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$535+ Cheap flights from Panama City (PTY) to Buffalo (BUF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/13. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Panama City to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$535
(Delta)
From Panama City Tocumen Intl to Buffalo
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Find flight deals from Panama City to Buffalo

Cheapest flights from Panama City to Buffalo
Explore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/134:41 pmPTY - BUF
2 stops20h 31mUnited Airlines
Sat 1/101:59 pmBUF - PTY
2 stops24h 46mUnited Airlines
Deal found 9/13$535
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1811:55 pmPTY - BUF
2 stops21h 22mUnited Airlines
Sat 1/105:23 pmBUF - PTY
2 stops23h 44mUnited Airlines
Deal found 9/13$542
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1511:55 pmPTY - BUF
2 stops13h 17mUnited Airlines
Sun 1/1111:24 amBUF - PTY
1 stop8h 38mUnited Airlines
Deal found 9/13$585
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1811:55 pmPTY - BUF
2 stops21h 22mUnited Airlines
Sun 1/1111:24 amBUF - PTY
1 stop8h 38mUnited Airlines
Deal found 9/13$592
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/134:41 pmPTY - BUF
2 stops20h 31mUnited Airlines
Tue 1/131:59 pmBUF - PTY
2 stops27h 08mUnited Airlines
Deal found 9/13$629
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1811:55 pmPTY - BUF
2 stops21h 22mUnited Airlines
Wed 1/141:59 pmBUF - PTY
2 stops24h 46mUnited Airlines
Deal found 9/13$636
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1910:00 amPTY - BUF
1 stop8h 40mUnited Airlines
Sat 1/1011:24 amBUF - PTY
1 stop8h 38mUnited Airlines
Deal found 9/13$653
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/133:46 pmPTY - BUF
1 stop8h 09mDelta
Tue 1/136:00 amBUF - PTY
1 stop8h 02mDelta
Deal found 9/13$661
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/134:37 pmPTY - BUF
2 stops18h 37mAmerican Airlines
Sun 1/116:16 amBUF - PTY
2 stops9h 19mAmerican Airlines
Deal found 9/13$666
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/142:50 pmPTY - BUF
2 stops21h 15mAmerican Airlines
Mon 1/1211:56 amBUF - PTY
2 stops27h 39mAmerican Airlines
Deal found 9/13$671
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1810:00 amPTY - BUF
1 stop8h 40mUnited Airlines
Tue 1/131:59 pmBUF - PTY
2 stops24h 46mUnited Airlines
Deal found 9/13$723
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/297:55 amPTY - BUF
2 stops14h 03mUnited Airlines
Wed 11/56:00 amBUF - PTY
1 stop7h 55mUnited Airlines
Deal found 9/14$724

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.

Fly from

Panama City

Fly to

Buffalo

Route

Depart

Return

Price

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 12/13

8:05 am-10:57 pm

2 stops14h 52m

Buffalo

Thu 1/15

6:50 pm-8:04 pm

1 stop25h 14m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 12/14

4:41 pm-9:48 am

2 stops17h 07m

Buffalo

Sat 1/10

5:23 pm-5:07 pm

2 stops23h 44m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 12/14

3:46 pm-10:41 am

2 stops18h 55m

Buffalo

Sun 1/11

12:09 pm-2:02 pm

1 stop25h 53m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 12/13

4:41 pm-1:12 pm

2 stops20h 31m

Buffalo

Sat 1/10

1:59 pm-2:45 pm

2 stops24h 46m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 12/13

8:05 am-10:57 pm

2 stops14h 52m

Buffalo

Mon 1/12

6:50 pm-2:02 pm

1 stop19h 12m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 12/14

3:46 pm-5:16 pm

1 stop25h 30m

Buffalo

Fri 1/16

6:00 am-2:02 pm

1 stop8h 02m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 12/13

8:05 am-11:04 am

1 stop26h 59m

Buffalo

Fri 1/16

6:00 am-2:02 pm

1 stop8h 02m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 12/13

8:05 am-11:55 pm

1 stop15h 50m

Buffalo

Sun 1/11

6:00 am-2:02 pm

1 stop8h 02m

$535

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Best time to book a flight from Panama City to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Buffalo?

    There are many flights that can get you from Panama City to Buffalo in 14h 52m. Fly via Delta or United Airlines to get the fastest option. The distance from Panama City to Buffalo is about 2339 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Panama City to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama City to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Buffalo.

  • Can I find deals for business class flights from Panama City to Buffalo?

    Yes. Cheapflights offers flight deals from Panama City to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Buffalo (average of $256). Flying from Panama City to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Alternative routes for Panama City to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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