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$306+ Cheap flights from Panama City (PTY) to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/23. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Aug 23 — Aug 301
Sat 8/23
Sat 8/30
1 adult, Economy
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Cheap flight deals from Panama City to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 18, 2025.

Round-trip from

$535
(Delta)

One-way from

$306
(United Airlines)
From Panama City Tocumen Intl to Buffalo
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One-way flight from Panama City Tocumen Intl to Buffalo
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Find flight deals from Panama City to Buffalo

Cheapest flights from Panama City to Buffalo
Explore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/193:30 pmPTY - BUF
2 stops24h 22mUnited Airlines
Tue 9/28:00 pmBUF - PTY
2 stops23h 37mUnited Airlines
Deal found 8/17$535
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:41 pmPTY - BUF
2 stops30h 17mUnited Airlines
Tue 11/46:00 amBUF - PTY
1 stop7h 55mUnited Airlines
Deal found 8/17$542
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:15 pmPTY - BUF
2 stops18h 26mAmerican Airlines
Tue 11/46:33 pmBUF - PTY
2 stops19h 03mAmerican Airlines
Deal found 8/17$548
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/192:05 pmPTY - BUF
1 stop8h 52mDelta
Mon 9/86:00 amBUF - PTY
1 stop7h 50mDelta
Deal found 8/16$704
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/193:30 pmPTY - BUF
2 stops19h 34mAmerican Airlines
Mon 9/85:37 pmBUF - PTY
2 stops20h 18mAmerican Airlines
Deal found 8/17$769
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2011:55 pmPTY - BUF
2 stops21h 22mUnited Airlines
Fri 1/27:48 pmBUF - PTY
2 stops18h 07mUnited Airlines
Deal found 8/16$860
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/317:55 amPTY - BUF
2 stops14h 03mUnited Airlines
Wed 11/56:00 amBUF - PTY
1 stop7h 55mUnited Airlines
Deal found 8/16$883
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/193:30 pmPTY - BUF
2 stops17h 23mUnited Airlines
Mon 9/86:30 amBUF - PTY
1 stop8h 20mUnited Airlines
Deal found 8/17$985
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:25 amPTY - BUF
1 stop8h 39mMultiple Airlines
Fri 1/27:04 pmBUF - PTY
2 stops25h 33mMultiple Airlines
Deal found 8/16$1,115

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.

Fly from

Panama City

Fly to

Buffalo

Route

Depart

Return

Price

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 10/31

2:21 pm-11:39 pm

1 stop8h 18m

Buffalo

Wed 11/5

6:00 am-1:56 pm

1 stop7h 56m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 10/31

3:41 pm-10:58 pm

2 stops30h 17m

Buffalo

Tue 11/4

6:00 am-1:55 pm

1 stop7h 55m

$542

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 10/31

3:15 pm-10:41 am

2 stops18h 26m

Buffalo

Wed 11/5

6:33 pm-1:36 pm

2 stops19h 03m

$548

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 10/31

3:15 pm-10:41 am

2 stops18h 26m

Buffalo

Tue 11/4

6:33 pm-1:36 pm

2 stops19h 03m

$548

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 10/31

3:41 pm-10:03 am

2 stops17h 22m

Buffalo

Wed 11/5

6:00 am-1:55 pm

1 stop7h 55m

$769

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 12/20

11:55 pm-9:17 pm

2 stops21h 22m

Buffalo

Fri 1/2

7:48 pm-1:55 pm

2 stops18h 07m

$860

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 12/20

9:25 am-6:04 pm

1 stop8h 39m

Buffalo

Fri 1/2

7:04 pm-8:37 pm

2 stops25h 33m

$1,115

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 10/31

7:55 am-9:00 pm

1 stop12h 05m

Buffalo

Tue 11/4

7:30 pm-1:31 pm

1 stop18h 01m

$2,093

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 8/23

3:30 pm-9:16 pm

2 stops28h 46m

$306

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 8/23

9:34 am-11:40 am

3 stops25h 06m

$428

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Best time to book a flight from Panama City to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Buffalo?

    There are many flights that can get you from Panama City to Buffalo in 8h 18m. Fly via Delta, United Airlines, or American Airlines to get the fastest option. The distance from Panama City to Buffalo is about 2339 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Panama City to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama City to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Buffalo.

  • Can I find deals for business class flights from Panama City to Buffalo?

    Yes. Cheapflights offers flight deals from Panama City to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Buffalo (average of $256). Flying from Panama City to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Alternative routes for Panama City to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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