Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Odessa to Madrid as you normally would.
Most people fly into Madrid Barajas (MAD) if they book a flight to Madrid from Odessa. On average, Barajas has 0 inbound flights from Odessa per day from 2 airlines. Madrid Barajas is conveniently located just 8.5 mi from Madrid’s city center.