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Guayaquil

$173+ Cheap flights from Santo Domingo (SDQ) to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/20. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — GYE
Mar 6 — Mar 131
Fri 3/6
Fri 3/13
1 adult, Economy
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Cheap flight deals from Santo Domingo to Guayaquil

Cheapest flights from Santo Domingo to Guayaquil
Explore the most affordable flight options available from Santo Domingo to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.

This KAYAK deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/32:20 pm
SDQ
-
GYE
1 stop9h 44m
Spirit Airlines
Tue 4/711:59 pm
GYE
-
SDQ
1 stop12h 16m
Spirit Airlines
Deal found 2/1$362
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/92:20 pm
SDQ
-
GYE
1 stop9h 44m
Spirit Airlines
Thu 4/1611:59 pm
GYE
-
SDQ
1 stop13h 33m
Spirit Airlines
Deal found 2/2$424
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/192:20 pm
SDQ
-
GYE
1 stop9h 44m
Spirit Airlines
Thu 3/2611:59 pm
GYE
-
SDQ
1 stop12h 16m
Spirit Airlines
Deal found 2/1$430
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:20 pm
SDQ
-
GYE
1 stop9h 44m
Spirit Airlines
Thu 4/1611:59 pm
GYE
-
SDQ
1 stop13h 33m
Spirit Airlines
Deal found 2/2$431
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:20 pm
SDQ
-
GYE
1 stop9h 44m
Spirit Airlines
Fri 4/1711:59 pm
GYE
-
SDQ
1 stop13h 33m
Spirit Airlines
Deal found 2/2$432
This Avianca deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/185:45 pm
SDQ
-
GYE
1 stop16h 30m
Avianca
Tue 3/314:05 am
GYE
-
SDQ
1 stop12h 50m
Avianca
Deal found 2/1$436
This Avianca deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/165:45 pm
SDQ
-
GYE
1 stop8h 20m
Avianca
Wed 2/183:30 am
GYE
-
SDQ
1 stop6h 55m
Avianca
Deal found 2/4$437
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/202:52 am
SDQ
-
GYE
1 stop21h 12m
Spirit Airlines
Sat 3/2811:59 pm
GYE
-
SDQ
1 stop12h 16m
Spirit Airlines
Deal found 2/3$448
This Avianca deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:45 pm
SDQ
-
GYE
2 stops16h 20m
Avianca
Thu 3/123:30 am
GYE
-
SDQ
1 stop12h 20m
Avianca
Deal found 2/4$457
This Copa Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/38:43 am
SDQ
-
GYE
1 stop5h 52m
Copa Airlines
Tue 4/712:22 pm
GYE
-
SDQ
1 stop9h 29m
Copa Airlines
Deal found 2/2$464
This Copa Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2011:57 am
SDQ
-
GYE
1 stop12h 58m
Copa Airlines
Sat 2/2812:20 pm
GYE
-
SDQ
1 stop12h 57m
Copa Airlines
Deal found 2/3$465

Find flight deals from Santo Domingo to Guayaquil

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$362
(KAYAK)

One-way from

$173
(Mytrip)

Popular in

March

Cheapest in

January

Average price

$424
Provider with most accurate pricing for Santo Domingo Las Americas-Guayaquil Jose Joaquin de Olmedo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Guayaquil Jose Joaquin de Olmedo flights.
Search Deals
From Santo Domingo Las Americas to Guayaquil Jose Joaquin de Olmedo
Search Deals
One-way flight from Santo Domingo Las Americas to Guayaquil Jose Joaquin de Olmedo
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($7 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($2 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Santo Domingo to Guayaquil that are best for you.

Fly from

Santo Domingo

Fly to

Guayaquil

Route

Depart

Return

Price

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Tue 4/7

2:20 pm-11:04 pm

1 stop9h 44m

Guayaquil Jose Joaquin de Olmedo

Wed 4/15

11:59 pm-2:32 pm

1 stop13h 33m

$431

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Thu 4/9

2:20 pm-11:04 pm

1 stop9h 44m

Guayaquil Jose Joaquin de Olmedo

Tue 4/14

11:59 pm-2:32 pm

1 stop13h 33m

$431

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Fri 4/10

2:20 pm-11:04 pm

1 stop9h 44m

Guayaquil Jose Joaquin de Olmedo

Sat 4/18

11:59 pm-2:32 pm

1 stop13h 33m

$431

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Fri 4/10

2:20 pm-11:04 pm

1 stop9h 44m

Guayaquil Jose Joaquin de Olmedo

Tue 4/14

11:59 pm-2:32 pm

1 stop13h 33m

$431

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Wed 4/8

2:20 pm-11:04 pm

1 stop9h 44m

Guayaquil Jose Joaquin de Olmedo

Thu 4/16

11:59 pm-2:32 pm

1 stop13h 33m

$431

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Sat 4/11

2:20 pm-11:04 pm

1 stop9h 44m

Guayaquil Jose Joaquin de Olmedo

Sat 4/18

11:59 pm-2:32 pm

1 stop13h 33m

$431

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Sat 4/11

2:20 pm-11:04 pm

1 stop9h 44m

Guayaquil Jose Joaquin de Olmedo

Thu 4/16

11:59 pm-2:32 pm

1 stop13h 33m

$431

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Wed 4/8

2:20 pm-11:04 pm

1 stop9h 44m

Guayaquil Jose Joaquin de Olmedo

Fri 4/17

11:59 pm-2:32 pm

1 stop13h 33m

$432

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Wed 3/18

5:45 pm-9:15 am

1 stop16h 30m

Guayaquil Jose Joaquin de Olmedo

Tue 3/31

4:05 am-5:55 pm

1 stop12h 50m

$436

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Mon 2/23

5:45 pm-11:35 pm

1 stop6h 50m

Guayaquil Jose Joaquin de Olmedo

Tue 2/24

3:30 am-4:50 pm

1 stop12h 20m

$437

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/2

Showing 1-10 of 18 results
1
2
  • Most accurate provider: When it comes to deals on Santo Domingo-Guayaquil flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Guayaquil flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Guayaquil flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Guayaquil flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Guayaquil

How far ahead should I book a flight from Santo Domingo to Guayaquil?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Guayaquil. Price data was last updated on January 30, 2026.

To ensure you get the cheapest price possible for a flight from Santo Domingo to Guayaquil, you should look to book at least 31 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Santo Domingo to Guayaquil?

Currently, August is the cheapest month in which you can book a flight from Santo Domingo to Guayaquil (average of $204). Flying from Santo Domingo to Guayaquil in February is currently the most expensive (average of $407). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Santo Domingo to Guayaquil?

Reviews of airlines servicing Guayaquil

Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated February 4, 2026.
Read reviews from past customers who have flown Copa Airlines and Avianca from Santo Domingo to Guayaquil. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,556 reviews

Overall

7.5

Comfort

7.4

Crew

8.1

Boarding

7.8

Entertainment

6.8

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.5
Good
1,556 reviews
Copa Airlines
7.5
Good
1,556 reviews

Overall

7.5

Comfort

7.4

Crew

8.1

Boarding

7.8

Entertainment

6.8

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Avianca
6.5
Okay
2,499 reviews
Copa Airlines
7.5
Good
1,556 reviews

Overall

7.5

Comfort

7.4

Crew

8.1

Boarding

7.8

Entertainment

6.8

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to Guayaquil?

    For as low as $431, Spirit Airlines can have you in Guayaquil from Santo Domingo in 9h 44m. The distance between Santo Domingo and Guayaquil is about 1582 mi.

  • What are the cheapest airlines flying from Santo Domingo to Guayaquil round-trip?

    According to our current data, Avianca ($372), and Copa Airlines ($413) offers the cheapest pricing from Santo Domingo to Guayaquil. These flights start at 13% lower than the current average price 3 months from now.

  • Can I find deals for flights from Santo Domingo to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Guayaquil.

  • Can I find deals for business class flights from Santo Domingo to Guayaquil?

    Yes. Cheapflights offers flight deals from Santo Domingo to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Guayaquil?

    Currently, August is the cheapest month in which you can book a flight from Santo Domingo to Guayaquil (average of $204). Flying from Santo Domingo to Guayaquil in February is currently the most expensive (average of $407). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Santo Domingo to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
Santo Domingo to Quito flights

Top 2 airlines flying from Santo Domingo to Guayaquil

Discover the top 2 airlines that operate flights from Santo Domingo to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$372Average$420FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$413Average$439FlexibilityNo cancel feeOn-time70%

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