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$535+ Cheap flights from Panama City (PTY) to Buffalo (BUF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
nov. 15 — nov. 221
sáb. 11/15
sáb. 11/22
1 adult, Economy
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Find flight deals from Panama City to Buffalo

Cheapest flights from Panama City to Buffalo
Explore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 16, 2025.

This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/303:41 pmPTY - BUF
2 stops30h 17mUnited Airlines
mar. 2/38:30 amBUF - PTY
2 stops11h 08mUnited Airlines
Deal found 10/16$535
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/302:21 pmPTY - BUF
1 stop8h 18mDelta
mar. 2/36:00 amBUF - PTY
1 stop8h 02mDelta
Deal found 10/16$661
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/302:43 pmPTY - BUF
2 stops20h 19mAmerican Airlines
dom. 12/77:20 pmBUF - PTY
2 stops20h 22mAmerican Airlines
Deal found 10/16$841
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/304:41 pmPTY - BUF
2 stops17h 22mUnited Airlines
dom. 12/711:35 amBUF - PTY
1 stop8h 27mUnited Airlines
Deal found 10/16$891
This United deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/303:41 pmPTY - BUF
2 stops30h 17mMultiple Airlines
mar. 2/32:49 pmBUF - PTY
3 stops24h 06mMultiple Airlines
Deal found 10/16$1,014
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/308:05 amPTY - BUF
1 stop15h 45mDelta
dom. 12/76:00 amBUF - PTY
1 stop8h 21mDelta
Deal found 10/16$1,264

Cheap flight deals from Panama City to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated octubre 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$841
(American Airlines)
Provider with most accurate pricing for Panama City Tocumen Intl-Buffalo flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Buffalo flights.
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From Panama City Tocumen Intl to Buffalo
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 16, 2025.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.

Fly from

Panama City

Fly to

Buffalo

Route

Depart

Return

Price

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

jue. 10/30

3:41 pm-10:58 pm

2 stops30h 17m

Buffalo

mar. 2/3

8:30 am-7:38 pm

2 stops11h 08m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

jue. 10/30

2:21 pm-11:39 pm

1 stop8h 18m

Buffalo

mar. 2/3

6:00 am-2:02 pm

1 stop8h 02m

$661

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

dom. 11/30

2:43 pm-11:02 am

2 stops20h 19m

Buffalo

dom. 12/7

7:20 pm-3:42 pm

2 stops20h 22m

$841

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

dom. 11/30

4:41 pm-10:03 am

2 stops17h 22m

Buffalo

dom. 12/7

11:35 am-8:02 pm

1 stop8h 27m

$891

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

jue. 10/30

3:41 pm-10:58 pm

2 stops30h 17m

Buffalo

mar. 2/3

2:49 pm-2:55 pm

3 stops24h 06m

$1,014

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

dom. 11/30

8:05 am-11:50 pm

1 stop15h 45m

Buffalo

dom. 12/7

6:00 am-2:21 pm

1 stop8h 21m

$1,264

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Compare providers for flights from Panama City to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Buffalo in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Buffalo?

    There are many flights that can get you from Panama City to Buffalo in 8h 18m. Fly via United Airlines, Delta, or American Airlines to get the fastest option. The distance from Panama City to Buffalo is about 2339 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Panama City to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama City to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Buffalo.

  • Can I find deals for business class flights from Panama City to Buffalo?

    Yes. Cheapflights offers flight deals from Panama City to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Alternative routes for Panama City to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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