$497+ Cheap flights from Detroit Metropolitan Wayne County Airport to La Crosse (DTW - LSE)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — LSE
Nov 23 — Nov 301
Round-trip
1 adult, Economy
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Find cheap flights from Detroit to La Crosse with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to La Crosse
Cheapest
Best
Last-minute
Cheapest flights from Detroit to La CrosseExplore the most affordable flight options available from Detroit to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
Explore the most affordable flight options available from Detroit to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:31 am -
1 stop6h 08m
Mon 12/287:05 pm -
1 stop3h 48m
Deal found 10/21![American Airlines logo]()
$497
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:15 am -
2 stops28h 51m
Sun 11/811:21 am -
1 stop20h 31m
Deal found 10/21![Multiple Airlines logo]()
$559
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop14h 11m
Sun 10/2511:11 am -
1 stop29h 45m
Deal found 10/19![Multiple Airlines logo]()
$591
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:42 am -
1 stop6h 11m
Tue 11/105:57 am -
1 stop6h 02m
Deal found 10/22![American Airlines logo]()
$640
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/19:12 pm -
1 stop15h 27m
Thu 12/312:09 pm -
1 stop8h 22m
Deal found 10/19![American Airlines logo]()
$734
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:30 am -
2 stops11h 46m
Sun 11/85:57 am -
2 stops10h 03m
Deal found 10/21![American Airlines logo]()
$865
Best flights from Detroit to La CrosseDiscover carefully curated flight deals from Detroit to La Crosse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
Discover carefully curated flight deals from Detroit to La Crosse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:31 am -
1 stop6h 08m
Mon 12/287:05 pm -
1 stop3h 48m
Deal found 10/23![American Airlines logo]()
$497
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:15 am -
2 stops28h 51m
Sun 11/811:21 am -
1 stop20h 31m
Deal found 10/21![Multiple Airlines logo]()
$559
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:42 am -
1 stop6h 11m
Tue 11/105:57 am -
1 stop6h 02m
Deal found 10/22![American Airlines logo]()
$640
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/54:06 pm -
1 stop3h 48m
Fri 4/96:37 pm -
1 stop13h 36m
Deal found 10/19![American Airlines logo]()
$721
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Tue 12/19:12 pm -
1 stop15h 27m
Thu 12/312:09 pm -
1 stop8h 22m
Deal found 10/19![American Airlines logo]()
$734
Last-minute flights from Detroit to La CrosseDiscover last-minute flight deals from Detroit to La Crosse. Data last updated October 24, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to La Crosse. Data last updated October 24, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop14h 11m
Sun 10/2511:11 am -
1 stop29h 45m
Deal found 10/19![Multiple Airlines logo]()
$591
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:05 am -
2 stops9h 15m
Sun 10/2512:23 pm -
2 stops11h 12m
Deal found 10/19![American Airlines logo]()
$963
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:15 am -
2 stops28h 51m
Sun 11/811:21 am -
1 stop20h 31m
Deal found 10/21![Multiple Airlines logo]()
$559
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:30 am -
2 stops11h 46m
Sun 11/85:57 am -
2 stops10h 03m
Deal found 10/21![American Airlines logo]()
$865
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:42 am -
1 stop6h 11m
Tue 11/105:57 am -
1 stop6h 02m
Deal found 10/22![American Airlines logo]()
$640
Find flight deals from Detroit to La Crosse
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to La Crosse (LSE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $497 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to La Crosse that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
DetroitLa Crosse
DTW Detroit Metropolitan Wayne County - LSE La Crosse
DTWLSE
Detroit Metropolitan Wayne County
Wed 12/16
6:31 am-11:39 am
1 stop6h 08m
La Crosse
Mon 12/28
7:05 pm-11:53 pm
1 stop3h 48m
$497
DetroitLa Crosse
DTW Detroit Metropolitan Wayne County - LSE La Crosse
DTWLSE
Detroit Metropolitan Wayne County
Thu 11/5
7:15 am-11:06 am
2 stops28h 51m
La Crosse
Sun 11/8
11:21 am-8:52 am
1 stop20h 31m
$559
DetroitLa Crosse
DTW Detroit Metropolitan Wayne County - LSE La Crosse
DTWLSE
Detroit Metropolitan Wayne County
Fri 11/6
6:42 am-11:53 am
1 stop6h 11m
La Crosse
Tue 11/10
5:57 am-12:59 pm
1 stop6h 02m
$640
DetroitLa Crosse
DTW Detroit Metropolitan Wayne County - LSE La Crosse
DTWLSE
Detroit Metropolitan Wayne County
Mon 4/5
4:06 pm-6:54 pm
1 stop3h 48m
La Crosse
Fri 4/9
6:37 pm-9:13 am
1 stop13h 36m
$721
DetroitLa Crosse
DTW Detroit Metropolitan Wayne County - LSE La Crosse
DTWLSE
Detroit Metropolitan Wayne County
Tue 12/1
9:12 pm-11:39 am
1 stop15h 27m
La Crosse
Thu 12/3
12:09 pm-9:31 pm
1 stop8h 22m
$734
Sorted by cheapest first
Compare providers for flights from Detroit to La Crosse
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to La Crosse in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-La Crosse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit Metropolitan Wayne County Airport-La Crosse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-La Crosse flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-La Crosse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-La Crosse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to La Crosse
Have a flexible travel schedule? Discover the best time to fly to La Crosse from Detroit with our price prediction graph.
DTW-LSE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Detroit to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near La Crosse?
Book flights to La Crosse if you plan to visit one of these locationsDecorah
Winona
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