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$351+ Cheap flights from Bruxelles-National (BRU) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
BRU — CHS
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Bruxelles-National to South Carolina

Cheapest flights from Bruxelles-National to South Carolina
Explore the most affordable flight options available from Bruxelles-National to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Flighttix deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:25 am
BRU
-
CLT
1 stop14h 30m
British Airways
Tue 3/317:25 pm
CLT
-
BRU
2 stops13h 50m
British Airways
Deal found 1/26$609
This Flighttix deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1311:45 am
BRU
-
CLT
1 stop13h 10m
British Airways
Fri 3/209:15 pm
CLT
-
BRU
1 stop11h 25m
British Airways
Deal found 1/27$610
This Finnair deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/137:05 am
BRU
-
CLT
2 stops32h 00m
Multiple Airlines
Fri 3/209:15 pm
CLT
-
BRU
1 stop15h 05m
Multiple Airlines
Deal found 1/27$613
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1311:45 am
BRU
-
CLT
1 stop13h 10m
American Airlines
Fri 3/209:15 pm
CLT
-
BRU
1 stop13h 10m
American Airlines
Deal found 1/27$614
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/510:15 am
BRU
-
CLT
1 stop14h 50m
American Airlines
Sun 2/812:08 pm
CLT
-
BRU
2 stops16h 42m
American Airlines
Deal found 1/26$616
This Finnair deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:05 am
BRU
-
CLT
2 stops30h 30m
Multiple Airlines
Tue 3/315:55 pm
CLT
-
BRU
1 stop15h 20m
Multiple Airlines
Deal found 1/28$617
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/294:00 pm
BRU
-
CLT
1 stop29h 55m
American Airlines
Thu 5/146:02 pm
CLT
-
BRU
2 stops16h 08m
American Airlines
Deal found 1/28$618
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/55:30 pm
BRU
-
CLT
1 stop26h 45m
American Airlines
Fri 2/208:20 pm
CLT
-
BRU
1 stop32h 10m
American Airlines
Deal found 1/28$619
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/55:30 pm
BRU
-
CLT
1 stop26h 45m
American Airlines
Mon 2/91:45 pm
CLT
-
BRU
2 stops15h 25m
American Airlines
Deal found 1/28$621
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/294:00 pm
BRU
-
FLO
2 stops37h 53m
American Airlines
Sun 5/34:16 pm
FLO
-
BRU
2 stops35h 49m
American Airlines
Deal found 1/26$659
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:05 pm
BRU
-
CHS
2 stops32h 33m
American Airlines
Wed 6/102:11 pm
CHS
-
BRU
2 stops18h 54m
American Airlines
Deal found 1/27$659
This British Airways deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:50 am
BRU
-
CHS
2 stops17h 21m
British Airways
Tue 5/1211:04 am
CHS
-
BRU
2 stops22h 11m
British Airways
Deal found 1/27$662

Find flight deals from Bruxelles-National to South Carolina

Keep the following information in mind while searching for Bruxelles-National to South Carolina flight deals. Data was last updated January 29, 2026.

Round-trip from

$609
(Flighttix)

One-way from

$351
(Kiwi.com)
From Brussels Bruxelles-National to South Carolina
Search Deals
One-way flight from Brussels Bruxelles-National to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Bruxelles-National to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Brussels Bruxelles-National Airport to South Carolina that are best for you.

Fly from

Bruxelles-National

Fly to

South Carolina

Route

Depart

Return

Price

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Wed 3/11

10:25 am-7:55 pm

1 stop14h 30m

Charlotte Douglas

Tue 3/31

7:25 pm-3:15 pm

2 stops13h 50m

$609

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Fri 3/13

11:45 am-7:55 pm

1 stop13h 10m

Charlotte Douglas

Fri 3/20

9:15 pm-1:40 pm

1 stop11h 25m

$610

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Fri 3/13

7:05 am-10:05 am

2 stops32h 00m

Charlotte Douglas

Fri 3/20

9:15 pm-5:20 pm

1 stop15h 05m

$613

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Fri 3/13

11:45 am-7:55 pm

1 stop13h 10m

Charlotte Douglas

Fri 3/20

9:15 pm-3:25 pm

1 stop13h 10m

$614

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Wed 4/29

4:00 pm-1:10 pm

1 stop27h 10m

Charlotte Douglas

Thu 5/14

6:02 pm-4:10 pm

2 stops16h 08m

$615

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Wed 3/11

7:05 am-8:35 am

2 stops30h 30m

Charlotte Douglas

Tue 3/31

5:55 pm-3:15 pm

1 stop15h 20m

$617

BrusselsCharlotte

BRU - CLT

BRUCLT

Brussels Bruxelles-National

Wed 4/29

9:15 pm-1:10 pm

1 stop21h 55m

Charlotte Douglas

Thu 5/14

11:45 pm-8:40 pm

1 stop14h 55m

$621

BrusselsFlorence

BRU - FLO

BRUFLO

Brussels Bruxelles-National

Wed 4/29

4:00 pm-11:53 pm

2 stops37h 53m

Florence

Sun 5/3

4:16 pm-10:05 am

2 stops35h 49m

$659

BrusselsCharleston

BRU - CHS

BRUCHS

Brussels Bruxelles-National

Wed 6/3

11:00 am-11:37 am

2 stops30h 37m

Charleston

Fri 6/12

12:11 pm-9:10 pm

2 stops26h 59m

$659

BrusselsCharleston

BRU - CHS

BRUCHS

Brussels Bruxelles-National

Mon 5/4

10:50 am-10:11 pm

2 stops17h 21m

Charleston

Tue 5/12

11:04 am-3:15 pm

2 stops22h 11m

$662

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 42 results
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Best time to book a flight from Bruxelles-National to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Bruxelles-National with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Brussels Bruxelles-National Airport to South Carolina

What is the cheapest month to book a flight from Brussels Bruxelles-National Airport to South Carolina?

Currently, April is the cheapest month in which you can book a flight from Brussels Bruxelles-National Airport to South Carolina (average of $575). Flying from Brussels Bruxelles-National Airport to South Carolina in December is currently the most expensive (average of $1,043). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Bruxelles-National to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Brussels Bruxelles-National Airport to South Carolina?

    Departing from Brussels Bruxelles-National Airport to South Carolina will take you 13h 10m. The distance between Brussels Bruxelles-National Airport and South Carolina is about 4194 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Brussels Bruxelles-National Airport to South Carolina?

    The most popular route from Brussels Bruxelles-National Airport to South Carolina is Brussels Bruxelles-National - Charlotte Douglas. You may also consider Brussels Bruxelles-National - Columbia Metropolitan or Brussels Bruxelles-National - Charleston.

  • Can I find deals for flights from Bruxelles-National to South Carolina that include hotel bookings?

    Yes. In addition to deals on Bruxelles-National to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Bruxelles-National to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Bruxelles-National to South Carolina.

  • Can I find deals for business class flights from Bruxelles-National to South Carolina?

    Yes. Cheapflights offers flight deals from Bruxelles-National to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Brussels Bruxelles-National Airport to South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Brussels Bruxelles-National Airport to South Carolina (average of $575). Flying from Brussels Bruxelles-National Airport to South Carolina in December is currently the most expensive (average of $1,043). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Bruxelles-National to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Charleroi Brussels to Atlanta flights
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