HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$257+ Cheap flights from Missoula to Knoxville (MSO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/4. Fares are subject to change and may not be available on all flights or dates of travel.
MSO — TYS
Jun 18 — Jun 251
Thu 6/18
Thu 6/25
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missoula to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missoula to Knoxville

Cheapest flights from Missoula to Knoxville
Explore the most affordable flight options available from Missoula to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 19, 2026.

This United Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:27 pm
MSO
-
TYS
1 stop5h 53m
United Airlines
Sat 11/78:45 am
TYS
-
MSO
1 stop9h 25m
United Airlines
Deal found 5/18$349
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/193:30 pm
MSO
-
TYS
1 stop5h 27m
Delta
Tue 5/263:05 pm
TYS
-
MSO
2 stops10h 35m
Delta
Deal found 5/18$526
This American Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/191:08 pm
MSO
-
TYS
1 stop6h 49m
American Airlines
Tue 5/265:36 am
TYS
-
MSO
1 stop9h 52m
American Airlines
Deal found 5/16$541
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/151:29 pm
MSO
-
TYS
1 stop5h 35m
American Airlines
Fri 10/306:00 am
TYS
-
MSO
1 stop8h 36m
American Airlines
Deal found 5/15$563
This American Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/92:15 pm
MSO
-
TYS
1 stop7h 40m
American Airlines
Tue 6/165:37 am
TYS
-
MSO
2 stops12h 37m
American Airlines
Deal found 5/17$576
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/32:08 pm
MSO
-
TYS
1 stop7h 44m
American Airlines
Thu 8/66:00 am
TYS
-
MSO
1 stop8h 35m
American Airlines
Deal found 5/18$591

Find flight deals from Missoula to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Missoula (MSO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$349
(United Airlines)

One-way from

$257
(Kiwi.com)

Popular in

January

Cheapest in

September

Average price

$543
Provider with most accurate pricing for Missoula Johnson-Bell Field-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Missoula Johnson-Bell Field-Knoxville McGhee Tyson flights.
Search Deals
From Missoula Johnson-Bell Field to Knoxville McGhee Tyson
Search Deals
One-way flight from Missoula Johnson-Bell Field to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($80 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missoula to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 19, 2026.
Use the filters below to find and compare flights from Missoula to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 10/31

2:27 pm-10:20 pm

1 stop5h 53m

Knoxville McGhee Tyson

Sat 11/7

8:45 am-4:10 pm

1 stop9h 25m

$349

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 10/15

1:29 pm-9:04 pm

1 stop5h 35m

Knoxville McGhee Tyson

Fri 10/30

6:00 am-12:36 pm

1 stop8h 36m

$563

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 6/9

2:15 pm-11:55 pm

1 stop7h 40m

Knoxville McGhee Tyson

Tue 6/16

5:37 am-4:14 pm

2 stops12h 37m

$576

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 10/31

7:00 am-7:20 pm

2 stops10h 20m

Knoxville McGhee Tyson

Sat 11/7

5:10 am-3:34 pm

2 stops12h 24m

$629

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 6/9

8:02 pm-10:58 am

2 stops12h 56m

Knoxville McGhee Tyson

Tue 6/16

1:54 pm-11:56 pm

2 stops12h 02m

$635

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 10/15

5:24 pm-9:45 am

2 stops14h 21m

Knoxville McGhee Tyson

Fri 10/30

4:25 pm-9:26 pm

1 stop7h 01m

$637

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 10/15

7:00 am-11:18 pm

2 stops14h 18m

Knoxville McGhee Tyson

Fri 10/30

6:00 am-10:51 pm

2 stops18h 51m

$648

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Mon 8/3

2:08 pm-11:52 pm

1 stop7h 44m

Knoxville McGhee Tyson

Thu 8/6

5:00 am-12:35 pm

2 stops9h 35m

$656
Quickest round-trip

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 6/9

12:33 pm-8:56 pm

1 stop6h 23m

Knoxville McGhee Tyson

Tue 6/16

6:00 am-11:32 am

1 stop7h 32m

$658
Cheapest one-way
Quickest one-way

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 7/4

12:34 pm-8:39 pm

1 stop6h 05m

$408

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/18

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

Compare providers for flights from Missoula to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Missoula to Knoxville in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Missoula-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Missoula-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Missoula-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Missoula-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Missoula-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Missoula to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missoula with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 19, 2026.
Read through reviews of airlines operating flights from Missoula to Knoxville, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,733 reviews

Boarding

7.7

Food

6.6

Overall

7.4

Comfort

7.3

Entertainment

7.1

Crew

8.1

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
United Airlines
7.4
Good
9,733 reviews
United Airlines
7.4
Good
9,733 reviews

Boarding

7.7

Food

6.6

Overall

7.4

Comfort

7.3

Entertainment

7.1

Crew

8.1

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
American Airlines
7.1
Good
11,645 reviews
United Airlines
7.4
Good
9,733 reviews

Boarding

7.7

Food

6.6

Overall

7.4

Comfort

7.3

Entertainment

7.1

Crew

8.1

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.

Related info for your journey

Find useful and relevant information for your journey from Missoula to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missoula to Knoxville?

    Airlines like United Airlines and American Airlines fly from Missoula to Knoxville in about 5h 35m. The time it takes to get you to your destination can typically vary by up to 18m. There are 1724 mi between Missoula and Knoxville. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Missoula to Knoxville round-trip?

    Currently priced at $288, American Airlines will fly you from Missoula to Knoxville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on United Airlines for as low as $343. These flights start at 46% lower than the current average price 3 months from now.

  • Can I find deals for flights from Missoula to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missoula to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missoula to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missoula to Knoxville.

  • Can I find deals for business class flights from Missoula to Knoxville?

    Yes. Cheapflights offers flight deals from Missoula to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from Missoula to Knoxville

Discover the top 2 airlines that operate flights from Missoula to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 19, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$288Average$529FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$343Average$574FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.