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$360+ Cheap flights from Missoula to Knoxville (MSO - TYS)

MSO — TYS
Oct 22 — Oct 291
Thu 10/22
Thu 10/29
1 adult, Economy
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Cheap flight deals from Missoula to Knoxville

Cheapest flights from Missoula to Knoxville

Fri 10/301:05 pm -
1 stop8h 13m
Sun 11/17:56 am -
1 stop6h 40m
Deal found 9/20$432
Fri 10/305:30 am -
2 stops10h 54m
Sun 11/111:45 am -
2 stops10h 09m
Deal found 9/20$550
Thu 11/191:18 pm -
1 stop8h 29m
Sun 11/228:50 pm -
1 stop17h 58m
Deal found 9/17$661
Fri 10/92:38 pm -
1 stop5h 36m
Tue 10/136:00 am -
1 stop7h 32m
Deal found 9/17$673
Mon 10/52:38 pm -
1 stop5h 36m
Fri 10/94:53 pm -
1 stop6h 39m
Deal found 9/20$679
Wed 12/237:55 pm -
1 stop24h 19m
Tue 12/2912:55 pm -
2 stops32h 10m
Deal found 9/20$701
Thu 10/86:15 am -
1 stop7h 34m
Sun 10/116:00 am -
1 stop7h 32m
Deal found 9/19$744

Find flight deals from Missoula to Knoxville

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$432
(American Airlines)

One-way from

$360
(United Airlines)

Popular in

January

Cheapest in

July

Average price

$449
Provider with most accurate pricing for Missoula Johnson-Bell Field-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Missoula Johnson-Bell Field-Knoxville McGhee Tyson flights.
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From Missoula Johnson-Bell Field to Knoxville McGhee Tyson
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One-way flight from Missoula Johnson-Bell Field to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 11% potential increase in price ($78 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Missoula to Knoxville that are best for you.

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Price

Cheapest round-trip
Quickest round-trip

MissoulaKnoxville

MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson

MSOTYS

Missoula Johnson-Bell Field

Wed 12/30

6:00 am-3:59 pm

1 stop7h 59m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-10:00 pm

Nonstop0h 00m

$360

MissoulaKnoxville

MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson

MSOTYS

Missoula Johnson-Bell Field

Fri 10/30

1:05 pm-11:18 pm

1 stop8h 13m

Knoxville McGhee Tyson

Sun 11/1

7:56 am-12:36 pm

1 stop6h 40m

$432

MissoulaKnoxville

MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson

MSOTYS

Missoula Johnson-Bell Field

Wed 12/30

10:27 am-5:43 pm

3 stops29h 16m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-10:00 pm

Nonstop0h 00m

$497

MissoulaKnoxville

MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson

MSOTYS

Missoula Johnson-Bell Field

Sat 1/30

6:15 am-2:36 pm

1 stop6h 21m

Knoxville McGhee Tyson

Wed 2/3

4:25 pm-9:26 pm

1 stop7h 01m

$499

MissoulaKnoxville

MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson

MSOTYS

Missoula Johnson-Bell Field

Sun 12/27

7:00 am-5:35 pm

1 stop8h 35m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-10:00 pm

Nonstop0h 00m

$575

MissoulaKnoxville

MSO Missoula Johnson-Bell Field - TYS Knoxville McGhee Tyson

MSOTYS

Missoula Johnson-Bell Field

Sun 12/27

6:16 pm-9:31 am

2 stops13h 15m

Knoxville McGhee Tyson

Wed 12/31

12:00 am-10:00 pm

Nonstop0h 00m

$723

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/18

Sorted by cheapest first

Compare providers for flights from Missoula to Knoxville

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Missoula to Knoxville in September.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Missoula-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Missoula-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Missoula-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Missoula-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Missoula-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Missoula to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missoula with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Missoula to Knoxville

How much does it cost to fly round-trip from Missoula to Knoxville?

Airfare is below average for this route at the moment.

Missoula to Knoxville flights typically cost between $481 and $568 in October.
The cheapest round-trip price found within the last 5 days was $432 on American Airlines (Oct 30-Nov 1).

Reviews of airlines servicing Knoxville

Read through reviews of airlines operating flights from Missoula to Knoxville, such as United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
10,226 reviews

Comfort

7.3

Food

6.7

Entertainment

7.1

Overall

7.4

Crew

8.1

Boarding

7.7

Reviews

1 / 20
8.0
Excellent

Asha,Sep 2026

LGA - IAH

The flight was on time and boardi g was very organized and timely. Snacks are awful and having one little glass of juice was terrible. Fortunately, I had my water to keep me hydrated.
United Airlines
7.4
Good
10,226 reviews
United Airlines
7.4
Good
10,226 reviews

Comfort

7.3

Food

6.7

Entertainment

7.1

Overall

7.4

Crew

8.1

Boarding

7.7

Reviews

1 / 20
8.0
Excellent

Asha,Sep 2026

LGA - IAH

The flight was on time and boardi g was very organized and timely. Snacks are awful and having one little glass of juice was terrible. Fortunately, I had my water to keep me hydrated.

Related info for your journey

  • How long is the flight from Missoula to Knoxville?

    Airlines like American Airlines and United Airlines fly from Missoula to Knoxville in about 6h 21m. The time it takes to get you to your destination can typically vary by up to 1h 52m. There are 1724 mi between Missoula and Knoxville. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Missoula to Knoxville round-trip?

    Currently priced at $380, United Airlines will fly you from Missoula to Knoxville and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. This flight start at 35% lower than the current average price 3 months from now.

  • Can I find deals for flights from Missoula to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missoula to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missoula to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missoula to Knoxville.

  • Can I find deals for business class flights from Missoula to Knoxville?

    Yes. Cheapflights offers flight deals from Missoula to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Missoula to Knoxville

AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$380Average$584FlexibilityNo cancel feeOn-time69%

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