$349+ Cheap flights from Mississippi to Buffalo (BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/19. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — BUF
Nov 29 — Dec 61
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Mississippi to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to Buffalo
Cheapest
Best
Last-minute
Cheapest flights from Mississippi to BuffaloExplore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:04 pm -
1 stop4h 55m
Sun 11/226:00 am -
1 stop4h 19m
Deal found 10/27![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:04 pm -
1 stop4h 55m
Mon 11/236:35 am -
2 stops7h 29m
Deal found 10/27![Delta logo]()
$354
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:49 pm -
1 stop4h 50m
Mon 11/237:44 pm -
1 stop5h 17m
Deal found 10/25![American Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:00 am -
1 stop4h 40m
Sun 11/1511:32 am -
1 stop7h 30m
Deal found 10/29![American Airlines logo]()
$537
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:30 am -
2 stops8h 30m
Wed 11/188:05 am -
2 stops10h 30m
Deal found 10/30![Southwest logo]()
$547
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:00 am -
1 stop4h 42m
Mon 11/2312:04 pm -
2 stops9h 37m
Deal found 10/29![American Airlines logo]()
$572
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:02 am -
1 stop4h 27m
Sun 11/811:32 am -
1 stop7h 30m
Deal found 10/29![American Airlines logo]()
$827
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:54 pm -
2 stops8h 50m
Mon 11/236:30 am -
3 stops34h 38m
Deal found 10/25![United Airlines logo]()
$838
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1010:55 am -
2 stops22h 13m
Sat 11/1410:51 am -
2 stops28h 17m
Deal found 10/26![United Airlines logo]()
$956
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:14 am -
1 stop7h 10m
Mon 11/26:58 pm -
1 stop4h 45m
Deal found 10/28![American Airlines logo]()
$1,037
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:00 pm -
1 stop4h 05m
Mon 11/23:05 pm -
2 stops8h 00m
Deal found 10/28![Southwest logo]()
$1,042
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:45 am -
2 stops22h 23m
Tue 11/106:00 am -
2 stops33h 08m
Deal found 10/27![United Airlines logo]()
$1,105
Best flights from Mississippi to BuffaloDiscover carefully curated flight deals from Mississippi to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Mississippi to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:04 am -
2 stops11h 49m
Sun 11/226:00 am -
1 stop4h 19m
Deal found 10/27![Delta logo]()
$354
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/66:45 am -
2 stops11h 47m
Sat 1/910:15 am -
2 stops10h 18m
Deal found 10/29![United Airlines logo]()
$469
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:30 am -
2 stops8h 30m
Wed 11/188:05 am -
2 stops10h 30m
Deal found 10/30![Southwest logo]()
$547
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:02 am -
2 stops8h 43m
Sun 11/156:00 am -
2 stops9h 20m
Deal found 10/29![American Airlines logo]()
$548
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:04 pm -
1 stop4h 55m
Mon 11/236:35 am -
2 stops7h 29m
Deal found 10/27![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/175:45 am -
1 stop4h 30m
Sun 2/216:00 am -
1 stop6h 22m
Deal found 10/26![Delta logo]()
$428
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:49 pm -
1 stop4h 50m
Mon 11/237:00 am -
2 stops11h 17m
Deal found 10/25![American Airlines logo]()
$590
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/65:17 pm -
2 stops22h 24m
Sat 1/910:15 am -
2 stops12h 44m
Deal found 10/29![United Airlines logo]()
$764
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:55 pm -
2 stops26h 56m
Mon 11/236:30 am -
3 stops34h 38m
Deal found 10/25![United Airlines logo]()
$892
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:54 pm -
2 stops8h 50m
Sun 11/2210:35 am -
3 stops9h 59m
Deal found 10/27![United Airlines logo]()
$944
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1010:55 am -
2 stops22h 13m
Sat 11/1410:51 am -
2 stops28h 17m
Deal found 10/26![United Airlines logo]()
$956
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/171:55 pm -
3 stops25h 55m
Sun 2/216:00 am -
2 stops16h 59m
Deal found 10/26![United Airlines logo]()
$1,011
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:05 am -
2 stops10h 46m
Wed 11/1810:35 am -
3 stops10h 51m
Deal found 10/30![United Airlines logo]()
$1,069
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:05 am -
2 stops10h 31m
Mon 11/236:30 am -
3 stops11h 04m
Deal found 10/29![United Airlines logo]()
$1,207
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/139:05 am -
3 stops10h 31m
Sun 11/156:00 am -
2 stops8h 19m
Deal found 10/29![United Airlines logo]()
$1,301
Last-minute flights from Mississippi to BuffaloDiscover last-minute flight deals from Mississippi to Buffalo. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to Buffalo. Data last updated October 30, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:14 am -
1 stop7h 10m
Mon 11/26:58 pm -
1 stop4h 45m
Deal found 10/28![American Airlines logo]()
$1,037
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:00 pm -
1 stop4h 05m
Mon 11/23:05 pm -
2 stops8h 00m
Deal found 10/28![Southwest logo]()
$1,042
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:02 am -
1 stop4h 27m
Sun 11/811:32 am -
1 stop7h 30m
Deal found 10/29![American Airlines logo]()
$827
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1010:55 am -
2 stops22h 13m
Sat 11/1410:51 am -
2 stops28h 17m
Deal found 10/26![United Airlines logo]()
$956
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:00 am -
1 stop4h 40m
Sun 11/1511:32 am -
1 stop7h 30m
Deal found 10/29![American Airlines logo]()
$537
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:30 am -
2 stops8h 30m
Wed 11/188:05 am -
2 stops10h 30m
Deal found 10/30![Southwest logo]()
$547
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:04 pm -
1 stop4h 55m
Sun 11/226:00 am -
1 stop4h 19m
Deal found 10/27![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:04 am -
2 stops11h 49m
Mon 11/236:35 am -
2 stops7h 29m
Deal found 10/27![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:54 pm -
2 stops8h 50m
Mon 11/236:30 am -
3 stops34h 38m
Deal found 10/25![United Airlines logo]()
$838
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:49 pm -
1 stop4h 50m
Mon 11/237:44 pm -
1 stop5h 17m
Deal found 10/25![American Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:00 am -
1 stop4h 42m
Mon 11/2312:04 pm -
2 stops9h 37m
Deal found 10/29![American Airlines logo]()
$572
Find flight deals from Mississippi to Buffalo
Keep the following information in mind while searching for Mississippi to Buffalo flight deals. Data was last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $349 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Mississippi to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GulfportBuffalo
GPT Gulfport Biloxi Regional - BUF Buffalo
GPTBUF
Gulfport Biloxi Regional
Thu 11/19
10:04 am-10:53 pm
2 stops11h 49m
Buffalo
Sun 11/22
6:00 am-9:19 am
1 stop4h 19m
$354
GulfportBuffalo
GPT Gulfport Biloxi Regional - BUF Buffalo
GPTBUF
Gulfport Biloxi Regional
Thu 11/19
6:04 pm-11:59 pm
1 stop4h 55m
Buffalo
Mon 11/23
6:35 am-1:04 pm
2 stops7h 29m
$354
Quickest round-trip
JacksonBuffalo
JAN Jackson-Evers Intl - BUF Buffalo
JANBUF
Jackson-Evers Intl
Wed 2/17
5:45 am-11:15 am
1 stop4h 30m
Buffalo
Sun 2/21
6:00 am-11:22 am
1 stop6h 22m
$428
GulfportBuffalo
GPT Gulfport Biloxi Regional - BUF Buffalo
GPTBUF
Gulfport Biloxi Regional
Wed 1/6
6:45 am-7:32 pm
2 stops11h 47m
Buffalo
Sat 1/9
10:15 am-7:33 pm
2 stops10h 18m
$469
JacksonBuffalo
JAN Jackson-Evers Intl - BUF Buffalo
JANBUF
Jackson-Evers Intl
Sat 11/14
6:30 am-4:00 pm
2 stops8h 30m
Buffalo
Wed 11/18
8:05 am-5:35 pm
2 stops10h 30m
$547
JacksonBuffalo
JAN Jackson-Evers Intl - BUF Buffalo
JANBUF
Jackson-Evers Intl
Fri 11/13
6:02 am-3:45 pm
2 stops8h 43m
Buffalo
Sun 11/15
6:00 am-2:20 pm
2 stops9h 20m
$548
GulfportBuffalo
GPT Gulfport Biloxi Regional - BUF Buffalo
GPTBUF
Gulfport Biloxi Regional
Fri 11/20
5:49 pm-11:39 pm
1 stop4h 50m
Buffalo
Mon 11/23
7:00 am-5:17 pm
2 stops11h 17m
$590
JacksonBuffalo
JAN Jackson-Evers Intl - BUF Buffalo
JANBUF
Jackson-Evers Intl
Wed 1/6
5:17 pm-4:41 pm
2 stops22h 24m
Buffalo
Sat 1/9
10:15 am-9:59 pm
2 stops12h 44m
$764
GulfportBuffalo
GPT Gulfport Biloxi Regional - BUF Buffalo
GPTBUF
Gulfport Biloxi Regional
Fri 11/20
4:55 pm-8:51 pm
2 stops26h 56m
Buffalo
Mon 11/23
6:30 am-4:08 pm
3 stops34h 38m
$892
GulfportBuffalo
GPT Gulfport Biloxi Regional - BUF Buffalo
GPTBUF
Gulfport Biloxi Regional
Thu 11/19
1:54 pm-11:44 pm
2 stops8h 50m
Buffalo
Sun 11/22
10:35 am-7:34 pm
3 stops9h 59m
$944
Showing 1-10 of 15 resultsSorted by cheapest first
Best time to book a flight from Mississippi to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Mississippi with our price prediction graph.
GPT-BUF
JAN-BUF
PIB-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to Buffalo
USMS-BUF
GPT-BUF
JAN-BUF
PIB-BUF
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Mississippi to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Mississippi to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mississippi to Buffalo by cabin class
Find flights from Mississippi to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mississippi and Buffalo flights
Browse other Mississippi and Buffalo flight options. Last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mississippi to Buffalo flights
Consider these flights traveling from Mississippi to Buffalo.
Top 2 airlines flying from Mississippi to Buffalo
Discover the top 2 airlines that operate flights from Mississippi to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$199 | Average$447 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$290 | Average$559 | FlexibilityNo cancel fee | On-time71% |