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$284+ Cheap flights from Biloxi, MS to Louisville (SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/7. Fares are subject to change and may not be available on all flights or dates of travel.
MSY — SDF
Apr 22 — Apr 291
Wed 4/22
Wed 4/29
1 adult, Economy
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Cheap flight deals from Biloxi to Louisville

Cheapest flights from Biloxi to Louisville
Explore the most affordable flight options available from Biloxi to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.

This Delta deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/235:55 pm
GPT
-
SDF
1 stop5h 04m
Delta
Mon 4/275:36 pm
SDF
-
GPT
1 stop5h 37m
Delta
Deal found 3/20$327
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/256:00 am
GPT
-
SDF
1 stop4h 36m
Delta
Sun 6/286:00 am
SDF
-
GPT
1 stop4h 37m
Delta
Deal found 3/19$328
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/35:57 pm
GPT
-
SDF
1 stop5h 00m
Delta
Tue 4/75:35 pm
SDF
-
GPT
1 stop5h 40m
Delta
Deal found 3/19$339
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:29 pm
GPT
-
SDF
1 stop6h 58m
American Airlines
Tue 4/71:18 pm
SDF
-
GPT
2 stops11h 08m
American Airlines
Deal found 3/19$344
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:09 pm
GPT
-
SDF
1 stop5h 16m
American Airlines
Mon 4/277:31 am
SDF
-
GPT
2 stops11h 02m
American Airlines
Deal found 3/22$384
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:00 am
GPT
-
SDF
1 stop6h 41m
American Airlines
Tue 6/21:21 pm
SDF
-
GPT
1 stop6h 58m
American Airlines
Deal found 3/21$391
This United Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/222:00 pm
GPT
-
SDF
1 stop5h 00m
United Airlines
Tue 8/259:30 am
SDF
-
GPT
1 stop7h 32m
United Airlines
Deal found 3/19$407

Find flight deals from Biloxi to Louisville

Keep the following information in mind while searching for Biloxi to Louisville flight deals. Data was last updated March 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$327
(Delta)

One-way from

$284
(American Airlines)

Popular in

October

Cheapest in

August
Provider with most accurate pricing for Gulfport Biloxi Regional-Louisville Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Gulfport Biloxi Regional-Louisville Intl flights.
Search Deals
From Biloxi to Louisville Intl
Search Deals
One-way flight from Biloxi to Louisville Intl
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($55 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($47 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Biloxi to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Biloxi to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

GulfportLouisville

GPT - SDF

GPTSDF

Gulfport Biloxi Regional

Thu 4/23

5:55 pm-11:59 pm

1 stop5h 04m

Louisville Intl

Mon 4/27

6:00 am-9:24 am

1 stop4h 24m

$327

GulfportLouisville

GPT - SDF

GPTSDF

Gulfport Biloxi Regional

Sat 5/30

6:32 am-11:53 am

1 stop4h 21m

Louisville Intl

Tue 6/2

1:00 pm-5:14 pm

1 stop5h 14m

$327

GulfportLouisville

GPT - SDF

GPTSDF

Gulfport Biloxi Regional

Fri 4/3

5:57 pm-11:57 pm

1 stop5h 00m

Louisville Intl

Tue 4/7

5:35 pm-10:15 pm

1 stop5h 40m

$339

GulfportLouisville

GPT - SDF

GPTSDF

Gulfport Biloxi Regional

Sat 5/30

5:00 am-12:41 pm

1 stop6h 41m

Louisville Intl

Tue 6/2

1:21 pm-7:19 pm

1 stop6h 58m

$391

GulfportLouisville

GPT - SDF

GPTSDF

Gulfport Biloxi Regional

Sat 8/22

2:00 pm-8:00 pm

1 stop5h 00m

Louisville Intl

Tue 8/25

9:30 am-1:26 pm

1 stop4h 56m

$407
Cheapest one-way
Quickest one-way

GulfportLouisville

GPT - SDF

GPTSDF

Gulfport Biloxi Regional

Tue 4/7

5:49 pm-11:30 pm

1 stop4h 41m

$284

GulfportLouisville

GPT - SDF

GPTSDF

Gulfport Biloxi Regional

Tue 4/7

7:10 am-2:31 pm

3 stops30h 21m

$639

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/20

Sorted by cheapest first

Best time to book a flight from Biloxi to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Biloxi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Biloxi to Louisville

What is the cheapest month to book a flight from Biloxi to Louisville?

Currently, February is the cheapest month in which you can book a flight from Biloxi to Louisville (average of $70). Flying from Biloxi to Louisville in January is currently the most expensive (average of $220). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated March 23, 2026.
Get a feel of what it's like to fly with Delta from Biloxi to Louisville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,319 reviews

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Boarding

8.1

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,319 reviews
Delta
7.9
Good
8,319 reviews

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Boarding

8.1

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Biloxi to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Louisville from Biloxi?

    Louisville Intl (SDF), located 5.3 mi from the city center, is the airport you fly into when you book flights from Biloxi to Louisville. 5 airlines have flights to Louisville Intl from Biloxi on a regular basis. Booking flights from Biloxi to Louisville Intl should not be difficult; the airport handles an average of 0 inbound flights from Biloxi per day.

  • How long is the flight from Biloxi to Louisville?

    Departing from Biloxi to Louisville will take you 5h 04m. Airlines will cover a distance of 569 mi.

  • Can I find deals for flights from Biloxi to Louisville that include hotel bookings?

    Yes. In addition to deals on Biloxi to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Biloxi to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Biloxi to Louisville.

  • Can I find deals for business class flights from Biloxi to Louisville?

    Yes. Cheapflights offers flight deals from Biloxi to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Biloxi to Louisville?

    Currently, February is the cheapest month in which you can book a flight from Biloxi to Louisville (average of $70). Flying from Biloxi to Louisville in January is currently the most expensive (average of $220). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Top 5 airlines flying from Biloxi to Louisville

Discover the top 5 airlines that operate flights from Biloxi to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$188Average$230FlexibilityNo cancel feeOn-time65%
Breeze AirwaysCheapest$211Average$284FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$226Average$335FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$272Average$506FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$287Average$386FlexibilityNo cancel feeOn-time71%

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