$532+ Cheap flights from Detroit Metropolitan Wayne County Airport to La Crosse (DTW - LSE)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/1. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — LSE
Oct 10 — Oct 171
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to La Crosse
Cheapest
Best
Last-minute
Cheapest flights from Detroit to La CrosseExplore the most affordable flight options available from Detroit to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Detroit to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:56 pm -
1 stop12h 24m
Sun 10/412:26 pm -
1 stop20h 04m
Deal found 9/6![American Airlines logo]()
$532
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:36 am -
1 stop18h 44m
Sun 10/412:26 pm -
1 stop20h 04m
Deal found 9/6![American Airlines logo]()
$575
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/248:21 am -
1 stop4h 01m
Sun 9/275:22 pm -
1 stop5h 12m
Deal found 9/6![American Airlines logo]()
$670
Best flights from Detroit to La CrosseDiscover carefully curated flight deals from Detroit to La Crosse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Detroit to La Crosse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:36 am -
1 stop18h 44m
Sun 10/412:26 pm -
1 stop20h 04m
Deal found 9/6![American Airlines logo]()
$575
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:56 pm -
1 stop12h 24m
Sun 10/412:26 pm -
2 stops11h 00m
Deal found 9/6![American Airlines logo]()
$632
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:30 am -
2 stops10h 22m
Sun 9/275:22 pm -
1 stop5h 12m
Deal found 9/6![American Airlines logo]()
$676
Last-minute flights from Detroit to La CrosseDiscover last-minute flight deals from Detroit to La Crosse. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to La Crosse. Data last updated September 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/248:21 am -
1 stop4h 01m
Sun 9/275:22 pm -
1 stop5h 12m
Deal found 9/6![American Airlines logo]()
$670
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:36 am -
1 stop18h 44m
Sun 10/412:26 pm -
1 stop20h 04m
Deal found 9/6![American Airlines logo]()
$575
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:56 pm -
1 stop12h 24m
Sun 10/412:26 pm -
1 stop20h 04m
Deal found 9/6![American Airlines logo]()
$532
Find flight deals from Detroit to La Crosse
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to La Crosse (LSE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 10, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $532 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to La Crosse that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitLa Crosse
DTW Detroit Metropolitan Wayne County - LSE La Crosse
DTWLSE
Detroit Metropolitan Wayne County
Sun 9/27
6:36 am-12:20 am
1 stop18h 44m
La Crosse
Sun 10/4
12:26 pm-9:30 am
1 stop20h 04m
$575
DetroitLa Crosse
DTW Detroit Metropolitan Wayne County - LSE La Crosse
DTWLSE
Detroit Metropolitan Wayne County
Thu 10/1
12:56 pm-12:20 am
1 stop12h 24m
La Crosse
Sun 10/4
12:26 pm-12:26 am
2 stops11h 00m
$632
Quickest round-trip
DetroitLa Crosse
DTW Detroit Metropolitan Wayne County - LSE La Crosse
DTWLSE
Detroit Metropolitan Wayne County
Fri 9/25
7:30 am-4:52 pm
2 stops10h 22m
La Crosse
Sun 9/27
5:22 pm-11:34 pm
1 stop5h 12m
$676
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-La Crosse flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Detroit Metropolitan Wayne County Airport-La Crosse flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-La Crosse flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-La Crosse flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-La Crosse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to La Crosse
Have a flexible travel schedule? Discover the best time to fly to La Crosse from Detroit with our price prediction graph.
DTW-LSE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Detroit to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near La Crosse?
Book flights to La Crosse if you plan to visit one of these locationsDecorah
Winona
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