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$598+ Cheap flights from Bruxelles-National (BRU) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
BRU — CHS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Bruxelles-National to South Carolina

Keep the following information in mind while searching for Bruxelles-National to South Carolina flight deals. Data was last updated October 30, 2025.

Round-trip from

$596
(Trip.com)
From Brussels Bruxelles-National to South Carolina
Search Deals

Find flight deals from Bruxelles-National to South Carolina

Cheapest flights from Bruxelles-National to South Carolina
Explore the most affordable flight options available from Bruxelles-National to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Trip.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1312:50 pmBRU - CLT
2 stops16h 18mMultiple Airlines
Thu 11/276:00 amCLT - BRU
2 stops23h 55mMultiple Airlines
Deal found 10/30$598
This Flighttix deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/139:00 amBRU - CLT
2 stops15h 51mLufthansa
Thu 11/272:50 pmCLT - BRU
1 stop10h 25mLufthansa
Deal found 10/29$632
This ResecentrumGruppen deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure ResecentrumGruppen is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:45 amBRU - CLT
1 stop16h 10mLufthansa
Fri 11/282:50 pmCLT - BRU
1 stop10h 25mLufthansa
Deal found 10/29$633
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2010:15 amBRU - CLT
1 stop14h 40mAmerican Airlines
Fri 11/288:20 pmCLT - BRU
1 stop13h 05mAmerican Airlines
Deal found 10/29$639
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1310:15 amBRU - CLT
1 stop14h 40mAmerican Airlines
Thu 11/278:20 pmCLT - BRU
1 stop17h 10mAmerican Airlines
Deal found 10/29$640
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2611:50 amBRU - CLT
2 stops16h 03mAmerican Airlines
Wed 12/38:20 pmCLT - BRU
1 stop17h 15mAmerican Airlines
Deal found 10/29$649
This Flighttix deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/97:00 amBRU - CLT
2 stops19h 57mMultiple Airlines
Wed 12/2411:02 amCLT - BRU
2 stops17h 08mMultiple Airlines
Deal found 10/30$654
This Flighttix deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/99:05 amBRU - CLT
1 stop13h 50mLufthansa
Wed 12/2411:02 amCLT - BRU
2 stops20h 33mLufthansa
Deal found 10/30$659
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2110:00 amBRU - CAE
2 stops41h 30mUnited Airlines
Fri 11/2810:34 amCAE - BRU
1 stop14h 41mUnited Airlines
Deal found 10/30$717
This KLM deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1511:00 amBRU - GSP
2 stops16h 17mKLM
Wed 11/191:58 pmGSP - BRU
2 stops13h 02mKLM
Deal found 10/30$729
This KLM deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1511:00 amBRU - CHS
2 stops15h 42mKLM
Wed 11/1912:53 pmCHS - BRU
1 stop14h 07mKLM
Deal found 10/30$729
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1511:00 amBRU - GSP
2 stops16h 17mDelta
Wed 11/1911:35 amGSP - BRU
1 stop15h 25mDelta
Deal found 10/30$752

Cheapflights Fare Finder

 
Customize your flight search to find flights from Bruxelles-National to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Brussels Bruxelles-National Airport to South Carolina that are best for you.

Fly from

Bruxelles-National

Fly to

South Carolina

Route

Depart

Return

Price

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Thu 11/13

12:50 pm-11:08 pm

2 stops16h 18m

Charlotte Douglas

Thu 11/27

6:00 am-11:55 am

2 stops23h 55m

$598

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Thu 11/13

9:00 am-6:51 pm

2 stops15h 51m

Charlotte Douglas

Thu 11/27

2:50 pm-7:15 am

1 stop10h 25m

$632

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Thu 2/26

5:30 pm-2:20 pm

1 stop26h 50m

Charlotte Douglas

Mon 3/2

11:00 pm-10:00 am

1 stop29h 00m

$638

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Wed 11/26

11:50 am-6:55 pm

1 stop13h 05m

Charlotte Douglas

Wed 12/3

8:20 pm-7:35 pm

1 stop17h 15m

$639

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Thu 11/20

10:15 am-9:53 pm

2 stops17h 38m

Charlotte Douglas

Fri 11/28

6:33 pm-3:25 pm

2 stops14h 52m

$653

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Tue 12/9

7:00 am-8:57 pm

2 stops19h 57m

Charlotte Douglas

Wed 12/24

11:02 am-10:10 am

2 stops17h 08m

$654

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Tue 12/9

9:05 am-4:55 pm

1 stop13h 50m

Charlotte Douglas

Wed 12/24

11:02 am-1:35 pm

2 stops20h 33m

$659

BrusselsCharleston

BRU - CHS

BRUCHS

Brussels Bruxelles-National

Wed 3/25

11:50 am-12:09 pm

2 stops29h 19m

Charleston

Sun 3/29

4:30 pm-6:00 pm

2 stops19h 30m

$702

BrusselsCharleston

BRU - CHS

BRUCHS

Brussels Bruxelles-National

Wed 1/14

11:50 am-11:07 pm

2 stops17h 17m

Charleston

Sun 1/18

3:16 pm-1:50 pm

2 stops16h 34m

$705

BrusselsColumbia

BRU - CAE

BRUCAE

Brussels Bruxelles-National

Fri 11/21

10:00 am-9:30 pm

2 stops41h 30m

Columbia Metropolitan

Fri 11/28

10:34 am-7:15 am

1 stop14h 41m

$717

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 27 results
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Best time to book a flight from Bruxelles-National to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Bruxelles-National with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Brussels Bruxelles-National Airport to South Carolina

What is the cheapest month to book a flight from Brussels Bruxelles-National Airport to South Carolina?

Currently, November is the cheapest month in which you can book a flight from Brussels Bruxelles-National Airport to South Carolina (average of $539). Flying from Brussels Bruxelles-National Airport to South Carolina in December is currently the most expensive (average of $958). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Brussels Bruxelles-National Airport to South Carolina?

Related info for your journey

Find useful and relevant information for your journey from Bruxelles-National to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Brussels Bruxelles-National Airport to South Carolina?

    Departing from Brussels Bruxelles-National Airport to South Carolina will take you 15h 51m. The distance between Brussels Bruxelles-National Airport and South Carolina is about 4194 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Brussels Bruxelles-National Airport to South Carolina?

    The most popular route from Brussels Bruxelles-National Airport to South Carolina is Brussels Bruxelles-National - Charlotte Douglas. You may also consider Brussels Bruxelles-National - Columbia Metropolitan or Brussels Bruxelles-National - Charleston.

  • Can I find deals for flights from Bruxelles-National to South Carolina that include hotel bookings?

    Yes. In addition to deals on Bruxelles-National to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Bruxelles-National to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Bruxelles-National to South Carolina.

  • Can I find deals for business class flights from Bruxelles-National to South Carolina?

    Yes. Cheapflights offers flight deals from Bruxelles-National to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Brussels Bruxelles-National Airport to South Carolina?

    Currently, November is the cheapest month in which you can book a flight from Brussels Bruxelles-National Airport to South Carolina (average of $539). Flying from Brussels Bruxelles-National Airport to South Carolina in December is currently the most expensive (average of $958). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Bruxelles-National to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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