How long is the flight from Missouri to South Africa?

Departing from Missouri to South Africa will take you 18h 35m. There are 9049 mi between Missouri and South Africa. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines to fly from Missouri to South Africa one-way?

To fly one-way, consider booking your trip with Qatar Airways, which is currently one of the cheapest options available, starting at $856. American Airlines flights start at $1,093 while deals on Delta start at $1,143 one-way.

In terms of precipitation, rainfall in South Africa ranges from 0.0 - 4.7 inches per month. January is typically the wettest month, when rainfall can reach 4.7 in. June is typically the driest time to visit South Africa when rainfall is around 0.0 in.

If weather is an important factor for your trip to South Africa, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 68.0 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 50.0 F).

Can I find deals for flights from Missouri to South Africa that include hotel bookings?

Yes. In addition to deals on Missouri to South Africa flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to South Africa?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Africa.

Can I find deals for business class flights from Missouri to South Africa?

Yes. Cheapflights offers flight deals from Missouri to South Africa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$720+ Cheap Flights from Missouri to South Africa

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Cheap flight deals from Missouri to South Africa

Round-trip from	$1,098 (American Airlines)
One-way from	$797 (Kiwi.com)
Popular in	July
Cheapest in	January
Average price	$1,499

From Missouri to South Africa

Search Deals

One-way flight from Missouri to South Africa

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($195 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($49 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Find flight deals from Missouri to South Africa

Cheapest flights from Missouri to South Africa
Explore the most affordable flight options available from Missouri to South Africa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

Sun 12/72:54 pmSTL - CPT

2 stops37h 16mAmerican Airlines

Sun 12/218:35 pmCPT - STL

2 stops28h 49mAmerican Airlines

Deal found 9/16

$1,098

Fri 12/55:58 pmSTL - CPT

2 stops34h 12mAmerican Airlines

Mon 12/1510:10 pmCPT - STL

2 stops26h 40mAmerican Airlines

Deal found 9/16

$1,147

Tue 11/111:43 pmSTL - JNB

2 stops33h 52mAmerican Airlines

Thu 2/510:00 pmJNB - STL

2 stops30h 23mAmerican Airlines

Deal found 9/16

$1,173

Fri 12/55:58 pmSTL - CPT

2 stops34h 12mAmerican Airlines

Wed 12/178:35 pmCPT - STL

2 stops28h 49mAmerican Airlines

Deal found 9/16

$1,197

Sat 11/82:17 pmSTL - CPT

2 stops33h 48mAmerican Airlines

Fri 11/216:55 pmCPT - STL

2 stops32h 34mAmerican Airlines

Deal found 9/16

$1,203

Tue 10/149:43 amSTL - JNB

2 stops47h 27mQatar Airways

Tue 10/218:25 pmJNB - STL

2 stops31h 28mQatar Airways

Deal found 9/16

$1,210

Mon 12/84:49 pmSTL - CPT

2 stops35h 21mAmerican Airlines

Fri 12/196:55 pmCPT - STL

2 stops35h 26mAmerican Airlines

Deal found 9/16

$1,212

Wed 10/18:50 amSTL - JNB

2 stops48h 20mQatar Airways

Fri 10/319:25 amJNB - STL

2 stops37h 58mQatar Airways

Deal found 9/16

$1,212

Tue 10/149:43 amSTL - JNB

2 stops40h 52mQatar Airways

Wed 11/121:45 pmJNB - STL

2 stops37h 45mQatar Airways

Deal found 9/16

$1,215

Wed 10/159:43 amSTL - JNB

2 stops47h 27mQatar Airways

Wed 10/221:55 pmJNB - STL

2 stops35h 27mQatar Airways

Deal found 9/17

$1,225

Sat 11/85:15 pmSTL - CPT

1 stop18h 00mVirgin Atlantic

Fri 11/219:30 pmCPT - STL

1 stop26h 37mVirgin Atlantic

Deal found 9/16

$1,234

Tue 10/146:00 amSTL - JNB

2 stops43h 20mMultiple Airlines

Wed 11/129:50 amJNB - STL

2 stops41h 37mMultiple Airlines

Deal found 9/15

$1,243

Best flights from Missouri to South Africa
Discover carefully curated flight deals from Missouri to South Africa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2025.

Mon 12/84:49 pmSTL - CPT

2 stops35h 21mAmerican Airlines

Mon 12/158:35 pmCPT - STL

2 stops28h 15mAmerican Airlines

Deal found 9/16

$1,098

Wed 10/229:43 amSTL - JNB

2 stops47h 27mQatar Airways

Tue 10/281:45 pmJNB - STL

2 stops35h 51mQatar Airways

Deal found 9/16

$1,210

Tue 10/146:00 amSTL - JNB

2 stops43h 20mMultiple Airlines

Wed 11/129:50 amJNB - STL

2 stops41h 37mMultiple Airlines

Deal found 9/15

$1,243

Thu 11/65:15 pmSTL - CPT

1 stop18h 00mVirgin Atlantic

Thu 11/209:30 pmCPT - STL

1 stop28h 27mVirgin Atlantic

Deal found 9/15

$1,265

Mon 11/101:55 pmSTL - CPT

1 stop21h 20mDelta

Thu 11/209:30 pmCPT - STL

1 stop23h 30mDelta

Deal found 9/16

$1,271

Fri 10/315:00 pmMCI - JNB

1 stop18h 35mUnited Airlines

Fri 11/77:45 pmJNB - MCI

2 stops34h 43mUnited Airlines

Deal found 9/16

$1,682

Tue 11/256:00 amMCI - DUR

2 stops51h 10mEmirates

Tue 1/277:10 pmDUR - MCI

2 stops50h 32mEmirates

Deal found 9/16

$1,948

Sun 12/72:54 pmSTL - CPT

2 stops37h 16mAmerican Airlines

Thu 12/1810:10 pmCPT - STL

2 stops27h 14mAmerican Airlines

Deal found 9/16

$1,147

Tue 10/149:43 amSTL - JNB

2 stops47h 27mQatar Airways

Tue 10/218:25 pmJNB - STL

2 stops31h 28mQatar Airways

Deal found 9/16

$1,210

Sat 12/64:49 pmSTL - CPT

2 stops33h 31mAmerican Airlines

Mon 12/1510:10 pmCPT - STL

2 stops26h 40mAmerican Airlines

Deal found 9/16

$1,147

Mon 11/101:55 pmSTL - CPT

1 stop21h 20mDelta

Sun 11/239:30 pmCPT - STL

1 stop23h 30mDelta

Deal found 9/16

$1,271

Wed 10/19:46 amSTL - JNB

2 stops39h 34mMultiple Airlines

Fri 10/319:50 amJNB - STL

2 stops34h 45mMultiple Airlines

Deal found 9/15

$1,308

Wed 10/18:50 amSTL - JNB

2 stops48h 20mQatar Airways

Fri 10/319:25 amJNB - STL

2 stops37h 58mQatar Airways

Deal found 9/16

$1,212

Fri 12/55:58 pmSTL - CPT

2 stops34h 12mAmerican Airlines

Sun 12/218:35 pmCPT - STL

2 stops28h 49mAmerican Airlines

Deal found 9/16

$1,147

Sat 11/810:30 amSTL - CPT

1 stop24h 45mDelta

Tue 11/189:30 pmCPT - STL

1 stop29h 05mDelta

Deal found 9/16

$1,271

Tue 10/149:43 amSTL - JNB

2 stops40h 52mQatar Airways

Wed 11/121:45 pmJNB - STL

2 stops37h 45mQatar Airways

Deal found 9/16

$1,215

Sun 12/1411:36 amMCI - JNB

3 stops37h 54mAir Canada

Sun 12/288:15 pmJNB - MCI

3 stops45h 03mAir Canada

Deal found 9/15

$3,028

Thu 11/611:36 amSTL - CPT

1 stop23h 39mDelta

Mon 11/249:30 pmCPT - STL

1 stop23h 30mDelta

Deal found 9/16

$1,271

Tue 11/111:43 pmSTL - JNB

2 stops33h 52mAmerican Airlines

Thu 2/510:00 pmJNB - STL

2 stops30h 23mAmerican Airlines

Deal found 9/16

$1,173

Sat 12/64:49 pmSTL - CPT

2 stops33h 31mAmerican Airlines

Sat 12/2010:10 pmCPT - STL

2 stops29h 20mAmerican Airlines

Deal found 9/16

$1,197

Thu 10/26:00 amMCI - JNB

1 stop28h 45mMultiple Airlines

Thu 10/308:15 pmJNB - MCI

2 stops32h 35mMultiple Airlines

Deal found 9/16

$1,631

Fri 12/55:58 pmSTL - CPT

2 stops34h 12mAmerican Airlines

Wed 12/178:35 pmCPT - STL

2 stops28h 49mAmerican Airlines

Deal found 9/16

$1,197

Wed 12/105:12 pmMCI - CPT

1 stop18h 03mVirgin Atlantic

Mon 12/229:30 pmCPT - MCI

1 stop28h 04mVirgin Atlantic

Deal found 9/16

$2,036

Fri 12/55:58 pmSTL - CPT

2 stops34h 12mAmerican Airlines

Sat 12/2010:10 pmCPT - STL

2 stops29h 20mAmerican Airlines

Deal found 9/16

$1,197

Wed 10/154:39 pmMCI - DUR

2 stops40h 56mEmirates

Sun 10/196:40 pmDUR - MCI

2 stops34h 05mEmirates

Deal found 9/16

$2,139

Wed 10/153:10 pmMCI - DUR

3 stops36h 25mQatar Airways

Sun 10/1912:05 pmDUR - MCI

3 stops41h 54mQatar Airways

Deal found 9/14

$1,708

Wed 12/106:10 amMCI - CPT

1 stop27h 50mMultiple Airlines

Mon 12/226:45 pmCPT - MCI

2 stops33h 34mMultiple Airlines

Deal found 9/16

$1,897

Sun 10/128:05 pmSTL - JNB

2 stops30h 20mAmerican Airlines

Sun 10/197:25 pmJNB - STL

2 stops27h 38mAmerican Airlines

Deal found 9/15

$1,273

Sat 11/16:15 pmMCI - CPT

1 stop18h 00mDelta

Sat 11/88:00 amCPT - MCI

2 stops41h 28mDelta

Deal found 9/17

$1,913

Sat 11/292:49 pmMCI - DUR

3 stops36h 06mQatar Airways

Sat 1/3112:25 pmDUR - MCI

3 stops43h 45mQatar Airways

Deal found 9/16

$1,785

Last-minute flights from Missouri to South Africa
Discover last-minute flight deals from Missouri to South Africa. Data last updated September 17, 2025 and is based on user searches.

Fri 9/266:55 pmSTL - JNB

2 stops31h 30mAmerican Airlines

Tue 10/79:15 pmJNB - STL

2 stops28h 31mAmerican Airlines

Deal found 9/15

$1,373

Wed 10/18:50 amSTL - JNB

2 stops48h 20mQatar Airways

Fri 10/319:25 amJNB - STL

2 stops37h 58mQatar Airways

Deal found 9/16

$1,212

Wed 10/19:46 amSTL - JNB

2 stops39h 34mMultiple Airlines

Fri 10/319:50 amJNB - STL

2 stops34h 45mMultiple Airlines

Deal found 9/15

$1,308

Thu 10/25:06 amMCI - JNB

2 stops45h 29mQatar Airways

Thu 10/308:20 pmJNB - MCI

2 stops31h 08mQatar Airways

Deal found 9/16

$1,298

Sun 10/128:05 pmSTL - JNB

2 stops30h 20mAmerican Airlines

Sun 10/197:25 pmJNB - STL

2 stops27h 38mAmerican Airlines

Deal found 9/15

$1,273

Tue 10/149:43 amSTL - JNB

2 stops47h 27mQatar Airways

Tue 10/218:25 pmJNB - STL

2 stops31h 28mQatar Airways

Deal found 9/16

$1,210

Tue 10/149:43 amSTL - JNB

2 stops40h 52mQatar Airways

Wed 11/121:45 pmJNB - STL

2 stops37h 45mQatar Airways

Deal found 9/16

$1,215

Tue 10/146:00 amSTL - JNB

2 stops43h 20mMultiple Airlines

Wed 11/129:50 amJNB - STL

2 stops41h 37mMultiple Airlines

Deal found 9/15

$1,243

Tue 10/144:34 pmSTL - JNB

2 stops33h 51mAmerican Airlines

Tue 10/217:25 pmJNB - STL

2 stops27h 38mAmerican Airlines

Deal found 9/15

$1,323

Wed 10/159:43 amSTL - JNB

2 stops47h 27mQatar Airways

Wed 10/221:55 pmJNB - STL

2 stops35h 27mQatar Airways

Deal found 9/17

$1,225

Thu 10/307:00 pmSTL - CPT

2 stops34h 10mMultiple Airlines

Thu 11/68:45 pmCPT - STL

2 stops30h 42mMultiple Airlines

Deal found 9/15

$1,365

Fri 10/3110:36 amSTL - CPT

2 stops38h 29mAmerican Airlines

Fri 11/76:55 pmCPT - STL

2 stops32h 34mAmerican Airlines

Deal found 9/15

$1,317

One-way flights from Missouri to South Africa
Search for one-way flight options from Missouri to South Africa. Find affordable one-way fares based on user searches. Data last updated September 17, 2025.

Sat 11/14:51 pmSTL - CPT

3 stops54h 09mMultiple Airlines

Deal found 9/17

$797

Sat 11/19:35 amSTL - JNB

2 stops40h 05mQatar Airways

Deal found 9/15

$856

Sat 11/17:00 amSTL - CPT

2 stops44h 30mQatar Airways

Deal found 9/17

$930

Mon 12/155:38 pmMCI - CPT

2 stops30h 27mAmerican Airlines

Deal found 9/17

$1,093

Sat 11/13:59 pmSTL - CPT

1 stop20h 16mVirgin Atlantic

Deal found 9/17

$1,143

Sat 11/13:59 pmSTL - JNB

1 stop20h 01mDelta

Deal found 9/15

$1,143

Mon 12/155:11 pmSTL - JNB

3 stops59h 24mMultiple Airlines

Deal found 9/16

$1,153

Sat 12/206:36 pmMCI - JNB

2 stops31h 49mBritish Airways

Deal found 9/16

$1,191

Sat 11/15:11 pmSTL - JNB

1 stop18h 24mUnited Airlines

Deal found 9/15

$1,203

Mon 12/1512:49 pmSTL - JNB

2 stops25h 16mKLM

Deal found 9/16

$1,217

Mon 12/156:00 amMCI - CPT

2 stops26h 10mUnited Airlines

Deal found 9/17

$1,263

Mon 12/157:00 amMCI - CPT

3 stops40h 30mMultiple Airlines

Deal found 9/17

$1,384

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to South Africa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisCape Town

STL - CPT

STLCPT

Lambert-St Louis

Mon 12/8

4:49 pm-12:10 pm

2 stops35h 21m

Cape Town Intl

Mon 12/15

8:35 pm-4:50 pm

2 stops28h 15m

$1,098

St. LouisCape Town

STL - CPT

STLCPT

Lambert-St Louis

Sun 12/7

2:54 pm-12:10 pm

2 stops37h 16m

Cape Town Intl

Thu 12/18

10:10 pm-5:24 pm

2 stops27h 14m

$1,147

St. LouisCape Town

STL - CPT

STLCPT

Lambert-St Louis

Sat 12/6

4:49 pm-10:20 am

2 stops33h 31m

Cape Town Intl

Mon 12/15

10:10 pm-4:50 pm

2 stops26h 40m

$1,147

St. LouisCape Town

STL - CPT

STLCPT

Lambert-St Louis

Fri 12/5

5:58 pm-12:10 pm

2 stops34h 12m

Cape Town Intl

Sun 12/21

8:35 pm-5:24 pm

2 stops28h 49m

$1,147

St. LouisJohannesburg

STL - JNB

STLJNB

Lambert-St Louis

Tue 11/11

1:43 pm-7:35 am

2 stops33h 52m

Johannesburg OR Tambo

Thu 2/5

10:00 pm-8:23 pm

2 stops30h 23m

$1,173

St. LouisCape Town

STL - CPT

STLCPT

Lambert-St Louis

Sat 12/6

4:49 pm-10:20 am

2 stops33h 31m

Cape Town Intl

Sat 12/20

10:10 pm-7:30 pm

2 stops29h 20m

$1,197

St. LouisCape Town

STL - CPT

STLCPT

Lambert-St Louis

Fri 12/5

5:58 pm-12:10 pm

2 stops34h 12m

Cape Town Intl

Wed 12/17

8:35 pm-5:24 pm

2 stops28h 49m

$1,197

St. LouisCape Town

STL - CPT

STLCPT

Lambert-St Louis

Fri 12/5

5:58 pm-12:10 pm

2 stops34h 12m

Cape Town Intl

Sat 12/20

10:10 pm-7:30 pm

2 stops29h 20m

$1,197

St. LouisJohannesburg

STL - JNB

STLJNB

Lambert-St Louis

Wed 10/22

9:43 am-4:10 pm

2 stops47h 27m

Johannesburg OR Tambo

Tue 10/28

1:45 pm-6:36 pm

2 stops35h 51m

$1,210

St. LouisJohannesburg

STL - JNB

STLJNB

Lambert-St Louis

Tue 10/14

9:43 am-4:10 pm

2 stops47h 27m

Johannesburg OR Tambo

Tue 10/21

8:25 pm-8:53 pm

2 stops31h 28m

$1,210

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 58 results

...

Best time to book a flight from Missouri to South Africa

Have a flexible travel schedule? Discover the best time to fly to South Africa from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South Africa

What is the cheapest month to book a flight from Missouri to South Africa?

Currently, January is the cheapest month in which you can book a flight from Missouri to South Africa (average of $1,173). Flying from Missouri to South Africa in July is currently the most expensive (average of $1,674). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ZA?

When flying from Missouri to South Africa, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

How long is the flight from Missouri to South Africa?
Departing from Missouri to South Africa will take you 18h 35m. There are 9049 mi between Missouri and South Africa. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines to fly from Missouri to South Africa one-way?
To fly one-way, consider booking your trip with Qatar Airways, which is currently one of the cheapest options available, starting at $856. American Airlines flights start at $1,093 while deals on Delta start at $1,143 one-way.
Can I find deals for flights from Missouri to South Africa that include hotel bookings?
Yes. In addition to deals on Missouri to South Africa flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to South Africa?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Africa.
Can I find deals for business class flights from Missouri to South Africa?
Yes. Cheapflights offers flight deals from Missouri to South Africa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to South Africa?
Currently, January is the cheapest month in which you can book a flight from Missouri to South Africa (average of $1,173). Flying from Missouri to South Africa in July is currently the most expensive (average of $1,674). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Missouri to South Africa

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John F Kennedy Intl to Cairo flights

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LaGuardia to Cairo flights

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Newark to Marrakech flights

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Dulles Intl to Casablanca flights

Newark to Casablanca flights

Newark to OR Tambo flights

O'Hare Intl to Lagos flights

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Baltimore to Cairo flights

LaGuardia to Lagos flights

John F Kennedy Intl to Cape Town flights

Newark to Cape Town flights

O'Hare Intl to Cairo flights

San Francisco to Cairo flights

John F Kennedy Intl to OR Tambo flights

Atlanta to Accra flights

Dallas/Fort Worth to Jomo Kenyatta Intl flights

Love Field to Lagos flights

Dallas/Fort Worth to Cairo flights

Newark to Jomo Kenyatta Intl flights

Dulles Intl to Jomo Kenyatta Intl flights

LaGuardia to Accra flights

Reagan-National to Accra flights

Seattle to Cairo flights

Baltimore to Accra flights

Los Angeles to Lagos flights

Atlanta to OR Tambo flights

Santa Ana to Cairo flights

Boston to Casablanca flights

LaGuardia to Jomo Kenyatta Intl flights

Ontario to Cairo flights

Dulles Intl to Cape Town flights

Complete your trip

South Africa car rentals

Johannesburg OR Tambo Airport car rentals

Cape Town Intl Airport car rentals

Durban King Shaka Intl Airport car rentals

Johannesburg Lanseria Airport car rentals

East London Airport car rentals

Bloemfontein Intl Airport car rentals

Nelspruit Kruger Mpumalanga Airport car rentals

Hoedspruit Airport car rentals

Polokwane Airport car rentals

Mthatha Umtata Airport car rentals

Phalaborwa Airport car rentals

Top 3 airlines flying from Missouri to South Africa

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$924	Average$1,229	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$1,080	Average$1,572	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$1,328	Average$1,870	FlexibilityNo cancel fee	On-timeN/A

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$720+ Cheap flights from Missouri to South Africa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/26. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Missouri to South Africa

Keep the following information in mind while searching for Missouri to South Africa flight deals. Data was last updated September 17, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Missouri to South Africa

Cheapest flights from Missouri to South AfricaExplore the most affordable flight options available from Missouri to South Africa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

Explore the most affordable flight options available from Missouri to South Africa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to South Africa that are best for you.

Best time to book a flight from Missouri to South Africa

Have a flexible travel schedule? Discover the best time to fly to South Africa from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South Africa

What is the cheapest month to book a flight from Missouri to South Africa?

What is the cheapest time of day to fly from MO to ZA?

Find hourly flight availability from Missouri to South Africa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South Africa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Missouri to South Africa?

What are the cheapest airlines to fly from Missouri to South Africa one-way?

Can I find deals for flights from Missouri to South Africa that include hotel bookings?

How can I find direct flights from Missouri to South Africa?

Can I find deals for business class flights from Missouri to South Africa?

What is the cheapest month to book a flight from Missouri to South Africa?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to South Africa

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Missouri to South Africa

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Cheapest flights from Missouri to South Africa
Explore the most affordable flight options available from Missouri to South Africa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.