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$314+ Cheap flights from Panama City (PTY) to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Feb 19 — Feb 261
Thu 2/19
Thu 2/26
1 adult, Economy
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Cheap flight deals from Panama City to Buffalo

Cheapest flights from Panama City to Buffalo
Explore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.

This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/210:55 pm
PTY
-
BUF
2 stops17h 15m
United Airlines
Fri 4/177:45 pm
BUF
-
PTY
2 stops19h 29m
United Airlines
Deal found 1/19$557
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/294:41 pm
PTY
-
BUF
2 stops27h 48m
United Airlines
Mon 2/211:24 am
BUF
-
PTY
1 stop8h 38m
United Airlines
Deal found 1/19$571
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/310:55 pm
PTY
-
BUF
2 stops20h 54m
United Airlines
Fri 4/177:45 pm
BUF
-
PTY
2 stops19h 29m
United Airlines
Deal found 1/19$608
This Faresmojo deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/142:20 pm
PTY
-
BUF
1 stop8h 38m
JetBlue
Thu 6/187:40 pm
BUF
-
PTY
1 stop18h 25m
JetBlue
Deal found 1/19$657
This Expedia deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/23:20 am
PTY
-
BUF
2 stops16h 23m
Multiple Airlines
Fri 4/177:02 pm
BUF
-
PTY
3 stops20h 53m
Multiple Airlines
Deal found 1/19$794
This Faresmojo deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1411:25 am
PTY
-
BUF
3 stops20h 35m
Multiple Airlines
Thu 6/187:39 pm
BUF
-
PTY
2 stops15h 51m
Multiple Airlines
Deal found 1/19$808
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/22:28 pm
PTY
-
BUF
1 stop8h 18m
Delta
Fri 4/1712:06 pm
BUF
-
PTY
1 stop25h 49m
Delta
Deal found 1/19$810

Find flight deals from Panama City to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$557
(United Airlines)

One-way from

$314
(Avianca)
Provider with most accurate pricing for Panama City Tocumen Intl-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Buffalo flights.
Search Deals
From Panama City Tocumen Intl to Buffalo
Search Deals
One-way flight from Panama City Tocumen Intl to Buffalo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.

Fly from

Panama City

Fly to

Buffalo

Route

Depart

Return

Price

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/2

10:55 pm-5:10 pm

2 stops17h 15m

Buffalo

Fri 4/17

7:45 pm-2:14 pm

2 stops19h 29m

$557

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 4/3

10:55 pm-8:49 pm

2 stops20h 54m

Buffalo

Fri 4/17

7:45 pm-2:14 pm

2 stops19h 29m

$608

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 4/4

10:55 pm-2:17 pm

2 stops14h 22m

Buffalo

Fri 4/17

7:45 pm-2:14 pm

2 stops19h 29m

$608

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 6/14

10:55 pm-5:59 pm

1 stop18h 04m

Buffalo

Thu 6/18

7:55 pm-4:04 am

2 stops33h 09m

$726

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/2

3:20 am-8:43 pm

2 stops16h 23m

Buffalo

Fri 4/17

7:02 pm-2:55 pm

3 stops20h 53m

$794

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Wed 2/18

7:50 pm-9:39 am

2 stops13h 49m

$314

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/2

10:55 pm-5:10 pm

2 stops17h 15m

$317

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 4/4

10:55 pm-2:17 pm

2 stops14h 22m

$368

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 4/3

3:30 pm-8:49 pm

2 stops28h 19m

$368

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/2

3:20 am-12:14 pm

3 stops31h 54m

$415

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

Showing 1-10 of 14 results
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Compare providers for flights from Panama City to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Buffalo in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Buffalo flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Buffalo?

    There are many flights that can get you from Panama City to Buffalo in 17h 15m. Fly via United Airlines to get the fastest option. The distance from Panama City to Buffalo is about 2339 mi.

  • Can I find deals for flights from Panama City to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama City to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Buffalo.

  • Can I find deals for business class flights from Panama City to Buffalo?

    Yes. Cheapflights offers flight deals from Panama City to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

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Alternative routes for Panama City to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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