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Cayman Islands

$321+ Cheap flights from Buffalo (BUF) to the Cayman Islands

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/7. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — GCM
May 19 — May 261
Tue 5/19
Tue 5/26
1 adult, Economy
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Cheap flight deals from Buffalo to Cayman Islands

Cheapest flights from Buffalo to Cayman Islands
Explore the most affordable flight options available from Buffalo to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 19, 2026.

This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:24 am
BUF
-
GCM
1 stop6h 32m
American Airlines
Wed 11/114:10 pm
GCM
-
BUF
1 stop7h 58m
American Airlines
Deal found 4/15$321
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:28 pm
BUF
-
GCM
2 stops16h 27m
American Airlines
Tue 5/192:10 pm
GCM
-
BUF
2 stops21h 55m
American Airlines
Deal found 4/15$327
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
BUF
-
GCM
2 stops11h 08m
American Airlines
Tue 7/145:12 pm
GCM
-
BUF
2 stops19h 17m
American Airlines
Deal found 4/14$331
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:54 pm
BUF
-
GCM
1 stop16h 36m
American Airlines
Tue 9/112:30 pm
GCM
-
BUF
1 stop8h 25m
American Airlines
Deal found 4/18$425
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:15 am
BUF
-
GCM
1 stop6h 39m
Delta
Tue 5/191:19 pm
GCM
-
BUF
1 stop9h 40m
Delta
Deal found 4/18$483
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/117:40 pm
BUF
-
GCM
2 stops16h 45m
American Airlines
Sat 7/184:07 pm
GCM
-
BUF
2 stops19h 49m
American Airlines
Deal found 4/16$486
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:00 am
BUF
-
GCM
1 stop6h 30m
American Airlines
Sun 7/195:12 pm
GCM
-
BUF
2 stops18h 44m
American Airlines
Deal found 4/16$491
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:28 pm
BUF
-
GCM
1 stop17h 03m
American Airlines
Thu 5/2112:33 pm
GCM
-
BUF
1 stop9h 03m
American Airlines
Deal found 4/14$521
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:00 am
BUF
-
GCM
1 stop10h 10m
United Airlines
Sat 7/184:15 pm
GCM
-
BUF
1 stop16h 36m
United Airlines
Deal found 4/16$545

Find flight deals from Buffalo to Cayman Islands

Keep the following information in mind while searching for Buffalo to Cayman Islands flight deals. Data was last updated April 19, 2026.

Round-trip from

$326
(American Airlines)

Popular in

December

Cheapest in

January

Average price

$642
From Buffalo to Cayman Islands
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($78 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($55 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 19, 2026.
Use the filters below to find and compare flights from Buffalo to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloGeorge Town

BUF - GCM

BUFGCM

Buffalo

Fri 8/28

6:59 pm-10:55 am

2 stops16h 56m

George Town Owen Roberts Intl

Thu 9/3

12:30 pm-10:18 am

2 stops20h 48m

$326
Quickest round-trip

BuffaloGeorge Town

BUF - GCM

BUFGCM

Buffalo

Wed 6/3

7:31 pm-11:30 am

1 stop16h 59m

George Town Owen Roberts Intl

Mon 6/8

12:33 pm-10:36 pm

1 stop9h 03m

$326

BuffaloGeorge Town

BUF - GCM

BUFGCM

Buffalo

Fri 5/15

7:28 pm-10:55 am

2 stops16h 27m

George Town Owen Roberts Intl

Tue 5/19

2:10 pm-10:51 am

2 stops19h 41m

$326

BuffaloGeorge Town

BUF - GCM

BUFGCM

Buffalo

Wed 7/8

7:34 pm-11:25 am

1 stop16h 51m

George Town Owen Roberts Intl

Tue 7/14

5:12 pm-11:00 am

2 stops16h 48m

$331

BuffaloGeorge Town

BUF - GCM

BUFGCM

Buffalo

Fri 8/28

4:49 pm-10:55 am

2 stops19h 06m

George Town Owen Roberts Intl

Tue 9/1

12:30 pm-9:55 pm

1 stop8h 25m

$430

BuffaloGeorge Town

BUF - GCM

BUFGCM

Buffalo

Thu 7/2

6:00 am-11:25 am

1 stop6h 25m

George Town Owen Roberts Intl

Fri 7/10

5:12 pm-2:19 pm

2 stops20h 07m

$430

BuffaloGeorge Town

BUF - GCM

BUFGCM

Buffalo

Thu 5/14

7:28 pm-11:31 am

1 stop17h 03m

George Town Owen Roberts Intl

Thu 5/21

5:12 pm-2:21 pm

2 stops20h 09m

$430

BuffaloGeorge Town

BUF - GCM

BUFGCM

Buffalo

Sat 7/11

7:40 pm-11:25 am

2 stops16h 45m

George Town Owen Roberts Intl

Sun 7/19

5:12 pm-12:56 pm

2 stops18h 44m

$491

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/18

Sorted by cheapest first

Best time to book a flight from Buffalo to Cayman Islands

Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to the Cayman Islands
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Cayman Islands

Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated April 19, 2026.
Peruse reviews from past customers who have flown with American Airlines from Buffalo to the Cayman Islands to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,619 reviews

Boarding

7.5

Comfort

7.2

Entertainment

6.9

Overall

7.1

Food

6.4

Crew

7.9

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.
American Airlines
7.1
Good
11,619 reviews
American Airlines
7.1
Good
11,619 reviews

Boarding

7.5

Comfort

7.2

Entertainment

6.9

Overall

7.1

Food

6.4

Crew

7.9

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to Cayman Islands?

    Located just 8.3 mi from the city center, Buffalo (BUF) is the airport most travelers will use when flying to Cayman Islands from Buffalo.

  • How long is the flight from Buffalo to Cayman Islands?

    A quick flight from Buffalo to Cayman Islands can take about 16h 56m. American Airlines provides one of the quickest options available for as low as $326. The distance between Buffalo and Cayman Islands is about 1640 mi.

  • Can I find deals for flights from Buffalo to Cayman Islands that include hotel bookings?

    Yes. In addition to deals on Buffalo to Cayman Islands flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Cayman Islands?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Cayman Islands.

  • Can I find deals for business class flights from Buffalo to Cayman Islands?

    Yes. Cheapflights offers flight deals from Buffalo to Cayman Islands by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Buffalo to Cayman Islands

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Buffalo to Cayman Islands

Discover the top airline that operate flights from Buffalo to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 19, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$339Average$555FlexibilityNo cancel feeOn-time71%

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