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$291+ Cheap flights from Missoula to Knoxville (MSO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel.
MSO — TYS
Jan 21 — Jan 281
Wed 1/21
Wed 1/28
1 adult, Economy
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Cheap flight deals from Missoula to Knoxville

Cheapest flights from Missoula to Knoxville
Explore the most affordable flight options available from Missoula to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 22, 2025.

This United Airlines deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amMSO - TYS
1 stop7h 05mUnited Airlines
Fri 1/94:25 pmTYS - MSO
1 stop7h 26mUnited Airlines
Deal found 12/20$494
This United Airlines deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amMSO - TYS
1 stop7h 05mUnited Airlines
Sat 1/35:45 amTYS - MSO
2 stops9h 51mUnited Airlines
Deal found 12/20$544
This United Airlines deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amMSO - TYS
1 stop7h 05mUnited Airlines
Mon 1/54:04 pmTYS - MSO
1 stop7h 37mUnited Airlines
Deal found 12/20$574
This United Airlines deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amMSO - TYS
1 stop7h 05mUnited Airlines
Tue 1/611:10 amTYS - MSO
2 stops12h 41mUnited Airlines
Deal found 12/20$579
This United Airlines deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amMSO - TYS
1 stop7h 05mUnited Airlines
Sun 1/45:45 amTYS - MSO
2 stops9h 51mUnited Airlines
Deal found 12/20$625
This Alaska Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amMSO - TYS
2 stops12h 43mAlaska Airlines
Tue 1/64:41 pmTYS - MSO
2 stops21h 42mAlaska Airlines
Deal found 12/21$659

Find flight deals from Missoula to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Missoula (MSO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 22, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$399
(United Airlines)

One-way from

$291
(American Airlines)

Popular in

May

Cheapest in

August

Average price

$678
Provider with most accurate pricing for Missoula Johnson-Bell Field-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Missoula Johnson-Bell Field-Knoxville McGhee Tyson flights.
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From Missoula Johnson-Bell Field to Knoxville McGhee Tyson
Search Deals
One-way flight from Missoula Johnson-Bell Field to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 30% potential increase in price ($262 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 13% potential price decrease ($70 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Missoula to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 22, 2025.
Use the filters below to find and compare flights from Missoula to Knoxville that are best for you.

Fly from

Missoula

Fly to

Knoxville

Route

Depart

Return

Price

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 1/31

2:37 pm-10:31 pm

1 stop5h 54m

Knoxville McGhee Tyson

Tue 2/3

4:25 pm-9:51 pm

1 stop7h 26m

$399

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 1/8

6:00 am-3:14 pm

1 stop7h 14m

Knoxville McGhee Tyson

Mon 1/12

9:30 am-9:51 pm

2 stops14h 21m

$429

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Wed 12/31

6:00 am-3:05 pm

1 stop7h 05m

Knoxville McGhee Tyson

Fri 1/9

4:25 pm-9:51 pm

1 stop7h 26m

$494

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Wed 12/31

6:00 am-3:05 pm

1 stop7h 05m

Knoxville McGhee Tyson

Wed 1/7

9:30 am-9:51 pm

2 stops14h 21m

$499

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Wed 12/31

6:00 am-3:05 pm

1 stop7h 05m

Knoxville McGhee Tyson

Tue 1/6

8:45 am-1:35 pm

1 stop6h 50m

$574

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 1/6

2:37 pm-10:31 pm

1 stop5h 54m

Knoxville McGhee Tyson

Fri 1/9

6:59 am-4:05 pm

2 stops11h 06m

$611

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Wed 12/31

6:00 am-5:00 pm

2 stops9h 00m

Knoxville McGhee Tyson

Mon 1/5

9:50 am-9:41 pm

2 stops13h 51m

$615

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sun 2/15

7:00 am-5:33 pm

1 stop8h 33m

$291

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 1/3

6:00 am-3:00 pm

1 stop7h 00m

$461

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sun 2/15

6:15 am-11:44 pm

3 stops15h 29m

$467

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/19

Showing 1-10 of 11 results
1
2

Compare providers for flights from Missoula to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Missoula to Knoxville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Missoula-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Missoula-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Missoula-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Missoula-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Missoula-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Missoula to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missoula with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 22, 2025.
Read through reviews of airlines operating flights from Missoula to Knoxville, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,102 reviews

Food

6.6

Boarding

7.7

Entertainment

7.1

Crew

8.1

Overall

7.4

Comfort

7.3

Reviews

1 / 20
10.0
Excellent

Michelle,Dec 2025

DEN - MKE

I liked that the plane waited 5 minutes for a family whose incoming plane was late. This was the last flight of the day to MKE. Flight attendants actually checked in throughout the flight. Although, not really friendly. Happy to see screens on seat backs again. This is my first time not flying first class in over 10 years. It was economy plus.
United Airlines
7.4
Good
9,102 reviews
United Airlines
7.4
Good
9,102 reviews

Food

6.6

Boarding

7.7

Entertainment

7.1

Crew

8.1

Overall

7.4

Comfort

7.3

Reviews

1 / 20
10.0
Excellent

Michelle,Dec 2025

DEN - MKE

I liked that the plane waited 5 minutes for a family whose incoming plane was late. This was the last flight of the day to MKE. Flight attendants actually checked in throughout the flight. Although, not really friendly. Happy to see screens on seat backs again. This is my first time not flying first class in over 10 years. It was economy plus.
American Airlines
7.2
Good
11,051 reviews
United Airlines
7.4
Good
9,102 reviews

Food

6.6

Boarding

7.7

Entertainment

7.1

Crew

8.1

Overall

7.4

Comfort

7.3

Reviews

1 / 20
10.0
Excellent

Michelle,Dec 2025

DEN - MKE

I liked that the plane waited 5 minutes for a family whose incoming plane was late. This was the last flight of the day to MKE. Flight attendants actually checked in throughout the flight. Although, not really friendly. Happy to see screens on seat backs again. This is my first time not flying first class in over 10 years. It was economy plus.

Related info for your journey

Find useful and relevant information for your journey from Missoula to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missoula to Knoxville?

    Airlines like United Airlines fly from Missoula to Knoxville in about 5h 54m. The time it takes to get you to your destination can typically vary by up to . There are 1724 mi between Missoula and Knoxville.

  • What are the cheapest airlines flying from Missoula to Knoxville round-trip?

    Currently priced at $240, American Airlines will fly you from Missoula to Knoxville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on United Airlines for as low as $360. These flights start at 60% lower than the current average price 3 months from now.

  • Can I find deals for flights from Missoula to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missoula to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missoula to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missoula to Knoxville.

  • Can I find deals for business class flights from Missoula to Knoxville?

    Yes. Cheapflights offers flight deals from Missoula to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Missoula to Knoxville

Discover the top 2 airlines that operate flights from Missoula to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$240Average$418FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$360Average$692FlexibilityNo cancel feeOn-time69%

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