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$358+ Cheap flights from Missoula to Knoxville (MSO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/18. Fares are subject to change and may not be available on all flights or dates of travel.
MSO — TYS
May 3 — May 101
Sun 5/3
Sun 5/10
1 adult, Economy
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Cheap flight deals from Missoula to Knoxville

Cheapest flights from Missoula to Knoxville
Explore the most affordable flight options available from Missoula to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.

This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:43 am
MSO
-
TYS
1 stop7h 12m
American Airlines
Wed 9/306:00 am
TYS
-
MSO
1 stop8h 36m
American Airlines
Deal found 3/29$389
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:45 am
MSO
-
TYS
1 stop6h 34m
American Airlines
Tue 5/265:36 am
TYS
-
MSO
1 stop9h 52m
American Airlines
Deal found 3/30$402
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/81:20 pm
MSO
-
TYS
1 stop7h 58m
American Airlines
Wed 8/126:00 am
TYS
-
MSO
1 stop8h 36m
American Airlines
Deal found 4/1$448
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/92:08 pm
MSO
-
TYS
1 stop7h 48m
American Airlines
Tue 6/165:36 am
TYS
-
MSO
1 stop9h 42m
American Airlines
Deal found 4/1$451
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:27 pm
MSO
-
TYS
1 stop5h 53m
United Airlines
Wed 11/44:25 pm
TYS
-
MSO
1 stop7h 01m
United Airlines
Deal found 3/29$469
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:15 am
MSO
-
TYS
2 stops12h 15m
United Airlines
Tue 8/254:56 pm
TYS
-
MSO
1 stop6h 30m
United Airlines
Deal found 3/30$474
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:08 pm
MSO
-
TYS
1 stop7h 48m
American Airlines
Tue 6/95:36 am
TYS
-
MSO
1 stop9h 42m
American Airlines
Deal found 3/31$483

Find flight deals from Missoula to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Missoula (MSO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$389
(American Airlines)

One-way from

$358
(American Airlines)

Popular in

May

Cheapest in

September

Average price

$461
Provider with most accurate pricing for Missoula Johnson-Bell Field-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Missoula Johnson-Bell Field-Knoxville McGhee Tyson flights.
Search Deals
From Missoula Johnson-Bell Field to Knoxville McGhee Tyson
Search Deals
One-way flight from Missoula Johnson-Bell Field to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($42 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missoula to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
Use the filters below to find and compare flights from Missoula to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 5/19

6:45 am-3:19 pm

1 stop6h 34m

Knoxville McGhee Tyson

Tue 5/26

5:36 am-1:28 pm

1 stop9h 52m

$441
Quickest round-trip

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Wed 4/15

6:15 am-3:06 pm

1 stop6h 51m

Knoxville McGhee Tyson

Sun 4/19

4:30 pm-9:30 pm

1 stop7h 00m

$490

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 8/22

6:15 am-3:54 pm

1 stop7h 39m

Knoxville McGhee Tyson

Tue 8/25

6:30 am-11:34 am

1 stop7h 04m

$494

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Fri 8/7

1:17 pm-9:38 am

2 stops18h 21m

Knoxville McGhee Tyson

Tue 8/11

6:15 pm-11:47 pm

1 stop7h 32m

$553

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Fri 8/7

5:55 am-11:01 pm

1 stop15h 06m

Knoxville McGhee Tyson

Thu 8/13

6:15 pm-11:47 pm

1 stop7h 32m

$558

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Fri 8/7

1:17 pm-9:38 am

2 stops18h 21m

Knoxville McGhee Tyson

Wed 8/12

6:15 pm-11:47 pm

1 stop7h 32m

$578
Cheapest one-way
Quickest one-way

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 7/18

2:08 pm-11:52 pm

1 stop7h 44m

$358

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 7/18

6:15 am-4:51 pm

2 stops8h 36m

$433

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 7/18

7:59 pm-11:13 am

2 stops13h 14m

$449

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/29

Sorted by cheapest first

Compare providers for flights from Missoula to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Missoula to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Missoula-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Missoula-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Missoula-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Missoula-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Missoula-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Missoula to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missoula with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missoula to Knoxville

How much does it cost to fly round-trip from Missoula to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 3, 2026.
Read through reviews of airlines operating flights from Missoula to Knoxville, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,538 reviews

Crew

8.1

Food

6.6

Entertainment

7.1

Comfort

7.3

Boarding

7.7

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,538 reviews
United Airlines
7.4
Good
9,538 reviews

Crew

8.1

Food

6.6

Entertainment

7.1

Comfort

7.3

Boarding

7.7

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
American Airlines
7.1
Good
11,551 reviews
United Airlines
7.4
Good
9,538 reviews

Crew

8.1

Food

6.6

Entertainment

7.1

Comfort

7.3

Boarding

7.7

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Missoula to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missoula to Knoxville?

    Airlines like American Airlines and United Airlines fly from Missoula to Knoxville in about 6h 34m. The time it takes to get you to your destination can typically vary by up to 17m. There are 1724 mi between Missoula and Knoxville. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Missoula to Knoxville round-trip?

    Currently priced at $288, American Airlines will fly you from Missoula to Knoxville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on United Airlines for as low as $343. These flights start at 48% lower than the current average price 3 months from now.

  • Can I find deals for flights from Missoula to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missoula to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missoula to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missoula to Knoxville.

  • Can I find deals for business class flights from Missoula to Knoxville?

    Yes. Cheapflights offers flight deals from Missoula to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Top 2 airlines flying from Missoula to Knoxville

Discover the top 2 airlines that operate flights from Missoula to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$288Average$567FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$343Average$574FlexibilityNo cancel feeOn-time69%

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