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Guayaquil

$216+ Cheap flights from Santo Domingo (SDQ) to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — GYE
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheapflights Tip: The best prices from Santo Domingo Las Americas to Guayaquil Jose Joaquin de Olmedo are usually found in October or November, booked 27 days in advance, depart on a Thursday or Tuesday and return on a Monday

Cheap flight deals from Santo Domingo to Guayaquil

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$434
(Priceline)

One-way from

$216
(Copa Airlines)

Popular in

March

Cheapest in

October

Average price

$437

Good one-way deal

$176 or less
From Santo Domingo Las Americas to Guayaquil Jose Joaquin de Olmedo
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One-way flight from Santo Domingo Las Americas to Guayaquil Jose Joaquin de Olmedo
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Highest demand for flights based on searches. 1% potential increase in price ($7 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a one-way flight from Santo Domingo Las Americas to Guayaquil Jose Joaquin de Olmedo.
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Find flight deals from Santo Domingo to Guayaquil

Cheapest flights from Santo Domingo to Guayaquil
Explore the most affordable flight options available from Santo Domingo to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Priceline deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:10 pmSDQ - GYE
1 stop6h 10mAvianca
Thu 10/3010:25 amGYE - SDQ
1 stop5h 25mAvianca
Deal found 9/13$434
This Priceline deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/235:45 pmSDQ - GYE
1 stop8h 20mAvianca
Wed 11/266:55 pmGYE - SDQ
1 stop15h 30mAvianca
Deal found 9/13$436
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1411:57 amSDQ - GYE
1 stop9h 37mCopa Airlines
Thu 10/304:28 amGYE - SDQ
1 stop5h 30mCopa Airlines
Deal found 9/15$437
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/111:57 amSDQ - GYE
1 stop6h 37mCopa Airlines
Sat 11/112:21 pmGYE - SDQ
1 stop13h 05mCopa Airlines
Deal found 9/14$451
This Priceline deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/15:45 pmSDQ - GYE
2 stops16h 15mAvianca
Thu 11/610:25 amGYE - SDQ
1 stop5h 25mAvianca
Deal found 9/12$456
This Priceline deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/223:43 amSDQ - GYE
1 stop11h 23mJetBlue
Wed 11/2611:40 amGYE - SDQ
1 stop26h 33mJetBlue
Deal found 9/13$507
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/122:10 pmSDQ - GYE
1 stop7h 24mCopa Airlines
Thu 10/304:28 amGYE - SDQ
1 stop5h 30mCopa Airlines
Deal found 9/15$513
This Priceline deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/235:45 pmSDQ - GYE
2 stops14h 50mAvianca
Sun 11/306:30 amGYE - SDQ
2 stops9h 20mAvianca
Deal found 9/13$517
This JetBlue deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/223:43 amSDQ - GYE
1 stop11h 23mJetBlue
Sun 11/303:30 pmGYE - SDQ
1 stop10h 27mJetBlue
Deal found 9/13$580

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Santo Domingo to Guayaquil that are best for you.

Fly from

Santo Domingo

Fly to

Guayaquil

Route

Depart

Return

Price

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Sun 11/23

5:45 pm-9:15 am

1 stop16h 30m

Guayaquil Jose Joaquin de Olmedo

Tue 11/25

3:30 am-4:50 pm

1 stop12h 20m

$436

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Thu 11/20

5:45 pm-11:35 pm

1 stop6h 50m

Guayaquil Jose Joaquin de Olmedo

Wed 11/26

3:30 am-11:25 am

1 stop6h 55m

$436

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Sun 11/23

5:45 pm-11:35 pm

1 stop6h 50m

Guayaquil Jose Joaquin de Olmedo

Sun 11/30

10:25 am-4:50 pm

1 stop5h 25m

$436

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Tue 10/14

5:25 am-11:15 am

1 stop6h 50m

Guayaquil Jose Joaquin de Olmedo

Thu 10/30

4:28 am-4:15 pm

1 stop10h 47m

$437

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Wed 10/1

11:57 am-5:34 pm

1 stop6h 37m

Guayaquil Jose Joaquin de Olmedo

Sat 11/1

12:21 pm-2:26 am

1 stop13h 05m

$451

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Sat 11/1

5:45 pm-9:00 am

2 stops16h 15m

Guayaquil Jose Joaquin de Olmedo

Thu 11/6

10:25 am-4:50 pm

1 stop5h 25m

$456

Santo DomingoGuayaquil

SDQ - GYE

SDQGYE

Santo Domingo Las Americas

Wed 10/15

11:57 am-8:34 pm

1 stop9h 37m

$216

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Best time to book a flight from Santo Domingo to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Guayaquil

How far ahead should I book a flight from Santo Domingo to Guayaquil?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Guayaquil. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from Santo Domingo to Guayaquil, you should look to book at least 27 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Santo Domingo to Guayaquil?

Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Guayaquil (average of $440). Flying from Santo Domingo to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to GYE?

Find hourly flight availability from Santo Domingo to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Santo Domingo to Guayaquil, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 30% versus a flight in the morning.

Reviews of airlines servicing Guayaquil

Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated September 15, 2025.
Read reviews from past customers who have flown Copa Airlines and Avianca from Santo Domingo to Guayaquil. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Entertainment

6.8

Food

6.8

Overall

7.6

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Entertainment

6.8

Food

6.8

Overall

7.6

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,435 reviews
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Entertainment

6.8

Food

6.8

Overall

7.6

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to Guayaquil?

    For as low as $436, Avianca can have you in Guayaquil from Santo Domingo in 16h 30m. The distance between Santo Domingo and Guayaquil is about 1582 mi.

  • What are the cheapest airlines flying from Santo Domingo to Guayaquil round-trip?

    According to our current data, Avianca ($372), and Copa Airlines ($404) offers the cheapest pricing from Santo Domingo to Guayaquil. These flights start at 11% lower than the current average price 3 months from now.

  • What are the cheapest flights from Santo Domingo to Guayaquil?

    Looking at all options, your cheapest flight can be booked for $176. While the most popular route (Santo Domingo Las Americas - Guayaquil Jose Joaquin de Olmedo) can be booked for $436 on average, our data indicates $176 when flying from Santo Domingo to Guayaquil.

  • Can I find deals for flights from Santo Domingo to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Guayaquil.

  • Can I find deals for business class flights from Santo Domingo to Guayaquil?

    Yes. Cheapflights offers flight deals from Santo Domingo to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Guayaquil?

    Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Guayaquil (average of $440). Flying from Santo Domingo to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santo Domingo to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
Santo Domingo to Quito flights

Top 2 airlines flying from Santo Domingo to Guayaquil

Discover the top 2 airlines that operate flights from Santo Domingo to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$372Average$420FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$404Average$430FlexibilityNo cancel feeOn-time70%

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