$121+ Cheap flights from Buffalo (BUF) to the Cayman Islands
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/25. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — GCM
May 4 — May 111
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Buffalo to Cayman IslandsExplore the most affordable flight options available from Buffalo to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2026.
Explore the most affordable flight options available from Buffalo to Cayman Islands. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2026.
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:00 am
BUF
- GCM
1 stop7h 44m
American Airlines
Sat 5/234:07 pm
GCM
- BUF
2 stops16h 24m
American Airlines
Deal found 4/1![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:55 pm
BUF
- GCM
2 stops19h 35m
United Airlines
Sat 5/162:40 pm
GCM
- BUF
1 stop7h 53m
United Airlines
Deal found 4/2![United Airlines logo]()
$347
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
BUF
- GCM
1 stop7h 30m
United Airlines
Wed 4/291:35 pm
GCM
- BUF
2 stops19h 18m
United Airlines
Deal found 4/4![United Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/44:46 pm
BUF
- GCM
1 stop20h 10m
American Airlines
Sat 12/122:00 pm
GCM
- BUF
1 stop9h 39m
American Airlines
Deal found 3/31![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:34 pm
BUF
- GCM
2 stops16h 27m
American Airlines
Tue 7/145:12 pm
GCM
- BUF
2 stops15h 20m
American Airlines
Deal found 3/31![American Airlines logo]()
$357
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:31 pm
BUF
- GCM
1 stop20h 36m
American Airlines
Tue 6/235:12 pm
GCM
- BUF
2 stops16h 40m
American Airlines
Deal found 4/1![American Airlines logo]()
$460
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/277:00 am
BUF
- GCM
1 stop6h 45m
United Airlines
Wed 4/291:35 pm
GCM
- BUF
2 stops19h 06m
United Airlines
Deal found 4/2![United Airlines logo]()
$472
Best flights from Buffalo to Cayman IslandsDiscover carefully curated flight deals from Buffalo to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 4, 2026.
Discover carefully curated flight deals from Buffalo to Cayman Islands that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 4, 2026.
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:00 am
BUF
- GCM
1 stop7h 44m
American Airlines
Sat 5/234:07 pm
GCM
- BUF
2 stops16h 24m
American Airlines
Deal found 4/1![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
BUF
- GCM
1 stop7h 30m
United Airlines
Wed 4/291:35 pm
GCM
- BUF
2 stops19h 18m
United Airlines
Deal found 4/4![United Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:00 am
BUF
- GCM
1 stop6h 31m
American Airlines
Sat 5/164:03 pm
GCM
- BUF
1 stop6h 47m
American Airlines
Deal found 4/2![American Airlines logo]()
$347
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:56 pm
BUF
- GCM
1 stop16h 14m
American Airlines
Tue 9/291:20 pm
GCM
- BUF
2 stops21h 04m
American Airlines
Deal found 3/30![American Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:00 am
BUF
- GCM
2 stops11h 03m
American Airlines
Wed 4/292:05 pm
GCM
- BUF
2 stops19h 46m
American Airlines
Deal found 4/4![American Airlines logo]()
$352
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:00 am
BUF
- GCM
1 stop6h 45m
United Airlines
Wed 4/291:50 pm
GCM
- BUF
2 stops19h 03m
United Airlines
Deal found 4/3![United Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:34 pm
BUF
- GCM
2 stops16h 27m
American Airlines
Tue 7/145:12 pm
GCM
- BUF
2 stops19h 17m
American Airlines
Deal found 4/2![American Airlines logo]()
$357
Last-minute flights from Buffalo to Cayman IslandsDiscover last-minute flight deals from Buffalo to Cayman Islands. Data last updated April 4, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Cayman Islands. Data last updated April 4, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/197:00 am
BUF
- GCM
1 stop6h 45m
United Airlines
Sun 4/261:50 pm
GCM
- BUF
2 stops19h 10m
United Airlines
Deal found 4/1![United Airlines logo]()
$504
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
BUF
- GCM
1 stop7h 30m
United Airlines
Wed 4/291:35 pm
GCM
- BUF
2 stops19h 18m
United Airlines
Deal found 4/4![United Airlines logo]()
$352
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/277:00 am
BUF
- GCM
1 stop6h 45m
United Airlines
Wed 4/291:35 pm
GCM
- BUF
2 stops19h 06m
United Airlines
Deal found 4/2![United Airlines logo]()
$472
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:55 pm
BUF
- GCM
2 stops19h 35m
United Airlines
Sat 5/162:40 pm
GCM
- BUF
1 stop7h 53m
United Airlines
Deal found 4/2![United Airlines logo]()
$347
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:00 am
BUF
- GCM
1 stop7h 44m
American Airlines
Sat 5/234:07 pm
GCM
- BUF
2 stops16h 24m
American Airlines
Deal found 4/1![American Airlines logo]()
$339
One-way flights from Buffalo to Cayman IslandsSearch for one-way flight options from Buffalo to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated April 4, 2026.
Search for one-way flight options from Buffalo to Cayman Islands. Find affordable one-way fares based on user searches. Data last updated April 4, 2026.
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
BUF
- GCM
1 stop7h 30m
United Airlines
Deal found 4/4![United Airlines logo]()
$121
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/97:38 pm
BUF
- GCM
2 stops16h 32m
American Airlines
Deal found 3/31![American Airlines logo]()
$127
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:00 am
BUF
- GCM
1 stop7h 00m
Delta
Deal found 4/1![Delta logo]()
$137
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:00 am
BUF
- GCM
2 stops29h 10m
American Airlines
Deal found 3/31![American Airlines logo]()
$162
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:00 am
BUF
- GCM
1 stop7h 30m
United Airlines
Deal found 3/31![United Airlines logo]()
$181
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:00 am
BUF
- GCM
1 stop6h 41m
Delta
Deal found 3/31![Delta logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/141:56 pm
BUF
- GCM
3 stops46h 39m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$328
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/911:35 am
BUF
- GCM
3 stops25h 00m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$338
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/812:29 pm
BUF
- GCM
3 stops24h 06m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$393
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1011:40 am
BUF
- GCM
3 stops26h 05m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$519
Find flight deals from Buffalo to Cayman Islands
Keep the following information in mind while searching for Buffalo to Cayman Islands flight deals. Data was last updated April 4, 2026.
Round-trip from | $339 (American Airlines) |
|---|---|
One-way from | $121 (United Airlines) |
Popular in | July |
Cheapest in | January |
Average price | $625 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2026.
Use the filters below to find and compare flights from Buffalo to the Cayman Islands that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Sat 5/16
5:00 am-11:44 am
1 stop7h 44m
George Town Owen Roberts Intl
Sat 5/23
4:07 pm-9:31 am
2 stops16h 24m
$339
Quickest round-trip
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Sun 5/10
6:00 am-11:31 am
1 stop6h 31m
George Town Owen Roberts Intl
Sat 5/16
4:03 pm-11:50 pm
1 stop6h 47m
$347
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Sat 4/25
7:00 am-1:30 pm
1 stop7h 30m
George Town Owen Roberts Intl
Wed 4/29
1:35 pm-9:53 am
2 stops19h 18m
$352
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Tue 9/22
7:56 pm-11:10 am
1 stop16h 14m
George Town Owen Roberts Intl
Tue 9/29
1:20 pm-11:24 am
2 stops21h 04m
$352
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Sat 4/25
5:00 am-3:03 pm
2 stops11h 03m
George Town Owen Roberts Intl
Wed 4/29
2:05 pm-10:51 am
2 stops19h 46m
$352
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Wed 7/8
7:34 pm-11:01 am
2 stops16h 27m
George Town Owen Roberts Intl
Tue 7/14
5:12 pm-1:29 pm
2 stops19h 17m
$357
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Mon 4/27
6:00 am-11:45 am
1 stop6h 45m
George Town Owen Roberts Intl
Wed 4/29
1:50 pm-9:53 am
2 stops19h 03m
$472
Cheapest one-way
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Sat 4/25
7:00 am-1:30 pm
1 stop7h 30m
$121
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Sat 4/25
6:00 am-3:03 pm
2 stops10h 03m
$121
BuffaloGeorge Town
BUF - GCM
BUFGCM
Buffalo
Mon 8/10
7:25 pm-11:41 am
2 stops17h 16m
$127
Showing 1-10 of 15 resultsSorted by cheapest first
Best time to book a flight from Buffalo to Cayman Islands
Have a flexible travel schedule? Discover the best time to fly to Cayman Islands from Buffalo with our price prediction graph.
BUF-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to the Cayman Islands
BUF-KY0
BUF-GCM
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Cayman Islands
Get insights into the airlines that provide service to Cayman Islands. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cayman Islands. Reviews last updated April 4, 2026.
Peruse reviews from past customers who have flown with American Airlines from Buffalo to the Cayman Islands to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Overall
7.1
Entertainment
6.9
Boarding
7.5
Comfort
7.2
Reviews
1 / 20
4.0
OkayElizabeth,Mar 2026
ORD - MIA
Crew
7.9
Food
6.4
Overall
7.1
Entertainment
6.9
Boarding
7.5
Comfort
7.2
Reviews
1 / 20
4.0
OkayElizabeth,Mar 2026
ORD - MIA
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Cayman Islands. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Cayman Islands by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Buffalo to Cayman Islands, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and Cayman Islands flights
Browse other Buffalo and Cayman Islands flight options. Last updated on April 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Cayman Islands regions
Consider these flights traveling to Cayman Islands regions.
Top airline flying from Buffalo to Cayman Islands
Discover the top airline that operate flights from Buffalo to Cayman Islands. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$339 | Average$556 | FlexibilityNo cancel fee | On-time71% |