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Santo Domingo

$151+ Cheap flights from Harrisburg (MDT) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/20. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — SDQ
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Harrisburg to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$333
(American Airlines)

One-way from

$151
(Delta)

Popular in

December

Cheapest in

October
From Harrisburg to Santo Domingo Las Americas
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One-way flight from Harrisburg to Santo Domingo Las Americas
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Highest demand for flights based on searches. 19% potential increase in price ($172 potential increase over avg. RT price).
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Cheapest flight prices on average. 11% potential price decrease ($75 potential savings vs. average RT price).
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Find flight deals from Harrisburg to Santo Domingo

Cheapest flights from Harrisburg to Santo Domingo
Explore the most affordable flight options available from Harrisburg to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:24 pmMDT - SDQ
2 stops15h 55mAmerican Airlines
Fri 11/146:14 pmSDQ - MDT
2 stops17h 52mAmerican Airlines
Deal found 9/17$333
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:00 amMDT - SDQ
2 stops9h 20mAmerican Airlines
Wed 10/157:00 amSDQ - MDT
2 stops13h 33mAmerican Airlines
Deal found 9/16$408
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/145:00 amMDT - SDQ
2 stops17h 50mAmerican Airlines
Sun 12/217:14 amSDQ - MDT
1 stop7h 03mAmerican Airlines
Deal found 9/16$426
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:15 amMDT - SDQ
2 stops19h 35mUnited Airlines
Fri 11/74:18 pmSDQ - MDT
2 stops18h 48mUnited Airlines
Deal found 9/16$581
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:00 amMDT - SDQ
1 stop7h 41mDelta
Wed 10/152:56 pmSDQ - MDT
1 stop8h 12mDelta
Deal found 9/16$626
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/276:30 amMDT - SDQ
2 stops16h 16mUnited Airlines
Tue 11/46:00 amSDQ - MDT
2 stops14h 15mUnited Airlines
Deal found 9/17$671
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:00 amMDT - SDQ
1 stop7h 41mDelta
Fri 11/143:57 pmSDQ - MDT
1 stop8h 17mDelta
Deal found 9/17$675
This Expedia deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:00 pmMDT - SDQ
1 stop13h 11mFrontier
Sat 1/37:55 pmSDQ - MDT
1 stop24h 10mFrontier
Deal found 9/15$862
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/217:30 amMDT - SDQ
2 stops13h 29mAmerican Airlines
Sat 1/37:13 amSDQ - MDT
1 stop12h 54mAmerican Airlines
Deal found 9/15$1,221
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/146:00 amMDT - SDQ
1 stop7h 42mDelta
Sun 12/213:57 pmSDQ - MDT
1 stop8h 39mDelta
Deal found 9/16$1,255

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Harrisburg to Santo Domingo that are best for you.

Fly from

Harrisburg

Fly to

Santo Domingo

Route

Depart

Return

Price

HarrisburgSanto Domingo

MDT - SDQ

MDTSDQ

Harrisburg

Fri 11/7

7:24 pm-12:19 pm

2 stops15h 55m

Santo Domingo Las Americas

Fri 11/14

6:14 pm-11:06 am

2 stops17h 52m

$333

HarrisburgSanto Domingo

MDT - SDQ

MDTSDQ

Harrisburg

Tue 3/3

5:02 pm-11:35 am

2 stops17h 33m

Santo Domingo Las Americas

Thu 3/5

6:20 pm-10:20 pm

2 stops29h 00m

$406

HarrisburgSanto Domingo

MDT - SDQ

MDTSDQ

Harrisburg

Tue 10/7

6:00 am-3:20 pm

2 stops9h 20m

Santo Domingo Las Americas

Wed 10/15

7:00 am-8:33 pm

2 stops13h 33m

$408

HarrisburgSanto Domingo

MDT - SDQ

MDTSDQ

Harrisburg

Sun 12/14

5:00 am-11:50 pm

2 stops17h 50m

Santo Domingo Las Americas

Sun 12/21

7:14 am-1:17 pm

1 stop7h 03m

$426

HarrisburgSanto Domingo

MDT - SDQ

MDTSDQ

Harrisburg

Tue 3/3

6:00 am-2:15 pm

1 stop7h 15m

Santo Domingo Las Americas

Thu 3/5

3:40 pm-11:40 pm

1 stop9h 00m

$566

HarrisburgSanto Domingo

MDT - SDQ

MDTSDQ

Harrisburg

Fri 10/24

6:15 am-1:50 am

2 stops19h 35m

Santo Domingo Las Americas

Fri 11/7

4:18 pm-10:06 am

2 stops18h 48m

$581

HarrisburgSanto Domingo

MDT - SDQ

MDTSDQ

Harrisburg

Tue 10/28

6:30 am-10:46 pm

2 stops16h 16m

Santo Domingo Las Americas

Wed 11/5

4:18 pm-9:35 am

2 stops18h 17m

$581

HarrisburgSanto Domingo

MDT - SDQ

MDTSDQ

Harrisburg

Tue 10/7

6:00 am-1:41 pm

1 stop7h 41m

Santo Domingo Las Americas

Wed 10/15

2:56 pm-11:08 pm

1 stop8h 12m

$626

HarrisburgSanto Domingo

MDT - SDQ

MDTSDQ

Harrisburg

Mon 10/20

6:00 am-1:41 pm

1 stop7h 41m

$151

HarrisburgSanto Domingo

MDT - SDQ

MDTSDQ

Harrisburg

Tue 10/21

5:38 pm-9:25 am

2 stops15h 47m

$179

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 20 results
1
2

Best time to book a flight from Harrisburg to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Santo Domingo

What is the cheapest month to book a flight from Harrisburg to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Harrisburg to Santo Domingo (average of $362). Flying from Harrisburg to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to SDQ?

Find hourly flight availability from Harrisburg to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

When flying from Harrisburg to Santo Domingo, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated September 17, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Harrisburg to Santo Domingo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Santo Domingo?

    American Airlines can get you from Harrisburg to Santo Domingo in just under 15h 55m. Your travel time can differ by up to . The distance between Harrisburg and Santo Domingo is about 1561 mi.

  • What are the cheapest airlines flying from Harrisburg to Santo Domingo round-trip?

    Flying on American Airlines is currently your cheapest option to Santo Domingo, with prices starting at $399. Another option worth looking into is Delta, starting at $420 round trip. These flights start at 43% lower than the current average price 3 months from now.

  • Can I find deals for flights from Harrisburg to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Santo Domingo.

  • Can I find deals for business class flights from Harrisburg to Santo Domingo?

    Yes. Cheapflights offers flight deals from Harrisburg to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Harrisburg to Santo Domingo (average of $362). Flying from Harrisburg to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Harrisburg to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
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Allentown to Puerto Plata flights
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Philadelphia to Nagua flights
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Top 2 airlines flying from Harrisburg to Santo Domingo

Discover the top 2 airlines that operate flights from Harrisburg to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$399Average$896FlexibilityNo cancel feeOn-time71%
DeltaCheapest$420Average$557FlexibilityNo cancel feeOn-timeN/A

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