$163+ Cheap flights from Mississippi to Buffalo (BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — BUF
Oct 10 — Oct 171
Round-trip
1 adult, Economy
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Find cheap flights from Mississippi to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to Buffalo
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Cheapest flights from Mississippi to BuffaloExplore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:20 am -
1 stop5h 26m
Tue 10/137:13 am -
1 stop4h 56m
Deal found 9/8![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/610:01 am -
1 stop4h 33m
Tue 10/135:57 pm -
1 stop5h 38m
Deal found 9/8![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:00 am -
1 stop4h 26m
Mon 11/236:00 am -
1 stop7h 34m
Deal found 9/8![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:20 am -
1 stop4h 05m
Mon 11/27:10 pm -
1 stop5h 10m
Deal found 9/7![Southwest logo]()
$371
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2210:56 am -
2 stops9h 34m
Sat 9/264:47 pm -
1 stop6h 52m
Deal found 9/6![American Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:36 pm -
2 stops8h 14m
Tue 10/135:45 pm -
1 stop6h 31m
Deal found 9/8![United Airlines logo]()
$378
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:44 am -
1 stop4h 22m
Mon 10/57:53 pm -
1 stop5h 02m
Deal found 9/6![American Airlines logo]()
$387
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:50 pm -
2 stops6h 35m
Tue 10/134:25 pm -
2 stops6h 55m
Deal found 9/8![Southwest logo]()
$388
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:12 am -
1 stop7h 39m
Sat 9/266:05 am -
1 stop6h 05m
Deal found 9/6![Delta logo]()
$388
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:20 am -
1 stop4h 05m
Sun 11/13:05 pm -
2 stops9h 15m
Deal found 9/10![Southwest logo]()
$391
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:36 pm -
1 stop5h 11m
Wed 10/73:05 pm -
2 stops9h 44m
Deal found 9/5![United Airlines logo]()
$392
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:10 pm -
2 stops5h 35m
Mon 10/192:50 pm -
2 stops9h 45m
Deal found 9/5![Southwest logo]()
$397
Best flights from Mississippi to BuffaloDiscover carefully curated flight deals from Mississippi to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Mississippi to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2210:56 am -
2 stops9h 34m
Sat 9/264:47 pm -
1 stop6h 52m
Deal found 9/6![American Airlines logo]()
$374
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:20 am -
1 stop4h 05m
Wed 10/77:00 pm -
1 stop4h 20m
Deal found 9/5![Southwest logo]()
$387
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:12 am -
1 stop7h 39m
Sat 9/266:05 am -
1 stop6h 05m
Deal found 9/6![Delta logo]()
$388
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:36 pm -
1 stop5h 11m
Wed 10/73:05 pm -
2 stops9h 44m
Deal found 9/5![United Airlines logo]()
$392
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:20 am -
1 stop4h 05m
Sun 11/13:05 pm -
2 stops9h 15m
Deal found 9/10![Southwest logo]()
$391
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:14 pm -
1 stop5h 38m
Tue 10/66:00 am -
1 stop5h 25m
Deal found 9/6![Delta logo]()
$407
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/237:00 am -
2 stops10h 05m
Wed 1/272:44 pm -
1 stop5h 26m
Deal found 9/8![United Airlines logo]()
$414
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:40 pm -
1 stop4h 35m
Wed 10/1412:35 pm -
2 stops9h 05m
Deal found 9/5![Southwest logo]()
$407
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/261:36 pm -
2 stops8h 24m
Fri 10/306:00 am -
1 stop4h 32m
Deal found 9/9![Delta logo]()
$408
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/69:15 am -
2 stops11h 02m
Sat 1/97:00 am -
2 stops14h 03m
Deal found 9/8![United Airlines logo]()
$419
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:25 am -
2 stops10h 05m
Mon 11/234:00 pm -
2 stops8h 40m
Deal found 9/6![Southwest logo]()
$407
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:09 pm -
1 stop4h 43m
Mon 10/56:59 pm -
1 stop4h 15m
Deal found 9/7![Delta logo]()
$423
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:00 pm -
2 stops8h 50m
Wed 10/286:30 am -
2 stops10h 38m
Deal found 9/9![United Airlines logo]()
$426
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:25 am -
2 stops10h 05m
Mon 11/234:00 pm -
2 stops8h 40m
Deal found 9/8![Southwest logo]()
$412
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:51 am -
2 stops12h 08m
Wed 11/116:30 am -
1 stop5h 20m
Deal found 9/9![United Airlines logo]()
$441
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:00 am -
1 stop4h 26m
Sat 11/286:02 am -
2 stops11h 53m
Deal found 9/6![American Airlines logo]()
$592
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:00 am -
1 stop4h 25m
Mon 11/237:10 pm -
1 stop5h 10m
Deal found 9/8![Southwest logo]()
$417
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2211:28 am -
2 stops11h 11m
Mon 11/2311:56 am -
2 stops12h 24m
Deal found 9/8![American Airlines logo]()
$617
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/612:05 pm -
2 stops9h 56m
Sat 1/96:00 am -
2 stops10h 18m
Deal found 9/10![United Airlines logo]()
$479
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:50 am -
1 stop5h 02m
Mon 9/286:00 am -
2 stops11h 31m
Deal found 9/9![Delta logo]()
$545
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/229:35 am -
2 stops12h 37m
Sat 9/2610:46 am -
2 stops9h 45m
Deal found 9/6![United Airlines logo]()
$499
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/711:57 am -
2 stops9h 27m
Sun 10/115:50 am -
1 stop6h 42m
Deal found 9/8![American Airlines logo]()
$670
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:00 am -
2 stops11h 00m
Tue 11/244:41 pm -
1 stop7h 39m
Deal found 9/8![American Airlines logo]()
$674
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:26 pm -
1 stop5h 33m
Tue 11/246:00 am -
1 stop6h 08m
Deal found 9/8![Delta logo]()
$626
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:56 am -
2 stops9h 34m
Tue 9/294:47 pm -
1 stop6h 52m
Deal found 9/10![American Airlines logo]()
$712
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:30 pm -
2 stops6h 10m
Sun 9/278:00 am -
2 stops11h 05m
Deal found 9/8![Southwest logo]()
$683
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:15 pm -
2 stops21h 53m
Sun 11/226:30 am -
2 stops12h 03m
Deal found 9/7![United Airlines logo]()
$658
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/67:00 am -
2 stops13h 17m
Sat 1/97:00 am -
2 stops15h 18m
Deal found 9/7![United Airlines logo]()
$751
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:20 am -
2 stops10h 27m
Tue 10/610:46 am -
3 stops10h 14m
Deal found 9/6![United Airlines logo]()
$1,015
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2312:00 pm -
3 stops10h 44m
Sun 9/276:00 am -
2 stops8h 33m
Deal found 9/8![United Airlines logo]()
$1,087
Last-minute flights from Mississippi to BuffaloDiscover last-minute flight deals from Mississippi to Buffalo. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to Buffalo. Data last updated September 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2210:56 am -
2 stops9h 34m
Sat 9/264:47 pm -
1 stop6h 52m
Deal found 9/6![American Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:12 am -
1 stop7h 39m
Sat 9/266:05 am -
1 stop6h 05m
Deal found 9/6![Delta logo]()
$388
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:44 am -
1 stop4h 22m
Mon 10/57:53 pm -
1 stop5h 02m
Deal found 9/6![American Airlines logo]()
$387
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:36 pm -
1 stop5h 11m
Wed 10/73:05 pm -
2 stops9h 44m
Deal found 9/5![United Airlines logo]()
$392
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:20 am -
1 stop5h 26m
Tue 10/137:13 am -
1 stop4h 56m
Deal found 9/8![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/610:01 am -
1 stop4h 33m
Tue 10/135:57 pm -
1 stop5h 38m
Deal found 9/8![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:36 pm -
2 stops8h 14m
Tue 10/135:45 pm -
1 stop6h 31m
Deal found 9/8![United Airlines logo]()
$378
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:50 pm -
2 stops6h 35m
Tue 10/134:25 pm -
2 stops6h 55m
Deal found 9/8![Southwest logo]()
$388
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/112:41 pm -
1 stop7h 09m
Wed 10/145:40 pm -
1 stop5h 50m
Deal found 9/5![American Airlines logo]()
$402
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:10 pm -
2 stops5h 35m
Mon 10/192:50 pm -
2 stops9h 45m
Deal found 9/5![Southwest logo]()
$397
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:20 am -
1 stop4h 05m
Mon 11/27:10 pm -
1 stop5h 10m
Deal found 9/7![Southwest logo]()
$371
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:20 am -
1 stop4h 05m
Sun 11/13:05 pm -
2 stops9h 15m
Deal found 9/10![Southwest logo]()
$391
One-way flights from Mississippi to BuffaloSearch for one-way flight options from Mississippi to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from Mississippi to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:35 am -
1 stop4h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Delta logo]()
$163
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:19 am -
1 stop6h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![American Airlines logo]()
$163
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1711:25 am -
2 stops9h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Southwest logo]()
$183
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:25 am -
1 stop10h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Southwest logo]()
$199
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/262:29 pm -
1 stop7h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![American Airlines logo]()
$202
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/261:36 pm -
2 stops8h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Delta logo]()
$207
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/115:14 am -
1 stop4h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![American Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/23:13 pm -
2 stops20h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$212
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:00 am -
2 stops8h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Southwest logo]()
$214
This Frontier deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:11 pm -
2 stops15h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Frontier logo]()
$222
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/211:25 am -
1 stop10h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Southwest logo]()
$224
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:49 am -
1 stop6h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![American Airlines logo]()
$228
Find flight deals from Mississippi to Buffalo
Keep the following information in mind while searching for Mississippi to Buffalo flight deals. Data was last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $325 (American Airlines) |
One-way from | $163 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Mississippi to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MemphisBuffalo
MEM Memphis - BUF Buffalo
MEMBUF
Memphis
Sat 10/31
10:35 am-4:09 pm
1 stop4h 34m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
JacksonBuffalo
JAN Jackson-Evers Intl - BUF Buffalo
JANBUF
Jackson-Evers Intl
Sat 10/17
7:19 am-3:06 pm
1 stop6h 47m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
JacksonBuffalo
JAN Jackson-Evers Intl - BUF Buffalo
JANBUF
Jackson-Evers Intl
Sat 10/17
11:25 am-9:45 pm
2 stops9h 20m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$183
MemphisBuffalo
MEM Memphis - BUF Buffalo
MEMBUF
Memphis
Sat 10/31
8:10 am-5:55 pm
2 stops8h 45m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$199
Baton RougeBuffalo
BTR Baton Rouge Ryan - BUF Buffalo
BTRBUF
Baton Rouge Ryan
Mon 10/26
1:36 pm-11:00 pm
2 stops8h 24m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$207
MemphisBuffalo
MEM Memphis - BUF Buffalo
MEMBUF
Memphis
Fri 11/20
5:00 am-10:25 am
1 stop4h 25m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$209
GulfportBuffalo
GPT Gulfport Biloxi Regional - BUF Buffalo
GPTBUF
Gulfport Biloxi Regional
Wed 9/23
7:49 am-3:40 pm
1 stop6h 51m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$228
GulfportBuffalo
GPT Gulfport Biloxi Regional - BUF Buffalo
GPTBUF
Gulfport Biloxi Regional
Sun 3/7
4:34 pm-11:50 pm
1 stop6h 16m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$240
GulfportBuffalo
GPT Gulfport Biloxi Regional - BUF Buffalo
GPTBUF
Gulfport Biloxi Regional
Fri 9/25
6:46 pm-12:50 pm
2 stops17h 04m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$241
GulfportBuffalo
GPT Gulfport Biloxi Regional - BUF Buffalo
GPTBUF
Gulfport Biloxi Regional
Wed 9/23
6:25 am-3:05 pm
2 stops7h 40m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$243
Showing 1-10 of 57 resultsSorted by cheapest first
Best time to book a flight from Mississippi to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Mississippi with our price prediction graph.
MEM-BUF
JAN-BUF
BTR-BUF
GPT-BUF
AEX-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to Buffalo
USMS-BUF
MEM-BUF
JAN-BUF
BTR-BUF
GPT-BUF
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Mississippi to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes
Buffalo flight routes
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Alternative routes for Mississippi to Buffalo
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mississippi to Buffalo by cabin class
Find flights from Mississippi to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mississippi and Buffalo flights
Browse other Mississippi and Buffalo flight options. Last updated on September 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mississippi to Buffalo flights
Consider these flights traveling from Mississippi to Buffalo.
Top 2 airlines flying from Mississippi to Buffalo
Discover the top 2 airlines that operate flights from Mississippi to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$199 | Average$447 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$365 | Average$488 | FlexibilityNo cancel fee | On-time71% |