$125+ Cheap flights from Missouri to Louisville (SDF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDF
May 20 — May 271
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to Louisville with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Missouri to LouisvilleExplore the most affordable flight options available from Missouri to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 20, 2026.
Explore the most affordable flight options available from Missouri to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 20, 2026.
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:40 am
STL
- SDF
1 stop5h 45m
Southwest
Sat 5/166:40 am
SDF
- STL
1 stop2h 45m
Southwest
Deal found 4/16![Southwest logo]()
$270
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:09 pm
STL
- SDF
1 stop3h 47m
United Airlines
Sat 5/163:44 pm
SDF
- STL
1 stop6h 29m
United Airlines
Deal found 4/17![United Airlines logo]()
$275
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:05 am
MCI
- SDF
1 stop4h 03m
Delta
Sat 5/165:47 pm
SDF
- MCI
1 stop4h 21m
Delta
Deal found 4/18![Delta logo]()
$275
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:06 pm
MCI
- SDF
1 stop6h 12m
Delta
Thu 5/146:00 am
SDF
- MCI
1 stop4h 29m
Delta
Deal found 4/17![Delta logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:44 am
MCI
- SDF
1 stop10h 40m
Allegiant Air
Sun 5/104:13 pm
SDF
- MCI
1 stop26h 51m
Allegiant Air
Deal found 4/19![Allegiant Air logo]()
$309
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:19 am
SGF
- SDF
1 stop4h 27m
American Airlines
Mon 5/117:55 pm
SDF
- SGF
1 stop5h 01m
American Airlines
Deal found 4/16![American Airlines logo]()
$309
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/29:06 am
JLN
- SDF
1 stop6h 54m
United Airlines
Wed 5/69:10 am
SDF
- JLN
1 stop5h 27m
United Airlines
Deal found 4/17![United Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:21 am
STL
- SDF
1 stop4h 38m
Delta
Sun 6/78:09 pm
SDF
- STL
1 stop4h 47m
Delta
Deal found 4/20![Delta logo]()
$326
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:10 pm
MCI
- SDF
2 stops5h 25m
Southwest
Sat 5/168:40 am
SDF
- MCI
1 stop4h 20m
Southwest
Deal found 4/18![Southwest logo]()
$333
This United Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:22 pm
SGF
- SDF
1 stop4h 34m
United Airlines
Sun 5/247:10 am
SDF
- SGF
1 stop4h 32m
United Airlines
Deal found 4/19![United Airlines logo]()
$333
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:35 am
STL
- SDF
1 stop6h 10m
Southwest
Sun 6/75:30 pm
SDF
- STL
1 stop6h 40m
Southwest
Deal found 4/17![Southwest logo]()
$335
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:19 am
MCI
- SDF
1 stop4h 40m
Delta
Tue 5/197:50 am
SDF
- MCI
1 stop6h 28m
Delta
Deal found 4/17![Delta logo]()
$335
Best flights from Missouri to LouisvilleDiscover carefully curated flight deals from Missouri to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 20, 2026.
Discover carefully curated flight deals from Missouri to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 20, 2026.
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:35 am
STL
- SDF
1 stop6h 10m
Southwest
Sat 5/166:40 am
SDF
- STL
1 stop2h 45m
Southwest
Deal found 4/19![Southwest logo]()
$270
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:19 am
SGF
- SDF
1 stop4h 27m
American Airlines
Mon 5/117:55 pm
SDF
- SGF
1 stop5h 01m
American Airlines
Deal found 4/16![American Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:52 pm
SGF
- SDF
1 stop4h 33m
Delta
Wed 5/275:47 pm
SDF
- SGF
1 stop5h 32m
Delta
Deal found 4/20![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/29:06 am
JLN
- SDF
1 stop6h 54m
United Airlines
Wed 5/69:10 am
SDF
- JLN
1 stop5h 27m
United Airlines
Deal found 4/17![United Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:44 am
MCI
- SDF
1 stop10h 40m
Multiple Airlines
Fri 5/810:33 am
SDF
- MCI
2 stops23h 56m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$336
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:10 pm
MCI
- SDF
2 stops5h 25m
Southwest
Sat 5/168:40 am
SDF
- MCI
1 stop4h 20m
Southwest
Deal found 4/18![Southwest logo]()
$333
This United Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:22 pm
SGF
- SDF
1 stop4h 34m
United Airlines
Sun 5/247:10 am
SDF
- SGF
1 stop4h 32m
United Airlines
Deal found 4/19![United Airlines logo]()
$333
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:19 am
MCI
- SDF
1 stop4h 40m
Delta
Tue 5/199:45 am
SDF
- MCI
1 stop7h 23m
Delta
Deal found 4/20![Delta logo]()
$345
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:30 pm
STL
- SDF
1 stop5h 35m
Southwest
Sun 6/75:25 am
SDF
- STL
2 stops6h 55m
Southwest
Deal found 4/17![Southwest logo]()
$340
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/91:50 pm
MCI
- SDF
1 stop7h 41m
United Airlines
Tue 5/123:36 pm
SDF
- MCI
1 stop7h 28m
United Airlines
Deal found 4/15![United Airlines logo]()
$345
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:30 am
MCI
- SDF
1 stop6h 21m
Delta
Fri 5/87:49 pm
SDF
- MCI
1 stop4h 27m
Delta
Deal found 4/16![Delta logo]()
$377
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:41 pm
STL
- SDF
1 stop5h 18m
United Airlines
Thu 6/47:10 am
SDF
- STL
1 stop6h 01m
United Airlines
Deal found 4/15![United Airlines logo]()
$363
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/145:50 am
STL
- SDF
1 stop7h 00m
Southwest
Tue 6/165:25 pm
SDF
- STL
2 stops7h 15m
Southwest
Deal found 4/20![Southwest logo]()
$380
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:19 pm
STL
- SDF
1 stop6h 07m
Delta
Sat 7/184:28 pm
SDF
- STL
1 stop6h 35m
Delta
Deal found 4/16![Delta logo]()
$395
This United Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:22 pm
SGF
- SDF
1 stop4h 34m
United Airlines
Sat 5/165:52 pm
SDF
- SGF
1 stop5h 10m
United Airlines
Deal found 4/19![United Airlines logo]()
$374
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:40 am
STL
- SDF
1 stop3h 25m
Southwest
Mon 5/186:55 am
SDF
- STL
2 stops6h 55m
Southwest
Deal found 4/19![Southwest logo]()
$382
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:13 pm
MCI
- SDF
1 stop6h 12m
Delta
Mon 5/255:47 pm
SDF
- MCI
1 stop5h 36m
Delta
Deal found 4/20![Delta logo]()
$405
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1311:30 am
MCI
- SDF
2 stops11h 29m
United Airlines
Thu 5/145:40 am
SDF
- MCI
1 stop4h 16m
United Airlines
Deal found 4/17![United Airlines logo]()
$382
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:20 pm
MCI
- SDF
2 stops7h 25m
Southwest
Mon 5/112:40 pm
SDF
- MCI
1 stop4h 00m
Southwest
Deal found 4/16![Southwest logo]()
$382
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:24 pm
SGF
- SDF
1 stop5h 01m
American Airlines
Sun 5/32:54 pm
SDF
- SGF
1 stop8h 51m
American Airlines
Deal found 4/18![American Airlines logo]()
$585
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/195:10 am
MCI
- SDF
1 stop5h 15m
Southwest
Sun 6/286:35 pm
SDF
- MCI
1 stop6h 10m
Southwest
Deal found 4/18![Southwest logo]()
$395
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:10 pm
MCI
- SDF
2 stops5h 25m
Southwest
Sat 6/135:05 pm
SDF
- MCI
2 stops5h 45m
Southwest
Deal found 4/18![Southwest logo]()
$436
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:22 pm
SGF
- SDF
1 stop4h 34m
United Airlines
Mon 5/115:40 am
SDF
- SGF
2 stops13h 47m
United Airlines
Deal found 4/16![United Airlines logo]()
$572
This United Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/49:06 am
JLN
- SDF
1 stop6h 54m
United Airlines
Fri 5/87:15 am
SDF
- JLN
1 stop7h 22m
United Airlines
Deal found 4/19![United Airlines logo]()
$645
Last-minute flights from Missouri to LouisvilleDiscover last-minute flight deals from Missouri to Louisville. Data last updated April 20, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Louisville. Data last updated April 20, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/29:06 am
JLN
- SDF
1 stop6h 54m
United Airlines
Wed 5/69:10 am
SDF
- JLN
1 stop5h 27m
United Airlines
Deal found 4/17![United Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:44 am
MCI
- SDF
1 stop10h 40m
Allegiant Air
Sun 5/104:13 pm
SDF
- MCI
1 stop26h 51m
Allegiant Air
Deal found 4/19![Allegiant Air logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:44 am
MCI
- SDF
1 stop10h 40m
Multiple Airlines
Fri 5/810:33 am
SDF
- MCI
2 stops23h 56m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$336
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:19 am
SGF
- SDF
1 stop4h 27m
American Airlines
Mon 5/117:55 pm
SDF
- SGF
1 stop5h 01m
American Airlines
Deal found 4/16![American Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:40 am
STL
- SDF
1 stop5h 45m
Southwest
Sat 5/166:40 am
SDF
- STL
1 stop2h 45m
Southwest
Deal found 4/16![Southwest logo]()
$270
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:09 pm
STL
- SDF
1 stop3h 47m
United Airlines
Sat 5/163:44 pm
SDF
- STL
1 stop6h 29m
United Airlines
Deal found 4/17![United Airlines logo]()
$275
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:05 am
MCI
- SDF
1 stop4h 03m
Delta
Sat 5/165:47 pm
SDF
- MCI
1 stop4h 21m
Delta
Deal found 4/18![Delta logo]()
$275
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:10 pm
MCI
- SDF
2 stops5h 25m
Southwest
Sat 5/168:40 am
SDF
- MCI
1 stop4h 20m
Southwest
Deal found 4/18![Southwest logo]()
$333
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:06 pm
MCI
- SDF
1 stop6h 12m
Delta
Thu 5/146:00 am
SDF
- MCI
1 stop4h 29m
Delta
Deal found 4/17![Delta logo]()
$307
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:29 am
STL
- SDF
1 stop5h 16m
American Airlines
Sun 5/177:01 pm
SDF
- STL
1 stop5h 55m
American Airlines
Deal found 4/19![American Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:22 pm
SGF
- SDF
1 stop4h 34m
United Airlines
Sun 5/247:10 am
SDF
- SGF
1 stop4h 32m
United Airlines
Deal found 4/19![United Airlines logo]()
$333
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:19 am
MCI
- SDF
1 stop4h 40m
Delta
Tue 5/197:50 am
SDF
- MCI
1 stop6h 28m
Delta
Deal found 4/17![Delta logo]()
$335
One-way flights from Missouri to LouisvilleSearch for one-way flight options from Missouri to Louisville. Find affordable one-way fares based on user searches. Data last updated April 20, 2026.
Search for one-way flight options from Missouri to Louisville. Find affordable one-way fares based on user searches. Data last updated April 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:16 pm
MCI
- SDF
2 stops40h 14m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:19 pm
MCI
- SDF
2 stops13h 17m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$129
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:25 am
MCI
- SDF
1 stop3h 25m
Southwest
Deal found 4/20![Southwest logo]()
$135
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:00 am
STL
- SDF
1 stop5h 08m
Delta
Deal found 4/19![Delta logo]()
$138
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/161:36 pm
MCI
- SDF
1 stop5h 14m
Delta
Deal found 4/20![Delta logo]()
$138
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/243:15 pm
STL
- SDF
2 stops6h 55m
Southwest
Deal found 4/16![Southwest logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:24 pm
MCI
- SDF
2 stops38h 04m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:34 pm
MCI
- SDF
3 stops41h 54m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$152
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:20 pm
STL
- SDF
1 stop5h 05m
Southwest
Deal found 4/20![Southwest logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:24 pm
MCI
- SDF
2 stops38h 04m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:24 pm
MCI
- SDF
2 stops40h 10m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/149:44 am
MCI
- SDF
1 stop9h 40m
Allegiant Air
Deal found 4/15![Allegiant Air logo]()
$162
Find flight deals from Missouri to Louisville
Keep the following information in mind while searching for Missouri to Louisville flight deals. Data was last updated April 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $270 (Southwest) |
One-way from | $125 (Kiwi.com) |
Popular in | June |
Cheapest in | May |
Average price | $508 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 20, 2026.
Use the filters below to find and compare flights from Missouri to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
St. LouisLouisville
STL - SDF
STLSDF
Lambert-St Louis
Tue 5/12
7:35 am-2:45 pm
1 stop6h 10m
Louisville Intl
Sat 5/16
6:40 am-8:25 am
1 stop2h 45m
$270
SpringfieldLouisville
SGF - SDF
SGFSDF
Springfield-Branson
Fri 5/8
5:19 am-10:46 am
1 stop4h 27m
Louisville Intl
Mon 5/11
7:55 pm-11:56 pm
1 stop5h 01m
$309
SpringfieldLouisville
SGF - SDF
SGFSDF
Springfield-Branson
Thu 5/14
6:52 pm-12:25 am
1 stop4h 33m
Louisville Intl
Wed 5/27
5:47 pm-10:19 pm
1 stop5h 32m
$309
JoplinLouisville
JLN - SDF
JLNSDF
Joplin
Sat 5/2
9:06 am-5:00 pm
1 stop6h 54m
Louisville Intl
Wed 5/6
9:10 am-1:37 pm
1 stop5h 27m
$314
Kansas CityLouisville
MCI - SDF
MCISDF
Kansas City
Tue 5/12
2:10 pm-8:35 pm
2 stops5h 25m
Louisville Intl
Sat 5/16
8:40 am-12:00 pm
1 stop4h 20m
$333
SpringfieldLouisville
SGF - SDF
SGFSDF
Springfield-Branson
Sun 5/17
6:22 pm-11:56 pm
1 stop4h 34m
Louisville Intl
Sun 5/24
7:10 am-10:42 am
1 stop4h 32m
$333
Kansas CityLouisville
MCI - SDF
MCISDF
Kansas City
Thu 5/7
8:44 am-8:24 pm
1 stop10h 40m
Louisville Intl
Fri 5/8
10:33 am-9:29 am
2 stops23h 56m
$336
St. LouisLouisville
STL - SDF
STLSDF
Lambert-St Louis
Wed 6/3
2:30 pm-9:05 pm
1 stop5h 35m
Louisville Intl
Sun 6/7
5:25 am-11:20 am
2 stops6h 55m
$340
Kansas CityLouisville
MCI - SDF
MCISDF
Kansas City
Sun 5/17
6:19 am-11:59 am
1 stop4h 40m
Louisville Intl
Tue 5/19
9:45 am-4:08 pm
1 stop7h 23m
$345
Kansas CityLouisville
MCI - SDF
MCISDF
Kansas City
Sat 5/9
1:50 pm-10:31 pm
1 stop7h 41m
Louisville Intl
Tue 5/12
3:36 pm-10:04 pm
1 stop7h 28m
$345
Showing 1-10 of 52 resultsSorted by cheapest first
Best time to book a flight from Missouri to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from Missouri with our price prediction graph.
STL-SDF
SGF-SDF
JLN-SDF
MCI-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Louisville
USMO-SDF
STL-SDF
SGF-SDF
JLN-SDF
MCI-SDF
What is the cheapest month to book a flight from Missouri to Louisville?
Currently, July is the cheapest month in which you can book a flight from Missouri to Louisville (average of $118). Flying from Missouri to Louisville in March is currently the most expensive (average of $298). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Louisville?
Related info for your journey
Find useful and relevant information for your journey from Missouri to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsShepherdsville
Elizabethtown
Corydon
Jeffersonville
Bardstown
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Louisville flight routes
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Top destinations
Alternative routes for Missouri to Louisville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Louisville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Louisville by cabin class
Find flights from Missouri to Louisville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Louisville
Explore flights to Louisville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 20, 2026.
Missouri and Louisville flights
Browse other Missouri and Louisville flight options. Last updated on April 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Louisville flights
Consider these flights traveling from Missouri to Louisville.
Top 3 airlines flying from Missouri to Louisville
Discover the top 3 airlines that operate flights from Missouri to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$191 | Average$446 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$196 | Average$370 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$310 | FlexibilityNo cancel fee | On-timeN/A |