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Guayaquil

$217+ Cheap flights from Santo Domingo (SDQ) to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/7. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — GYE
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheap flight deals from Santo Domingo to Guayaquil

Cheapest flights from Santo Domingo to Guayaquil
Explore the most affordable flight options available from Santo Domingo to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This Copa Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/212:11 pm
SDQ
-
GYE
1 stop7h 35m
Copa Airlines
Tue 1/272:35 pm
GYE
-
SDQ
1 stop7h 20m
Copa Airlines
Deal found 1/19$369
This Copa Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/36:00 am
SDQ
-
GYE
1 stop8h 34m
Copa Airlines
Sun 2/156:33 pm
GYE
-
SDQ
1 stop15h 17m
Copa Airlines
Deal found 1/19$380
This Priceline deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/165:45 pm
SDQ
-
GYE
1 stop16h 30m
Avianca
Wed 2/186:55 pm
GYE
-
SDQ
1 stop15h 30m
Avianca
Deal found 1/19$385
This Copa Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/272:11 pm
SDQ
-
GYE
1 stop10h 31m
Copa Airlines
Sun 2/156:33 pm
GYE
-
SDQ
1 stop15h 17m
Copa Airlines
Deal found 1/18$393
This Copa Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/208:50 am
SDQ
-
GYE
1 stop5h 44m
Copa Airlines
Sat 2/2812:20 pm
GYE
-
SDQ
1 stop9h 19m
Copa Airlines
Deal found 1/20$415
This Priceline deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:10 pm
SDQ
-
GYE
1 stop5h 30m
Avianca
Sun 4/269:45 am
GYE
-
SDQ
1 stop6h 30m
Avianca
Deal found 1/19$436
This Copa Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/118:48 am
SDQ
-
GYE
1 stop12h 58m
Copa Airlines
Wed 3/252:35 pm
GYE
-
SDQ
1 stop10h 43m
Copa Airlines
Deal found 1/18$440
This Avianca deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/185:45 pm
SDQ
-
GYE
1 stop6h 50m
Avianca
Tue 3/319:45 am
GYE
-
SDQ
1 stop6h 30m
Avianca
Deal found 1/18$448
This Avianca Connect deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:10 pm
SDQ
-
GYE
1 stop15h 25m
Avianca
Wed 4/156:30 pm
GYE
-
SDQ
1 stop15h 20m
Avianca
Deal found 1/21$454
This Copa Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2312:43 pm
SDQ
-
GYE
1 stop9h 10m
Copa Airlines
Tue 7/284:28 am
GYE
-
SDQ
1 stop10h 47m
Copa Airlines
Deal found 1/20$464

Find flight deals from Santo Domingo to Guayaquil

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$369
(Copa Airlines)

One-way from

$217
(Copa Airlines)

Popular in

March

Cheapest in

May

Average price

$441
Provider with most accurate pricing for Santo Domingo Las Americas-Guayaquil Jose Joaquin de Olmedo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Guayaquil Jose Joaquin de Olmedo flights.
Search Deals
From Santo Domingo Las Americas to Guayaquil Jose Joaquin de Olmedo
Search Deals
One-way flight from Santo Domingo Las Americas to Guayaquil Jose Joaquin de Olmedo
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($7 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($1 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Santo Domingo to Guayaquil that are best for you.

Fly from

Santo Domingo

Fly to

Guayaquil

Route

Depart

Return

Price

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Thu 2/5

8:50 am-8:46 pm

1 stop12h 56m

Guayaquil Jose Joaquin de Olmedo

Thu 2/19

12:20 pm-10:39 pm

1 stop9h 19m

$369

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Tue 2/3

6:00 am-1:34 pm

1 stop8h 34m

Guayaquil Jose Joaquin de Olmedo

Sun 2/15

6:33 pm-10:50 am

1 stop15h 17m

$380

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Wed 2/4

11:57 am-8:46 pm

1 stop9h 49m

Guayaquil Jose Joaquin de Olmedo

Sun 2/15

6:33 pm-10:50 am

1 stop15h 17m

$380

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Mon 2/16

5:45 pm-9:15 am

1 stop16h 30m

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

6:55 pm-11:25 am

1 stop15h 30m

$385

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Fri 2/20

11:57 am-8:46 pm

1 stop9h 49m

Guayaquil Jose Joaquin de Olmedo

Sat 2/28

2:35 pm-10:39 pm

1 stop7h 04m

$415

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Thu 2/5

8:50 am-1:34 pm

1 stop5h 44m

Guayaquil Jose Joaquin de Olmedo

Wed 2/25

4:33 am-1:09 pm

1 stop7h 36m

$415

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Tue 7/7

12:43 pm-12:02 am

1 stop12h 19m

$217

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Wed 5/6

8:45 am-1:33 pm

1 stop5h 48m

$217

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Thu 7/9

12:13 pm-12:02 am

1 stop12h 49m

$217

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Tue 1/27

2:11 pm-11:42 pm

1 stop10h 31m

$242

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

  • Most accurate provider: When it comes to deals on Santo Domingo-Guayaquil flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Guayaquil flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Guayaquil flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Guayaquil flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Guayaquil

How far ahead should I book a flight from Santo Domingo to Guayaquil?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Guayaquil. Price data was last updated on January 16, 2026.

To ensure you get the cheapest price possible for a flight from Santo Domingo to Guayaquil, you should look to book at least 31 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Santo Domingo to Guayaquil?

Currently, August is the cheapest month in which you can book a flight from Santo Domingo to Guayaquil (average of $204). Flying from Santo Domingo to Guayaquil in February is currently the most expensive (average of $407). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Guayaquil

Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated January 21, 2026.
Read reviews from past customers who have flown Copa Airlines and Avianca from Santo Domingo to Guayaquil. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,559 reviews

Boarding

7.8

Overall

7.6

Entertainment

6.8

Comfort

7.4

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.6
Good
1,559 reviews
Copa Airlines
7.6
Good
1,559 reviews

Boarding

7.8

Overall

7.6

Entertainment

6.8

Comfort

7.4

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Avianca
6.6
Okay
2,496 reviews
Copa Airlines
7.6
Good
1,559 reviews

Boarding

7.8

Overall

7.6

Entertainment

6.8

Comfort

7.4

Crew

8.1

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to Guayaquil?

    For as low as $369, Copa Airlines can have you in Guayaquil from Santo Domingo in 12h 56m. The distance between Santo Domingo and Guayaquil is about 1582 mi.

  • What are the cheapest airlines flying from Santo Domingo to Guayaquil round-trip?

    According to our current data, Avianca ($372), and Copa Airlines ($413) offers the cheapest pricing from Santo Domingo to Guayaquil. These flights start at 14% lower than the current average price 3 months from now.

  • Can I find deals for flights from Santo Domingo to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Guayaquil.

  • Can I find deals for business class flights from Santo Domingo to Guayaquil?

    Yes. Cheapflights offers flight deals from Santo Domingo to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Guayaquil?

    Currently, August is the cheapest month in which you can book a flight from Santo Domingo to Guayaquil (average of $204). Flying from Santo Domingo to Guayaquil in February is currently the most expensive (average of $407). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santo Domingo to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
Santo Domingo to Quito flights

Top 2 airlines flying from Santo Domingo to Guayaquil

Discover the top 2 airlines that operate flights from Santo Domingo to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$372Average$420FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$413Average$439FlexibilityNo cancel feeOn-time70%

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