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$145+ Cheap flights from Key West to Buffalo (EYW - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — BUF
Apr 3 — Apr 101
Fri 4/3
Fri 4/10
1 adult, Economy
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Cheap flight deals from Key West to Buffalo

Cheapest flights from Key West to Buffalo
Explore the most affordable flight options available from Key West to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 4, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/71:01 pm
EYW
-
BUF
2 stops22h 32m
Multiple Airlines
Sun 4/124:49 pm
BUF
-
EYW
1 stop16h 20m
Multiple Airlines
Deal found 3/3$230
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/71:01 pm
EYW
-
BUF
2 stops22h 32m
Multiple Airlines
Mon 4/136:55 pm
BUF
-
EYW
1 stop17h 26m
Multiple Airlines
Deal found 3/3$241
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/71:01 pm
EYW
-
BUF
2 stops22h 32m
Multiple Airlines
Fri 4/106:41 pm
BUF
-
EYW
1 stop16h 23m
Multiple Airlines
Deal found 3/3$254
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/69:49 am
EYW
-
BUF
2 stops26h 28m
Multiple Airlines
Sun 4/124:49 pm
BUF
-
EYW
1 stop16h 20m
Multiple Airlines
Deal found 3/3$263
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/69:49 am
EYW
-
BUF
2 stops26h 28m
Multiple Airlines
Mon 4/136:55 pm
BUF
-
EYW
1 stop17h 26m
Multiple Airlines
Deal found 3/3$274
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/69:49 am
EYW
-
BUF
2 stops26h 28m
Multiple Airlines
Fri 4/106:41 pm
BUF
-
EYW
1 stop16h 23m
Multiple Airlines
Deal found 3/3$287
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:51 am
EYW
-
BUF
1 stop7h 08m
Multiple Airlines
Sun 4/124:49 pm
BUF
-
EYW
1 stop16h 20m
Multiple Airlines
Deal found 3/3$304
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:51 am
EYW
-
BUF
1 stop7h 08m
Multiple Airlines
Mon 4/136:55 pm
BUF
-
EYW
1 stop17h 26m
Multiple Airlines
Deal found 3/3$315
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:51 am
EYW
-
BUF
1 stop7h 08m
Multiple Airlines
Fri 4/106:41 pm
BUF
-
EYW
1 stop16h 23m
Multiple Airlines
Deal found 3/3$328
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/94:22 pm
EYW
-
BUF
2 stops19h 55m
Multiple Airlines
Sun 4/124:49 pm
BUF
-
EYW
1 stop16h 20m
Multiple Airlines
Deal found 3/3$330

Find flight deals from Key West to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$230
(Kiwi.com)

One-way from

$145
(Kiwi.com)
Provider with most accurate pricing for Key West-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Buffalo flights.
Search Deals
From Key West to Buffalo
Search Deals
One-way flight from Key West to Buffalo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 4, 2026.
Use the filters below to find and compare flights from Key West to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Thu 4/9

11:01 am-12:17 pm

2 stops25h 16m

Buffalo

Mon 4/13

6:55 pm-12:21 pm

1 stop17h 26m

$407

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Tue 4/7

6:25 pm-11:46 pm

1 stop5h 21m

Buffalo

Wed 4/15

12:09 pm-7:40 pm

1 stop7h 31m

$444

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Mon 4/6

6:25 pm-11:46 pm

1 stop5h 21m

Buffalo

Tue 4/14

6:00 am-5:23 pm

2 stops11h 23m

$463

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Tue 4/7

6:25 pm-11:46 pm

1 stop5h 21m

Buffalo

Sat 4/11

6:02 am-12:42 pm

1 stop6h 40m

$479

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Fri 5/29

2:26 pm-10:31 pm

1 stop8h 05m

Buffalo

Tue 6/2

7:00 am-3:07 pm

1 stop8h 07m

$495

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Sat 3/14

5:30 pm-11:35 pm

1 stop6h 05m

Buffalo

Wed 3/18

10:32 am-4:36 pm

1 stop6h 04m

$603

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Wed 4/8

4:38 pm-8:43 pm

2 stops28h 05m

Buffalo

Fri 4/10

7:45 pm-4:42 pm

1 stop20h 57m

$656

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Wed 5/27

11:46 am-11:00 am

2 stops23h 14m

$166

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Tue 4/14

5:25 pm-10:40 pm

1 stop5h 15m

$304

Key WestBuffalo

EYW - BUF

EYWBUF

Key West

Tue 3/31

6:34 pm-11:28 pm

1 stop4h 54m

$314

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/27

Showing 1-10 of 14 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Key West-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated March 4, 2026.
Read reviews from past customers who have flown American Airlines from Key West to Buffalo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,379 reviews

Boarding

7.5

Entertainment

6.9

Comfort

7.2

Crew

8.0

Food

6.4

Overall

7.1

Reviews

1 / 20
4.0
Okay

Susie,Jan 2026

TPA - CLT

I was sitting at the back of the plane and the flight attendants were so loud, talking to each other and laughing! I thought they were having a party back there.
American Airlines
7.1
Good
11,379 reviews
American Airlines
7.1
Good
11,379 reviews

Boarding

7.5

Entertainment

6.9

Comfort

7.2

Crew

8.0

Food

6.4

Overall

7.1

Reviews

1 / 20
4.0
Okay

Susie,Jan 2026

TPA - CLT

I was sitting at the back of the plane and the flight attendants were so loud, talking to each other and laughing! I thought they were having a party back there.

Related info for your journey

Find useful and relevant information for your journey from Key West to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to Buffalo?

    Delta can get you from Key West to Buffalo in just under 5h 21m. Your travel time can differ by up to . Key West and Buffalo are separated by a distance of 1281 mi.

  • What is the cheapest airline to fly from Key West to Buffalo round-trip?

    Flying on American Airlines is currently your cheapest option to Buffalo, with prices starting at $268.

  • Can I find deals for flights from Key West to Buffalo that include hotel bookings?

    Yes. In addition to deals on Key West to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Buffalo.

  • Can I find deals for business class flights from Key West to Buffalo?

    Yes. Cheapflights offers flight deals from Key West to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

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Top airline flying from Key West to Buffalo

Discover the top airline that operate flights from Key West to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$268Average$349FlexibilityNo cancel feeOn-time71%

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