HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$291+ Cheap flights from Missoula to Knoxville (MSO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel.
MSO — TYS
Feb 6 — Feb 131
Fri 2/6
Fri 2/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missoula to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missoula to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Missoula (MSO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 7, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$359
(United Airlines)

One-way from

$291
(American Airlines)

Popular in

May

Cheapest in

August

Average price

$641
Provider with most accurate pricing for Missoula Johnson-Bell Field-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Missoula Johnson-Bell Field-Knoxville McGhee Tyson flights.
Search Deals
From Missoula Johnson-Bell Field to Knoxville McGhee Tyson
Search Deals
One-way flight from Missoula Johnson-Bell Field to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 25% potential increase in price ($217 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($66 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Find flight deals from Missoula to Knoxville

Cheapest flights from Missoula to Knoxville
Explore the most affordable flight options available from Missoula to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 7, 2026.

This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/291:21 pmMSO - TYS
1 stop6h 48mAmerican Airlines
Thu 2/57:54 amTYS - MSO
1 stop6h 56mAmerican Airlines
Deal found 1/5$309
This United Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/216:00 amMSO - TYS
1 stop7h 14mUnited Airlines
Sat 1/244:25 pmTYS - MSO
1 stop7h 26mUnited Airlines
Deal found 1/7$359
This United Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/216:00 amMSO - TYS
2 stops10h 05mUnited Airlines
Sun 1/258:45 amTYS - MSO
1 stop6h 50mUnited Airlines
Deal found 1/6$364
This American Airlines deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/111:21 pmMSO - TYS
1 stop6h 48mAmerican Airlines
Sat 2/144:29 pmTYS - MSO
1 stop7h 27mAmerican Airlines
Deal found 1/4$394
This United Airlines deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/116:00 amMSO - TYS
2 stops12h 52mUnited Airlines
Sat 2/149:40 amTYS - MSO
2 stops14h 17mUnited Airlines
Deal found 1/4$410
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:08 pmMSO - TYS
1 stop7h 37mAmerican Airlines
Tue 6/95:31 pmTYS - MSO
1 stop7h 03mAmerican Airlines
Deal found 1/6$413

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missoula to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
Use the filters below to find and compare flights from Missoula to Knoxville that are best for you.

Fly from

Missoula

Fly to

Knoxville

Route

Depart

Return

Price

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 1/29

1:21 pm-10:09 pm

1 stop6h 48m

Knoxville McGhee Tyson

Thu 2/5

7:54 am-12:50 pm

1 stop6h 56m

$309

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Wed 1/21

2:37 pm-10:31 pm

1 stop5h 54m

Knoxville McGhee Tyson

Sun 1/25

4:25 pm-9:51 pm

1 stop7h 26m

$359

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 1/20

2:37 pm-10:31 pm

1 stop5h 54m

Knoxville McGhee Tyson

Sat 1/24

4:25 pm-9:51 pm

1 stop7h 26m

$359

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 1/22

2:37 pm-10:31 pm

1 stop5h 54m

Knoxville McGhee Tyson

Mon 1/26

4:25 pm-9:51 pm

1 stop7h 26m

$359

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Wed 1/21

6:00 am-8:52 pm

2 stops12h 52m

Knoxville McGhee Tyson

Sat 1/24

4:25 pm-9:51 pm

1 stop7h 26m

$364

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 1/20

7:00 am-9:21 pm

2 stops12h 21m

Knoxville McGhee Tyson

Sat 1/24

7:44 am-8:45 pm

2 stops15h 01m

$370

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sun 2/15

6:15 am-5:31 pm

1 stop9h 16m

$291

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sun 2/15

6:15 am-7:29 pm

2 stops11h 14m

$341

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/4

Compare providers for flights from Missoula to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Missoula to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Missoula-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Missoula-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Missoula-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Missoula-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Missoula-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Missoula to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missoula with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 7, 2026.
Read through reviews of airlines operating flights from Missoula to Knoxville, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,139 reviews

Overall

7.4

Entertainment

7.1

Comfort

7.3

Boarding

7.7

Food

6.6

Crew

8.1

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

IAD - TYS

It was a short flight on a small express plane, so no time for amenities. Quickly on, quickly off. No complaints.
United Airlines
7.4
Good
9,139 reviews
United Airlines
7.4
Good
9,139 reviews

Overall

7.4

Entertainment

7.1

Comfort

7.3

Boarding

7.7

Food

6.6

Crew

8.1

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

IAD - TYS

It was a short flight on a small express plane, so no time for amenities. Quickly on, quickly off. No complaints.
American Airlines
7.2
Good
11,095 reviews
United Airlines
7.4
Good
9,139 reviews

Overall

7.4

Entertainment

7.1

Comfort

7.3

Boarding

7.7

Food

6.6

Crew

8.1

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

IAD - TYS

It was a short flight on a small express plane, so no time for amenities. Quickly on, quickly off. No complaints.

Related info for your journey

Find useful and relevant information for your journey from Missoula to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missoula to Knoxville?

    Airlines like American Airlines and United Airlines fly from Missoula to Knoxville in about 5h 54m. The time it takes to get you to your destination can typically vary by up to 54m. There are 1724 mi between Missoula and Knoxville. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Missoula to Knoxville round-trip?

    Currently priced at $240, American Airlines will fly you from Missoula to Knoxville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on United Airlines for as low as $426. These flights start at 62% lower than the current average price 3 months from now.

  • Can I find deals for flights from Missoula to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missoula to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missoula to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missoula to Knoxville.

  • Can I find deals for business class flights from Missoula to Knoxville?

    Yes. Cheapflights offers flight deals from Missoula to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from Missoula to Knoxville

Discover the top 2 airlines that operate flights from Missoula to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$240Average$418FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$426Average$708FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.