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$109+ Cheap flights from Myrtle Beach to Buffalo (MYR - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BUF
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$180
(Southwest)

One-way from

$109
(Delta)

Popular in

February

Cheapest in

September

Average price

$292
From Myrtle Beach Intl to Buffalo
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One-way flight from Myrtle Beach Intl to Buffalo
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High demand for flights, 0% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Myrtle Beach to Buffalo

Cheapest flights from Myrtle Beach to Buffalo
Explore the most affordable flight options available from Myrtle Beach to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/235:57 pmMYR - BUF
1 stop4h 45mUnited Airlines
Wed 10/296:00 amBUF - MYR
1 stop7h 09mUnited Airlines
Deal found 9/11$214
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2310:01 amMYR - BUF
1 stop4h 43mAmerican Airlines
Wed 10/2911:00 amBUF - MYR
2 stops7h 45mAmerican Airlines
Deal found 9/11$219
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/812:20 pmMYR - BUF
1 stop4h 42mDelta
Sun 10/126:03 amBUF - MYR
1 stop5h 22mDelta
Deal found 9/9$236
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:24 pmMYR - BUF
1 stop4h 40mAmerican Airlines
Sun 10/55:38 amBUF - MYR
1 stop5h 10mAmerican Airlines
Deal found 9/10$270
This Booking.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/34:04 pmMYR - BUF
2 stops26h 10mFrontier
Sun 10/57:41 pmBUF - MYR
2 stops19h 38mFrontier
Deal found 9/10$271
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:44 amMYR - BUF
1 stop4h 20mAmerican Airlines
Fri 10/177:38 pmBUF - MYR
1 stop4h 21mAmerican Airlines
Deal found 9/10$279
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/912:20 pmMYR - BUF
1 stop4h 42mDelta
Sun 10/126:03 amBUF - MYR
1 stop5h 22mDelta
Deal found 9/9$297
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:50 pmMYR - BUF
1 stop5h 00mDelta
Mon 11/246:00 amBUF - MYR
1 stop5h 31mDelta
Deal found 9/10$309
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/812:18 pmMYR - BUF
1 stop5h 34mAmerican Airlines
Mon 10/136:00 amBUF - MYR
1 stop4h 26mAmerican Airlines
Deal found 9/9$320

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.

Fly from

Myrtle Beach

Fly to

Buffalo

Route

Depart

Return

Price

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 10/23

5:57 pm-10:42 pm

1 stop4h 45m

Buffalo

Wed 10/29

6:00 am-1:09 pm

1 stop7h 09m

$214

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 10/23

10:01 am-2:44 pm

1 stop4h 43m

Buffalo

Wed 10/29

11:00 am-6:45 pm

2 stops7h 45m

$219

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 10/8

12:20 pm-5:02 pm

1 stop4h 42m

Buffalo

Sun 10/12

6:03 am-11:25 am

1 stop5h 22m

$236

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 10/3

6:24 pm-11:04 pm

1 stop4h 40m

Buffalo

Sun 10/5

5:38 am-10:48 am

1 stop5h 10m

$270

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Mon 10/13

6:44 am-11:04 am

1 stop4h 20m

Buffalo

Fri 10/17

7:38 pm-11:59 pm

1 stop4h 21m

$279

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 10/9

12:20 pm-5:02 pm

1 stop4h 42m

Buffalo

Sun 10/12

6:03 am-11:25 am

1 stop5h 22m

$297

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Fri 11/21

6:50 pm-11:50 pm

1 stop5h 00m

Buffalo

Mon 11/24

6:00 am-11:31 am

1 stop5h 31m

$309

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 10/8

12:18 pm-5:52 pm

1 stop5h 34m

Buffalo

Mon 10/13

6:00 am-10:26 am

1 stop4h 26m

$320

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Tue 12/2

6:56 pm-11:55 pm

1 stop4h 59m

$109

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Sat 9/20

4:23 pm-11:22 am

3 stops18h 59m

$144

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 17 results
1
2

Best time to book a flight from Myrtle Beach to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Buffalo

What is the cheapest month to book a flight from Myrtle Beach to Buffalo?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $256). Flying from Myrtle Beach to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to BUF?

Find hourly flight availability from Myrtle Beach to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s typically best to fly out from Myrtle Beach to Buffalo in the afternoon. Doing so could potentially save you 11% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from Myrtle Beach to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,248 reviews
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,960 reviews
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Buffalo?

    There are many flights that can get you from Myrtle Beach to Buffalo in 4h 42m. Fly via United Airlines, American Airlines, or Delta to get the fastest option. There are 639 mi between Myrtle Beach and Buffalo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Myrtle Beach to Buffalo round-trip?

    According to our current data, American Airlines ($195), Delta ($256), and Southwest ($276) offers the cheapest pricing from Myrtle Beach to Buffalo. American Airlines is priced at 47% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Myrtle Beach to Buffalo one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $109. American Airlines flights start at $166 while deals on Frontier start at $181 one-way.

  • Can I find deals for flights from Myrtle Beach to Buffalo that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Buffalo.

  • Can I find deals for business class flights from Myrtle Beach to Buffalo?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $256). Flying from Myrtle Beach to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Alternative routes for Myrtle Beach to Buffalo

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Top 3 airlines flying from Myrtle Beach to Buffalo

Discover the top 3 airlines that operate flights from Myrtle Beach to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$195Average$356FlexibilityNo cancel feeOn-time71%
DeltaCheapest$256Average$316FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$276Average$396FlexibilityNo cancel feeOn-time63%

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