$359+ Cheap flights from Missoula to Knoxville (MSO - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
MSO — TYS
Oct 7 — Oct 141
Round-trip
1 adult, Economy
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Find cheap flights from Missoula to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missoula to Knoxville
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Best
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Cheapest flights from Missoula to KnoxvilleExplore the most affordable flight options available from Missoula to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
Explore the most affordable flight options available from Missoula to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:05 pm -
1 stop8h 13m
Mon 11/27:52 am -
1 stop6h 44m
Deal found 9/4![American Airlines logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:39 pm -
1 stop22h 13m
Thu 11/126:30 am -
2 stops11h 55m
Deal found 9/3![Multiple Airlines logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/209:49 pm -
1 stop15h 39m
Thu 9/248:20 am -
1 stop14h 39m
Deal found 9/5![Allegiant Air logo]()
$512
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:18 pm -
1 stop8h 29m
Sun 11/227:39 am -
1 stop7h 09m
Deal found 9/3![American Airlines logo]()
$532
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/231:48 pm -
1 stop8h 11m
Mon 10/265:07 pm -
1 stop21h 28m
Deal found 9/5![American Airlines logo]()
$537
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/231:48 pm -
1 stop8h 11m
Sun 10/256:55 pm -
1 stop19h 40m
Deal found 9/5![American Airlines logo]()
$602
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:13 pm -
1 stop26h 36m
Sun 10/256:30 am -
2 stops15h 19m
Deal found 9/5![Multiple Airlines logo]()
$674
Best flights from Missoula to KnoxvilleDiscover carefully curated flight deals from Missoula to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
Discover carefully curated flight deals from Missoula to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/209:49 pm -
1 stop15h 39m
Thu 9/248:20 am -
1 stop14h 39m
Deal found 9/5![Allegiant Air logo]()
$512
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:18 pm -
1 stop8h 29m
Sun 11/227:39 am -
1 stop7h 09m
Deal found 9/3![American Airlines logo]()
$532
This Alaska Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:03 am -
2 stops14h 15m
Fri 10/235:07 pm -
2 stops21h 19m
Deal found 9/3![Alaska Airlines logo]()
$761
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/92:38 pm -
2 stops17h 07m
Tue 10/136:00 am -
1 stop7h 32m
Deal found 9/6![United Airlines logo]()
$762
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/231:48 pm -
1 stop8h 11m
Sun 10/256:55 pm -
1 stop19h 40m
Deal found 9/5![American Airlines logo]()
$602
This Alaska Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:06 pm -
2 stops18h 59m
Wed 10/286:00 am -
2 stops18h 54m
Deal found 9/3![Alaska Airlines logo]()
$767
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:28 pm -
1 stop6h 21m
Sun 10/116:00 am -
1 stop7h 32m
Deal found 9/3![United Airlines logo]()
$780
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:00 am -
2 stops12h 45m
Mon 9/214:50 pm -
1 stop6h 44m
Deal found 9/4![United Airlines logo]()
$786
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:48 pm -
1 stop26h 32m
Sun 10/255:07 pm -
1 stop21h 28m
Deal found 9/5![American Airlines logo]()
$803
Last-minute flights from Missoula to KnoxvilleDiscover last-minute flight deals from Missoula to Knoxville. Data last updated September 7, 2026 and is based on user searches.
Discover last-minute flight deals from Missoula to Knoxville. Data last updated September 7, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/209:49 pm -
1 stop15h 39m
Thu 9/248:20 am -
1 stop14h 39m
Deal found 9/5![Allegiant Air logo]()
$512
This Alaska Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:03 am -
2 stops14h 15m
Fri 10/235:07 pm -
2 stops21h 19m
Deal found 9/3![Alaska Airlines logo]()
$761
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:13 pm -
1 stop26h 36m
Sun 10/256:30 am -
2 stops15h 19m
Deal found 9/5![Multiple Airlines logo]()
$674
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:48 pm -
1 stop26h 32m
Sun 10/257:58 pm -
2 stops18h 37m
Deal found 9/5![American Airlines logo]()
$757
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/231:48 pm -
1 stop8h 11m
Mon 10/265:07 pm -
1 stop21h 28m
Deal found 9/5![American Airlines logo]()
$537
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/231:48 pm -
1 stop8h 11m
Sun 10/256:55 pm -
1 stop19h 40m
Deal found 9/5![American Airlines logo]()
$602
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:05 pm -
1 stop8h 13m
Mon 11/27:52 am -
1 stop6h 44m
Deal found 9/4![American Airlines logo]()
$359
Find flight deals from Missoula to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Missoula (MSO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $359 (American Airlines) |
Popular in | January |
Cheapest in | July |
Average price | $449 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missoula to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
Use the filters below to find and compare flights from Missoula to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MissoulaKnoxville
MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson
MSOTYS
Missoula Johnson-Bell Field
Sun 9/20
9:49 pm-3:28 pm
1 stop15h 39m
Knoxville McGhee Tyson
Thu 9/24
8:20 am-8:59 pm
1 stop14h 39m
$512
MissoulaKnoxville
MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson
MSOTYS
Missoula Johnson-Bell Field
Thu 11/19
1:18 pm-11:47 pm
1 stop8h 29m
Knoxville McGhee Tyson
Sun 11/22
7:39 am-12:48 pm
1 stop7h 09m
$532
MissoulaKnoxville
MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson
MSOTYS
Missoula Johnson-Bell Field
Fri 10/23
1:48 pm-11:59 pm
1 stop8h 11m
Knoxville McGhee Tyson
Sun 10/25
6:55 pm-12:35 pm
1 stop19h 40m
$602
MissoulaKnoxville
MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson
MSOTYS
Missoula Johnson-Bell Field
Tue 10/20
7:03 am-11:18 pm
2 stops14h 15m
Knoxville McGhee Tyson
Fri 10/23
5:07 pm-12:26 pm
2 stops21h 19m
$761
MissoulaKnoxville
MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson
MSOTYS
Missoula Johnson-Bell Field
Fri 10/9
2:38 pm-9:45 am
2 stops17h 07m
Knoxville McGhee Tyson
Tue 10/13
6:00 am-11:32 am
1 stop7h 32m
$762
MissoulaKnoxville
MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson
MSOTYS
Missoula Johnson-Bell Field
Sat 10/17
2:06 pm-11:05 am
2 stops18h 59m
Knoxville McGhee Tyson
Wed 10/28
6:00 am-10:54 pm
2 stops18h 54m
$767
Quickest round-trip
MissoulaKnoxville
MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson
MSOTYS
Missoula Johnson-Bell Field
Thu 10/8
12:28 pm-8:49 pm
1 stop6h 21m
Knoxville McGhee Tyson
Sun 10/11
6:00 am-11:32 am
1 stop7h 32m
$780
MissoulaKnoxville
MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson
MSOTYS
Missoula Johnson-Bell Field
Sat 9/12
7:00 am-9:45 pm
2 stops12h 45m
Knoxville McGhee Tyson
Mon 9/21
4:50 pm-9:34 pm
1 stop6h 44m
$786
MissoulaKnoxville
MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson
MSOTYS
Missoula Johnson-Bell Field
Thu 10/22
1:48 pm-6:20 pm
1 stop26h 32m
Knoxville McGhee Tyson
Sun 10/25
5:07 pm-12:35 pm
1 stop21h 28m
$803
Sorted by cheapest first
Compare providers for flights from Missoula to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Missoula to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Missoula-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Missoula-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Missoula-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Missoula-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Missoula-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Missoula to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missoula with our price prediction graph.
MSO-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 7, 2026.
Read through reviews of airlines operating flights from Missoula to Knoxville, such as United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.7
Comfort
7.3
Overall
7.4
Food
6.6
Entertainment
7.1
Crew
8.1
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Boarding
7.7
Comfort
7.3
Overall
7.4
Food
6.6
Entertainment
7.1
Crew
8.1
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Related info for your journey
Find useful and relevant information for your journey from Missoula to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 7, 2026.
Missoula and Knoxville flights
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Top airline flying from Missoula to Knoxville
Discover the top airline that operate flights from Missoula to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$380 | Average$584 | FlexibilityNo cancel fee | On-time69% |