It’s generally more expensive to depart on a Thursday, if you have to leave on this day you can still search on Cheapflights to find great options that meet your needs.
Flights from Panama City to Bilbao lean towards being more expensive in April. Prices are generally better when you fly from Panama City to Bilbao in February, with the cheapest ticket starting at $548.
It’s typically best to fly out from Panama City to Bilbao in the morning. Doing so could potentially save you 24% on the flight price compared to flying in the afternoon, which is usually more expensive.