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$784+ Cheap flights from Sioux Falls (FSD) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — SCL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Sioux Falls to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$784
(LATAM Airlines)
From Sioux Falls Joe Foss Field to Santiago Arturo Merino Benitez
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Find flight deals from Sioux Falls to Santiago

Cheapest flights from Sioux Falls to Santiago
Explore the most affordable flight options available from Sioux Falls to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/85:05 amFSD - SCL
2 stops31h 25mDelta
Thu 12/115:15 amSCL - FSD
2 stops20h 58mDelta
Deal found 9/9$784
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/35:30 amFSD - SCL
1 stop23h 10mDelta
Thu 11/1311:10 pmSCL - FSD
2 stops16h 40mDelta
Deal found 9/10$788
This Orbitz deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/35:30 amFSD - SCL
1 stop23h 10mLATAM Airlines
Thu 11/1311:10 pmSCL - FSD
1 stop27h 01mLATAM Airlines
Deal found 9/10$813
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/88:00 amFSD - SCL
3 stops21h 50mUnited Airlines
Thu 12/1110:45 pmSCL - FSD
2 stops17h 06mUnited Airlines
Deal found 9/9$838
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/107:00 amFSD - SCL
2 stops23h 00mAmerican Airlines
Fri 10/179:55 pmSCL - FSD
2 stops20h 40mAmerican Airlines
Deal found 9/10$868
This Orbitz deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/105:30 amFSD - SCL
2 stops23h 15mLATAM Airlines
Fri 10/179:40 pmSCL - FSD
1 stop27h 16mLATAM Airlines
Deal found 9/10$899
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/81:09 pmFSD - SCL
1 stop15h 41mAmerican Airlines
Thu 12/1111:15 pmSCL - FSD
1 stop16h 03mAmerican Airlines
Deal found 9/10$944

Cheapflights Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Sioux Falls to Santiago that are best for you.

Fly from

Sioux Falls

Fly to

Santiago

Route

Depart

Return

Price

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Mon 12/8

5:05 am-11:05 am

3 stops27h 00m

Santiago Arturo Merino Benitez

Wed 12/10

4:35 am-11:13 pm

2 stops21h 38m

$784

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Mon 12/8

5:05 am-7:40 am

1 stop23h 35m

Santiago Arturo Merino Benitez

Thu 12/11

8:10 am-11:13 pm

2 stops18h 03m

$784

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Mon 11/3

5:30 am-7:40 am

1 stop23h 10m

Santiago Arturo Merino Benitez

Thu 11/13

5:15 am-11:11 pm

2 stops20h 56m

$784

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Mon 11/3

5:30 am-7:40 am

1 stop23h 10m

Santiago Arturo Merino Benitez

Wed 11/12

12:55 am-11:11 pm

2 stops25h 16m

$784

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from Sioux Falls to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Sioux Falls with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Sioux Falls to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Sioux Falls to Santiago?

    A quick flight from Sioux Falls to Santiago can take about 23h 35m. LATAM Airlines provides one of the quickest options available for as low as $784. Sioux Falls and Santiago are separated by a distance of 5561 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Sioux Falls to Santiago that include hotel bookings?

    Yes. In addition to deals on Sioux Falls to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Sioux Falls to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Sioux Falls to Santiago.

  • Can I find deals for business class flights from Sioux Falls to Santiago?

    Yes. Cheapflights offers flight deals from Sioux Falls to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Sioux Falls to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Sioux Falls to Santiago (average of $752). Flying from Sioux Falls to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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