$155+ Cheap flights from Mississippi to Buffalo (BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/9. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — BUF
Aug 28 — Sep 41
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Mississippi to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to Buffalo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mississippi to BuffaloExplore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.
Explore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:08 am
JAN
- BUF
1 stop5h 44m
Delta
Sat 9/196:05 am
BUF
- JAN
1 stop4h 40m
Delta
Deal found 7/27![Delta logo]()
$311
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:11 pm
MEM
- BUF
1 stop4h 48m
Delta
Thu 10/156:10 am
BUF
- MEM
1 stop4h 41m
Delta
Deal found 7/27![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/52:53 pm
MEM
- BUF
1 stop6h 47m
American Airlines
Fri 9/114:31 pm
BUF
- MEM
1 stop7h 23m
American Airlines
Deal found 7/26![American Airlines logo]()
$326
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/293:25 pm
MEM
- BUF
1 stop4h 15m
Southwest
Sat 10/37:20 am
BUF
- MEM
2 stops8h 05m
Southwest
Deal found 7/24![Southwest logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/168:34 am
MEM
- BUF
2 stops48h 55m
Multiple Airlines
Wed 8/196:54 pm
BUF
- MEM
1 stop20h 01m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$332
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:27 pm
JAN
- BUF
1 stop5h 20m
American Airlines
Sat 9/196:38 am
BUF
- JAN
1 stop6h 11m
American Airlines
Deal found 7/27![American Airlines logo]()
$347
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:00 pm
MEM
- BUF
1 stop4h 59m
Delta
Fri 9/43:54 pm
BUF
- MEM
1 stop6h 17m
Delta
Deal found 7/26![Delta logo]()
$358
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:40 pm
MEM
- BUF
2 stops10h 00m
Southwest
Mon 10/196:00 am
BUF
- MEM
1 stop5h 50m
Southwest
Deal found 7/29![Southwest logo]()
$363
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/263:57 pm
BTR
- BUF
1 stop7h 02m
Delta
Wed 9/25:13 pm
BUF
- BTR
1 stop5h 48m
Delta
Deal found 7/29![Delta logo]()
$364
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:37 pm
MOB
- BUF
1 stop6h 15m
Delta
Mon 10/56:59 pm
BUF
- MOB
1 stop5h 21m
Delta
Deal found 7/26![Delta logo]()
$367
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/122:35 pm
MEM
- BUF
1 stop8h 05m
Southwest
Thu 10/152:50 pm
BUF
- MEM
2 stops7h 55m
Southwest
Deal found 7/27![Southwest logo]()
$369
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:11 pm
MEM
- BUF
1 stop4h 48m
Delta
Tue 10/136:10 am
BUF
- MEM
1 stop4h 41m
Delta
Deal found 7/26![Delta logo]()
$370
Best flights from Mississippi to BuffaloDiscover carefully curated flight deals from Mississippi to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2026.
Discover carefully curated flight deals from Mississippi to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2026.
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:00 am
MEM
- BUF
2 stops9h 45m
Southwest
Sat 10/312:30 pm
BUF
- MEM
2 stops6h 55m
Southwest
Deal found 7/24![Southwest logo]()
$335
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:27 pm
JAN
- BUF
1 stop5h 20m
American Airlines
Sat 9/196:38 am
BUF
- JAN
1 stop6h 11m
American Airlines
Deal found 7/27![American Airlines logo]()
$347
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:11 pm
MEM
- BUF
1 stop4h 48m
Delta
Tue 10/136:55 pm
BUF
- MEM
1 stop5h 29m
Delta
Deal found 7/28![Delta logo]()
$358
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:35 am
BTR
- BUF
2 stops13h 09m
United Airlines
Wed 9/26:55 am
BUF
- BTR
2 stops11h 38m
United Airlines
Deal found 7/25![United Airlines logo]()
$413
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:25 pm
GPT
- BUF
1 stop22h 41m
Multiple Airlines
Sun 8/1611:29 am
BUF
- GPT
2 stops21h 12m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$525
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:20 am
MEM
- BUF
2 stops8h 30m
Southwest
Mon 8/3111:25 am
BUF
- MEM
1 stop7h 25m
Southwest
Deal found 7/27![Southwest logo]()
$358
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/263:57 pm
BTR
- BUF
1 stop7h 02m
Delta
Wed 9/25:13 pm
BUF
- BTR
1 stop5h 48m
Delta
Deal found 7/29![Delta logo]()
$364
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:37 pm
MOB
- BUF
1 stop6h 15m
Delta
Mon 10/56:59 pm
BUF
- MOB
1 stop5h 21m
Delta
Deal found 7/26![Delta logo]()
$367
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:45 pm
MEM
- BUF
2 stops9h 55m
Southwest
Mon 10/192:50 pm
BUF
- MEM
2 stops9h 40m
Southwest
Deal found 7/29![Southwest logo]()
$368
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/92:27 pm
BTR
- BUF
1 stop7h 34m
American Airlines
Thu 8/135:38 pm
BUF
- BTR
1 stop5h 27m
American Airlines
Deal found 7/25![American Airlines logo]()
$433
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/59:30 am
MOB
- BUF
2 stops12h 07m
United Airlines
Wed 12/97:00 am
BUF
- MOB
2 stops10h 09m
United Airlines
Deal found 7/24![United Airlines logo]()
$438
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:10 pm
MEM
- BUF
2 stops5h 30m
Southwest
Sun 10/185:50 am
BUF
- MEM
2 stops9h 00m
Southwest
Deal found 7/25![Southwest logo]()
$381
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/314:46 pm
MEM
- BUF
1 stop6h 13m
Delta
Fri 9/47:19 pm
BUF
- MEM
1 stop5h 05m
Delta
Deal found 7/24![Delta logo]()
$390
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/314:39 pm
MEM
- BUF
1 stop5h 33m
United Airlines
Fri 9/42:53 pm
BUF
- MEM
2 stops9h 25m
United Airlines
Deal found 7/25![United Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:15 am
MEM
- BUF
1 stop6h 44m
American Airlines
Sun 8/167:54 pm
BUF
- MEM
1 stop5h 04m
American Airlines
Deal found 7/25![American Airlines logo]()
$467
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1712:40 pm
JAN
- BUF
2 stops9h 05m
Southwest
Sat 9/1910:50 am
BUF
- JAN
2 stops9h 20m
Southwest
Deal found 7/27![Southwest logo]()
$387
This Delta deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:01 pm
JAN
- BUF
1 stop5h 58m
Delta
Sun 9/66:05 am
BUF
- JAN
1 stop4h 38m
Delta
Deal found 7/25![Delta logo]()
$414
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:00 am
MOB
- BUF
2 stops11h 07m
United Airlines
Sat 8/296:55 am
BUF
- MOB
2 stops10h 14m
United Airlines
Deal found 7/27![United Airlines logo]()
$467
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:15 am
MEM
- BUF
2 stops10h 45m
United Airlines
Fri 9/112:53 pm
BUF
- MEM
2 stops9h 36m
United Airlines
Deal found 7/26![United Airlines logo]()
$469
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1112:00 pm
BTR
- BUF
2 stops10h 12m
United Airlines
Sat 8/156:55 am
BUF
- BTR
2 stops9h 35m
United Airlines
Deal found 7/27![United Airlines logo]()
$480
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/314:00 pm
BTR
- BUF
1 stop6h 59m
Delta
Fri 9/44:13 pm
BUF
- BTR
1 stop6h 48m
Delta
Deal found 7/29![Delta logo]()
$517
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:07 pm
AEX
- BUF
1 stop5h 52m
Delta
Wed 8/1212:16 pm
BUF
- AEX
1 stop5h 09m
Delta
Deal found 7/24![Delta logo]()
$530
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/131:50 pm
GPT
- BUF
2 stops8h 46m
American Airlines
Sun 8/162:51 pm
BUF
- GPT
2 stops10h 08m
American Airlines
Deal found 7/27![American Airlines logo]()
$741
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1310:59 am
MOB
- BUF
2 stops11h 45m
United Airlines
Mon 8/1710:30 am
BUF
- MOB
2 stops12h 29m
United Airlines
Deal found 7/29![United Airlines logo]()
$597
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:05 pm
BTR
- BUF
2 stops10h 06m
United Airlines
Sun 10/117:00 am
BUF
- BTR
2 stops9h 32m
United Airlines
Deal found 7/26![United Airlines logo]()
$619
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/319:20 am
JAN
- BUF
2 stops13h 24m
United Airlines
Tue 9/15:58 pm
BUF
- JAN
2 stops18h 17m
United Airlines
Deal found 7/25![United Airlines logo]()
$667
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:20 pm
JAN
- BUF
2 stops28h 17m
United Airlines
Tue 12/86:00 am
BUF
- JAN
2 stops30h 13m
United Airlines
Deal found 7/27![United Airlines logo]()
$705
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:45 am
AEX
- BUF
2 stops27h 33m
United Airlines
Wed 9/26:55 am
BUF
- AEX
2 stops14h 05m
United Airlines
Deal found 7/27![United Airlines logo]()
$712
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/95:00 am
BTR
- BUF
2 stops10h 41m
United Airlines
Thu 8/1310:30 am
BUF
- BTR
2 stops8h 03m
United Airlines
Deal found 7/25![United Airlines logo]()
$734
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:05 am
JAN
- BUF
2 stops13h 41m
United Airlines
Sat 10/316:00 am
BUF
- JAN
2 stops15h 26m
United Airlines
Deal found 7/29![United Airlines logo]()
$746
Last-minute flights from Mississippi to BuffaloDiscover last-minute flight deals from Mississippi to Buffalo. Data last updated July 29, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to Buffalo. Data last updated July 29, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/14:07 pm
BTR
- BUF
1 stop6h 35m
Delta
Tue 8/46:27 am
BUF
- BTR
2 stops7h 20m
Delta
Deal found 7/27![Delta logo]()
$418
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/89:04 am
MEM
- BUF
2 stops24h 25m
Multiple Airlines
Wed 8/127:57 pm
BUF
- MEM
1 stop23h 28m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$391
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/168:34 am
MEM
- BUF
2 stops48h 55m
Multiple Airlines
Wed 8/196:54 pm
BUF
- MEM
1 stop20h 01m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$332
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/1612:40 pm
MEM
- BUF
1 stop5h 50m
Southwest
Wed 8/1912:35 pm
BUF
- MEM
1 stop10h 50m
Southwest
Deal found 7/24![Southwest logo]()
$396
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2011:21 am
MEM
- BUF
1 stop5h 41m
American Airlines
Tue 8/255:38 pm
BUF
- MEM
1 stop6h 10m
American Airlines
Deal found 7/26![American Airlines logo]()
$325
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:15 am
MEM
- BUF
2 stops9h 10m
Southwest
Tue 8/256:25 pm
BUF
- MEM
1 stop5h 00m
Southwest
Deal found 7/26![Southwest logo]()
$377
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:20 am
MEM
- BUF
2 stops8h 30m
Southwest
Mon 8/316:30 am
BUF
- MEM
2 stops10h 40m
Southwest
Deal found 7/27![Southwest logo]()
$383
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/263:57 pm
BTR
- BUF
1 stop7h 02m
Delta
Wed 9/25:13 pm
BUF
- BTR
1 stop5h 48m
Delta
Deal found 7/29![Delta logo]()
$364
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:15 am
MEM
- BUF
2 stops9h 10m
Southwest
Mon 8/316:30 am
BUF
- MEM
2 stops10h 40m
Southwest
Deal found 7/26![Southwest logo]()
$428
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/297:15 am
BTR
- BUF
2 stops8h 42m
United Airlines
Wed 9/210:30 am
BUF
- BTR
2 stops8h 03m
United Airlines
Deal found 7/27![United Airlines logo]()
$413
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:00 pm
MEM
- BUF
1 stop4h 59m
Delta
Fri 9/43:54 pm
BUF
- MEM
1 stop6h 17m
Delta
Deal found 7/26![Delta logo]()
$358
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:10 am
MEM
- BUF
1 stop5h 28m
American Airlines
Fri 9/412:56 pm
BUF
- MEM
1 stop5h 26m
American Airlines
Deal found 7/25![American Airlines logo]()
$371
One-way flights from Mississippi to BuffaloSearch for one-way flight options from Mississippi to Buffalo. Find affordable one-way fares based on user searches. Data last updated July 29, 2026.
Search for one-way flight options from Mississippi to Buffalo. Find affordable one-way fares based on user searches. Data last updated July 29, 2026.
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am
JAN
- BUF
1 stop6h 53m
American Airlines
Deal found 7/26![American Airlines logo]()
$155
This Trip.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/44:36 pm
MEM
- BUF
1 stop25h 30m
Frontier
Deal found 7/24![Frontier logo]()
$181
This Trip.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:10 pm
MEM
- BUF
1 stop22h 56m
Frontier
Deal found 7/24![Frontier logo]()
$182
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:05 am
JAN
- BUF
2 stops7h 20m
Southwest
Deal found 7/26![Southwest logo]()
$194
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:15 pm
MEM
- BUF
1 stop4h 25m
Southwest
Deal found 7/25![Southwest logo]()
$196
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/213:48 pm
BTR
- BUF
1 stop7h 04m
Delta
Deal found 7/27![Delta logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1310:50 am
MEM
- BUF
3 stops47h 43m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$218
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/31:50 pm
GPT
- BUF
1 stop7h 05m
American Airlines
Deal found 7/24![American Airlines logo]()
$242
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1312:20 pm
MEM
- BUF
2 stops8h 30m
Southwest
Deal found 7/24![Southwest logo]()
$254
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/73:57 pm
BTR
- BUF
1 stop7h 02m
Delta
Deal found 7/28![Delta logo]()
$293
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/44:08 pm
MEM
- BUF
1 stop5h 58m
United Airlines
Deal found 7/27![United Airlines logo]()
$295
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/72:27 pm
BTR
- BUF
2 stops8h 35m
American Airlines
Deal found 7/28![American Airlines logo]()
$298
Find flight deals from Mississippi to Buffalo
Keep the following information in mind while searching for Mississippi to Buffalo flight deals. Data was last updated July 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $311 (Delta) |
One-way from | $155 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
Use the filters below to find and compare flights from Mississippi to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Tue 9/29
7:00 am-5:45 pm
2 stops9h 45m
Buffalo
Sat 10/3
12:30 pm-6:25 pm
2 stops6h 55m
$335
JacksonBuffalo
JAN - BUF
JANBUF
Jackson-Evers Intl
Thu 9/17
3:27 pm-9:47 pm
1 stop5h 20m
Buffalo
Sat 9/19
6:38 am-11:49 am
1 stop6h 11m
$347
Quickest round-trip
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Fri 10/9
6:11 pm-11:59 pm
1 stop4h 48m
Buffalo
Tue 10/13
6:55 pm-11:24 pm
1 stop5h 29m
$358
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Mon 8/24
11:20 am-8:50 pm
2 stops8h 30m
Buffalo
Mon 8/31
11:25 am-5:50 pm
1 stop7h 25m
$358
Baton RougeBuffalo
BTR - BUF
BTRBUF
Baton Rouge Ryan
Wed 8/26
3:57 pm-11:59 pm
1 stop7h 02m
Buffalo
Wed 9/2
5:13 pm-10:01 pm
1 stop5h 48m
$364
MobileBuffalo
MOB - BUF
MOBBUF
Mobile
Fri 10/2
4:37 pm-11:52 pm
1 stop6h 15m
Buffalo
Mon 10/5
6:59 pm-11:20 pm
1 stop5h 21m
$367
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Fri 10/16
12:45 pm-11:40 pm
2 stops9h 55m
Buffalo
Mon 10/19
2:50 pm-11:30 pm
2 stops9h 40m
$368
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Thu 10/15
5:10 pm-11:40 pm
2 stops5h 30m
Buffalo
Sun 10/18
5:50 am-1:50 pm
2 stops9h 00m
$381
JacksonBuffalo
JAN - BUF
JANBUF
Jackson-Evers Intl
Thu 9/17
12:40 pm-10:45 pm
2 stops9h 05m
Buffalo
Sat 9/19
10:50 am-7:10 pm
2 stops9h 20m
$387
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Mon 8/31
4:46 pm-11:59 pm
1 stop6h 13m
Buffalo
Fri 9/4
7:19 pm-11:24 pm
1 stop5h 05m
$390
Showing 1-10 of 48 resultsSorted by cheapest first
Best time to book a flight from Mississippi to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Mississippi with our price prediction graph.
MEM-BUF
JAN-BUF
BTR-BUF
GPT-BUF
MOB-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to Buffalo
USMS-BUF
MEM-BUF
JAN-BUF
BTR-BUF
GPT-BUF
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Mississippi to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Mississippi to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 29, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mississippi to Buffalo by cabin class
Find flights from Mississippi to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mississippi and Buffalo flights
Browse other Mississippi and Buffalo flight options. Last updated on July 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mississippi to Buffalo flights
Consider these flights traveling from Mississippi to Buffalo.
Top 2 airlines flying from Mississippi to Buffalo
Discover the top 2 airlines that operate flights from Mississippi to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$199 | Average$469 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$365 | Average$488 | FlexibilityNo cancel fee | On-time71% |