What are the cheapest airlines to fly from South Carolina to Detroit Metropolitan Wayne County Airport one-way?

One-way options have recently been found by users for as low as $34 on Spirit Airlines. Other airlines that offer cheap prices include Southwest from $80 and JetBlue from $81 one-way.

In terms of precipitation, rainfall in Detroit Metropolitan Wayne County Airport ranges from 1.8 - 3.1 inches per month. August is typically the wettest month, when rainfall can reach 3.1 in. January is typically the driest time to visit Detroit Metropolitan Wayne County Airport when rainfall is around 1.8 in.

If weather is an important factor for your trip to Detroit Metropolitan Wayne County Airport, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

What are the most popular routes from South Carolina to Detroit Metropolitan Wayne County Airport?

When deciding which route to take from South Carolina to Detroit Metropolitan Wayne County Airport consider Charlotte Douglas - Detroit Metropolitan Wayne County, Charleston - Detroit Metropolitan Wayne County or Savannah/Hilton Head - Detroit Metropolitan Wayne County as they are the most popular.

What are the most popular airlines that fly from South Carolina to Detroit Metropolitan Wayne County Airport?

Consider American Airlines, Delta or Spirit Airlines when booking your flight. These represent the most popular airlines when flying from South Carolina to Detroit Metropolitan Wayne County Airport.

What is the cheapest month to fly from South Carolina to Detroit Metropolitan Wayne County Airport?

The best pricing can be found in the month of August. Prices to Detroit Metropolitan Wayne County Airport from South Carolina average $251. You can even find prices in August for less than $251, as users have found deals to Detroit Metropolitan Wayne County Airport from as low as $117. The month of February appears to be one of the more expensive times to travel to Detroit Metropolitan Wayne County Airport from South Carolina. Flying in the targeted month can save you up to 67%.

What airport do you fly into for flights to Detroit from South Carolina?

If you book a flight to Detroit from South Carolina, you will be flying to Detroit Metropolitan Wayne County, which is the city’s only airport. Detroit Metropolitan Wayne County (DTW) is located 17.3 mi from the center of Detroit.

Can I find deals for flights from South Carolina to Detroit that include hotel bookings?

Yes. In addition to deals on South Carolina to Detroit flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Carolina to Detroit?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Detroit.

Can I find deals for business class flights from South Carolina to Detroit?

Yes. Cheapflights offers flight deals from South Carolina to Detroit by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$34+ Flights from South Carolina to Detroit Metropolitan Wayne County Airport

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Cheap flight deals from South Carolina to Detroit

Round-trip from	$79 (Cheapflightsfares)
One-way from	$34 (Cheapflightsfares)
Popular in	February
Cheapest in	August
Average price	$192
Good round-trip deal	$151 or less
Good one-way deal	$109 or less

From South Carolina to Detroit Metropolitan Wayne County

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One-way flight from South Carolina to Detroit Metropolitan Wayne County

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Highest demand for flights based on searches. 20% potential increase in price ($62 potential increase over avg. RT price).

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Cheapest flight prices on average. 6% potential price decrease ($16 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Price to beat on a round-trip flight from South Carolina to Detroit Metropolitan Wayne County.

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Price to beat on a one-way flight from South Carolina to Detroit Metropolitan Wayne County.

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Find flight deals from South Carolina to Detroit

Cheapest flights from South Carolina to Detroit
Explore the most affordable flight options available from South Carolina to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Fri 9/199:10 amCHS - DTW

Nonstop2h 05mSpirit Airlines

Mon 9/226:11 amDTW - CHS

Nonstop2h 04mSpirit Airlines

Deal found 7/27

$79

Thu 8/288:48 pmMYR - DTW

Nonstop1h 58mSpirit Airlines

Mon 9/16:00 pmDTW - MYR

Nonstop1h 53mSpirit Airlines

Deal found 7/28

$107

Fri 10/172:30 pmSAV - DTW

Nonstop2h 10mSpirit Airlines

Mon 10/2011:29 amDTW - SAV

Nonstop2h 06mSpirit Airlines

Deal found 7/29

$118

Thu 8/283:10 pmCLT - DTW

1 stop8h 30mSpirit Airlines

Mon 9/111:22 amDTW - CLT

Nonstop1h 48mSpirit Airlines

Deal found 7/28

$126

Thu 8/2811:20 amCHS - DTW

Nonstop2h 01mDelta

Wed 9/39:50 pmDTW - CHS

Nonstop2h 05mDelta

Deal found 7/28

$139

Sat 9/275:20 pmCLT - DTW

Nonstop1h 50mDelta

Tue 9/302:00 pmDTW - CLT

Nonstop1h 49mDelta

Deal found 7/28

$139

Fri 8/2911:23 amSAV - DTW

Nonstop2h 07mDelta

Sun 8/318:30 amDTW - SAV

Nonstop2h 08mDelta

Deal found 7/28

$159

Fri 9/2611:34 amMYR - DTW

Nonstop1h 56mDelta

Mon 9/298:45 amDTW - MYR

Nonstop1h 54mDelta

Deal found 7/27

$159

Sat 10/46:27 amCHS - DTW

2 stops5h 36mAmerican Airlines

Tue 10/76:00 amDTW - CHS

1 stop5h 06mAmerican Airlines

Deal found 7/27

$164

Thu 8/142:14 pmCLT - DTW

Nonstop1h 43mMultiple Airlines

Sun 8/176:00 amDTW - CLT

1 stop10h 26mMultiple Airlines

Deal found 7/29

$166

Thu 8/285:00 amSAV - DTW

1 stop4h 12mAmerican Airlines

Sun 8/316:55 amDTW - SAV

1 stop4h 42mAmerican Airlines

Deal found 7/29

$178

Thu 8/289:38 amMYR - DTW

1 stop5h 38mAmerican Airlines

Sun 9/76:00 amDTW - MYR

1 stop4h 26mAmerican Airlines

Deal found 7/27

$179

Best flights from South Carolina to Detroit
Discover carefully curated flight deals from South Carolina to Detroit that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2025.

Fri 9/199:10 amCHS - DTW

Nonstop2h 05mSpirit Airlines

Mon 9/226:11 amDTW - CHS

Nonstop2h 04mSpirit Airlines

Deal found 7/27

$79

Thu 8/2811:20 amCHS - DTW

Nonstop2h 01mDelta

Wed 9/39:50 pmDTW - CHS

Nonstop2h 05mDelta

Deal found 7/28

$139

Sat 10/46:27 amCHS - DTW

2 stops5h 36mAmerican Airlines

Tue 10/76:00 amDTW - CHS

1 stop5h 06mAmerican Airlines

Deal found 7/27

$164

Thu 8/142:14 pmCLT - DTW

Nonstop1h 43mMultiple Airlines

Sun 8/176:00 amDTW - CLT

1 stop10h 26mMultiple Airlines

Deal found 7/29

$166

Tue 11/46:07 amCHS - DTW

1 stop7h 17mJetBlue

Fri 11/72:40 pmDTW - CHS

1 stop7h 43mJetBlue

Deal found 7/29

$181

Thu 8/288:48 pmMYR - DTW

Nonstop1h 58mSpirit Airlines

Mon 9/16:00 pmDTW - MYR

Nonstop1h 53mSpirit Airlines

Deal found 7/28

$107

Fri 9/51:55 pmSAV - DTW

2 stops9h 12mUnited Airlines

Mon 9/86:00 amDTW - SAV

1 stop4h 51mUnited Airlines

Deal found 7/28

$224

Tue 8/198:00 amSAV - DTW

1 stop5h 55mSouthwest

Sat 8/235:50 amDTW - SAV

2 stops8h 05mSouthwest

Deal found 7/28

$242

Fri 10/172:30 pmSAV - DTW

Nonstop2h 10mSpirit Airlines

Mon 10/2011:29 amDTW - SAV

Nonstop2h 06mSpirit Airlines

Deal found 7/29

$118

Sat 9/275:20 pmCLT - DTW

Nonstop1h 50mDelta

Tue 9/302:00 pmDTW - CLT

Nonstop1h 49mDelta

Deal found 7/28

$139

Thu 8/283:10 pmCLT - DTW

1 stop8h 30mSpirit Airlines

Mon 9/111:22 amDTW - CLT

Nonstop1h 48mSpirit Airlines

Deal found 7/28

$126

Fri 8/2911:23 amSAV - DTW

Nonstop2h 07mDelta

Sun 8/318:30 amDTW - SAV

Nonstop2h 08mDelta

Deal found 7/28

$159

Last-minute flights from South Carolina to Detroit
Discover last-minute flight deals from South Carolina to Detroit. Data last updated July 29, 2025 and is based on user searches.

Tue 8/58:58 pmMYR - DTW

Nonstop2h 04mSpirit Airlines

Wed 8/136:00 pmDTW - MYR

Nonstop1h 53mSpirit Airlines

Deal found 7/29

$153

Tue 8/55:16 pmMYR - DTW

1 stop6h 53mAmerican Airlines

Wed 8/134:00 pmDTW - MYR

2 stops7h 11mAmerican Airlines

Deal found 7/29

$344

Wed 8/611:29 amCHS - DTW

Nonstop2h 01mDelta

Wed 8/208:35 amDTW - CHS

Nonstop2h 03mDelta

Deal found 7/28

$279

Wed 8/66:00 amCHS - DTW

1 stop6h 52mAmerican Airlines

Wed 8/207:05 amDTW - CHS

1 stop4h 26mAmerican Airlines

Deal found 7/29

$299

Wed 8/62:48 pmCHS - DTW

1 stop8h 39mMultiple Airlines

Thu 8/77:45 amDTW - CHS

Nonstop2h 00mMultiple Airlines

Deal found 7/28

$322

Thu 8/76:29 pmCLT - DTW

Nonstop1h 48mSpirit Airlines

Fri 8/83:25 pmDTW - CLT

Nonstop1h 52mSpirit Airlines

Deal found 7/28

$157

Thu 8/76:29 pmCLT - DTW

Nonstop1h 48mMultiple Airlines

Sat 8/99:52 amDTW - CLT

1 stop8h 26mMultiple Airlines

Deal found 7/29

$167

Thu 8/710:53 amCHS - DTW

Nonstop2h 02mSpirit Airlines

Sun 8/107:45 amDTW - CHS

Nonstop2h 00mSpirit Airlines

Deal found 7/27

$183

Thu 8/77:03 pmCLT - DTW

1 stop13h 44mFrontier

Tue 8/127:15 amDTW - CLT

1 stop9h 21mFrontier

Deal found 7/27

$195

Fri 8/812:00 pmSAV - DTW

1 stop4h 10mMultiple Airlines

Thu 8/146:15 amDTW - SAV

1 stop7h 50mMultiple Airlines

Deal found 7/27

$268

Fri 8/84:37 pmCAE - DTW

1 stop7h 51mSpirit Airlines

Tue 8/125:11 amDTW - CAE

1 stop8h 53mSpirit Airlines

Deal found 7/28

$273

Fri 8/87:34 pmCAE - DTW

1 stop4h 05mAmerican Airlines

Mon 8/256:00 amDTW - CAE

1 stop4h 00mAmerican Airlines

Deal found 7/27

$279

One-way flights from South Carolina to Detroit
Search for one-way flight options from South Carolina to Detroit. Find affordable one-way fares based on user searches. Data last updated July 29, 2025.

Thu 8/282:14 pmCLT - DTW

Nonstop1h 43mSpirit Airlines

Deal found 7/28

$34

Mon 8/2510:38 amCHS - DTW

Nonstop2h 05mSpirit Airlines

Deal found 7/27

$50

Mon 8/118:58 pmMYR - DTW

Nonstop2h 04mSpirit Airlines

Deal found 7/28

$54

Fri 10/172:30 pmSAV - DTW

Nonstop2h 10mSpirit Airlines

Deal found 7/27

$59

Tue 10/285:35 amCHS - DTW

1 stop6h 30mSouthwest

Deal found 7/29

$80

Wed 10/17:00 pmCHS - DTW

1 stop4h 59mJetBlue

Deal found 7/28

$81

Tue 8/264:35 pmMYR - DTW

1 stop5h 40mSouthwest

Deal found 7/27

$90

Sun 8/243:18 pmCAE - DTW

1 stop8h 22mMultiple Airlines

Deal found 7/27

$94

Sat 8/167:03 pmCLT - DTW

1 stop14h 09mFrontier

Deal found 7/27

$97

Sat 8/305:44 pmAGS - DTW

1 stop4h 16mDelta

Deal found 7/29

$109

Wed 8/273:25 pmGSP - DTW

1 stop6h 50mSouthwest

Deal found 7/28

$119

Fri 9/2611:34 amMYR - DTW

Nonstop1h 56mDelta

Deal found 7/28

$120

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Detroit Metropolitan Wayne County Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonDetroit

CHS - DTW

CHSDTW

Charleston

Fri 9/19

9:10 am-11:15 am

Nonstop2h 05m

Detroit Metropolitan Wayne County

Mon 9/22

6:11 am-8:15 am

Nonstop2h 04m

$79

Myrtle BeachDetroit

MYR - DTW

MYRDTW

Myrtle Beach Intl

Thu 8/28

8:48 pm-10:46 pm

Nonstop1h 58m

Detroit Metropolitan Wayne County

Mon 9/1

6:00 pm-7:53 pm

Nonstop1h 53m

$107

SavannahDetroit

SAV - DTW

SAVDTW

Savannah/Hilton Head

Fri 10/17

2:30 pm-4:40 pm

Nonstop2h 10m

Detroit Metropolitan Wayne County

Mon 10/20

11:29 am-1:35 pm

Nonstop2h 06m

$118

CharlotteDetroit

CLT - DTW

CLTDTW

Charlotte Douglas

Thu 8/28

3:10 pm-11:40 pm

1 stop8h 30m

Detroit Metropolitan Wayne County

Mon 9/1

11:22 am-1:10 pm

Nonstop1h 48m

$126

CharlestonDetroit

CHS - DTW

CHSDTW

Charleston

Thu 8/28

11:20 am-1:21 pm

Nonstop2h 01m

Detroit Metropolitan Wayne County

Wed 9/3

9:50 pm-11:55 pm

Nonstop2h 05m

$139

CharlotteDetroit

CLT - DTW

CLTDTW

Charlotte Douglas

Sat 9/27

5:20 pm-7:10 pm

Nonstop1h 50m

Detroit Metropolitan Wayne County

Tue 9/30

2:00 pm-3:49 pm

Nonstop1h 49m

$139

SavannahDetroit

SAV - DTW

SAVDTW

Savannah/Hilton Head

Fri 8/29

11:23 am-1:30 pm

Nonstop2h 07m

Detroit Metropolitan Wayne County

Sun 8/31

8:30 am-10:38 am

Nonstop2h 08m

$159

Myrtle BeachDetroit

MYR - DTW

MYRDTW

Myrtle Beach Intl

Fri 9/26

11:34 am-1:30 pm

Nonstop1h 56m

Detroit Metropolitan Wayne County

Mon 9/29

8:45 am-10:39 am

Nonstop1h 54m

$159

CharlestonDetroit

CHS - DTW

CHSDTW

Charleston

Sat 10/4

6:27 am-12:03 pm

2 stops5h 36m

Detroit Metropolitan Wayne County

Tue 10/7

6:00 am-11:06 am

1 stop5h 06m

$164

CharlotteDetroit

CLT - DTW

CLTDTW

Charlotte Douglas

Thu 8/14

2:14 pm-3:57 pm

Nonstop1h 43m

Detroit Metropolitan Wayne County

Sun 8/17

6:00 am-4:26 pm

1 stop10h 26m

$166

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 60 results

...

Best time to book a flight from South Carolina to Detroit

Have a flexible travel schedule? Discover the best time to fly to Detroit from South Carolina with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Detroit Metropolitan Wayne County Airport

What is the cheapest month to book a flight from South Carolina to Detroit Metropolitan Wayne County Airport?

Currently, April is the cheapest month in which you can book a flight from South Carolina to Detroit Metropolitan Wayne County Airport (average of $257). Flying from South Carolina to Detroit Metropolitan Wayne County Airport in March is currently the most expensive (average of $305). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to DTW?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Detroit Metropolitan Wayne County Airport as you normally would.

Weekly flight availability from South Carolina to Detroit Metropolitan Wayne County Airport

The most flights from USSC to DTW are scheduled on a Monday (11 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (6 on average).

Reviews of airlines servicing Detroit

Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from South Carolina to Detroit Metropolitan Wayne County Airport by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Southwest

8.0

Very good

4,238 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

Delta

8.0

Very good

7,977 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

United Airlines

7.4

Good

8,899 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

JetBlue

7.3

Good

2,913 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

Related info for your journey

What airport do you fly into for flights to Detroit from South Carolina?
If you book a flight to Detroit from South Carolina, you will be flying to Detroit Metropolitan Wayne County, which is the city’s only airport. Detroit Metropolitan Wayne County (DTW) is located 17.3 mi from the center of Detroit.
What are the cheapest airlines to fly from South Carolina to Detroit Metropolitan Wayne County Airport one-way?
One-way options have recently been found by users for as low as $34 on Spirit Airlines. Other airlines that offer cheap prices include Southwest from $80 and JetBlue from $81 one-way.
What are the most popular routes from South Carolina to Detroit Metropolitan Wayne County Airport?
When deciding which route to take from South Carolina to Detroit Metropolitan Wayne County Airport consider Charlotte Douglas - Detroit Metropolitan Wayne County, Charleston - Detroit Metropolitan Wayne County or Savannah/Hilton Head - Detroit Metropolitan Wayne County as they are the most popular.
What are the most reliable airlines from South Carolina to Detroit Metropolitan Wayne County Airport?
Before booking your flight to Detroit Metropolitan Wayne County Airport from South Carolina, check out the most reliable airlines to get you to your destination on time: Spirit Airlines (98%), Korean Air (87%), Virgin Atlantic( 84%).
What are the cheapest flights from South Carolina to Detroit Metropolitan Wayne County Airport?
The cheapest flight price from South Carolina to Detroit Metropolitan Wayne County Airport is $59. On average you can expect to pay $298. The most popular route, (Charlotte Douglas - Detroit Metropolitan Wayne County), can usually be booked for $68.
Can I find deals for flights from South Carolina to Detroit that include hotel bookings?
Yes. In addition to deals on South Carolina to Detroit flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Carolina to Detroit?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Detroit.
Can I find deals for business class flights from South Carolina to Detroit?
Yes. Cheapflights offers flight deals from South Carolina to Detroit by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Carolina to Detroit Metropolitan Wayne County Airport?
Currently, April is the cheapest month in which you can book a flight from South Carolina to Detroit Metropolitan Wayne County Airport (average of $257). Flying from South Carolina to Detroit Metropolitan Wayne County Airport in March is currently the most expensive (average of $305). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Sterling Heights

Warren

Dearborn

Troy

Novi

Southfield

Clarkston

Romulus

Plymouth

Auburn Hills

Utica

Monroe

Roseville

Wixom

Port Huron

Belleville

Brighton

Livonia

Fremont

Madison Heights

Browse thousands of different options on Cheapflights for your next trip

Top 4 airlines flying from South Carolina to Detroit

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$68	Average$168	FlexibilityNo cancel fee	On-time65%
Delta	Cheapest$149	Average$371	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$178	Average$388	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$312	Average$438	FlexibilityNo cancel fee	On-time63%

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$34+ Cheap flights from South Carolina to Detroit Metropolitan Wayne County Airport (DTW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from South Carolina to Detroit with Cheapflights

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2. Select your favorite providers

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Cheap flight deals from South Carolina to Detroit

Keep the following information in mind while searching for South Carolina to Detroit flight deals. Data was last updated July 29, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from South Carolina to Detroit

Cheapest flights from South Carolina to DetroitExplore the most affordable flight options available from South Carolina to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Explore the most affordable flight options available from South Carolina to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Detroit Metropolitan Wayne County Airport that are best for you.

Best time to book a flight from South Carolina to Detroit

Have a flexible travel schedule? Discover the best time to fly to Detroit from South Carolina with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Detroit Metropolitan Wayne County Airport

What is the cheapest month to book a flight from South Carolina to Detroit Metropolitan Wayne County Airport?

What is the cheapest time of day to fly from SC to DTW?

Find hourly flight availability from South Carolina to Detroit. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

Weekly flight availability from South Carolina to Detroit Metropolitan Wayne County Airport

Reviews of airlines servicing Detroit

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Detroit. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Detroit from South Carolina?

What are the cheapest airlines to fly from South Carolina to Detroit Metropolitan Wayne County Airport one-way?

What are the most popular routes from South Carolina to Detroit Metropolitan Wayne County Airport?

What are the most reliable airlines from South Carolina to Detroit Metropolitan Wayne County Airport?

What are the cheapest flights from South Carolina to Detroit Metropolitan Wayne County Airport?

Can I find deals for flights from South Carolina to Detroit that include hotel bookings?

How can I find direct flights from South Carolina to Detroit?

Can I find deals for business class flights from South Carolina to Detroit?

What is the cheapest month to book a flight from South Carolina to Detroit Metropolitan Wayne County Airport?

Traveling to a place near Detroit Metropolitan Wayne County Airport?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Detroit

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from South Carolina to Detroit

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Cheapest flights from South Carolina to Detroit
Explore the most affordable flight options available from South Carolina to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.