 2026.
This eDestinos deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/319:00 pm
CLT
- MDE
1 stop17h 22m
Spirit Airlines
Wed 4/82:17 pm
MDE
- CLT
1 stop17h 04m
Spirit Airlines
Deal found 3/28![Spirit Airlines logo]()
$262
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/259:54 pm
CLT
- MDE
1 stop16h 14m
Multiple Airlines
Sat 5/22:06 pm
MDE
- CLT
1 stop23h 06m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$306
This Spirit deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Spirit is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/259:54 pm
CLT
- MDE
1 stop16h 14m
Spirit Airlines
Sat 5/21:55 pm
MDE
- CLT
1 stop17h 14m
Spirit Airlines
Deal found 3/26![Spirit Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/89:15 am
CLT
- MDE
1 stop16h 06m
Multiple Airlines
Tue 4/142:17 pm
MDE
- CLT
1 stop17h 53m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:56 am
CLT
- MDE
1 stop29h 12m
Multiple Airlines
Thu 4/302:06 pm
MDE
- CLT
1 stop23h 12m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$316
This Cheapflightsfares deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/89:54 pm
CLT
- MDE
1 stop16h 14m
Spirit Airlines
Sun 5/171:55 pm
MDE
- CLT
1 stop9h 04m
Spirit Airlines
Deal found 3/24![Spirit Airlines logo]()
$317
This Cheapflightsfares deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:00 pm
CLT
- MDE
1 stop17h 22m
Spirit Airlines
Mon 4/131:52 pm
MDE
- CLT
1 stop18h 26m
Spirit Airlines
Deal found 3/25![Spirit Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/79:00 pm
CLT
- MDE
1 stop28h 21m
Spirit Airlines
Fri 5/12:06 pm
MDE
- CLT
1 stop18h 04m
Spirit Airlines
Deal found 3/24![Spirit Airlines logo]()
$319
This Cheapflightsfares deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/111:20 pm
CLT
- MDE
1 stop12h 01m
Spirit Airlines
Sat 4/182:06 pm
MDE
- CLT
1 stop18h 04m
Spirit Airlines
Deal found 3/27![Spirit Airlines logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:45 pm
SAV
- MDE
1 stop11h 36m
Multiple Airlines
Thu 4/164:53 pm
MDE
- SAV
2 stops28h 55m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:45 pm
SAV
- MDE
1 stop11h 36m
Multiple Airlines
Fri 4/172:06 pm
MDE
- SAV
1 stop7h 42m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:45 pm
SAV
- MDE
1 stop11h 36m
Multiple Airlines
Mon 4/208:50 am
MDE
- SAV
2 stops12h 58m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$372
Best flights from South Carolina to MedellínDiscover carefully curated flight deals from South Carolina to Medellín that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 29, 2026.
Discover carefully curated flight deals from South Carolina to Medellín that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 29, 2026.
This Spirit deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Spirit is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/259:54 pm
CLT
- MDE
1 stop16h 14m
Spirit Airlines
Sat 5/21:55 pm
MDE
- CLT
1 stop17h 14m
Spirit Airlines
Deal found 3/26![Spirit Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/262:12 pm
GSP
- MDE
2 stops23h 56m
Multiple Airlines
Sun 5/32:06 pm
MDE
- GSP
1 stop25h 47m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$452
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:49 pm
CLT
- MDE
2 stops26h 21m
United Airlines
Tue 8/259:45 am
MDE
- CLT
2 stops27h 05m
United Airlines
Deal found 3/26![United Airlines logo]()
$464
This FlightHub deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:12 pm
CHS
- MDE
1 stop18h 50m
JetBlue
Tue 5/193:07 pm
MDE
- CHS
2 stops18h 21m
JetBlue
Deal found 3/26![JetBlue logo]()
$523
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:09 pm
GSP
- MDE
1 stop6h 49m
American Airlines
Sun 8/1612:25 am
MDE
- GSP
1 stop16h 49m
American Airlines
Deal found 3/24![American Airlines logo]()
$550
This BusinessClass deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:00 am
SAV
- MDE
2 stops16h 05m
LATAM Airlines
Sun 8/28:25 am
MDE
- SAV
2 stops14h 28m
LATAM Airlines
Deal found 3/28![LATAM Airlines logo]()
$659
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:01 am
SAV
- MDE
2 stops15h 39m
Delta
Sun 4/195:45 am
MDE
- SAV
2 stops26h 42m
Delta
Deal found 3/26![Delta logo]()
$778
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:05 am
CLT
- MDE
2 stops14h 05m
United Airlines
Wed 5/209:45 am
MDE
- CLT
2 stops23h 17m
United Airlines
Deal found 3/27![United Airlines logo]()
$489
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:55 pm
MYR
- MDE
1 stop20h 13m
Spirit Airlines
Sun 4/262:06 pm
MDE
- MYR
1 stop8h 23m
Spirit Airlines
Deal found 3/24![Spirit Airlines logo]()
$497
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:34 pm
CHS
- MDE
2 stops40h 41m
Multiple Airlines
Sat 5/231:55 pm
MDE
- CHS
1 stop17h 43m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$512
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/77:44 pm
CLT
- MDE
2 stops26h 26m
United Airlines
Sat 8/229:45 am
MDE
- CLT
2 stops14h 19m
United Airlines
Deal found 3/28![United Airlines logo]()
$504
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/98:02 am
GSP
- MDE
2 stops13h 13m
American Airlines
Sat 5/161:53 pm
MDE
- GSP
2 stops17h 42m
American Airlines
Deal found 3/25![American Airlines logo]()
$585
This Mytrip deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:31 pm
MYR
- MDE
2 stops26h 44m
Multiple Airlines
Sun 4/265:00 am
MDE
- MYR
2 stops17h 29m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$532
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:05 am
CLT
- MDE
2 stops38h 05m
United Airlines
Tue 8/49:45 am
MDE
- CLT
1 stop11h 14m
United Airlines
Deal found 3/27![United Airlines logo]()
$508
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:45 pm
GSP
- MDE
1 stop19h 03m
American Airlines
Tue 5/126:00 am
MDE
- GSP
1 stop11h 15m
American Airlines
Deal found 3/24![American Airlines logo]()
$591
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/267:40 pm
CLT
- MDE
2 stops26h 30m
United Airlines
Tue 5/59:45 am
MDE
- CLT
2 stops23h 08m
United Airlines
Deal found 3/28![United Airlines logo]()
$513
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:52 am
SAV
- MDE
1 stop10h 23m
American Airlines
Fri 5/156:00 am
MDE
- SAV
1 stop16h 59m
American Airlines
Deal found 3/24![American Airlines logo]()
$593
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:30 pm
CLT
- MDE
2 stops26h 40m
United Airlines
Wed 5/69:45 am
MDE
- CLT
1 stop10h 54m
United Airlines
Deal found 3/29![United Airlines logo]()
$513
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2911:32 am
GSP
- MDE
2 stops13h 26m
American Airlines
Wed 8/126:00 am
MDE
- GSP
1 stop11h 14m
American Airlines
Deal found 3/25![American Airlines logo]()
$606
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:49 pm
CLT
- MDE
2 stops26h 21m
United Airlines
Sat 9/129:45 am
MDE
- CLT
2 stops23h 50m
United Airlines
Deal found 3/24![United Airlines logo]()
$523
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/235:00 am
MYR
- MDE
2 stops16h 15m
American Airlines
Sun 4/261:50 pm
MDE
- MYR
2 stops19h 36m
American Airlines
Deal found 3/24![American Airlines logo]()
$620
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:00 am
CLT
- MDE
2 stops40h 10m
United Airlines
Wed 6/179:45 am
MDE
- CLT
2 stops38h 00m
United Airlines
Deal found 3/24![United Airlines logo]()
$539
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:25 pm
SAV
- MDE
1 stop6h 33m
American Airlines
Sun 8/26:00 am
MDE
- SAV
1 stop17h 13m
American Airlines
Deal found 3/28![American Airlines logo]()
$636
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:00 am
CHS
- MDE
2 stops16h 10m
United Airlines
Sat 5/239:45 am
MDE
- CHS
2 stops23h 23m
United Airlines
Deal found 3/24![United Airlines logo]()
$572
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:40 am
GSP
- MDE
2 stops11h 30m
United Airlines
Tue 5/129:45 am
MDE
- GSP
2 stops23h 02m
United Airlines
Deal found 3/24![United Airlines logo]()
$585
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2010:30 am
GSP
- MDE
2 stops35h 40m
United Airlines
Fri 7/179:45 am
MDE
- GSP
2 stops23h 10m
United Airlines
Deal found 3/25![United Airlines logo]()
$602
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/245:41 pm
GSP
- MDE
2 stops28h 29m
United Airlines
Thu 5/289:45 am
MDE
- GSP
1 stop11h 14m
United Airlines
Deal found 3/26![United Airlines logo]()
$609
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:30 am
MYR
- MDE
2 stops34h 40m
United Airlines
Sat 5/169:45 am
MDE
- MYR
2 stops23h 57m
United Airlines
Deal found 3/25![United Airlines logo]()
$626
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/59:50 am
SAV
- MDE
2 stops12h 20m
United Airlines
Thu 5/79:45 am
MDE
- SAV
2 stops28h 28m
United Airlines
Deal found 3/24![United Airlines logo]()
$634
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/43:14 pm
MYR
- MDE
2 stops30h 56m
United Airlines
Thu 5/79:45 am
MDE
- MYR
2 stops27h 33m
United Airlines
Deal found 3/24![United Airlines logo]()
$675
Last-minute flights from South Carolina to MedellínDiscover last-minute flight deals from South Carolina to Medellín. Data last updated March 29, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Medellín. Data last updated March 29, 2026 and is based on user searches.
This eDestinos deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/319:00 pm
CLT
- MDE
1 stop17h 22m
Spirit Airlines
Wed 4/82:17 pm
MDE
- CLT
1 stop17h 04m
Spirit Airlines
Deal found 3/28![Spirit Airlines logo]()
$262
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/79:00 pm
CLT
- MDE
1 stop28h 21m
Spirit Airlines
Thu 4/302:06 pm
MDE
- CLT
1 stop18h 04m
Spirit Airlines
Deal found 3/24![Spirit Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/89:15 am
CLT
- MDE
1 stop16h 06m
Multiple Airlines
Tue 4/142:17 pm
MDE
- CLT
1 stop17h 53m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$310
This Cheapflightsfares deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:00 pm
CLT
- MDE
1 stop17h 22m
Spirit Airlines
Mon 4/131:52 pm
MDE
- CLT
1 stop18h 26m
Spirit Airlines
Deal found 3/25![Spirit Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:45 pm
SAV
- MDE
1 stop11h 36m
Multiple Airlines
Thu 4/164:53 pm
MDE
- SAV
2 stops28h 55m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:45 pm
SAV
- MDE
1 stop11h 36m
Multiple Airlines
Fri 4/172:06 pm
MDE
- SAV
1 stop7h 42m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:45 pm
SAV
- MDE
1 stop11h 36m
Multiple Airlines
Mon 4/208:50 am
MDE
- SAV
2 stops12h 58m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$372
This Cheapflightsfares deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/111:20 pm
CLT
- MDE
1 stop12h 01m
Spirit Airlines
Sat 4/182:06 pm
MDE
- CLT
1 stop18h 04m
Spirit Airlines
Deal found 3/27![Spirit Airlines logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:56 am
CLT
- MDE
1 stop29h 12m
Multiple Airlines
Thu 4/302:06 pm
MDE
- CLT
1 stop23h 12m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$316
This FlightHub deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/259:32 pm
CLT
- MDE
1 stop16h 28m
Spirit Airlines
Fri 5/11:55 pm
MDE
- CLT
1 stop17h 14m
Spirit Airlines
Deal found 3/27![Spirit Airlines logo]()
$306
This Spirit deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Spirit is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/259:54 pm
CLT
- MDE
1 stop16h 14m
Spirit Airlines
Sat 5/21:55 pm
MDE
- CLT
1 stop17h 14m
Spirit Airlines
Deal found 3/26![Spirit Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/254:36 pm
CLT
- MDE
1 stop21h 32m
Multiple Airlines
Fri 5/82:06 pm
MDE
- CLT
1 stop20h 59m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$321
One-way flights from South Carolina to MedellínSearch for one-way flight options from South Carolina to Medellín. Find affordable one-way fares based on user searches. Data last updated March 29, 2026.
Search for one-way flight options from South Carolina to Medellín. Find affordable one-way fares based on user searches. Data last updated March 29, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:54 pm
CLT
- MDE
1 stop16h 14m
Spirit Airlines
Deal found 3/28![Spirit Airlines logo]()
$122
This Booking.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/259:54 pm
CLT
- MDE
1 stop16h 14m
Spirit Airlines
Deal found 3/24![Spirit Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/269:54 pm
CLT
- MDE
2 stops35h 11m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/254:36 pm
CLT
- MDE
2 stops41h 33m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$128
This Mytrip deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:54 pm
CLT
- MDE
2 stops26h 07m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$149
This Trip.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/310:49 pm
CLT
- MDE
1 stop12h 02m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:58 pm
CLT
- MDE
1 stop18h 02m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/219:07 pm
CLT
- MDE
1 stop16h 36m
Spirit Airlines
Deal found 3/28![Spirit Airlines logo]()
$163
This Mytrip deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/89:07 pm
CLT
- MDE
2 stops16h 53m
Spirit Airlines
Deal found 3/28![Spirit Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:30 am
CLT
- MDE
1 stop14h 55m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$178
This Trip.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/47:45 pm
CLT
- MDE
1 stop15h 06m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/38:18 pm
GSP
- MDE
1 stop14h 33m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$192
Find flight deals from South Carolina to Medellín
Keep the following information in mind while searching for South Carolina to Medellín flight deals. Data was last updated March 29, 2026.
Round-trip from | $306 (Kiwi.com) |
|---|---|
One-way from | $122 (Cheapflightsfares) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Medellín that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 29, 2026.
Use the filters below to find and compare flights from South Carolina to Medellín that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteMedellín
CLT - MDE
CLTMDE
Charlotte Douglas
Sat 4/25
9:54 pm-1:08 pm
1 stop16h 14m
Medellín Jose Maria Cordova Intl
Sat 5/2
1:55 pm-8:09 am
1 stop17h 14m
$307
GreenvilleMedellín
GSP - MDE
GSPMDE
Greenville
Sun 4/26
2:12 pm-1:08 pm
2 stops23h 56m
Medellín Jose Maria Cordova Intl
Sun 5/3
2:06 pm-4:53 pm
1 stop25h 47m
$452
CharlotteMedellín
CLT - MDE
CLTMDE
Charlotte Douglas
Tue 8/18
7:49 pm-9:10 pm
2 stops26h 21m
Medellín Jose Maria Cordova Intl
Tue 8/25
9:45 am-1:50 pm
2 stops27h 05m
$464
CharlotteMedellín
CLT - MDE
CLTMDE
Charlotte Douglas
Mon 5/4
8:05 am-9:10 pm
2 stops14h 05m
Medellín Jose Maria Cordova Intl
Wed 5/20
9:45 am-10:02 am
2 stops23h 17m
$489
Myrtle BeachMedellín
MYR - MDE
MYRMDE
Myrtle Beach Intl
Wed 4/22
5:55 pm-1:08 pm
1 stop20h 13m
Medellín Jose Maria Cordova Intl
Sun 4/26
2:06 pm-11:29 pm
1 stop8h 23m
$497
CharlotteMedellín
CLT - MDE
CLTMDE
Charlotte Douglas
Fri 8/7
7:44 pm-9:10 pm
2 stops26h 26m
Medellín Jose Maria Cordova Intl
Sat 8/22
9:45 am-1:04 am
2 stops14h 19m
$504
CharlotteMedellín
CLT - MDE
CLTMDE
Charlotte Douglas
Tue 7/21
8:05 am-9:10 pm
2 stops38h 05m
Medellín Jose Maria Cordova Intl
Tue 8/4
9:45 am-9:59 pm
1 stop11h 14m
$508
CharlestonMedellín
CHS - MDE
CHSMDE
Charleston
Wed 5/13
4:34 pm-8:15 am
2 stops40h 41m
Medellín Jose Maria Cordova Intl
Sat 5/23
1:55 pm-8:38 am
1 stop17h 43m
$512
CharlotteMedellín
CLT - MDE
CLTMDE
Charlotte Douglas
Sun 4/26
7:40 pm-9:10 pm
2 stops26h 30m
Medellín Jose Maria Cordova Intl
Tue 5/5
9:45 am-9:53 am
2 stops23h 08m
$513
CharlotteMedellín
CLT - MDE
CLTMDE
Charlotte Douglas
Tue 4/28
7:30 pm-9:10 pm
2 stops26h 40m
Medellín Jose Maria Cordova Intl
Wed 5/6
9:45 am-9:39 pm
1 stop10h 54m
$513
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Medellín
Have a flexible travel schedule? Discover the best time to fly to Medellín from South Carolina with our price prediction graph.
CLT-MDE
SAV-MDE
GSP-MDE
CHS-MDE
MYR-MDE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Medellín
USSC-CO1
CLT-MDE
SAV-MDE
GSP-MDE
CHS-MDE
What is the cheapest month to book a flight from South Carolina to Medellín?
Currently, September is the cheapest month in which you can book a flight from South Carolina to Medellín (average of $169). Flying from South Carolina to Medellín in January is currently the most expensive (average of $599). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Medellín. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for South Carolina to Medellín
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Medellín by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Medellín by cabin class
Find flights from South Carolina to Medellín, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Medellín flights
Browse other South Carolina and Medellín flight options. Last updated on March 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Medellín flights
Consider these flights traveling from South Carolina to Medellín.
Top 2 airlines flying from South Carolina to Medellín
Discover the top 2 airlines that operate flights from South Carolina to Medellín. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$327 | Average$395 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$515 | Average$689 | FlexibilityNo cancel fee | On-time71% |