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$128+ Cheap flights from Myrtle Beach to Buffalo (MYR - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BUF
ene. 11 — ene. 181
dom. 1/11
dom. 1/18
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Buffalo

Cheapest flights from Myrtle Beach to Buffalo
Explore the most affordable flight options available from Myrtle Beach to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.

This Southwest deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/258:00 amMYR - BUF
1 stop4h 05mSouthwest
sáb. 12/275:50 amBUF - MYR
1 stop6h 25mSouthwest
Deal found 12/10$429
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/2510:38 amMYR - BUF
1 stop5h 40mAmerican Airlines
sáb. 12/276:00 amBUF - MYR
1 stop6h 07mAmerican Airlines
Deal found 12/11$481
This Southwest deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/258:00 amMYR - BUF
1 stop4h 05mSouthwest
dom. 12/286:05 pmBUF - MYR
1 stop3h 45mSouthwest
Deal found 12/10$573
This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/1710:32 amMYR - BUF
1 stop6h 46mDelta
vie. 12/196:12 amBUF - MYR
1 stop4h 22mDelta
Deal found 12/10$577
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/173:29 pmMYR - BUF
2 stops7h 22mAmerican Airlines
vie. 12/193:55 pmBUF - MYR
2 stops8h 00mAmerican Airlines
Deal found 12/10$587
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/267:42 pmMYR - BUF
1 stop3h 50mAmerican Airlines
mar. 12/305:22 pmBUF - MYR
2 stops6h 33mAmerican Airlines
Deal found 12/11$634
This Southwest deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/238:15 pmMYR - BUF
1 stop3h 50mSouthwest
dom. 12/286:05 pmBUF - MYR
1 stop3h 45mSouthwest
Deal found 12/9$637

Find flight deals from Myrtle Beach to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated diciembre 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$297
(Delta)

One-way from

$128
(Delta)

Popular in

December

Cheapest in

September

Average price

$462
Provider with most accurate pricing for Myrtle Beach Intl-Buffalo flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Buffalo flights.
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From Myrtle Beach Intl to Buffalo
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One-way flight from Myrtle Beach Intl to Buffalo
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($7 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Buffalo that are best for you.

Fly from

Myrtle Beach

Fly to

Buffalo

Route

Depart

Return

Price

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

mié. 1/7

12:14 pm-4:57 pm

1 stop4h 43m

Buffalo

mié. 1/14

11:50 am-6:00 pm

1 stop6h 10m

$297

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

mié. 1/7

6:00 am-1:14 pm

1 stop7h 14m

Buffalo

mié. 1/14

6:00 am-11:42 am

1 stop5h 42m

$297

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

mar. 1/13

8:15 am-12:30 pm

1 stop4h 15m

Buffalo

lun. 1/19

2:40 pm-9:05 pm

1 stop6h 25m

$311

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

dom. 1/4

6:59 pm-11:50 pm

1 stop4h 51m

Buffalo

mié. 1/14

6:00 am-11:42 am

1 stop5h 42m

$342

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

vie. 1/16

6:40 pm-10:30 pm

1 stop3h 50m

Buffalo

lun. 1/19

2:40 pm-9:05 pm

1 stop6h 25m

$346

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

jue. 2/12

10:31 am-5:31 pm

1 stop7h 00m

Buffalo

jue. 2/19

6:35 pm-11:57 pm

1 stop5h 22m

$346

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

vie. 1/16

3:30 pm-10:43 pm

2 stops7h 13m

Buffalo

lun. 1/19

5:12 am-1:23 pm

2 stops8h 11m

$356

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

dom. 3/8

6:00 am-11:01 am

1 stop5h 01m

Buffalo

dom. 3/15

6:02 am-11:48 am

1 stop5h 46m

$367

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

jue. 12/25

6:00 am-1:01 pm

1 stop7h 01m

$128

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

vie. 1/30

8:15 pm-12:44 pm

2 stops40h 29m

$146

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/9

Showing 1-10 of 17 results
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2

Compare providers for flights from Myrtle Beach to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Buffalo in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Buffalo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Myrtle Beach-Buffalo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Buffalo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Buffalo

What is the cheapest month to book a flight from Myrtle Beach to Buffalo?

Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $46). Flying from Myrtle Beach to Buffalo in March is currently the most expensive (average of $177). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to BUF?

Find hourly flight availability from Myrtle Beach to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 12, 2025.

It’s typically best to fly out from Myrtle Beach to Buffalo in the afternoon. Doing so could potentially save you 10% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated diciembre 12, 2025.
Get a feel of what it's like to fly with Southwest and American Airlines from Myrtle Beach to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,253 reviews

Boarding

8.1

Overall

7.9

Comfort

8.0

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
7.9
Good
4,253 reviews
Southwest
7.9
Good
4,253 reviews

Boarding

8.1

Overall

7.9

Comfort

8.0

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,050 reviews
Southwest
7.9
Good
4,253 reviews

Boarding

8.1

Overall

7.9

Comfort

8.0

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Buffalo?

    There are many flights that can get you from Myrtle Beach to Buffalo in 4h 15m. Fly via American Airlines, Delta, or Southwest to get the fastest option. There are 639 mi between Myrtle Beach and Buffalo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Myrtle Beach to Buffalo round-trip?

    According to our current data, American Airlines ($195), and Southwest ($286) offers the cheapest pricing from Myrtle Beach to Buffalo. American Airlines is priced at 48% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Myrtle Beach to Buffalo one-way?

    To fly one-way, consider booking your trip with Southwest, which is currently one of the cheapest options available, starting at $108. Delta flights start at $108 while deals on American Airlines start at $128 one-way.

  • Can I find deals for flights from Myrtle Beach to Buffalo that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Buffalo.

  • Can I find deals for business class flights from Myrtle Beach to Buffalo?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Buffalo?

    Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Buffalo (average of $46). Flying from Myrtle Beach to Buffalo in March is currently the most expensive (average of $177). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Alternative routes for Myrtle Beach to Buffalo

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Top 2 airlines flying from Myrtle Beach to Buffalo

Discover the top 2 airlines that operate flights from Myrtle Beach to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$195Average$344FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$286Average$400FlexibilityNo cancel feeOn-time63%

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