What is the cheapest flight from Florence, South Carolina to anywhere?

Users have flown out of Florence, South Carolina for as low as $208 to Charlotte (prices may vary depending on the airline and departure time). On average, users have booked flights for $581 to fly from Florence, South Carolina.

What is the cheapest month to fly from Florence, South Carolina?

April is currently the cheapest month to fly from Florence, South Carolina . At this moment in time March is the most expensive month. These prices are determined by multiple factors and booking in advance can help keep costs down if your schedule is not as flexible.

$107+ Flights from Florence, SC

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What to know about flights from Florence

Cheapest one-way flight	$250
Cheapest round-trip flight	$208
Cheapest airline	American Airlines
Most popular destination	Charlotte Douglas (CLT)
Good round-trip deal	$391 or less
Good one-way deal	$417 or less

The cheapest one-way flight from Florence is currently to Charlotte Douglas.

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The cheapest round-trip flight from Florence is currently to Charlotte Douglas.

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On average, American Airlines currently has the cheapest one-way flight from Florence (avg. price of $381).

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Charlotte Douglas (CLT) is currently the most popular flight destination from Florence (average round-trip price of $693).

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Price to beat on a round-trip flight from Florence.

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Price to beat on a one-way flight from Florence.

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Find flights from Florence

Cheapest flights from Florence
Explore the most affordable flight options available from Florence. Find the lowest fares based on data from user searches, with prices last updated on September 11, 2025.

Sat 10/1111:11 amFLO - ORD

1 stop5h 54mAmerican Airlines

Sat 10/187:10 amORD - FLO

1 stop5h 54mAmerican Airlines

Deal found 9/11$159

Fri 9/2612:27 pmFLO - HOU

2 stops8h 44mAmerican Airlines

Tue 9/302:33 pmHOU - FLO

2 stops7h 43mAmerican Airlines

Deal found 9/11$289

Sat 10/255:14 amFLO - ATL

2 stops14h 13mAmerican Airlines

Sat 11/18:48 amATL - FLO

2 stops10h 59mAmerican Airlines

Deal found 9/10$306

Fri 9/265:37 pmFLO - ORD

1 stop6h 35mAmerican Airlines

Tue 9/309:51 amORD - FLO

1 stop6h 21mAmerican Airlines

Deal found 9/11$320

Wed 3/42:33 pmFLO - ORD

1 stop5h 56mAmerican Airlines

Sat 3/77:00 amORD - FLO

1 stop6h 03mAmerican Airlines

Deal found 9/10$346

Wed 9/246:14 amFLO - MCO

2 stops13h 30mAmerican Airlines

Wed 10/16:10 amMCO - FLO

2 stops11h 02mAmerican Airlines

Deal found 9/10$369

Fri 9/266:14 amFLO - SFO

1 stop8h 16mAmerican Airlines

Tue 9/3012:30 pmSFO - FLO

1 stop7h 46mAmerican Airlines

Deal found 9/11$375

Wed 11/2611:11 amFLO - SFO

1 stop9h 43mAmerican Airlines

Tue 12/27:15 amSFO - FLO

1 stop6h 54mAmerican Airlines

Deal found 9/10$377

Tue 11/2511:11 amFLO - SFO

2 stops12h 03mAmerican Airlines

Tue 12/27:15 amSFO - FLO

1 stop6h 54mAmerican Airlines

Deal found 9/10$382

Fri 10/1711:11 amFLO - JAN

2 stops11h 50mAmerican Airlines

Tue 10/217:20 amJAN - FLO

2 stops14h 53mAmerican Airlines

Deal found 9/9$385

Sat 10/182:29 pmFLO - JAN

1 stop4h 49mAmerican Airlines

Tue 10/218:08 amJAN - FLO

1 stop5h 46mAmerican Airlines

Deal found 9/9$387

Wed 10/86:14 amFLO - JAN

1 stop4h 18mAmerican Airlines

Sat 10/115:10 amJAN - FLO

1 stop4h 36mAmerican Airlines

Deal found 9/9$397

Best flights from Florence
Discover carefully curated flight deals from Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2025.

Sat 10/1111:11 amFLO - ORD

1 stop5h 54mAmerican Airlines

Sat 10/187:10 amORD - FLO

1 stop5h 54mAmerican Airlines

Deal found 9/11$159

Fri 9/2612:27 pmFLO - HOU

2 stops8h 44mAmerican Airlines

Tue 9/302:33 pmHOU - FLO

2 stops7h 43mAmerican Airlines

Deal found 9/11$289

Sat 10/255:14 amFLO - ATL

2 stops14h 13mAmerican Airlines

Sat 11/18:48 amATL - FLO

2 stops10h 59mAmerican Airlines

Deal found 9/10$306

Fri 9/265:37 pmFLO - ORD

1 stop6h 35mAmerican Airlines

Tue 9/309:51 amORD - FLO

1 stop6h 21mAmerican Airlines

Deal found 9/11$320

Wed 3/42:33 pmFLO - ORD

1 stop5h 56mAmerican Airlines

Sat 3/77:00 amORD - FLO

1 stop6h 03mAmerican Airlines

Deal found 9/10$346

Wed 9/246:14 amFLO - MCO

2 stops13h 30mAmerican Airlines

Wed 10/16:10 amMCO - FLO

2 stops11h 02mAmerican Airlines

Deal found 9/10$369

Fri 9/266:14 amFLO - SFO

1 stop8h 16mAmerican Airlines

Tue 9/3012:30 pmSFO - FLO

1 stop7h 46mAmerican Airlines

Deal found 9/11$375

Wed 11/2611:11 amFLO - SFO

1 stop9h 43mAmerican Airlines

Tue 12/27:15 amSFO - FLO

1 stop6h 54mAmerican Airlines

Deal found 9/10$377

Tue 11/2511:11 amFLO - SFO

2 stops12h 03mAmerican Airlines

Tue 12/27:15 amSFO - FLO

1 stop6h 54mAmerican Airlines

Deal found 9/10$382

Fri 10/1711:11 amFLO - JAN

2 stops11h 50mAmerican Airlines

Tue 10/217:20 amJAN - FLO

2 stops14h 53mAmerican Airlines

Deal found 9/9$385

Sat 10/182:29 pmFLO - JAN

1 stop4h 49mAmerican Airlines

Tue 10/218:08 amJAN - FLO

1 stop5h 46mAmerican Airlines

Deal found 9/9$387

Wed 10/226:14 amFLO - JAN

1 stop4h 18mAmerican Airlines

Sat 10/2511:01 amJAN - FLO

1 stop7h 09mAmerican Airlines

Deal found 9/9$387

Last-minute flights from Florence
Discover last-minute flight deals departing from Florence. Data last updated September 11, 2025 and is based on user searches.

Fri 9/1912:27 pmFLO - HOU

2 stops8h 44mAmerican Airlines

Sun 9/216:00 amHOU - FLO

2 stops9h 32mAmerican Airlines

Deal found 9/10$379

Wed 9/246:14 amFLO - MCO

2 stops13h 30mAmerican Airlines

Wed 10/16:10 amMCO - FLO

2 stops11h 02mAmerican Airlines

Deal found 9/10$369

Fri 9/265:37 pmFLO - ORD

1 stop6h 35mAmerican Airlines

Tue 9/309:51 amORD - FLO

1 stop6h 21mAmerican Airlines

Deal found 9/11$320

Fri 9/266:14 amFLO - SFO

1 stop8h 16mAmerican Airlines

Tue 9/3012:30 pmSFO - FLO

1 stop7h 46mAmerican Airlines

Deal found 9/11$375

Sat 10/45:37 pmFLO - JAN

1 stop3h 53mAmerican Airlines

Tue 10/78:08 amJAN - FLO

1 stop5h 46mAmerican Airlines

Deal found 9/10$407

Sat 10/45:37 pmFLO - MCO

1 stop6h 05mAmerican Airlines

Sun 10/125:00 amMCO - FLO

1 stop5h 46mAmerican Airlines

Deal found 9/10$421

Wed 10/86:14 amFLO - JAN

1 stop4h 18mAmerican Airlines

Sat 10/115:10 amJAN - FLO

1 stop4h 36mAmerican Airlines

Deal found 9/9$397

Sat 10/1111:11 amFLO - ORD

1 stop5h 54mAmerican Airlines

Sat 10/187:10 amORD - FLO

1 stop5h 54mAmerican Airlines

Deal found 9/11$159

Wed 10/153:19 pmFLO - JAN

1 stop6h 18mAmerican Airlines

Mon 10/205:10 amJAN - FLO

1 stop4h 36mAmerican Airlines

Deal found 9/9$411

Fri 10/1711:11 amFLO - JAN

2 stops11h 50mAmerican Airlines

Tue 10/217:20 amJAN - FLO

2 stops14h 53mAmerican Airlines

Deal found 9/9$385

Sat 10/1811:11 amFLO - JAN

1 stop5h 52mAmerican Airlines

Wed 10/225:46 pmJAN - FLO

1 stop4h 27mAmerican Airlines

Deal found 9/9$387

Sat 10/255:14 amFLO - ATL

2 stops14h 13mAmerican Airlines

Sat 11/18:48 amATL - FLO

2 stops10h 59mAmerican Airlines

Deal found 9/10$306

One-way flights from Florence
Search for one-way flight options from Florence. Find affordable one-way fares based on user searches. Data last updated September 11, 2025.

Wed 10/153:19 pmFLO - SFO

1 stop9h 37mAmerican Airlines

Deal found 9/10$107

Sat 11/85:15 amFLO - SFO

2 stops12h 48mAmerican Airlines

Deal found 9/11$112

Sun 11/95:15 amFLO - SEA

1 stop10h 38mAmerican Airlines

Deal found 9/10$367

Fly to

Route

Depart

Return

Price

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sat 10/11

11:11 am-4:05 pm

1 stop5h 54m

Chicago O'Hare Intl

Sat 10/18

7:10 am-2:04 pm

1 stop5h 54m

$159

FlorenceHouston

FLO - HOU

FLOHOU

Florence

Fri 9/26

12:27 pm-8:11 pm

2 stops8h 44m

Houston Hobby

Tue 9/30

2:33 pm-11:16 pm

2 stops7h 43m

$289

FlorenceAtlanta

FLO - ATL

FLOATL

Florence

Sat 10/25

5:14 am-7:27 pm

2 stops14h 13m

Atlanta Hartsfield-Jackson

Sat 11/1

8:48 am-7:47 pm

2 stops10h 59m

$306

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 9/26

5:37 pm-11:12 pm

1 stop6h 35m

Chicago O'Hare Intl

Tue 9/30

9:51 am-5:12 pm

1 stop6h 21m

$320

FlorenceChicago

FLO - ORD

FLOORD

Florence

Wed 3/4

2:33 pm-7:29 pm

1 stop5h 56m

Chicago O'Hare Intl

Sat 3/7

7:00 am-2:03 pm

1 stop6h 03m

$346

FlorenceOrlando

FLO - MCO

FLOMCO

Florence

Wed 9/24

6:14 am-7:44 pm

2 stops13h 30m

Orlando

Wed 10/1

6:10 am-5:12 pm

2 stops11h 02m

$369

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 9/26

6:14 am-11:30 am

1 stop8h 16m

San Francisco

Tue 9/30

12:30 pm-11:16 pm

1 stop7h 46m

$375

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 11/26

11:11 am-5:54 pm

1 stop9h 43m

San Francisco

Tue 12/2

7:15 am-5:09 pm

1 stop6h 54m

$377

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Tue 11/25

11:11 am-8:14 pm

2 stops12h 03m

San Francisco

Tue 12/2

7:15 am-5:09 pm

1 stop6h 54m

$382

FlorenceJackson

FLO - JAN

FLOJAN

Florence

Fri 10/17

11:11 am-10:01 pm

2 stops11h 50m

Jackson-Evers Intl

Tue 10/21

7:20 am-11:13 pm

2 stops14h 53m

$385

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Showing 1-10 of 34 results

Best time to book a flight from Florence

Have a flexible travel schedule? Discover the best time to fly from Florence with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Florence

Get recent, data-driven insights about flights from Florence including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Florence, South Carolina?

Currently, April is the cheapest month in which you can book a flight from Florence, South Carolina (average of $165). Flying from Florence, South Carolina in March will prove the most costly (average of $423). There are multiple factors that influence the price of a flight so comparing airlines, departure airports and times can help keep costs down.

What is the cheapest place to fly to from Florence, South Carolina?

The cheapest city to fly to from Florence, South Carolina is Charlotte Douglas, with prices starting at $208. Explore other affordable destinations below.

Charlotte Douglas

From $208

Browse thousands of different options on Cheapflights for your next trip

Airports servicing Florence

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Related info for your journey

What is the cheapest flight from Florence, South Carolina to anywhere?
Users have flown out of Florence, South Carolina for as low as $208 to Charlotte (prices may vary depending on the airline and departure time). On average, users have booked flights for $581 to fly from Florence, South Carolina.
What is the cheapest month to fly from Florence, South Carolina?
April is currently the cheapest month to fly from Florence, South Carolina. At this moment in time March is the most expensive month. These prices are determined by multiple factors and booking in advance can help keep costs down if your schedule is not as flexible.

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$107+ Cheap flights from Florence, SC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/8. Fares are subject to change and may not be available on all flights or dates of travel.

What to know about flights from Florence

Cheapest one-way flight

Cheapest round-trip flight

Cheapest airline

Most popular destination

Good round-trip deal

Good one-way deal

Find flights from Florence

Cheapest flights from FlorenceExplore the most affordable flight options available from Florence. Find the lowest fares based on data from user searches, with prices last updated on September 11, 2025.

Explore the most affordable flight options available from Florence. Find the lowest fares based on data from user searches, with prices last updated on September 11, 2025.

Find flights from Florence within your budget

Best time to book a flight from Florence

Have a flexible travel schedule? Discover the best time to fly from Florence with our price prediction graph.

Travel insights for flights from Florence

Get recent, data-driven insights about flights from Florence including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Florence, South Carolina?

What is the cheapest place to fly to from Florence, South Carolina?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Airports servicing Florence

Fly out of one of these airports located in Florence.

Related info for your journey

What is the cheapest flight from Florence, South Carolina to anywhere?

What is the cheapest month to fly from Florence, South Carolina?

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Book with Flexibility

Travel Smart

Cheapest flights from Florence
Explore the most affordable flight options available from Florence. Find the lowest fares based on data from user searches, with prices last updated on September 11, 2025.