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$289+ Cheap flights from Missoula to Knoxville (MSO - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
MSO — TYS
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Missoula to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Missoula (MSO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$289
(American Airlines)

Popular in

May

Cheapest in

August

Average price

$264
From Missoula Johnson-Bell Field to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 31% potential increase in price ($269 potential increase over avg. RT price).
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Cheapest flight prices on average. 10% potential price decrease ($59 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Missoula to Knoxville

Cheapest flights from Missoula to Knoxville
Explore the most affordable flight options available from Missoula to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/251:50 pmMSO - TYS
1 stop8h 01mAmerican Airlines
Wed 10/14:49 pmTYS - MSO
1 stop8h 29mAmerican Airlines
Deal found 8/14$289
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/186:25 amMSO - TYS
1 stop6h 41mUnited Airlines
Sat 10/254:40 pmTYS - MSO
1 stop6h 46mUnited Airlines
Deal found 8/13$343
This Delta deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:20 pmMSO - TYS
2 stops13h 24mDelta
Mon 9/291:52 pmTYS - MSO
2 stops12h 26mDelta
Deal found 8/11$354
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2512:50 pmMSO - TYS
2 stops9h 17mAmerican Airlines
Mon 9/292:08 pmTYS - MSO
2 stops11h 10mAmerican Airlines
Deal found 8/11$470
This Alaska Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/254:14 pmMSO - TYS
2 stops16h 37mAlaska Airlines
Wed 10/12:07 pmTYS - MSO
2 stops12h 20mAlaska Airlines
Deal found 8/14$574
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:25 amMSO - TYS
1 stop6h 41mUnited Airlines
Wed 10/17:00 amTYS - MSO
1 stop6h 50mUnited Airlines
Deal found 8/14$603
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/217:00 amMSO - TYS
1 stop8h 28mAmerican Airlines
Sun 11/3012:08 pmTYS - MSO
1 stop9h 47mAmerican Airlines
Deal found 8/12$920
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:20 pmMSO - TYS
2 stops13h 00mDelta
Sun 11/212:47 pmTYS - MSO
2 stops13h 30mDelta
Deal found 8/14$934
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:25 amMSO - TYS
1 stop6h 18mUnited Airlines
Sun 11/24:55 pmTYS - MSO
1 stop6h 52mUnited Airlines
Deal found 8/13$978

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missoula to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Missoula to Knoxville that are best for you.

Fly from

Missoula

Fly to

Knoxville

Route

Depart

Return

Price

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 9/25

1:50 pm-11:51 pm

1 stop8h 01m

Knoxville McGhee Tyson

Wed 10/1

4:49 pm-11:18 pm

1 stop8h 29m

$289

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 9/25

1:50 pm-11:51 pm

1 stop8h 01m

Knoxville McGhee Tyson

Mon 9/29

6:00 am-1:00 pm

1 stop9h 00m

$289

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 10/18

6:25 am-3:06 pm

1 stop6h 41m

Knoxville McGhee Tyson

Sat 10/25

4:40 pm-9:26 pm

1 stop6h 46m

$343

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 9/25

6:20 pm-9:44 am

2 stops13h 24m

Knoxville McGhee Tyson

Mon 9/29

1:52 pm-12:18 am

2 stops12h 26m

$354

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 10/18

6:20 pm-9:20 am

2 stops13h 00m

Knoxville McGhee Tyson

Sat 10/25

12:47 pm-11:13 pm

2 stops12h 26m

$354

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 9/25

2:14 pm-10:51 am

2 stops18h 37m

Knoxville McGhee Tyson

Wed 10/1

2:07 pm-12:27 am

2 stops12h 20m

$574

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Best time to book a flight from Missoula to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missoula with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missoula to Knoxville

What is the cheapest month to book a flight from Missoula to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Missoula to Knoxville (average of $294). Flying from Missoula to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 14, 2025.
Read through reviews of airlines operating flights from Missoula to Knoxville, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,916 reviews

Crew

8.1

Comfort

7.3

Overall

7.4

Entertainment

7.1

Boarding

7.7

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
United Airlines
7.4
Good
8,916 reviews
United Airlines
7.4
Good
8,916 reviews

Crew

8.1

Comfort

7.3

Overall

7.4

Entertainment

7.1

Boarding

7.7

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,916 reviews

Crew

8.1

Comfort

7.3

Overall

7.4

Entertainment

7.1

Boarding

7.7

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from Missoula to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Missoula to Knoxville round-trip?

    Currently priced at $240, American Airlines will fly you from Missoula to Knoxville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on United Airlines for as low as $360. These flights start at 59% lower than the current average price 3 months from now.

  • Can I find deals for flights from Missoula to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missoula to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missoula to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missoula to Knoxville.

  • Can I find deals for business class flights from Missoula to Knoxville?

    Yes. Cheapflights offers flight deals from Missoula to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missoula to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Missoula to Knoxville (average of $294). Flying from Missoula to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Missoula to Knoxville

Discover the top 2 airlines that operate flights from Missoula to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$240Average$443FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$360Average$643FlexibilityNo cancel feeOn-time69%

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