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$269+ Cheap flights from Key West to Buffalo (EYW - BUF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/18. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — BUF
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Key West to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$269
(Delta)

One-way from

$269
(Delta)

Popular in

February

Cheapest in

October

Average price

$418
From Key West to Buffalo
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One-way flight from Key West to Buffalo
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Highest demand for flights based on searches. 30% potential increase in price ($189 potential increase over avg. RT price).
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Cheapest flight prices on average. 15% potential price decrease ($56 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Key West to Buffalo

Cheapest flights from Key West to Buffalo
Explore the most affordable flight options available from Key West to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:05 pmEYW - BUF
1 stop5h 50mDelta
Mon 1/56:00 amBUF - EYW
1 stop5h 03mDelta
Deal found 9/17$269
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:10 pmEYW - BUF
2 stops9h 47mDelta
Sun 1/47:00 amBUF - EYW
1 stop6h 40mDelta
Deal found 9/16$274
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:10 pmEYW - BUF
2 stops9h 47mDelta
Tue 1/610:30 amBUF - EYW
2 stops9h 14mDelta
Deal found 9/16$279
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/189:52 amEYW - BUF
2 stops25h 27mMultiple Airlines
Sun 10/196:48 pmBUF - EYW
1 stop14h 12mMultiple Airlines
Deal found 9/15$286
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:05 pmEYW - BUF
1 stop5h 50mDelta
Tue 1/62:00 pmBUF - EYW
1 stop5h 44mDelta
Deal found 9/17$294
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:05 pmEYW - BUF
1 stop5h 50mDelta
Sat 1/36:10 amBUF - EYW
2 stops11h 02mDelta
Deal found 9/16$299
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:10 pmEYW - BUF
2 stops9h 47mDelta
Sat 1/36:10 amBUF - EYW
2 stops11h 02mDelta
Deal found 9/16$304
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/110:47 amEYW - BUF
2 stops24h 35mMultiple Airlines
Sun 10/57:41 pmBUF - EYW
1 stop12h 34mMultiple Airlines
Deal found 9/16$312
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:05 pmEYW - BUF
1 stop5h 50mDelta
Fri 1/27:00 amBUF - EYW
1 stop6h 40mDelta
Deal found 9/17$319
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:05 pmEYW - BUF
1 stop5h 50mDelta
Sun 1/46:10 amBUF - EYW
2 stops11h 02mDelta
Deal found 9/16$324

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Key West to Buffalo that are best for you.

Fly from

Key West

Fly to

Buffalo

Route

Depart

Return

Price

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Wed 12/24

4:25 pm-11:48 pm

1 stop7h 23m

Buffalo

Tue 1/6

6:16 am-12:44 pm

1 stop6h 28m

$269

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Thu 12/18

6:05 pm-11:55 pm

1 stop5h 50m

Buffalo

Sun 1/4

7:00 am-1:40 pm

1 stop6h 40m

$269

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Tue 12/23

6:20 pm-11:48 pm

1 stop5h 28m

Buffalo

Sun 1/4

7:00 am-1:40 pm

1 stop6h 40m

$269

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Thu 12/18

6:05 pm-11:55 pm

1 stop5h 50m

Buffalo

Tue 1/6

6:16 am-12:44 pm

1 stop6h 28m

$269

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Wed 12/24

1:10 pm-10:57 pm

2 stops9h 47m

Buffalo

Mon 1/5

6:00 am-11:03 am

1 stop5h 03m

$274

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Tue 12/23

6:20 pm-11:48 pm

1 stop5h 28m

Buffalo

Tue 1/6

6:16 am-5:12 pm

2 stops10h 56m

$274

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Sat 10/18

9:52 am-11:19 am

2 stops25h 27m

Buffalo

Sun 10/19

6:48 pm-9:00 am

1 stop14h 12m

$286

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Thu 12/18

6:05 pm-11:55 pm

1 stop5h 50m

Buffalo

Fri 1/2

7:00 am-1:40 pm

1 stop6h 40m

$294

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Mon 12/22

2:30 pm-10:54 pm

1 stop8h 24m

Buffalo

Sun 1/4

7:00 am-1:40 pm

1 stop6h 40m

$294

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Mon 12/22

2:30 pm-10:54 pm

1 stop8h 24m

Buffalo

Mon 1/5

6:16 am-12:44 pm

1 stop6h 28m

$294

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 19 results
1
2

Best time to book a flight from Key West to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated September 17, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Key West to Buffalo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Key West to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to Buffalo?

    Delta can get you from Key West to Buffalo in just under 5h 50m. Your travel time can differ by up to . Key West and Buffalo are separated by a distance of 1281 mi.

  • What are the cheapest airlines flying from Key West to Buffalo round-trip?

    Flying on American Airlines is currently your cheapest option to Buffalo, with prices starting at $208. Another option worth looking into is Delta, starting at $259 round trip. American Airlines is currently priced 50% below the average price you’ll pay for this route.

  • Can I find deals for flights from Key West to Buffalo that include hotel bookings?

    Yes. In addition to deals on Key West to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Buffalo.

  • Can I find deals for business class flights from Key West to Buffalo?

    Yes. Cheapflights offers flight deals from Key West to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Key West to Buffalo (average of $256). Flying from Key West to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Top 2 airlines flying from Key West to Buffalo

Discover the top 2 airlines that operate flights from Key West to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$208Average$408FlexibilityNo cancel feeOn-time71%
DeltaCheapest$259Average$323FlexibilityNo cancel feeOn-timeN/A

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