$159+ Cheap flights from Mississippi to Buffalo (BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/28. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — BUF
Jul 16 — Jul 231
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Mississippi to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to Buffalo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mississippi to BuffaloExplore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.
Explore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/44:54 pm
GPT
- BUF
1 stop6h 14m
American Airlines
Tue 11/107:12 pm
BUF
- GPT
1 stop5h 45m
American Airlines
Deal found 6/14![American Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 pm
GPT
- BUF
1 stop4h 55m
Delta
Tue 11/106:16 am
BUF
- GPT
2 stops12h 01m
Delta
Deal found 6/14![Delta logo]()
$316
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:08 pm
MEM
- BUF
1 stop5h 23m
United Airlines
Wed 7/810:57 am
BUF
- MEM
1 stop4h 45m
United Airlines
Deal found 6/12![United Airlines logo]()
$317
This Booking.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/307:10 pm
MEM
- BUF
1 stop22h 56m
Frontier
Mon 8/37:57 pm
BUF
- MEM
1 stop20h 44m
Frontier
Deal found 6/12![Frontier logo]()
$323
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:59 am
MOB
- BUF
2 stops9h 08m
United Airlines
Wed 8/196:55 am
BUF
- MOB
2 stops10h 14m
United Airlines
Deal found 6/16![United Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:20 am
MEM
- BUF
2 stops8h 00m
Southwest
Wed 7/86:25 am
BUF
- MEM
1 stop5h 20m
Southwest
Deal found 6/14![Southwest logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:05 pm
MEM
- BUF
2 stops20h 29m
Multiple Airlines
Sun 8/237:52 pm
BUF
- MEM
1 stop13h 13m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$345
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/119:15 am
MOB
- BUF
1 stop4h 51m
Delta
Sat 8/225:13 pm
BUF
- MOB
1 stop4h 48m
Delta
Deal found 6/16![Delta logo]()
$357
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:38 pm
MEM
- BUF
1 stop5h 15m
American Airlines
Tue 7/287:35 pm
BUF
- MEM
1 stop5h 10m
American Airlines
Deal found 6/12![American Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
MEM
- BUF
1 stop4h 20m
Southwest
Fri 8/213:55 pm
BUF
- MEM
2 stops7h 00m
Southwest
Deal found 6/14![Southwest logo]()
$367
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:00 am
MEM
- BUF
1 stop4h 25m
Southwest
Tue 11/178:05 am
BUF
- MEM
1 stop4h 45m
Southwest
Deal found 6/13![Southwest logo]()
$371
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:38 pm
MEM
- BUF
1 stop5h 15m
American Airlines
Tue 7/145:20 am
BUF
- MEM
1 stop6h 25m
American Airlines
Deal found 6/13![American Airlines logo]()
$372
Best flights from Mississippi to BuffaloDiscover carefully curated flight deals from Mississippi to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 16, 2026.
Discover carefully curated flight deals from Mississippi to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 16, 2026.
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:08 pm
MEM
- BUF
1 stop5h 23m
United Airlines
Wed 7/810:57 am
BUF
- MEM
1 stop4h 45m
United Airlines
Deal found 6/14![United Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/42:15 pm
GPT
- BUF
2 stops8h 44m
Delta
Tue 11/106:16 am
BUF
- GPT
2 stops8h 19m
Delta
Deal found 6/14![Delta logo]()
$321
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:20 am
MEM
- BUF
2 stops8h 00m
Southwest
Wed 7/86:25 am
BUF
- MEM
1 stop5h 20m
Southwest
Deal found 6/14![Southwest logo]()
$340
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/14:24 pm
JAN
- BUF
1 stop4h 37m
American Airlines
Thu 8/66:50 am
BUF
- JAN
1 stop5h 46m
American Airlines
Deal found 6/14![American Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
MEM
- BUF
1 stop4h 20m
Southwest
Fri 8/213:55 pm
BUF
- MEM
2 stops7h 00m
Southwest
Deal found 6/14![Southwest logo]()
$367
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/410:36 am
GPT
- BUF
1 stop7h 08m
American Airlines
Sat 7/116:01 am
BUF
- GPT
1 stop5h 10m
American Airlines
Deal found 6/15![American Airlines logo]()
$393
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:47 am
MEM
- BUF
1 stop6h 09m
United Airlines
Wed 8/2610:30 am
BUF
- MEM
1 stop5h 16m
United Airlines
Deal found 6/15![United Airlines logo]()
$397
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am
MOB
- BUF
1 stop4h 15m
Delta
Fri 10/306:00 am
BUF
- MOB
1 stop6h 33m
Delta
Deal found 6/15![Delta logo]()
$408
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:00 am
MEM
- BUF
2 stops8h 25m
Southwest
Tue 11/174:55 pm
BUF
- MEM
1 stop5h 50m
Southwest
Deal found 6/13![Southwest logo]()
$376
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/302:56 pm
MEM
- BUF
1 stop6h 55m
American Airlines
Mon 8/37:35 pm
BUF
- MEM
1 stop5h 10m
American Airlines
Deal found 6/15![American Airlines logo]()
$407
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/104:15 pm
MOB
- BUF
1 stop6h 40m
Delta
Sun 10/117:40 pm
BUF
- MOB
1 stop4h 17m
Delta
Deal found 6/12![Delta logo]()
$408
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/119:00 am
MOB
- BUF
2 stops11h 07m
United Airlines
Sat 8/226:55 am
BUF
- MOB
2 stops12h 38m
United Airlines
Deal found 6/16![United Airlines logo]()
$429
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1012:06 pm
MOB
- BUF
1 stop5h 49m
Delta
Wed 8/196:05 am
BUF
- MOB
1 stop6h 15m
Delta
Deal found 6/16![Delta logo]()
$408
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/44:28 pm
MOB
- BUF
1 stop5h 23m
American Airlines
Sat 8/84:49 pm
BUF
- MOB
1 stop4h 47m
American Airlines
Deal found 6/11![American Airlines logo]()
$411
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/304:10 pm
MEM
- BUF
2 stops7h 05m
Southwest
Mon 8/37:55 pm
BUF
- MEM
1 stop4h 15m
Southwest
Deal found 6/12![Southwest logo]()
$412
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1010:40 am
JAN
- BUF
1 stop9h 05m
Southwest
Sun 10/119:10 am
BUF
- JAN
2 stops11h 45m
Southwest
Deal found 6/12![Southwest logo]()
$417
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:35 am
BTR
- BUF
2 stops10h 32m
United Airlines
Sat 9/56:55 am
BUF
- BTR
2 stops9h 35m
United Airlines
Deal found 6/13![United Airlines logo]()
$469
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:00 pm
MOB
- BUF
1 stop5h 59m
Delta
Wed 8/197:00 am
BUF
- MOB
2 stops12h 08m
Delta
Deal found 6/16![Delta logo]()
$431
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:29 pm
MOB
- BUF
1 stop5h 21m
American Airlines
Tue 7/76:00 am
BUF
- MOB
2 stops11h 03m
American Airlines
Deal found 6/13![American Airlines logo]()
$442
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:00 am
MOB
- BUF
2 stops12h 19m
Delta
Fri 8/216:05 am
BUF
- MOB
1 stop6h 15m
Delta
Deal found 6/16![Delta logo]()
$451
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:35 am
BTR
- BUF
2 stops10h 32m
United Airlines
Sat 8/296:12 am
BUF
- BTR
2 stops8h 05m
United Airlines
Deal found 6/14![United Airlines logo]()
$505
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/71:44 pm
MOB
- BUF
1 stop7h 11m
American Airlines
Sat 8/154:49 pm
BUF
- MOB
1 stop4h 47m
American Airlines
Deal found 6/14![American Airlines logo]()
$462
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2411:25 am
JAN
- BUF
2 stops9h 15m
Southwest
Mon 7/278:45 am
BUF
- JAN
2 stops12h 00m
Southwest
Deal found 6/16![Southwest logo]()
$503
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/73:20 pm
BTR
- BUF
1 stop7h 35m
Delta
Sun 10/116:00 am
BUF
- BTR
1 stop7h 50m
Delta
Deal found 6/14![Delta logo]()
$459
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/112:42 pm
MOB
- BUF
1 stop4h 58m
American Airlines
Sat 7/115:20 am
BUF
- MOB
2 stops11h 43m
American Airlines
Deal found 6/14![American Airlines logo]()
$511
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/134:37 pm
MOB
- BUF
1 stop6h 22m
Delta
Tue 8/186:01 am
BUF
- MOB
2 stops10h 49m
Delta
Deal found 6/16![Delta logo]()
$471
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:35 am
JAN
- BUF
2 stops8h 15m
Southwest
Wed 7/19:00 am
BUF
- JAN
2 stops12h 40m
Southwest
Deal found 6/11![Southwest logo]()
$529
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:55 am
GPT
- BUF
2 stops21h 31m
United Airlines
Sat 10/317:00 am
BUF
- GPT
2 stops10h 02m
United Airlines
Deal found 6/15![United Airlines logo]()
$586
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1812:20 pm
JAN
- BUF
2 stops9h 55m
Southwest
Sun 7/2612:25 pm
BUF
- JAN
2 stops10h 40m
Southwest
Deal found 6/11![Southwest logo]()
$565
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:45 am
AEX
- BUF
2 stops30h 11m
United Airlines
Tue 9/110:30 am
BUF
- AEX
2 stops30h 00m
United Airlines
Deal found 6/11![United Airlines logo]()
$628
Last-minute flights from Mississippi to BuffaloDiscover last-minute flight deals from Mississippi to Buffalo. Data last updated June 16, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to Buffalo. Data last updated June 16, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:00 am
MEM
- BUF
1 stop6h 54m
American Airlines
Tue 7/76:00 am
BUF
- MEM
1 stop5h 05m
American Airlines
Deal found 6/12![American Airlines logo]()
$402
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/410:36 am
GPT
- BUF
1 stop7h 08m
American Airlines
Sat 7/116:01 am
BUF
- GPT
1 stop5h 10m
American Airlines
Deal found 6/15![American Airlines logo]()
$393
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:08 pm
MEM
- BUF
1 stop5h 23m
United Airlines
Wed 7/810:57 am
BUF
- MEM
1 stop4h 45m
United Airlines
Deal found 6/12![United Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:20 am
MEM
- BUF
2 stops8h 00m
Southwest
Wed 7/86:25 am
BUF
- MEM
1 stop5h 20m
Southwest
Deal found 6/14![Southwest logo]()
$340
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:38 pm
MEM
- BUF
1 stop5h 15m
American Airlines
Tue 7/145:20 am
BUF
- MEM
1 stop6h 25m
American Airlines
Deal found 6/13![American Airlines logo]()
$372
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/112:56 pm
MEM
- BUF
1 stop6h 05m
American Airlines
Sat 7/187:36 pm
BUF
- MEM
1 stop5h 09m
American Airlines
Deal found 6/13![American Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/112:22 pm
MEM
- BUF
2 stops8h 37m
United Airlines
Sat 7/1810:57 am
BUF
- MEM
1 stop4h 45m
United Airlines
Deal found 6/13![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/165:38 pm
MEM
- BUF
1 stop5h 15m
American Airlines
Sat 7/186:01 am
BUF
- MEM
1 stop5h 33m
American Airlines
Deal found 6/14![American Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:38 pm
MEM
- BUF
1 stop5h 15m
American Airlines
Tue 7/287:35 pm
BUF
- MEM
1 stop5h 10m
American Airlines
Deal found 6/12![American Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/244:10 pm
MEM
- BUF
2 stops7h 05m
Southwest
Tue 7/286:25 am
BUF
- MEM
1 stop5h 20m
Southwest
Deal found 6/12![Southwest logo]()
$386
This Booking.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/307:10 pm
MEM
- BUF
1 stop22h 56m
Frontier
Mon 8/37:57 pm
BUF
- MEM
1 stop20h 44m
Frontier
Deal found 6/12![Frontier logo]()
$323
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:52 pm
MEM
- BUF
1 stop5h 07m
Delta
Mon 8/36:27 am
BUF
- MEM
1 stop4h 10m
Delta
Deal found 6/13![Delta logo]()
$407
One-way flights from Mississippi to BuffaloSearch for one-way flight options from Mississippi to Buffalo. Find affordable one-way fares based on user searches. Data last updated June 16, 2026.
Search for one-way flight options from Mississippi to Buffalo. Find affordable one-way fares based on user searches. Data last updated June 16, 2026.
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:08 pm
MEM
- BUF
1 stop5h 23m
United Airlines
Deal found 6/16![United Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/118:49 am
MEM
- BUF
2 stops24h 40m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$171
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2811:20 am
MEM
- BUF
2 stops9h 10m
Southwest
Deal found 6/13![Southwest logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:31 pm
GPT
- BUF
3 stops39h 58m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$194
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:57 pm
GPT
- BUF
1 stop5h 02m
Delta
Deal found 6/15![Delta logo]()
$203
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/265:52 pm
MEM
- BUF
1 stop5h 07m
Delta
Deal found 6/16![Delta logo]()
$212
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:00 am
MEM
- BUF
1 stop4h 20m
Southwest
Deal found 6/12![Southwest logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:25 pm
GPT
- BUF
2 stops39h 08m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$234
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/262:12 pm
BTR
- BUF
1 stop7h 38m
American Airlines
Deal found 6/16![American Airlines logo]()
$280
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/244:08 pm
MEM
- BUF
1 stop5h 32m
United Airlines
Deal found 6/12![United Airlines logo]()
$290
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/114:07 pm
BTR
- BUF
1 stop6h 35m
Delta
Deal found 6/13![Delta logo]()
$294
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3012:42 pm
MOB
- BUF
1 stop5h 01m
American Airlines
Deal found 6/15![American Airlines logo]()
$297
Find flight deals from Mississippi to Buffalo
Keep the following information in mind while searching for Mississippi to Buffalo flight deals. Data was last updated June 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $311 (American Airlines) |
One-way from | $159 (Southwest) |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
Use the filters below to find and compare flights from Mississippi to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Tue 7/7
4:08 pm-10:31 pm
1 stop5h 23m
Buffalo
Wed 7/8
10:57 am-2:42 pm
1 stop4h 45m
$317
GulfportBuffalo
GPT - BUF
GPTBUF
Gulfport Biloxi Regional
Wed 11/4
2:15 pm-11:59 pm
2 stops8h 44m
Buffalo
Tue 11/10
6:16 am-1:35 pm
2 stops8h 19m
$321
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Tue 7/7
5:20 am-2:20 pm
2 stops8h 00m
Buffalo
Wed 7/8
6:25 am-10:45 am
1 stop5h 20m
$340
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Tue 8/18
6:00 am-11:20 am
1 stop4h 20m
Buffalo
Fri 8/21
3:55 pm-9:55 pm
2 stops7h 00m
$367
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Sun 11/15
5:00 am-2:25 pm
2 stops8h 25m
Buffalo
Tue 11/17
4:55 pm-9:45 pm
1 stop5h 50m
$376
JacksonBuffalo
JAN - BUF
JANBUF
Jackson-Evers Intl
Sat 8/1
4:24 pm-10:01 pm
1 stop4h 37m
Buffalo
Thu 8/6
6:50 am-11:36 am
1 stop5h 46m
$381
GulfportBuffalo
GPT - BUF
GPTBUF
Gulfport Biloxi Regional
Sat 7/4
10:36 am-6:44 pm
1 stop7h 08m
Buffalo
Sat 7/11
6:01 am-10:11 am
1 stop5h 10m
$393
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Tue 8/25
9:47 am-4:56 pm
1 stop6h 09m
Buffalo
Wed 8/26
10:30 am-2:46 pm
1 stop5h 16m
$397
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Thu 7/30
2:56 pm-10:51 pm
1 stop6h 55m
Buffalo
Mon 8/3
7:35 pm-11:45 pm
1 stop5h 10m
$407
MobileBuffalo
MOB - BUF
MOBBUF
Mobile
Sat 10/24
6:00 am-11:15 am
1 stop4h 15m
Buffalo
Fri 10/30
6:00 am-11:33 am
1 stop6h 33m
$408
Showing 1-10 of 56 resultsSorted by cheapest first
Best time to book a flight from Mississippi to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Mississippi with our price prediction graph.
MEM-BUF
GPT-BUF
BTR-BUF
MOB-BUF
JAN-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to Buffalo
USMS-BUF
MEM-BUF
GPT-BUF
BTR-BUF
MOB-BUF
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Mississippi to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Batavia
Williamsville
Orchard Park
Eden
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Mississippi to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 16, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mississippi to Buffalo by cabin class
Find flights from Mississippi to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mississippi and Buffalo flights
Browse other Mississippi and Buffalo flight options. Last updated on June 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mississippi to Buffalo flights
Consider these flights traveling from Mississippi to Buffalo.
Top 2 airlines flying from Mississippi to Buffalo
Discover the top 2 airlines that operate flights from Mississippi to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$199 | Average$455 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$365 | Average$488 | FlexibilityNo cancel fee | On-time71% |