$1,028+ Cheap flights from Knoxville (TYS) to Cusco (CUZ)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CUZ
Oct 6 — Oct 131
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to Cuzco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Cuzco
Cheapest
Best
Last-minute
Cheapest flights from Knoxville to CuzcoExplore the most affordable flight options available from Knoxville to Cuzco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
Explore the most affordable flight options available from Knoxville to Cuzco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:53 am -
2 stops26h 40m
Wed 11/119:21 pm -
2 stops22h 56m
Deal found 9/2![American Airlines logo]()
$1,028
This Ovago deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/311:50 am -
2 stops20h 45m
Wed 11/1111:15 pm -
3 stops24h 44m
Deal found 9/2![LATAM Airlines logo]()
$1,153
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:40 pm -
2 stops13h 25m
Thu 9/109:15 pm -
2 stops24h 52m
Deal found 9/2![American Airlines logo]()
$1,341
This BusinessClass deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:30 am -
3 stops16h 55m
Thu 9/1011:20 pm -
2 stops34h 24m
Deal found 9/1![LATAM Airlines logo]()
$1,572
This KAYAK deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/39:45 am -
3 stops21h 25m
Thu 9/1011:35 am -
3 stops46h 59m
Deal found 9/1![Multiple Airlines logo]()
$5,030
Best flights from Knoxville to CuzcoDiscover carefully curated flight deals from Knoxville to Cuzco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
Discover carefully curated flight deals from Knoxville to Cuzco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
This Ovago deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/311:50 am -
2 stops20h 45m
Wed 11/1111:15 pm -
3 stops24h 44m
Deal found 9/2![LATAM Airlines logo]()
$1,153
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:12 pm -
3 stops17h 21m
Wed 11/119:21 pm -
3 stops18h 06m
Deal found 9/2![American Airlines logo]()
$2,744
Last-minute flights from Knoxville to CuzcoDiscover last-minute flight deals from Knoxville to Cuzco. Data last updated September 6, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Cuzco. Data last updated September 6, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:40 pm -
2 stops13h 25m
Thu 9/109:15 pm -
2 stops24h 52m
Deal found 9/2![American Airlines logo]()
$1,341
This BusinessClass deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:30 am -
3 stops16h 55m
Thu 9/1011:20 pm -
2 stops34h 24m
Deal found 9/1![LATAM Airlines logo]()
$1,572
This KAYAK deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/39:45 am -
3 stops21h 25m
Thu 9/1011:35 am -
3 stops46h 59m
Deal found 9/1![Multiple Airlines logo]()
$5,030
Find flight deals from Knoxville to Cuzco
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Cuzco (CUZ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 6, 2026.
Most accurate provider | AranGrant 3 stars |
|---|---|
Most trusted provider | AranGrant 3 stars |
Round-trip from | $1,028 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Cuzco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 6, 2026.
Use the filters below to find and compare flights from Knoxville to Cusco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleCusco
TYS Knoxville McGhee Tyson - CUZ Cusco Velazco Astete
TYSCUZ
Knoxville McGhee Tyson
Tue 11/3
11:50 am-8:35 am
2 stops20h 45m
Cusco Velazco Astete
Wed 11/11
11:15 pm-11:59 pm
3 stops24h 44m
$1,153
Quickest round-trip
KnoxvilleCusco
TYS Knoxville McGhee Tyson - CUZ Cusco Velazco Astete
TYSCUZ
Knoxville McGhee Tyson
Tue 11/3
4:12 pm-9:33 am
3 stops17h 21m
Cusco Velazco Astete
Wed 11/11
9:21 pm-3:27 pm
3 stops18h 06m
$2,744
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Knoxville-Cusco flights, users find the pricing of AranGrant to be most consistent on Cheapflights vs. AranGrant Users can find the same prices on Knoxville-Cusco flight deals on Cheapflights vs. AranGrant >95% of the time. Price accuracy is based on data collected from Knoxville-Cusco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Cusco flights, Cheapflights users trust AranGrant the most. AranGrant has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Cusco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Cuzco
Have a flexible travel schedule? Discover the best time to fly to Cuzco from Knoxville with our price prediction graph.
TYS-CUZ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Cuzco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Cuzco flight routes
Flights by cabin class
Other flight options
Other flights from Knoxville
Popular flights