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Grand Cayman

$227+ Cheap flights from Des Moines (DSM) to Grand Cayman

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GCM
Mar 9 — Mar 161
Mon 3/9
Mon 3/16
1 adult, Economy
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Cheap flight deals from Des Moines to Grand Cayman

Cheapest flights from Des Moines to Grand Cayman
Explore the most affordable flight options available from Des Moines to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 7, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:27 pm
DSM
-
GCM
2 stops15h 08m
Multiple Airlines
Thu 3/52:49 pm
GCM
-
DSM
1 stop9h 02m
Multiple Airlines
Deal found 2/4$552
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:15 am
DSM
-
GCM
2 stops12h 00m
American Airlines
Tue 4/77:45 am
GCM
-
DSM
2 stops13h 30m
American Airlines
Deal found 2/7$560
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:00 am
DSM
-
GCM
1 stop8h 35m
American Airlines
Wed 3/41:05 pm
GCM
-
DSM
1 stop11h 54m
American Airlines
Deal found 2/4$572
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:44 pm
DSM
-
GCM
1 stop17h 00m
American Airlines
Sat 3/142:44 pm
GCM
-
DSM
1 stop8h 56m
American Airlines
Deal found 2/4$585
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:03 pm
DSM
-
GCM
2 stops15h 30m
American Airlines
Thu 4/302:10 pm
GCM
-
DSM
2 stops18h 16m
American Airlines
Deal found 2/4$590
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/217:44 pm
DSM
-
GCM
1 stop18h 00m
American Airlines
Sat 3/2811:40 am
GCM
-
DSM
1 stop12h 16m
American Airlines
Deal found 2/4$593
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:05 pm
DSM
-
GCM
2 stops18h 05m
American Airlines
Fri 6/52:10 pm
GCM
-
DSM
2 stops18h 13m
American Airlines
Deal found 2/4$602
This United Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:15 am
DSM
-
GCM
1 stop28h 15m
United Airlines
Wed 5/201:35 pm
GCM
-
DSM
1 stop9h 10m
United Airlines
Deal found 2/6$609
This Southwest deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:30 pm
DSM
-
GCM
2 stops17h 40m
Southwest
Thu 5/211:05 pm
GCM
-
DSM
2 stops10h 00m
Southwest
Deal found 2/6$612
This United Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/142:58 pm
DSM
-
GCM
1 stop21h 32m
United Airlines
Fri 5/221:35 pm
GCM
-
DSM
2 stops20h 46m
United Airlines
Deal found 2/6$613

Find flight deals from Des Moines to Grand Cayman

Keep the following information in mind while searching for Des Moines to Grand Cayman flight deals. Data was last updated February 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$552
(Kiwi.com)

One-way from

$227
(Southwest)

Popular in

April

Cheapest in

November

Average price

$778
Provider with most accurate pricing for Des Moines-George Town Owen Roberts Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-George Town Owen Roberts Intl flights.
Search Deals
From Des Moines to Grand Cayman
Search Deals
One-way flight from Des Moines to Grand Cayman
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($159 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($33 potential savings vs. average RT price).
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Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Grand Cayman that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 7, 2026.
Use the filters below to find and compare flights from Des Moines to Grand Cayman that are best for you.

Fly from

Des Moines

Fly to

Grand Cayman

Route

Depart

Return

Price

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Tue 3/31

7:00 am-7:15 pm

1 stop12h 15m

George Town Owen Roberts Intl

Tue 4/7

7:45 am-11:49 pm

2 stops16h 04m

$560

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Wed 2/25

5:00 am-2:35 pm

1 stop8h 35m

George Town Owen Roberts Intl

Wed 3/4

1:05 pm-11:59 pm

1 stop11h 54m

$572

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Sat 3/7

7:44 pm-1:44 pm

1 stop17h 00m

George Town Owen Roberts Intl

Sat 3/14

2:44 pm-11:40 pm

1 stop8h 56m

$585

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 5/15

7:10 pm-12:05 pm

2 stops16h 55m

$227

Des MoinesGeorge Town

DSM - GCM

DSMGCM

Des Moines

Fri 5/15

3:20 pm-1:30 pm

1 stop22h 10m

$333

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/6

Best time to book a flight from Des Moines to Grand Cayman

Have a flexible travel schedule? Discover the best time to fly to Grand Cayman from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Grand Cayman

What is the cheapest month to book a flight from Des Moines to Grand Cayman?

Currently, December is the cheapest month in which you can book a flight from Des Moines to Grand Cayman (average of $496). Flying from Des Moines to Grand Cayman in April is currently the most expensive (average of $748). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Grand Cayman

Get insights into the airlines that provide service to Grand Cayman. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Grand Cayman. Reviews last updated February 7, 2026.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Des Moines to Grand Cayman. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,169 reviews

Boarding

8.1

Crew

8.5

Food

7.2

Overall

7.9

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,169 reviews
Delta
7.9
Good
8,169 reviews

Boarding

8.1

Crew

8.5

Food

7.2

Overall

7.9

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,250 reviews
Delta
7.9
Good
8,169 reviews

Boarding

8.1

Crew

8.5

Food

7.2

Overall

7.9

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,248 reviews
Delta
7.9
Good
8,169 reviews

Boarding

8.1

Crew

8.5

Food

7.2

Overall

7.9

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Grand Cayman. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Grand Cayman?

    If you book a flight to Grand Cayman from Des Moines, you will be flying from Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • How long is the flight from Des Moines to Grand Cayman?

    Departing from Des Moines to Grand Cayman will take you 12h 15m. The distance from Des Moines to Grand Cayman is about 1697 mi.

  • Can I find deals for flights from Des Moines to Grand Cayman that include hotel bookings?

    Yes. In addition to deals on Des Moines to Grand Cayman flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Grand Cayman?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Grand Cayman.

  • Can I find deals for business class flights from Des Moines to Grand Cayman?

    Yes. Cheapflights offers flight deals from Des Moines to Grand Cayman by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Grand Cayman?

    Currently, December is the cheapest month in which you can book a flight from Des Moines to Grand Cayman (average of $496). Flying from Des Moines to Grand Cayman in April is currently the most expensive (average of $748). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Des Moines to Grand Cayman

See prices for flight routes from nearby airports that may be better suited for you.
Des Moines to George Town flights
Omaha to George Town flights
Moline to George Town flights

Top 3 airlines flying from Des Moines to Grand Cayman

Discover the top 3 airlines that operate flights from Des Moines to Grand Cayman. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$496Average$605FlexibilityNo cancel feeOn-time69%
DeltaCheapest$565Average$634FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$575Average$615FlexibilityNo cancel feeOn-time71%

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