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$119+ Cheap flights from Des Moines to Buffalo (DSM - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
jul. 6 — jul. 131
dom. 7/6
dom. 7/13
1 adult, Economy
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Cheap flight deals from Des Moines to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated julio 1, 2025.

Round-trip from

$237
(American Airlines)

One-way from

$119
(Delta)

Popular in

December

Cheapest in

November

Average price

$359
From Des Moines to Buffalo
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One-way flight from Des Moines to Buffalo
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Highest demand for flights based on searches. 16% potential increase in price ($83 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Des Moines to Buffalo

Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 1, 2025.

This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/146:12 pmDSM - BUF
1 stop4h 57mAmerican Airlines
lun. 8/186:33 pmBUF - DSM
1 stop5h 25mAmerican Airlines
Deal found 6/29$237
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/153:12 pmDSM - BUF
1 stop7h 12mDelta
mar. 8/1912:17 pmBUF - DSM
1 stop5h 28mDelta
Deal found 6/28$281
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/143:38 pmDSM - BUF
1 stop4h 23mUnited Airlines
jue. 8/217:05 amBUF - DSM
2 stops10h 08mUnited Airlines
Deal found 7/1$286
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/156:00 amDSM - BUF
2 stops9h 45mSouthwest
mar. 8/191:20 pmBUF - DSM
2 stops9h 05mSouthwest
Deal found 6/28$291

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 1, 2025.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Des Moines

Fly to

Buffalo

Route

Depart

Return

Price

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jue. 8/14

6:12 pm-12:09 am

1 stop4h 57m

Buffalo

lun. 8/18

6:33 pm-10:58 pm

1 stop5h 25m

$237

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

vie. 8/15

3:12 pm-11:24 pm

1 stop7h 12m

Buffalo

mar. 8/19

12:17 pm-4:45 pm

1 stop5h 28m

$281

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jue. 8/14

3:38 pm-9:01 pm

1 stop4h 23m

Buffalo

jue. 8/21

7:05 am-4:13 pm

2 stops10h 08m

$286

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

vie. 8/15

6:00 am-4:45 pm

2 stops9h 45m

Buffalo

mar. 8/19

1:20 pm-9:25 pm

2 stops9h 05m

$291

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

mié. 8/13

11:23 am-6:10 pm

1 stop5h 47m

$119

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

vie. 8/15

8:17 am-1:50 pm

1 stop4h 33m

$163

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

sáb. 7/12

6:00 am-3:45 pm

2 stops8h 45m

$269

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

mar. 7/29

11:25 am-11:38 pm

2 stops11h 13m

$324

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/29

Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Buffalo

What is the cheapest month to book a flight from Des Moines to Buffalo?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $256). Flying from Des Moines to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated julio 1, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,273 reviews

Entertainment

7.6

Food

7.0

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,273 reviews
Southwest
8.0
Very good
4,273 reviews

Entertainment

7.6

Food

7.0

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,973 reviews
Southwest
8.0
Very good
4,273 reviews

Entertainment

7.6

Food

7.0

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,858 reviews
Southwest
8.0
Very good
4,273 reviews

Entertainment

7.6

Food

7.0

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,273 reviews

Entertainment

7.6

Food

7.0

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Buffalo round-trip?

    American Airlines, at $237, was found to be the cheapest airline from Des Moines to Buffalo.Alternate airlines to your destination round-trip include Delta and United Airlines. These flights start at 45% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Buffalo one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $119. However, be on the lookout for offers from American Airlines and Southwest, as they are both options that can get you from Des Moines to Buffalo for a low price.

  • Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.

  • Can I find deals for business class flights from Des Moines to Buffalo?

    Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $256). Flying from Des Moines to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Williamsville
Orchard Park
Batavia
Eden
Amherst
West Seneca

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Alternative routes for Des Moines to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to Buffalo

Discover the top 3 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$214Average$346FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$292Average$356FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$341Average$447FlexibilityNo cancel feeOn-time69%

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