What are the cheapest airlines to fly from Myrtle Beach to Key Largo one-way?

The cheapest airlines for a one-way flight from Myrtle Beach to Key Largo are American Airlines ($102), Delta ($151), and Southwest ($154).

In terms of precipitation, rainfall in Key Largo ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Key Largo when rainfall is around 1.6 in.

If weather is an important factor for your trip to Key Largo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

What are the most popular airlines that fly from Myrtle Beach to Key Largo?

American Airlines, Delta and Southwest are the most popular airlines when flying from Myrtle Beach to Key Largo.

What airport do you fly from for flights from Myrtle Beach to Key Largo?

If you book a flight to Key Largo from Myrtle Beach, you will be flying from Myrtle Beach Intl, which is the city’s only airport. Myrtle Beach Intl (MYR) is located 2.1 mi from the center of Myrtle Beach. There are 0 flights from Myrtle Beach Intl to Key Largo per day from 4 different airlines.

Can I find deals for flights from Myrtle Beach to Key Largo that include hotel bookings?

Yes. In addition to deals on Myrtle Beach to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Myrtle Beach to Key Largo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Key Largo.

Can I find deals for business class flights from Myrtle Beach to Key Largo?

Yes. Cheapflights offers flight deals from Myrtle Beach to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

Find Cheap Flights from Myrtle Beach to Key Largo

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Find flight deals from Myrtle Beach to Key Largo

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Popular in	November
Cheapest in	December
Average price	$400

Provider with most accurate pricing for Myrtle Beach Intl-Miami flight deals.

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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Miami flights.

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Highest demand for flights based on searches. 6% potential increase in price ($29 potential increase over avg. RT price).

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Cheapest flight prices on average. 6% potential price decrease ($27 potential savings vs. average RT price).

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Average for round-trip flights in October 2026

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Everything you need to know about your flight from Myrtle Beach to Key Largo

What is the cheapest time of day to fly from MYR to KE9?

Unlike at noon, when flights are generally more expensive, you can save up to 25% on flights from Myrtle Beach to Key Largo by exploring options for tickets in the morning.

What is the cheapest day to fly from Myrtle Beach to Key Largo?

Travelers seeking maximum savings on their Myrtle Beach to Key Largo flight should consider departing on Sunday at noon when fares are most often at their lowest. Monday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Key Largo

Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Myrtle Beach to Key Largo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

7.9

Good

4,228 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Southwest

7.9

Good

4,228 reviews

Southwest

7.9

Good

4,228 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Delta

7.8

Good

8,652 reviews

Southwest

7.9

Good

4,228 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

American Airlines

7.0

Good

12,152 reviews

Southwest

7.9

Good

4,228 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Related info for your journey

What airport do you fly from for flights from Myrtle Beach to Key Largo?
If you book a flight to Key Largo from Myrtle Beach, you will be flying from Myrtle Beach Intl, which is the city’s only airport. Myrtle Beach Intl (MYR) is located 2.1 mi from the center of Myrtle Beach. There are 0 flights from Myrtle Beach Intl to Key Largo per day from 4 different airlines.
What are the cheapest airlines to fly from Myrtle Beach to Key Largo one-way?
The cheapest airlines for a one-way flight from Myrtle Beach to Key Largo are American Airlines ($102), Delta ($151), and Southwest ($154).
Can I find deals for flights from Myrtle Beach to Key Largo that include hotel bookings?
Yes. In addition to deals on Myrtle Beach to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Myrtle Beach to Key Largo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Key Largo.
Can I find deals for business class flights from Myrtle Beach to Key Largo?
Yes. Cheapflights offers flight deals from Myrtle Beach to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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Top 4 airlines flying from Myrtle Beach to Key Largo

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$100	Average$479	FlexibilityNo cancel fee	On-timeN/A
Breeze Airways	Cheapest$125	Average$210	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$270	Average$434	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$302	Average$478	FlexibilityNo cancel fee	On-time63%

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Cheap flights from Myrtle Beach (MYR) to Key Largo, FL

Find cheap flights from Myrtle Beach to Key Largo with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Myrtle Beach to Key Largo

Most accurate provider

Most trusted provider

Popular in

Cheapest in

Average price

Cheapflights Insights

What is the cheapest time of day to fly from MYR to KE9?

Unlike at noon, when flights are generally more expensive, you can save up to 25% on flights from Myrtle Beach to Key Largo by exploring options for tickets in the morning.

What is the cheapest day to fly from Myrtle Beach to Key Largo?

Travelers seeking maximum savings on their Myrtle Beach to Key Largo flight should consider departing on Sunday at noon when fares are most often at their lowest. Monday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Key Largo

Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Myrtle Beach to Key Largo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What airport do you fly from for flights from Myrtle Beach to Key Largo?

What are the cheapest airlines to fly from Myrtle Beach to Key Largo one-way?

Can I find deals for flights from Myrtle Beach to Key Largo that include hotel bookings?

How can I find direct flights from Myrtle Beach to Key Largo?

Can I find deals for business class flights from Myrtle Beach to Key Largo?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to Key Largo

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Complete your trip

Complete your trip to Key Largo by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Myrtle Beach to Key Largo by cabin class

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Myrtle Beach and Key Largo flights

Browse other Myrtle Beach and Key Largo flight options. Last updated on October 10, 2026.

Other flights from Myrtle Beach

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Top 4 airlines flying from Myrtle Beach to Key Largo

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