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Cayman Islands

$313+ Cheap flights from Mississippi to the Cayman Islands

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — GCM
Feb 19 — Feb 261
Thu 2/19
Thu 2/26
1 adult, Economy
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Cheap flight deals from Mississippi to Cayman Islands

Keep the following information in mind while searching for Mississippi to Cayman Islands flight deals. Data was last updated January 20, 2026.

Round-trip from

$415
(American Airlines)
From Mississippi to Cayman Islands
Search Deals

Find flight deals from Mississippi to Cayman Islands

Cheapest flights from Mississippi to Cayman Islands
Explore the most affordable flight options available from Mississippi to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.

This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:00 am
MEM
-
GCM
1 stop5h 29m
Delta
Wed 2/251:54 pm
GCM
-
MEM
1 stop10h 29m
Delta
Deal found 1/19$313
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:05 am
MEM
-
GCM
1 stop6h 09m
American Airlines
Wed 3/48:45 am
GCM
-
MEM
1 stop16h 10m
American Airlines
Deal found 1/19$415
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:00 am
MEM
-
GCM
2 stops13h 15m
American Airlines
Wed 2/2512:58 pm
GCM
-
MEM
1 stop10h 55m
American Airlines
Deal found 1/19$420
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:59 pm
MEM
-
GCM
1 stop18h 26m
American Airlines
Thu 3/1212:00 pm
GCM
-
MEM
1 stop11h 51m
American Airlines
Deal found 1/19$439
This Kiwi.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/197:04 pm
MEM
-
GCM
2 stops15h 31m
Multiple Airlines
Sun 2/222:49 pm
GCM
-
MEM
1 stop26h 28m
Multiple Airlines
Deal found 1/19$454
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:00 am
MEM
-
GCM
1 stop6h 32m
American Airlines
Sun 4/262:10 pm
GCM
-
MEM
2 stops18h 08m
American Airlines
Deal found 1/19$495
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:39 pm
MEM
-
GCM
1 stop17h 21m
American Airlines
Wed 6/102:40 pm
GCM
-
MEM
1 stop7h 31m
American Airlines
Deal found 1/19$517
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:38 pm
GPT
-
GCM
1 stop16h 42m
American Airlines
Sat 6/62:10 pm
GCM
-
GPT
2 stops20h 45m
American Airlines
Deal found 1/19$531
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/215:38 am
MEM
-
GCM
1 stop10h 38m
American Airlines
Sat 3/287:45 am
GCM
-
MEM
1 stop16h 07m
American Airlines
Deal found 1/19$532
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:00 am
MOB
-
GCM
1 stop5h 30m
United Airlines
Mon 4/131:35 pm
GCM
-
MOB
1 stop8h 24m
United Airlines
Deal found 1/19$536
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/195:45 am
MEM
-
GCM
1 stop8h 00m
American Airlines
Sun 2/228:45 am
GCM
-
MEM
1 stop16h 10m
American Airlines
Deal found 1/19$547
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/179:25 am
BTR
-
GCM
1 stop6h 05m
United Airlines
Sun 3/224:45 pm
GCM
-
BTR
1 stop6h 00m
United Airlines
Deal found 1/19$564

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
Use the filters below to find and compare flights from Mississippi to the Cayman Islands that are best for you.

Fly from

Mississippi

Fly to

Cayman Islands

Route

Depart

Return

Price

MemphisGeorge Town

MEM - GCM

MEMGCM

Memphis

Wed 2/18

6:00 am-12:29 pm

1 stop5h 29m

George Town Owen Roberts Intl

Wed 2/25

1:54 pm-11:23 pm

1 stop10h 29m

$313

MemphisGeorge Town

MEM - GCM

MEMGCM

Memphis

Wed 4/22

5:25 am-11:24 am

1 stop5h 59m

George Town Owen Roberts Intl

Sun 4/26

12:45 pm-8:45 pm

1 stop8h 00m

$415

MemphisGeorge Town

MEM - GCM

MEMGCM

Memphis

Thu 2/26

8:53 am-8:15 pm

2 stops10h 22m

George Town Owen Roberts Intl

Wed 3/4

3:45 pm-11:55 pm

1 stop9h 10m

$420

MemphisGeorge Town

MEM - GCM

MEMGCM

Memphis

Sun 3/8

7:59 pm-2:25 pm

1 stop18h 26m

George Town Owen Roberts Intl

Thu 3/12

12:00 pm-11:51 pm

1 stop11h 51m

$439

MemphisGeorge Town

MEM - GCM

MEMGCM

Memphis

Thu 2/19

7:04 pm-11:35 am

2 stops15h 31m

George Town Owen Roberts Intl

Sun 2/22

2:49 pm-4:17 pm

1 stop26h 28m

$454

MemphisGeorge Town

MEM - GCM

MEMGCM

Memphis

Wed 4/22

5:00 am-11:32 am

1 stop6h 32m

George Town Owen Roberts Intl

Sun 4/26

2:10 pm-8:18 am

2 stops18h 08m

$495

MemphisGeorge Town

MEM - GCM

MEMGCM

Memphis

Fri 6/5

5:39 pm-11:00 am

1 stop17h 21m

George Town Owen Roberts Intl

Wed 6/10

2:40 pm-10:11 pm

1 stop7h 31m

$517

GulfportGeorge Town

GPT - GCM

GPTGCM

Gulfport Biloxi Regional

Sat 5/30

7:47 pm-1:10 pm

2 stops17h 23m

George Town Owen Roberts Intl

Sat 6/6

2:10 pm-10:55 am

2 stops20h 45m

$531

MobileGeorge Town

MOB - GCM

MOBGCM

Mobile

Wed 4/8

7:00 am-12:30 pm

1 stop5h 30m

George Town Owen Roberts Intl

Mon 4/13

1:35 pm-9:59 pm

1 stop8h 24m

$536

MemphisGeorge Town

MEM - GCM

MEMGCM

Memphis

Thu 2/19

7:05 am-2:14 pm

1 stop6h 09m

George Town Owen Roberts Intl

Sun 2/22

8:45 am-11:55 pm

1 stop16h 10m

$547

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

Showing 1-10 of 23 results
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Best time to book a flight from Mississippi to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to the Cayman Islands
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mississippi to Cayman Islands?

    Delta, American Airlines, and United Airlines can get you from Mississippi to Cayman Islands in just under 5h 29m. Your travel time can differ by up to 4h 53m. The distance from Mississippi to Cayman Islands is about 1208 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Mississippi to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Mississippi to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Cayman Islands.

  • Can I find deals for business class flights from Mississippi to Cayman Islands?

    Yes. Cheapflights offers flight deals from Mississippi to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mississippi to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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