$117+ Cheap flights from Missouri to Louisville (SDF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDF
Apr 7 — Apr 141
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Missouri to Louisville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Louisville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Missouri to LouisvilleExplore the most affordable flight options available from Missouri to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.
Explore the most affordable flight options available from Missouri to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:00 am
STL
- SDF
1 stop8h 18m
American Airlines
Wed 4/86:00 am
SDF
- STL
1 stop11h 00m
American Airlines
Deal found 3/4![American Airlines logo]()
$223
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:51 am
STL
- SDF
1 stop9h 14m
American Airlines
Sat 4/1811:16 am
SDF
- STL
1 stop6h 25m
American Airlines
Deal found 3/3![American Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:35 pm
STL
- SDF
1 stop4h 45m
Southwest
Sat 4/256:40 am
SDF
- STL
1 stop2h 45m
Southwest
Deal found 3/4![Southwest logo]()
$250
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:25 am
MCI
- SDF
1 stop3h 25m
Southwest
Wed 4/85:50 pm
SDF
- MCI
1 stop5h 50m
Southwest
Deal found 3/3![Southwest logo]()
$255
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/152:30 pm
STL
- SDF
2 stops7h 25m
Southwest
Sat 4/186:40 am
SDF
- STL
1 stop2h 45m
Southwest
Deal found 3/3![Southwest logo]()
$256
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1411:55 am
MCI
- SDF
2 stops7h 40m
Southwest
Sat 4/186:40 am
SDF
- MCI
2 stops6h 05m
Southwest
Deal found 3/3![Southwest logo]()
$265
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:10 am
STL
- SDF
2 stops7h 45m
Southwest
Wed 4/88:55 am
SDF
- STL
1 stop3h 35m
Southwest
Deal found 3/4![Southwest logo]()
$280
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:27 pm
STL
- SDF
1 stop8h 03m
American Airlines
Thu 4/169:00 am
SDF
- STL
1 stop8h 41m
American Airlines
Deal found 3/4![American Airlines logo]()
$290
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:54 pm
STL
- SDF
1 stop4h 31m
American Airlines
Wed 5/138:36 am
SDF
- STL
1 stop9h 05m
American Airlines
Deal found 3/3![American Airlines logo]()
$293
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/173:30 pm
SGF
- SDF
1 stop4h 21m
Delta
Sat 11/215:45 pm
SDF
- SGF
1 stop5h 47m
Delta
Deal found 3/4![Delta logo]()
$294
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:51 am
STL
- SDF
1 stop3h 55m
American Airlines
Sat 5/29:43 am
SDF
- STL
1 stop4h 39m
American Airlines
Deal found 3/6![American Airlines logo]()
$297
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:20 am
STL
- SDF
1 stop5h 35m
Southwest
Mon 4/205:45 am
SDF
- STL
1 stop6h 05m
Southwest
Deal found 3/4![Southwest logo]()
$299
Best flights from Missouri to LouisvilleDiscover carefully curated flight deals from Missouri to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 8, 2026.
Discover carefully curated flight deals from Missouri to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 8, 2026.
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:25 am
MCI
- SDF
1 stop3h 25m
Southwest
Sat 5/166:40 am
SDF
- MCI
1 stop3h 55m
Southwest
Deal found 3/3![Southwest logo]()
$255
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:54 pm
STL
- SDF
1 stop4h 31m
American Airlines
Wed 5/138:36 am
SDF
- STL
1 stop9h 05m
American Airlines
Deal found 3/3![American Airlines logo]()
$293
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/206:55 pm
SGF
- SDF
1 stop4h 02m
Delta
Tue 3/247:05 am
SDF
- SGF
1 stop5h 03m
Delta
Deal found 3/4![Delta logo]()
$299
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/129:14 am
STL
- SDF
1 stop10h 03m
United Airlines
Wed 5/137:15 am
SDF
- STL
1 stop14h 58m
United Airlines
Deal found 3/5![United Airlines logo]()
$303
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:25 am
MCI
- SDF
1 stop3h 25m
Southwest
Wed 4/85:50 pm
SDF
- MCI
1 stop5h 50m
Southwest
Deal found 3/3![Southwest logo]()
$255
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/152:30 pm
STL
- SDF
2 stops7h 25m
Southwest
Sat 4/186:40 am
SDF
- STL
1 stop2h 45m
Southwest
Deal found 3/3![Southwest logo]()
$256
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/182:05 pm
STL
- SDF
2 stops5h 45m
Southwest
Sat 4/255:35 am
SDF
- STL
2 stops9h 00m
Southwest
Deal found 3/4![Southwest logo]()
$265
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/221:54 pm
JLN
- SDF
1 stop7h 57m
United Airlines
Wed 8/269:00 am
SDF
- JLN
1 stop5h 18m
United Airlines
Deal found 3/4![United Airlines logo]()
$324
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:12 pm
MCI
- SDF
1 stop5h 47m
Delta
Wed 4/297:25 pm
SDF
- MCI
1 stop4h 36m
Delta
Deal found 3/6![Delta logo]()
$325
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:56 pm
MCI
- SDF
1 stop4h 00m
United Airlines
Sat 5/2310:00 am
SDF
- MCI
1 stop5h 45m
United Airlines
Deal found 3/3![United Airlines logo]()
$325
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:10 am
STL
- SDF
2 stops7h 45m
Southwest
Wed 4/88:55 am
SDF
- STL
1 stop3h 35m
Southwest
Deal found 3/4![Southwest logo]()
$280
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:38 pm
MCI
- SDF
1 stop4h 47m
Delta
Mon 5/117:50 pm
SDF
- MCI
1 stop4h 26m
Delta
Deal found 3/6![Delta logo]()
$343
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/46:50 pm
SGF
- SDF
1 stop4h 09m
United Airlines
Wed 4/85:00 am
SDF
- SGF
1 stop6h 48m
United Airlines
Deal found 3/4![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:38 pm
MCI
- SDF
1 stop4h 47m
Delta
Mon 6/87:30 pm
SDF
- MCI
1 stop5h 25m
Delta
Deal found 3/5![Delta logo]()
$359
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:40 am
STL
- SDF
1 stop3h 15m
Southwest
Wed 5/1312:10 pm
SDF
- STL
2 stops8h 50m
Southwest
Deal found 3/3![Southwest logo]()
$304
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:17 am
MCI
- SDF
1 stop6h 05m
United Airlines
Mon 5/115:52 pm
SDF
- MCI
1 stop6h 39m
United Airlines
Deal found 3/5![United Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2010:21 am
SGF
- SDF
1 stop10h 09m
American Airlines
Wed 4/2211:16 am
SDF
- SGF
1 stop10h 49m
American Airlines
Deal found 3/4![American Airlines logo]()
$463
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:25 am
STL
- SDF
1 stop3h 40m
Southwest
Thu 4/167:30 am
SDF
- STL
2 stops8h 55m
Southwest
Deal found 3/4![Southwest logo]()
$304
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/910:30 am
SGF
- SDF
1 stop10h 46m
American Airlines
Mon 7/137:20 pm
SDF
- SGF
1 stop4h 19m
American Airlines
Deal found 3/6![American Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/310:21 am
SGF
- SDF
1 stop7h 11m
American Airlines
Sun 5/176:00 am
SDF
- SGF
1 stop4h 51m
American Airlines
Deal found 3/5![American Airlines logo]()
$507
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/132:05 pm
MCI
- SDF
2 stops6h 40m
Southwest
Tue 4/148:55 am
SDF
- MCI
2 stops6h 40m
Southwest
Deal found 3/3![Southwest logo]()
$347
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:05 am
SGF
- SDF
1 stop6h 06m
Delta
Sun 5/171:00 pm
SDF
- SGF
1 stop6h 06m
Delta
Deal found 3/5![Delta logo]()
$498
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/245:15 pm
MCI
- SDF
1 stop6h 15m
Southwest
Wed 5/274:40 pm
SDF
- MCI
2 stops6h 50m
Southwest
Deal found 3/3![Southwest logo]()
$360
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2611:55 am
MCI
- SDF
2 stops7h 40m
Southwest
Fri 5/2912:20 pm
SDF
- MCI
2 stops10h 45m
Southwest
Deal found 3/3![Southwest logo]()
$366
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:00 am
SGF
- SDF
2 stops12h 42m
United Airlines
Mon 5/113:30 pm
SDF
- SGF
1 stop8h 02m
United Airlines
Deal found 3/5![United Airlines logo]()
$583
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:45 am
SGF
- SDF
1 stop4h 32m
United Airlines
Fri 3/275:45 pm
SDF
- SGF
1 stop21h 53m
United Airlines
Deal found 3/6![United Airlines logo]()
$589
Last-minute flights from Missouri to LouisvilleDiscover last-minute flight deals from Missouri to Louisville. Data last updated March 8, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Louisville. Data last updated March 8, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/206:55 pm
SGF
- SDF
1 stop4h 02m
Delta
Tue 3/247:05 am
SDF
- SGF
1 stop5h 03m
Delta
Deal found 3/4![Delta logo]()
$299
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:00 am
STL
- SDF
1 stop8h 18m
American Airlines
Wed 4/86:00 am
SDF
- STL
1 stop11h 00m
American Airlines
Deal found 3/4![American Airlines logo]()
$223
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:10 am
STL
- SDF
2 stops7h 45m
Southwest
Wed 4/88:55 am
SDF
- STL
1 stop3h 35m
Southwest
Deal found 3/4![Southwest logo]()
$280
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:25 am
MCI
- SDF
1 stop3h 25m
Southwest
Wed 4/85:50 pm
SDF
- MCI
1 stop5h 50m
Southwest
Deal found 3/3![Southwest logo]()
$255
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1411:55 am
MCI
- SDF
2 stops7h 40m
Southwest
Sat 4/186:40 am
SDF
- MCI
2 stops6h 05m
Southwest
Deal found 3/3![Southwest logo]()
$265
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:27 pm
STL
- SDF
1 stop8h 03m
American Airlines
Thu 4/169:00 am
SDF
- STL
1 stop8h 41m
American Airlines
Deal found 3/4![American Airlines logo]()
$290
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:25 am
STL
- SDF
1 stop3h 40m
Southwest
Thu 4/167:30 am
SDF
- STL
2 stops8h 55m
Southwest
Deal found 3/4![Southwest logo]()
$304
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:51 am
STL
- SDF
1 stop9h 14m
American Airlines
Sat 4/1811:16 am
SDF
- STL
1 stop6h 25m
American Airlines
Deal found 3/3![American Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/152:30 pm
STL
- SDF
2 stops7h 25m
Southwest
Sat 4/186:40 am
SDF
- STL
1 stop2h 45m
Southwest
Deal found 3/3![Southwest logo]()
$256
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:35 pm
STL
- SDF
1 stop4h 45m
Southwest
Sat 4/256:40 am
SDF
- STL
1 stop2h 45m
Southwest
Deal found 3/4![Southwest logo]()
$250
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:20 am
STL
- SDF
1 stop5h 35m
Southwest
Mon 4/205:45 am
SDF
- STL
1 stop6h 05m
Southwest
Deal found 3/4![Southwest logo]()
$299
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:51 am
STL
- SDF
1 stop3h 55m
American Airlines
Sat 5/29:43 am
SDF
- STL
1 stop4h 39m
American Airlines
Deal found 3/6![American Airlines logo]()
$297
One-way flights from Missouri to LouisvilleSearch for one-way flight options from Missouri to Louisville. Find affordable one-way fares based on user searches. Data last updated March 8, 2026.
Search for one-way flight options from Missouri to Louisville. Find affordable one-way fares based on user searches. Data last updated March 8, 2026.
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:05 am
STL
- SDF
1 stop8h 00m
American Airlines
Deal found 3/3![American Airlines logo]()
$117
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:45 am
STL
- SDF
2 stops8h 00m
Southwest
Deal found 3/3![Southwest logo]()
$133
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:49 am
MCI
- SDF
1 stop4h 53m
Delta
Deal found 3/4![Delta logo]()
$138
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/281:40 pm
MCI
- SDF
2 stops6h 25m
Southwest
Deal found 3/6![Southwest logo]()
$143
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:10 am
MCI
- SDF
1 stop5h 21m
Delta
Deal found 3/5![Delta logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/712:24 pm
MCI
- SDF
2 stops21h 50m
Spirit Airlines
Deal found 3/7![Spirit Airlines logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3112:24 pm
MCI
- SDF
2 stops21h 50m
Spirit Airlines
Deal found 3/4![Spirit Airlines logo]()
$159
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:40 pm
MCI
- SDF
2 stops6h 25m
Southwest
Deal found 3/3![Southwest logo]()
$163
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:30 am
MCI
- SDF
1 stop6h 21m
Delta
Deal found 3/3![Delta logo]()
$168
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/44:02 pm
MCI
- SDF
1 stop6h 07m
Delta
Deal found 3/5![Delta logo]()
$172
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:33 am
MCI
- SDF
2 stops9h 05m
American Airlines
Deal found 3/4![American Airlines logo]()
$173
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:20 am
MCI
- SDF
2 stops6h 40m
Southwest
Deal found 3/5![Southwest logo]()
$177
Find flight deals from Missouri to Louisville
Keep the following information in mind while searching for Missouri to Louisville flight deals. Data was last updated March 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $223 (American Airlines) |
One-way from | $117 (American Airlines) |
Popular in | July |
Cheapest in | April |
Average price | $550 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
Use the filters below to find and compare flights from Missouri to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Kansas CityLouisville
MCI - SDF
MCISDF
Kansas City
Wed 5/13
5:25 am-9:50 am
1 stop3h 25m
Louisville Intl
Sat 5/16
6:40 am-9:35 am
1 stop3h 55m
$255
Kansas CityLouisville
MCI - SDF
MCISDF
Kansas City
Wed 4/8
5:25 am-9:50 am
1 stop3h 25m
Louisville Intl
Wed 4/8
5:50 pm-10:40 pm
1 stop5h 50m
$255
St. LouisLouisville
STL - SDF
STLSDF
Lambert-St Louis
Wed 4/15
2:30 pm-10:55 pm
2 stops7h 25m
Louisville Intl
Sat 4/18
6:40 am-8:25 am
1 stop2h 45m
$256
St. LouisLouisville
STL - SDF
STLSDF
Lambert-St Louis
Sat 4/18
2:05 pm-8:50 pm
2 stops5h 45m
Louisville Intl
Sat 4/25
5:35 am-1:35 pm
2 stops9h 00m
$265
St. LouisLouisville
STL - SDF
STLSDF
Lambert-St Louis
Wed 4/1
6:10 am-2:55 pm
2 stops7h 45m
Louisville Intl
Wed 4/8
8:55 am-11:30 am
1 stop3h 35m
$280
St. LouisLouisville
STL - SDF
STLSDF
Lambert-St Louis
Mon 5/11
6:54 pm-12:25 am
1 stop4h 31m
Louisville Intl
Wed 5/13
8:36 am-4:41 pm
1 stop9h 05m
$293
SpringfieldLouisville
SGF - SDF
SGFSDF
Springfield-Branson
Fri 3/20
6:55 pm-11:57 pm
1 stop4h 02m
Louisville Intl
Tue 3/24
7:05 am-11:08 am
1 stop5h 03m
$299
St. LouisLouisville
STL - SDF
STLSDF
Lambert-St Louis
Tue 5/12
9:14 am-8:17 pm
1 stop10h 03m
Louisville Intl
Wed 5/13
7:15 am-9:13 pm
1 stop14h 58m
$303
St. LouisLouisville
STL - SDF
STLSDF
Lambert-St Louis
Mon 5/11
5:40 am-9:55 am
1 stop3h 15m
Louisville Intl
Wed 5/13
12:10 pm-8:00 pm
2 stops8h 50m
$304
St. LouisLouisville
STL - SDF
STLSDF
Lambert-St Louis
Tue 4/14
10:25 am-3:05 pm
1 stop3h 40m
Louisville Intl
Thu 4/16
7:30 am-3:25 pm
2 stops8h 55m
$304
Showing 1-10 of 51 resultsSorted by cheapest first
Best time to book a flight from Missouri to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from Missouri with our price prediction graph.
STL-SDF
MCI-SDF
SGF-SDF
JLN-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Louisville
USMO-SDF
STL-SDF
MCI-SDF
SGF-SDF
JLN-SDF
What is the cheapest month to book a flight from Missouri to Louisville?
Currently, November is the cheapest month in which you can book a flight from Missouri to Louisville (average of $146). Flying from Missouri to Louisville in January is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsShepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Louisville flight routes
Other flight options
Popular flights
Top destinations
Alternative routes for Missouri to Louisville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Louisville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Louisville by cabin class
Find flights from Missouri to Louisville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Louisville
Explore flights to Louisville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 8, 2026.
Missouri and Louisville flights
Browse other Missouri and Louisville flight options. Last updated on March 8, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Louisville flights
Consider these flights traveling from Missouri to Louisville.
Top 3 airlines flying from Missouri to Louisville
Discover the top 3 airlines that operate flights from Missouri to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$118 | Average$361 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$196 | Average$312 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$216 | Average$482 | FlexibilityNo cancel fee | On-time63% |