$117+ Cheap flights from Buffalo (BUF) to the Cayman Islands
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/11. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — GCM
Mar 22 — Mar 291
1 adult, Economy
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Cheapest flights from Buffalo to Cayman IslandsExplore the most affordable flight options available from Buffalo to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2026.
Explore the most affordable flight options available from Buffalo to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2026.
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:30 pm
BUF
- GCM
2 stops18h 40m
American Airlines
Tue 7/142:10 pm
GCM
- BUF
2 stops18h 26m
American Airlines
Deal found 2/19![American Airlines logo]()
$312
This United Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:00 am
BUF
- GCM
1 stop6h 45m
United Airlines
Sat 12/122:50 pm
GCM
- BUF
1 stop18h 59m
United Airlines
Deal found 2/16![United Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:02 pm
BUF
- GCM
2 stops19h 31m
American Airlines
Sun 5/245:11 pm
GCM
- BUF
2 stops18h 06m
American Airlines
Deal found 2/19![American Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:45 pm
BUF
- GCM
1 stop22h 48m
American Airlines
Fri 5/812:00 pm
GCM
- BUF
2 stops21h 18m
American Airlines
Deal found 2/19![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:02 pm
BUF
- GCM
1 stop20h 42m
American Airlines
Mon 3/232:44 pm
GCM
- BUF
1 stop20h 05m
American Airlines
Deal found 2/19![American Airlines logo]()
$320
This United Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
BUF
- GCM
1 stop7h 15m
United Airlines
Wed 3/111:25 pm
GCM
- BUF
2 stops9h 17m
United Airlines
Deal found 2/16![United Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:00 am
BUF
- GCM
1 stop6h 29m
Delta
Tue 3/101:12 pm
GCM
- BUF
1 stop9h 34m
Delta
Deal found 2/16![Delta logo]()
$330
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
BUF
- GCM
1 stop6h 20m
American Airlines
Wed 7/152:10 pm
GCM
- BUF
2 stops18h 26m
American Airlines
Deal found 2/17![American Airlines logo]()
$332
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:30 am
BUF
- GCM
1 stop8h 55m
American Airlines
Thu 3/53:15 pm
GCM
- BUF
1 stop8h 35m
American Airlines
Deal found 2/19![American Airlines logo]()
$339
Best flights from Buffalo to Cayman IslandsDiscover carefully curated flight deals from Buffalo to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 20, 2026.
Discover carefully curated flight deals from Buffalo to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 20, 2026.
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:30 pm
BUF
- GCM
2 stops18h 40m
American Airlines
Tue 7/142:10 pm
GCM
- BUF
2 stops18h 26m
American Airlines
Deal found 2/19![American Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:45 pm
BUF
- GCM
1 stop16h 15m
Delta
Mon 3/91:12 pm
GCM
- BUF
1 stop9h 34m
Delta
Deal found 2/16![Delta logo]()
$330
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:28 pm
BUF
- GCM
2 stops18h 42m
American Airlines
Fri 5/82:10 pm
GCM
- BUF
2 stops21h 55m
American Airlines
Deal found 2/19![American Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:00 am
BUF
- GCM
1 stop6h 29m
Delta
Tue 3/101:12 pm
GCM
- BUF
1 stop9h 34m
Delta
Deal found 2/16![Delta logo]()
$330
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:02 pm
BUF
- GCM
1 stop20h 42m
American Airlines
Mon 3/232:44 pm
GCM
- BUF
1 stop20h 05m
American Airlines
Deal found 2/19![American Airlines logo]()
$320
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:00 am
BUF
- GCM
1 stop6h 29m
Delta
Tue 3/101:12 pm
GCM
- BUF
1 stop9h 34m
Delta
Deal found 2/16![Delta logo]()
$330
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:45 pm
BUF
- GCM
1 stop16h 15m
Delta
Sat 3/141:00 pm
GCM
- BUF
1 stop10h 14m
Delta
Deal found 2/16![Delta logo]()
$330
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/36:00 am
BUF
- GCM
1 stop6h 29m
Delta
Mon 3/91:12 pm
GCM
- BUF
1 stop9h 34m
Delta
Deal found 2/16![Delta logo]()
$330
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:00 am
BUF
- GCM
1 stop6h 29m
Delta
Sat 3/1412:09 pm
GCM
- BUF
1 stop9h 46m
Delta
Deal found 2/16![Delta logo]()
$330
Last-minute flights from Buffalo to Cayman IslandsDiscover last-minute flight deals from Buffalo to Cayman Islands. Data last updated February 20, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Cayman Islands. Data last updated February 20, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/196:00 am
BUF
- GCM
1 stop7h 15m
United Airlines
Mon 2/232:50 pm
GCM
- BUF
1 stop9h 09m
United Airlines
Deal found 2/17![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:30 am
BUF
- GCM
1 stop8h 55m
American Airlines
Thu 3/53:15 pm
GCM
- BUF
1 stop8h 35m
American Airlines
Deal found 2/19![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:41 pm
BUF
- GCM
2 stops16h 48m
Delta
Thu 3/51:54 pm
GCM
- BUF
2 stops21h 15m
Delta
Deal found 2/16![Delta logo]()
$344
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:41 pm
BUF
- GCM
1 stop16h 27m
American Airlines
Wed 3/112:44 pm
GCM
- BUF
1 stop7h 56m
American Airlines
Deal found 2/16![American Airlines logo]()
$383
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:00 am
BUF
- GCM
1 stop6h 29m
Delta
Tue 3/101:12 pm
GCM
- BUF
1 stop9h 34m
Delta
Deal found 2/16![Delta logo]()
$330
This United Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
BUF
- GCM
1 stop7h 15m
United Airlines
Wed 3/111:25 pm
GCM
- BUF
2 stops9h 17m
United Airlines
Deal found 2/16![United Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:02 pm
BUF
- GCM
1 stop20h 42m
American Airlines
Mon 3/232:44 pm
GCM
- BUF
1 stop20h 05m
American Airlines
Deal found 2/19![American Airlines logo]()
$320
This United Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:00 am
BUF
- GCM
1 stop6h 45m
United Airlines
Mon 3/231:50 pm
GCM
- BUF
2 stops23h 24m
United Airlines
Deal found 2/18![United Airlines logo]()
$368
One-way flights from Buffalo to Cayman IslandsSearch for one-way flight options from Buffalo to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated February 20, 2026.
Search for one-way flight options from Buffalo to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated February 20, 2026.
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:40 pm
BUF
- GCM
1 stop16h 30m
American Airlines
Deal found 2/19![American Airlines logo]()
$117
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:30 pm
BUF
- GCM
2 stops18h 15m
United Airlines
Deal found 2/19![United Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:15 am
BUF
- GCM
3 stops35h 45m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$1,398
Find flight deals from Buffalo to Cayman Islands
Keep the following information in mind while searching for Buffalo to Cayman Islands flight deals. Data was last updated February 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $312 (American Airlines) |
One-way from | $117 (American Airlines) |
Popular in | July |
Cheapest in | January |
Average price | $579 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
Use the filters below to find and compare flights from Buffalo to the Cayman Islands that are best for you.
Fly from
Buffalo
Fly to
Cayman Islands
Route
Depart
Return
Price
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Wed 7/8
7:30 pm-1:10 pm
2 stops18h 40m
George Town Owen Roberts Intl
Tue 7/14
2:10 pm-9:36 am
2 stops18h 26m
$312
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Fri 5/1
7:28 pm-1:10 pm
2 stops18h 42m
George Town Owen Roberts Intl
Fri 5/8
2:10 pm-1:05 pm
2 stops21h 55m
$312
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Thu 3/19
6:02 pm-1:44 pm
1 stop20h 42m
George Town Owen Roberts Intl
Mon 3/23
2:44 pm-11:49 am
1 stop20h 05m
$320
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Fri 3/6
6:45 pm-11:00 am
1 stop16h 15m
George Town Owen Roberts Intl
Mon 3/9
1:12 pm-11:46 pm
1 stop9h 34m
$330
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Mon 3/2
6:00 am-12:29 pm
1 stop6h 29m
George Town Owen Roberts Intl
Tue 3/10
1:12 pm-11:46 pm
1 stop9h 34m
$330
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Thu 3/5
6:00 am-12:29 pm
1 stop6h 29m
George Town Owen Roberts Intl
Tue 3/10
1:12 pm-11:46 pm
1 stop9h 34m
$330
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Fri 3/6
6:45 pm-11:00 am
1 stop16h 15m
George Town Owen Roberts Intl
Sat 3/14
1:00 pm-12:14 am
1 stop10h 14m
$330
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Tue 3/3
6:00 am-12:29 pm
1 stop6h 29m
George Town Owen Roberts Intl
Mon 3/9
1:12 pm-11:46 pm
1 stop9h 34m
$330
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Mon 3/2
6:00 am-12:29 pm
1 stop6h 29m
George Town Owen Roberts Intl
Sat 3/14
12:09 pm-10:55 pm
1 stop9h 46m
$330
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Wed 3/11
7:40 pm-11:10 am
1 stop16h 30m
$117
Showing 1-10 of 12 results
Best time to book a flight from Buffalo to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Buffalo with our price prediction graph.
BUF-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to the Cayman Islands
BUF-KY0
BUF-GCM
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Cayman Islands
Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated February 20, 2026.
Peruse reviews from past customers who have flown with American Airlines from Buffalo to the Cayman Islands to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.4
Boarding
7.5
Overall
7.2
Comfort
7.2
Entertainment
6.9
Crew
8.0
Reviews
1 / 20
2.0
MediocreSusie,Jan 2026
CLT - TPA
Food
6.4
Boarding
7.5
Overall
7.2
Comfort
7.2
Entertainment
6.9
Crew
8.0
Reviews
1 / 20
2.0
MediocreSusie,Jan 2026
CLT - TPA
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to Cayman Islands
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Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
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Buffalo and Cayman Islands flights
Browse other Buffalo and Cayman Islands flight options. Last updated on February 20, 2026.
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Top airline flying from Buffalo to Cayman Islands
Discover the top airline that operate flights from Buffalo to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$339 | Average$550 | FlexibilityNo cancel fee | On-time71% |