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$535+ Cheap flights from Panama City (PTY) to Buffalo (BUF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Jan 20 — Jan 271
Tue 1/20
Tue 1/27
1 adult, Economy
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Cheap flight deals from Panama City to Buffalo

Cheapest flights from Panama City to Buffalo
Explore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 21, 2025.

This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/268:00 amPTY - BUF
2 stops15h 28mDelta
Thu 1/16:10 amBUF - PTY
2 stops13h 50mDelta
Deal found 12/21$535
This Faresmojo deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:25 pmPTY - BUF
3 stops18h 10mMultiple Airlines
Thu 1/16:10 amBUF - PTY
3 stops14h 10mMultiple Airlines
Deal found 12/21$1,023

Find flight deals from Panama City to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 21, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$535
(United Airlines)
Provider with most accurate pricing for Panama City Tocumen Intl-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Buffalo flights.
Search Deals
From Panama City Tocumen Intl to Buffalo
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 21, 2025.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.

Fly from

Panama City

Fly to

Buffalo

Route

Depart

Return

Price

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 1/17

4:41 pm-4:44 pm

2 stops24h 03m

Buffalo

Sat 1/24

6:00 am-7:38 pm

2 stops13h 38m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Wed 1/21

4:41 pm-1:24 pm

2 stops20h 43m

Buffalo

Sat 1/24

11:24 am-8:02 pm

1 stop8h 38m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 1/16

4:41 pm-8:29 pm

2 stops27h 48m

Buffalo

Thu 1/22

5:23 pm-5:07 pm

2 stops23h 44m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 1/16

4:41 pm-8:29 pm

2 stops27h 48m

Buffalo

Fri 1/23

5:23 pm-7:38 pm

2 stops26h 15m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Wed 1/21

4:41 pm-4:44 pm

2 stops24h 03m

Buffalo

Wed 1/28

5:23 pm-2:45 pm

2 stops21h 22m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 1/17

4:41 pm-4:44 pm

2 stops24h 03m

Buffalo

Fri 1/23

8:30 am-7:38 pm

2 stops11h 08m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 1/29

4:41 pm-5:40 pm

2 stops24h 59m

Buffalo

Sun 2/1

8:30 am-7:38 pm

2 stops11h 08m

$548

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 1/18

10:26 am-10:49 am

1 stop24h 23m

Buffalo

Sun 1/25

11:02 am-12:40 am

2 stops37h 38m

$597

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 1/13

2:27 pm-10:51 am

2 stops20h 24m

Buffalo

Mon 1/19

6:00 am-3:38 pm

2 stops9h 38m

$641

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/19

Compare providers for flights from Panama City to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Buffalo in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Buffalo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Buffalo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Buffalo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Buffalo?

    There are many flights that can get you from Panama City to Buffalo in 24h 03m. Fly via United Airlines to get the fastest option. The distance from Panama City to Buffalo is about 2339 mi.

  • Can I find deals for flights from Panama City to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama City to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Buffalo.

  • Can I find deals for business class flights from Panama City to Buffalo?

    Yes. Cheapflights offers flight deals from Panama City to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

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