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$224+ Cheap flights from Quito (UIO) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/13. Fares are subject to change and may not be available on all flights or dates of travel.
UIO — SCL
May 24 — May 311
Sun 5/24
Sun 5/31
1 adult, Economy
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Cheap flight deals from Quito to Santiago

Cheapest flights from Quito to Santiago
Explore the most affordable flight options available from Quito to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/194:49 pm
UIO
-
SCL
1 stop10h 22m
JetSMART
Fri 7/104:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 4/20$298
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/214:49 pm
UIO
-
SCL
1 stop10h 22m
JetSMART
Wed 7/84:41 am
SCL
-
UIO
1 stop12h 23m
JetSMART
Deal found 4/20$299
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:49 pm
UIO
-
SCL
1 stop10h 27m
JetSMART
Sun 6/74:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 4/19$300
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/74:49 pm
UIO
-
SCL
1 stop10h 22m
JetSMART
Fri 6/124:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 4/20$304
This Booking.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/104:49 pm
UIO
-
SCL
1 stop10h 27m
JetSMART
Fri 6/124:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 4/21$310
This Booking.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:49 pm
UIO
-
SCL
1 stop10h 22m
JetSMART
Fri 6/124:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 4/21$312
This CheapOair deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/104:49 pm
UIO
-
SCL
1 stop10h 27m
JetSMART
Sun 6/144:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 4/21$322
This CheapOair deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/74:49 pm
UIO
-
SCL
1 stop10h 22m
JetSMART
Sun 6/144:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 4/23$325
This JetSMART deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:49 pm
UIO
-
SCL
1 stop10h 22m
JetSMART
Sun 6/74:56 am
SCL
-
UIO
1 stop12h 08m
JetSMART
Deal found 4/20$327

Find flight deals from Quito to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Quito (UIO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$298
(Kiwi.com)

One-way from

$224
(Kiwi.com)

Popular in

February

Cheapest in

June

Average price

$343
Provider with most accurate pricing for Quito Mariscal Sucr-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Quito Mariscal Sucr-Santiago Arturo Merino Benitez flights.
Search Deals
From Quito Mariscal Sucr to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Quito Mariscal Sucr to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($45 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Quito to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
Use the filters below to find and compare flights from Quito to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 6/3

4:49 pm-4:16 am

1 stop10h 27m

Santiago Arturo Merino Benitez

Wed 7/15

4:41 am-4:04 pm

1 stop12h 23m

$443

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Tue 5/5

9:14 am-11:39 pm

1 stop13h 25m

Santiago Arturo Merino Benitez

Fri 6/5

8:31 am-4:04 pm

1 stop8h 33m

$445

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Tue 5/19

3:07 am-10:43 pm

1 stop18h 36m

Santiago Arturo Merino Benitez

Sat 5/23

2:22 am-2:09 pm

1 stop12h 47m

$456

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Thu 5/7

3:09 pm-5:10 am

1 stop13h 01m

Santiago Arturo Merino Benitez

Sat 5/9

4:09 am-2:10 pm

1 stop11h 01m

$456

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 5/31

3:07 am-10:43 pm

1 stop18h 36m

Santiago Arturo Merino Benitez

Tue 6/2

4:09 am-2:09 pm

1 stop11h 00m

$456
Quickest round-trip

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 5/27

8:27 am-7:23 pm

1 stop9h 56m

Santiago Arturo Merino Benitez

Sat 5/30

4:41 am-2:10 pm

1 stop10h 29m

$456

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 5/6

8:27 am-11:26 pm

1 stop13h 59m

Santiago Arturo Merino Benitez

Wed 5/13

4:41 am-2:09 pm

1 stop10h 28m

$456

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Tue 5/5

3:09 pm-2:20 am

1 stop10h 11m

Santiago Arturo Merino Benitez

Thu 6/4

12:38 am-2:09 pm

1 stop14h 31m

$456

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Thu 5/7

3:07 am-7:23 pm

1 stop15h 16m

Santiago Arturo Merino Benitez

Thu 5/21

2:22 am-2:09 pm

1 stop12h 47m

$456

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Mon 5/11

6:30 pm-5:10 am

1 stop9h 40m

Santiago Arturo Merino Benitez

Thu 5/21

4:09 am-2:09 pm

1 stop11h 00m

$456

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Showing 1-10 of 22 resultsSorted by cheapest first
1
2
3
  • Most accurate provider: When it comes to deals on Quito-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Quito-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Quito-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Quito-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Quito-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Quito to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Quito with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Quito to Santiago

How far ahead should I book a flight from Quito to Santiago?

The price you pay for your flight from Quito to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 67 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Quito to Santiago?

Currently, June is the cheapest month in which you can book a flight from Quito to Santiago (average of $299). Flying from Quito to Santiago in February is currently the most expensive (average of $515). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Quito to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated April 24, 2026.
Read reviews from past customers who have flown Copa Airlines,LATAM Airlines, andJetSMART from Quito to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,577 reviews

Entertainment

6.8

Crew

8.1

Boarding

7.8

Comfort

7.4

Overall

7.5

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Copa Airlines
7.5
Good
1,577 reviews
Copa Airlines
7.5
Good
1,577 reviews

Entertainment

6.8

Crew

8.1

Boarding

7.8

Comfort

7.4

Overall

7.5

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
LATAM Airlines
7.4
Good
1,911 reviews
Copa Airlines
7.5
Good
1,577 reviews

Entertainment

6.8

Crew

8.1

Boarding

7.8

Comfort

7.4

Overall

7.5

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
JetSMART
6.7
Okay
296 reviews
Copa Airlines
7.5
Good
1,577 reviews

Entertainment

6.8

Crew

8.1

Boarding

7.8

Comfort

7.4

Overall

7.5

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Avianca
6.5
Okay
2,514 reviews
Copa Airlines
7.5
Good
1,577 reviews

Entertainment

6.8

Crew

8.1

Boarding

7.8

Comfort

7.4

Overall

7.5

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.

Related info for your journey

Find useful and relevant information for your journey from Quito to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Quito to Santiago?

    JetSMART and Copa Airlines can get you from Quito to Santiago in just under 10h 27m. Your travel time can differ by up to 8h 09m. There are 2349 mi between Quito and Santiago. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Quito to Santiago round-trip?

    Currently priced at $161, JetSMART will fly you from Quito to Santiago and back. In addition to JetSMART, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Avianca and Copa Airlines - these airlines can fly you to your destination from $183 and $275, respectively. JetSMART is priced at 59% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Quito to Santiago one-way?

    The cheapest airlines for a one-way flight from Quito to Santiago are JetSMART ($185), Avianca ($238), and Copa Airlines ($275).

  • Can I find deals for flights from Quito to Santiago that include hotel bookings?

    Yes. In addition to deals on Quito to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Quito to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Quito to Santiago.

  • Can I find deals for business class flights from Quito to Santiago?

    Yes. Cheapflights offers flight deals from Quito to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Quito to Santiago?

    Currently, June is the cheapest month in which you can book a flight from Quito to Santiago (average of $299). Flying from Quito to Santiago in February is currently the most expensive (average of $515). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Lastarria car rentals

Top 4 airlines flying from Quito to Santiago

Discover the top 4 airlines that operate flights from Quito to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetSMARTCheapest$161Average$379FlexibilityNo cancel feeOn-timeN/A
AviancaCheapest$183Average$480FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$275Average$528FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$343Average$573FlexibilityNo cancel feeOn-time81%

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