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Cayman Islands

$190+ Cheap flights from Missouri to the Cayman Islands

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/4. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Missouri to Cayman Islands

Keep the following information in mind while searching for Missouri to Cayman Islands flight deals. Data was last updated June 12, 2025.

Round-trip from

$430
(American Airlines)

One-way from

$190
(Delta)

Popular in

December

Cheapest in

July

Average price

$597
From Missouri to Cayman Islands
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One-way flight from Missouri to Cayman Islands
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Highest demand for flights based on searches. 6% potential increase in price ($38 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Missouri to Cayman Islands

Cheapest flights from Missouri to Cayman Islands
Explore the most affordable flight options available from Missouri to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/15:28 amSTL - GCM
1 stop5h 42mAmerican Airlines
Tue 10/78:30 amGCM - STL
1 stop14h 39mAmerican Airlines
Deal found 6/11$430
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/303:00 pmMCI - GCM
2 stops20h 10mAmerican Airlines
Sat 9/1312:25 pmGCM - MCI
1 stop9h 01mAmerican Airlines
Deal found 6/12$461
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/205:45 amMCI - GCM
1 stop5h 37mDelta
Fri 7/2512:37 pmGCM - MCI
1 stop10h 19mDelta
Deal found 6/9$484
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/266:33 amSTL - GCM
1 stop6h 57mUnited Airlines
Sat 8/24:45 pmGCM - STL
1 stop16h 43mUnited Airlines
Deal found 6/11$510
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/256:30 amMCI - GCM
1 stop6h 00mUnited Airlines
Fri 8/11:35 pmGCM - MCI
2 stops20h 54mUnited Airlines
Deal found 6/10$514
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/2610:45 amSTL - GCM
3 stops34h 35mMultiple Airlines
Sat 8/28:50 amGCM - STL
3 stops25h 02mMultiple Airlines
Deal found 6/11$751
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/307:50 pmMCI - GCM
2 stops20h 20mMultiple Airlines
Fri 7/47:00 amGCM - MCI
3 stops39h 01mMultiple Airlines
Deal found 6/11$868
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:10 amMCI - GCM
1 stop6h 25mSouthwest
Fri 11/281:30 pmGCM - MCI
1 stop10h 05mSouthwest
Deal found 6/10$926
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/279:30 pmSTL - GCM
2 stops14h 05mSouthwest
Wed 12/311:30 pmGCM - STL
2 stops9h 30mSouthwest
Deal found 6/10$950
This Air Canada deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/166:00 amMCI - GCM
2 stops29h 55mAir Canada
Mon 7/2812:50 pmGCM - MCI
2 stops34h 41mAir Canada
Deal found 6/9$1,431

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Missouri to the Cayman Islands that are best for you.

Fly from

Missouri

Fly to

Cayman Islands

Route

Depart

Return

Price

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Wed 10/1

5:28 am-11:10 am

1 stop5h 42m

George Town Owen Roberts Intl

Tue 10/7

8:30 am-11:09 pm

1 stop14h 39m

$430

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sat 8/30

3:00 pm-11:10 am

2 stops20h 10m

George Town Owen Roberts Intl

Sat 9/13

12:25 pm-9:26 pm

1 stop9h 01m

$461

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Sun 7/20

5:45 am-11:22 am

1 stop5h 37m

George Town Owen Roberts Intl

Fri 7/25

12:37 pm-10:56 pm

1 stop10h 19m

$484

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sat 7/26

6:33 am-1:30 pm

1 stop6h 57m

George Town Owen Roberts Intl

Sat 8/2

4:45 pm-9:28 am

1 stop16h 43m

$510

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Fri 7/25

6:30 am-12:30 pm

1 stop6h 00m

George Town Owen Roberts Intl

Fri 8/1

1:35 pm-10:29 am

2 stops20h 54m

$514

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Sat 7/26

10:45 am-9:20 pm

3 stops34h 35m

George Town Owen Roberts Intl

Sat 8/2

8:50 am-9:52 am

3 stops25h 02m

$751

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Mon 6/30

7:50 pm-4:10 pm

2 stops20h 20m

George Town Owen Roberts Intl

Fri 7/4

7:00 am-10:01 pm

3 stops39h 01m

$868

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Mon 11/24

5:10 am-12:35 pm

1 stop6h 25m

George Town Owen Roberts Intl

Fri 11/28

1:30 pm-10:35 pm

1 stop10h 05m

$926

Kansas CityGeorge Town

MCI - GCM

MCIGCM

Kansas City

Wed 7/16

6:00 am-11:55 am

2 stops29h 55m

George Town Owen Roberts Intl

Mon 7/28

12:50 pm-11:31 pm

2 stops34h 41m

$1,431

St. LouisGeorge Town

STL - GCM

STLGCM

Lambert-St Louis

Thu 9/4

6:00 am-11:31 am

1 stop5h 31m

$190

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 12 results
1
2

Best time to book a flight from Missouri to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to the Cayman Islands

What is the cheapest month to book a flight from Missouri to Cayman Islands?

Currently, January is the cheapest month in which you can book a flight from Missouri to Cayman Islands (average of $467). Flying from Missouri to Cayman Islands in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to KY?

Find hourly flight availability from Missouri to Cayman Islands. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Cayman Islands as you normally would.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated June 12, 2025.
To help decide which airline to fly from Missouri to Cayman Islands, see what other customers have to say about Southwest, Delta and United Airlines. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,287 reviews

Boarding

8.2

Food

7.1

Crew

8.6

Comfort

8.0

Overall

8.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,287 reviews
Southwest
8.0
Very good
4,287 reviews

Boarding

8.2

Food

7.1

Crew

8.6

Comfort

8.0

Overall

8.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,950 reviews
Southwest
8.0
Very good
4,287 reviews

Boarding

8.2

Food

7.1

Crew

8.6

Comfort

8.0

Overall

8.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,790 reviews
Southwest
8.0
Very good
4,287 reviews

Boarding

8.2

Food

7.1

Crew

8.6

Comfort

8.0

Overall

8.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,287 reviews

Boarding

8.2

Food

7.1

Crew

8.6

Comfort

8.0

Overall

8.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Air Canada
7.1
Good
9,531 reviews
Southwest
8.0
Very good
4,287 reviews

Boarding

8.2

Food

7.1

Crew

8.6

Comfort

8.0

Overall

8.0

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • Can I find deals for flights from Missouri to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Missouri to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Cayman Islands.

  • Can I find deals for business class flights from Missouri to Cayman Islands?

    Yes. Cheapflights offers flight deals from Missouri to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Cayman Islands?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Cayman Islands (average of $467). Flying from Missouri to Cayman Islands in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 4 airlines flying from Missouri to Cayman Islands

Discover the top 4 airlines that operate flights from Missouri to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$238Average$598FlexibilityNo cancel feeOn-time69%
DeltaCheapest$266Average$598FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$434Average$607FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$483Average$619FlexibilityNo cancel feeOn-time63%

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